The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great cha...The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great challenges due to the blood brain barrier(BBB)and limited drug distribution in the AD nidus sites.Thus,in this study,using vinpocetine(VIN)as a model drug,the objective is to explore the feasibility of tackling the above bottleneck via intranasal drug delivery in combination with a brain guider,borneol(BOR),using nanoemulsion(NE)as the carrier.First of all,the NE were prepared and characterized.In vivo behavior of the NE after intranasal administration was investigated.Influence of BOR dose,BOR administration route on drug brain targeting behavior was evaluated,and the influence of BOR addition on drug brain subregion distribution was probed.It was demonstrated that all the NE had comparable size and similar retention behavior after intranasal delivery.Compared to intravenous injection,improved brain targeting effect was observed by intranasal route,and drug targeting index(DTI)of the VIN–NE group was 154.1%,with the nose-to-brain direct transport percentage(DTP)35.1%.Especially,remarkably enhanced brain distribution was achieved after BOR addition in the NE,with the extent depending on BOR dose.VIN brain concentration was the highest in the VIN-1-BOR-NE group at BOR dose of 1 mg/kg,with the DTI reaching 596.1%and the DTP increased to 83.1%.BOR could exert better nose to brain delivery when administrated together with the drug via intranasal route.Notably,BOR can remarkably enhance drug distribution in both hippocampus and cortex,the nidus areas of AD.In conclusion,in combination with intranasal delivery and the intrinsic brain guiding effect of BOR,drug distribution not only in the brain but also in the cortex and hippocampus can be enhanced significantly,providing the perquisite for improved therapeutic efficacy of AD.展开更多
International cooperation is vital for the polar regions.China’s past polar cooperation has tended to focus on intergovernmental and bilateral mechanisms rather than regional cooperation.However,regional and subregio...International cooperation is vital for the polar regions.China’s past polar cooperation has tended to focus on intergovernmental and bilateral mechanisms rather than regional cooperation.However,regional and subregional cooperation is playing an increasing role in the polar regions with the rapid development of geopolitics and global climate change.Involvement in three subregional polar organizations—the Asian Forum for Polar Sciences(AFoPS),the Pacific Arctic Group(PAG),and the China-Nordic Arctic Research Center(CNARC)—in the last two decades reflects China’s improved skills and flexibility in participating in international polar cooperation and represents an exercise in the“win-win”principle under China’s Arctic policy.This paper presents a review of the development of polar subregional cooperation,examines China’s participation in three of subregional organizations and provides feasible suggestions for China’s future engagement with these organizations.展开更多
Impact processes between flexible bodies often lead to local stress concentration and wave propagation of high frequency. Therefore, the modeling of flexible multibody systems involving impact should consider the loca...Impact processes between flexible bodies often lead to local stress concentration and wave propagation of high frequency. Therefore, the modeling of flexible multibody systems involving impact should consider the local plastic deformation and the strict requirements of the spatial discretization. Owing to the nonlinearity of the stiffness matrix, the reduction of the element number is extremely important. For the contact-impact problem, since different regions have different requirements regarding the element size, a new subregion mesh method is proposed to reduce the number of the unnecessary elements. A dynamic model for flexible multibody systems with elastic-plastic contact impact is established based on a floating frame of reference formulation and complete Lagrange incremental nonlinear finite-element method to investigate the effect of the elastic-plastic deformation as well as spatial discretization.Experiments on the impact between two bodies are carried out to validate the correctness of the elastic-plastic model.The proposed formulation is applied to a slider-crank system with elastic-plastic impact.展开更多
The general features of the seasonal suuface heat budget in the tropical western Pacific Ocean,20°S-20°N, western boundary-160°E, were documented by Qu (1995) using a high-resolution generalcirculation ...The general features of the seasonal suuface heat budget in the tropical western Pacific Ocean,20°S-20°N, western boundary-160°E, were documented by Qu (1995) using a high-resolution generalcirculation model (GCM, Semtner & Chervin,1992) ard existing observations.Close inspection of thesmaller areas, with the whole region further partitioned into six parts, showed different mechanisms balancethe seasonal surface heat budget in different parts of the region The results of study on five subregionsare detailed in this article. In the equatorial (3°S - 3°N) aed North Equatorial Countercurrent(3°N-9°N) region, the surface the flux the does not change significantly throughout the year, so the surface heat content is determined largely by vertical motion near the equator and roughly helf due to horizontal and halfdue to vertical circulation in the region of the North Equatorial Countercurrent(NECC). In the othersubregions (9°N-20°N, 20°S -11°S aed 11°S -3°S ), however, in addition to ocean展开更多
In this paper,the solution to the structure consisting of a bead and a board is given as aresult of the application of the subregion function method which was suggested in ref.[1].The same problem is also computed wit...In this paper,the solution to the structure consisting of a bead and a board is given as aresult of the application of the subregion function method which was suggested in ref.[1].The same problem is also computed with finite element method.The comparison betweenthe two results shows that the application of the subregion function in the method of weightedresiduals is practical and effective,especially for solving compound structures.展开更多
The random-value impulse noise(RVIN)detection approach in image denoising,which is dependent on manually defined detection thresholds or local window information,does not have strong generalization performance and can...The random-value impulse noise(RVIN)detection approach in image denoising,which is dependent on manually defined detection thresholds or local window information,does not have strong generalization performance and cannot successfully cope with damaged pictures with high noise levels.The fusion of the K-means clustering approach in the noise detection stage is reviewed in this research,and the internal relationship between the flat region and the detail area of the damaged picture is thoroughly explored to suggest an unique two-stage method for gray image denoising.Based on the concept of pixel clustering and grouping,all pixels in the damaged picture are separated into various groups based on gray distance similarity features,and the best detection threshold of each group is solved to identify the noise.In the noise reduction step,a partition decision filter based on the gray value characteristics of pixels in the flat and detail areas is given.For the noise pixels in flat and detail areas,local consensus index(LCI)weighted filter and edge direction filter are designed respectively to recover the pixels damaged by the RVIN.The experimental results show that the accuracy of the proposed noise detection method is more than 90%,and is superior to most mainstream methods.At the same time,the proposed filtering method not only has good noise reduction and generalization performance for natural images and medical images with medium and high noise but also is superior to other advanced filtering technologies in visual effect and objective quality evaluation.展开更多
基金supported by the Distinguished Professor Project of Liaoning Province.
文摘The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great challenges due to the blood brain barrier(BBB)and limited drug distribution in the AD nidus sites.Thus,in this study,using vinpocetine(VIN)as a model drug,the objective is to explore the feasibility of tackling the above bottleneck via intranasal drug delivery in combination with a brain guider,borneol(BOR),using nanoemulsion(NE)as the carrier.First of all,the NE were prepared and characterized.In vivo behavior of the NE after intranasal administration was investigated.Influence of BOR dose,BOR administration route on drug brain targeting behavior was evaluated,and the influence of BOR addition on drug brain subregion distribution was probed.It was demonstrated that all the NE had comparable size and similar retention behavior after intranasal delivery.Compared to intravenous injection,improved brain targeting effect was observed by intranasal route,and drug targeting index(DTI)of the VIN–NE group was 154.1%,with the nose-to-brain direct transport percentage(DTP)35.1%.Especially,remarkably enhanced brain distribution was achieved after BOR addition in the NE,with the extent depending on BOR dose.VIN brain concentration was the highest in the VIN-1-BOR-NE group at BOR dose of 1 mg/kg,with the DTI reaching 596.1%and the DTP increased to 83.1%.BOR could exert better nose to brain delivery when administrated together with the drug via intranasal route.Notably,BOR can remarkably enhance drug distribution in both hippocampus and cortex,the nidus areas of AD.In conclusion,in combination with intranasal delivery and the intrinsic brain guiding effect of BOR,drug distribution not only in the brain but also in the cortex and hippocampus can be enhanced significantly,providing the perquisite for improved therapeutic efficacy of AD.
文摘International cooperation is vital for the polar regions.China’s past polar cooperation has tended to focus on intergovernmental and bilateral mechanisms rather than regional cooperation.However,regional and subregional cooperation is playing an increasing role in the polar regions with the rapid development of geopolitics and global climate change.Involvement in three subregional polar organizations—the Asian Forum for Polar Sciences(AFoPS),the Pacific Arctic Group(PAG),and the China-Nordic Arctic Research Center(CNARC)—in the last two decades reflects China’s improved skills and flexibility in participating in international polar cooperation and represents an exercise in the“win-win”principle under China’s Arctic policy.This paper presents a review of the development of polar subregional cooperation,examines China’s participation in three of subregional organizations and provides feasible suggestions for China’s future engagement with these organizations.
基金supported by the National Natural Science Foundation of China (Grants 11132007, 11272203)
文摘Impact processes between flexible bodies often lead to local stress concentration and wave propagation of high frequency. Therefore, the modeling of flexible multibody systems involving impact should consider the local plastic deformation and the strict requirements of the spatial discretization. Owing to the nonlinearity of the stiffness matrix, the reduction of the element number is extremely important. For the contact-impact problem, since different regions have different requirements regarding the element size, a new subregion mesh method is proposed to reduce the number of the unnecessary elements. A dynamic model for flexible multibody systems with elastic-plastic contact impact is established based on a floating frame of reference formulation and complete Lagrange incremental nonlinear finite-element method to investigate the effect of the elastic-plastic deformation as well as spatial discretization.Experiments on the impact between two bodies are carried out to validate the correctness of the elastic-plastic model.The proposed formulation is applied to a slider-crank system with elastic-plastic impact.
基金This study was supported by the Australial CSIRO Division of Oceanographythe National Natural Science Foundation of China (No.49176255)
文摘The general features of the seasonal suuface heat budget in the tropical western Pacific Ocean,20°S-20°N, western boundary-160°E, were documented by Qu (1995) using a high-resolution generalcirculation model (GCM, Semtner & Chervin,1992) ard existing observations.Close inspection of thesmaller areas, with the whole region further partitioned into six parts, showed different mechanisms balancethe seasonal surface heat budget in different parts of the region The results of study on five subregionsare detailed in this article. In the equatorial (3°S - 3°N) aed North Equatorial Countercurrent(3°N-9°N) region, the surface the flux the does not change significantly throughout the year, so the surface heat content is determined largely by vertical motion near the equator and roughly helf due to horizontal and halfdue to vertical circulation in the region of the North Equatorial Countercurrent(NECC). In the othersubregions (9°N-20°N, 20°S -11°S aed 11°S -3°S ), however, in addition to ocean
文摘In this paper,the solution to the structure consisting of a bead and a board is given as aresult of the application of the subregion function method which was suggested in ref.[1].The same problem is also computed with finite element method.The comparison betweenthe two results shows that the application of the subregion function in the method of weightedresiduals is practical and effective,especially for solving compound structures.
基金supported by the National Natural Science Foundation of China (30825014,81061120529,30970814,81371488,91132727 and 30830046)the Key Program for Clinical Medicine and Science and Technology,Jiangsu Provincial Clinical Medical Research Center,China (BL2013025)
文摘在迟了生活的消沉(LLD ) 的海马趾的畸形的地区性的特性在以前的研究被表明了。在这研究，我们寻求了检验功能的连接(FC ) 在汇寄的迟了发作的消沉(rLOD ) 的海马趾的分区的模式， LLD 的一种特殊子类型。十四个 rLOD 病人和 18 健康控制象功能的磁性的回声成像在基线并且在 21 月后续扫描的休息状态一样经历了临床、认知的评估。每马头鱼尾的怪兽被划分成三部分，角 ammonis (CA ) ，有牙齿的回转，和 subicular 建筑群，然后六个基于种子的海马趾的分区网络被建立。六个网络的纵的变化直接随着时间的过去在 rLOD 和控制组之间被比较。从基线到后续，在左 CA 的连接给更大的衰落看到双边的以后的 cingulate cortex/precuneus (PCC/PCUN ) ，但是出现的 rLOD 组与正面的外皮(双边的中间的前额的 cortex/anterior cingulate 外皮和增补马达区域) 增加了恰好海马趾的分区网络的连接。进一步的关联词分析表明在在左 CA 和 PCC/PCUN 之间的 FC 的纵的变化断然在标志位形式测试与纵的变化被相关( r = 0.624 ， P = 0.017 )并且位跨度测试( r = 0.545 ， P = 0.044 )在 rLOD 组得分。这些结果可以提供卓见进在 rLOD 病人位于认知机能障碍下面的 neurobiological 机制。
基金This work is supported by the Hainan Provincial Natural Science Foundation of China(621MS019)Major Science and Technology Project of Haikou(Grant:2020-009)+2 种基金Innovative Research Project of Postgraduates in Hainan Province(Qhyb2021-10)National Natural Science Foundation of China(Grant:62062030)Key R&D Project of Hainan province(Grant:ZDYF2021SHFZ243).
文摘The random-value impulse noise(RVIN)detection approach in image denoising,which is dependent on manually defined detection thresholds or local window information,does not have strong generalization performance and cannot successfully cope with damaged pictures with high noise levels.The fusion of the K-means clustering approach in the noise detection stage is reviewed in this research,and the internal relationship between the flat region and the detail area of the damaged picture is thoroughly explored to suggest an unique two-stage method for gray image denoising.Based on the concept of pixel clustering and grouping,all pixels in the damaged picture are separated into various groups based on gray distance similarity features,and the best detection threshold of each group is solved to identify the noise.In the noise reduction step,a partition decision filter based on the gray value characteristics of pixels in the flat and detail areas is given.For the noise pixels in flat and detail areas,local consensus index(LCI)weighted filter and edge direction filter are designed respectively to recover the pixels damaged by the RVIN.The experimental results show that the accuracy of the proposed noise detection method is more than 90%,and is superior to most mainstream methods.At the same time,the proposed filtering method not only has good noise reduction and generalization performance for natural images and medical images with medium and high noise but also is superior to other advanced filtering technologies in visual effect and objective quality evaluation.
