A method for the conversion of α-acetamido-β-substituted phenyl acrylic acid (αtβSPAA)into substituted phenyl lactic acid(SPLA)is described and an improved Clemmensen reduction reagent is used.
By the condensation of tryptamine with appropriate substituted benzalde- hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo- lines(THβCs)were obtained.After dehydrogenation using sulfur,...By the condensation of tryptamine with appropriate substituted benzalde- hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo- lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te- traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro.展开更多
The polymerization of acrylamide (AAM)in H_2O/DMF or in H_2O/CH_3CN mixed solvent initiated with ceric ion (Ce^(4+) )/N-(substituted phenyl)-acetamide systems have been studied. The redox polymerization was revealed b...The polymerization of acrylamide (AAM)in H_2O/DMF or in H_2O/CH_3CN mixed solvent initiated with ceric ion (Ce^(4+) )/N-(substituted phenyl)-acetamide systems have been studied. The redox polymerization was revealed by the low value of overall activation energy (E_α) of AAM polymerization using ceric ion/N-(substituted phenyl) acetamide system as an initiator. The end group of polymer formed was detected by IR spectrum analysis method, it revealed the presence of N-(m-acetoxy-methylphenyl) acetamide (m-AAe) moiety end group in the polymer obtained with ceric ion/m-AAe initiation system.展开更多
Eight new complexes with the formula [PhC_2C(OH)R^2R^2]Co_2(CO)_6 were prepared from phenyl substituted propargylic alcohols and dicobalt octacarbonyl.The reactions of these propargylio alcohol complexes with active m...Eight new complexes with the formula [PhC_2C(OH)R^2R^2]Co_2(CO)_6 were prepared from phenyl substituted propargylic alcohols and dicobalt octacarbonyl.The reactions of these propargylio alcohol complexes with active methylene compounds,2,4-pentanedione or ethyl acetoacetate,in the presnce of an acid,HBF_4(40％)+P_2O_5(in excess)or BF_3·Et_2O,at room temperature in dichlorome- thane were investigated.From the 1-alkyl substituted tertiary propargylic alcohol complexes,three new conjugated ene-yne complexes produced by intramolecular dehydration reaction were isolated in high yields(82—95％).On the other hand,four new alkylated complexes were obtained with satisfactory yields(44—66％)from the secondary propargylic alcohol complexes.The influence of other acids,phosphorus pentoxide and polyphosphoric acid,on both dehydration reaction and alkylated reaction was also studied.展开更多
文摘A method for the conversion of α-acetamido-β-substituted phenyl acrylic acid (αtβSPAA)into substituted phenyl lactic acid(SPLA)is described and an improved Clemmensen reduction reagent is used.
基金Project supported by National Natural Science Foundation of China(No.2870083)
文摘By the condensation of tryptamine with appropriate substituted benzalde- hyde followed by Pictet-Spengler reaction,a series of 1-aryl-tetrahydro-β-carbo- lines(THβCs)were obtained.After dehydrogenation using sulfur,Pd-C or lead te- traacetate(LTA),these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro.
基金The project supported by the National Natural Science Foundation of China
文摘The polymerization of acrylamide (AAM)in H_2O/DMF or in H_2O/CH_3CN mixed solvent initiated with ceric ion (Ce^(4+) )/N-(substituted phenyl)-acetamide systems have been studied. The redox polymerization was revealed by the low value of overall activation energy (E_α) of AAM polymerization using ceric ion/N-(substituted phenyl) acetamide system as an initiator. The end group of polymer formed was detected by IR spectrum analysis method, it revealed the presence of N-(m-acetoxy-methylphenyl) acetamide (m-AAe) moiety end group in the polymer obtained with ceric ion/m-AAe initiation system.
基金Work supported by the National Natural Science Foundation of China.
文摘Eight new complexes with the formula [PhC_2C(OH)R^2R^2]Co_2(CO)_6 were prepared from phenyl substituted propargylic alcohols and dicobalt octacarbonyl.The reactions of these propargylio alcohol complexes with active methylene compounds,2,4-pentanedione or ethyl acetoacetate,in the presnce of an acid,HBF_4(40％)+P_2O_5(in excess)or BF_3·Et_2O,at room temperature in dichlorome- thane were investigated.From the 1-alkyl substituted tertiary propargylic alcohol complexes,three new conjugated ene-yne complexes produced by intramolecular dehydration reaction were isolated in high yields(82—95％).On the other hand,four new alkylated complexes were obtained with satisfactory yields(44—66％)from the secondary propargylic alcohol complexes.The influence of other acids,phosphorus pentoxide and polyphosphoric acid,on both dehydration reaction and alkylated reaction was also studied.
