A substitution on an amino acid sequence can be defined as "intolerant" (non-neutral) or "tolerant" (neutral) according to whether or not it detectably alters protein phenotypes (e.g.,
基金supported by the National Natural Science Foundation of China (30870827)
文摘A substitution on an amino acid sequence can be defined as "intolerant" (non-neutral) or "tolerant" (neutral) according to whether or not it detectably alters protein phenotypes (e.g.,