A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assiste...A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6（5H）-ones for high-throughput screening in medicinal chemistry.展开更多
基金supported by the National Natural Science Foundation of China (21921001,U21A20508,92161125,22075283,and 21827813)the Youth Innovation Promotion Association of Chinese Academy of Sciences (2021300,and 2020303)Fujian Science&Technology Innovation Laboratory for Optoelectronic Information (2020ZZ108)。
基金the Chongqing Research Program of Basic Research and Frontier Technology(Nos.cstc2015jcyj A1328 and cstc2015zdcy-ztzx0191)the Scientific Research Foundation of Chongqing University of Arts and Sciences(Nos.R2013XY01 and R2013XY02)Sichuan Provincial Science Fund for Distinguished Young Scholars(No.2015JQO055)
文摘A series of quinolino[3,4-b]quinoxalin-6（5H）-ones have been synthesized using an Ugi/deprotection/cyclization（UDC） strategy, followed by a nucleophilic aromatic substitution reaction. This facile microwave-assisted method provided good yields and could potentially be used for the construction of a diverse library of quinolino[3,4-b]quinoxalin-6（5H）-ones for high-throughput screening in medicinal chemistry.
