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Electrooxidation of sulfanilamide and its voltammetric determination in pharmaceutical formulation,human urine and serum on glassy carbon electrode 被引量:2
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作者 Bruno R.L.Ferraz Tiago Guimaraes +1 位作者 Demetrius Profeti Luciene P.R.Profeti 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2018年第1期55-59,共5页
For the first time, sulfanilamide(SFD) was determined in otologic solution, human urine and serum by electroanalytical techniques on glassy carbon electrode(GCE). The cyclic voltammetry(CV) experiments showed an irrev... For the first time, sulfanilamide(SFD) was determined in otologic solution, human urine and serum by electroanalytical techniques on glassy carbon electrode(GCE). The cyclic voltammetry(CV) experiments showed an irreversible oxidation peak at t 1.06 V in 0.1 mol/L BRBS(p H ? 2.0) at 50 m V/s. Different voltammetric scan rates(from 10 to 250 m V/s) suggested that the oxidation of SFD on the GCE was a diffusioncontrolled process. Square-wave voltammetry(SWV) method under optimized conditions showed a linear response to SFD from 5.0 to 74.7 μmol/L(R ? 0.999) with detection and quantification limits of 0.92 and3.10 μmol/L, respectively. The developed SWV method showed better results for detection limit and linear range than the chronoamperometry method. It has been successfully applied to determine SFD concentration in pharmaceutical formulation, human urine and serum samples with recovery close to 100%. 展开更多
关键词 SQUARE-WAVE VOLTAMMETRY SULFANILAMIDE GLASSY carbon electrode Biological FLUIDS
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Synthesis of Sulfanilamide Derivatives of BISA
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作者 Xu Hansheng Zhang Lun Liu Xiufang 《Wuhan University Journal of Natural Sciences》 CAS 1997年第4期79-81,共3页
Ebselen was selected as the lead compound and a series of derivatives of benzisoselenazolone was designed and synthesized with pharmacological interest. Under ether water NaHCO 3 reaction system, 2 chloroselenoben... Ebselen was selected as the lead compound and a series of derivatives of benzisoselenazolone was designed and synthesized with pharmacological interest. Under ether water NaHCO 3 reaction system, 2 chloroselenobenzoyl chloride was treated with a series of sulfanilamide and ten Ebselen derivatives with SO 2NHR group attached to the p position of 2 phenyl moiety were prepared in good yields. All these new conpounds were characterized by 1H NMR, IR, UV spectra and elemental analysis. 展开更多
关键词 benzisoselenazolone sulfanilamide derivatives EBSELEN SYNTHESIS
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Synthesis,Crystal Structure and Fluorescent Property of a New Sulfanilamide Schiff-base Compound
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作者 唐云志 温和瑞 +1 位作者 张剑 谭育慧 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第1期69-73,共5页
A new sulfanilamide Schiff-base compound N,N -(p-phenyl sulfanilamide)-5,6-dimethoxy-pyrimidine-(2-hydroxyl benzene) methylidene has been synthesized by the condensation of equimolar salicylaldehyde and 4-(p-amin... A new sulfanilamide Schiff-base compound N,N -(p-phenyl sulfanilamide)-5,6-dimethoxy-pyrimidine-(2-hydroxyl benzene) methylidene has been synthesized by the condensation of equimolar salicylaldehyde and 4-(p-amino phenyl sulfanilamide)-5,6-dimethoxy-pyrimidine in an anhydrous ethanol solution.The compound was characterized by elemental analysis,IR spectra,and single-crystal X-ray diffraction.The crystal belongs to the monoclinic system,space group P21/c with a=19.0425(11),b=11.1914(6),c=9.0075(5),β=93.9650(10)°,Z= 4, V= 1915.01(18) A3,Dc = 1.437 g/cm^3, Mr = 414.43, λ(MoKa) = 0.71073 A,μ= 2.09 mm^-1, F(000) = 864, R = 0.0385 and wR = 0.1224. 展开更多
关键词 Schiff base SULFANILAMIDE crystal structure fluorescent property
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Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy
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作者 Tracy O.Ehiwe Bruce D.Alexander +2 位作者 John C.Mitchell Martin J.Snowden Laura J.Waters 《Journal of Pharmaceutical Analysis》 SCIE CAS 2016年第3期179-183,共5页
This study investigated the development of a novel approach to surface characterization of drug poly- morphism and the extension of the capabilities of this method to perform 'real time' in situ measure- ments. This... This study investigated the development of a novel approach to surface characterization of drug poly- morphism and the extension of the capabilities of this method to perform 'real time' in situ measure- ments. This was achieved using diffuse reflectance visible (DRV) spectroscopy and dye deposition, using the pH sensitive dye, thymol blue (TB). Two polymorphs, SFN-β and SFN-γ, of the drug substance sulfanilamide (SFN) were examined. The interaction of adsorbed dye with polymorphs showed different behavior, and thus reported different DRV spectra. Consideration of the acid/base properties of the morphological forms of the drug molecule provided a rationalization of the mechanism of differential coloration by indicator dyes. The kinetics of the polymorphic transformation of SFN polymorphs was monitored using treatment with TB dye and DRV spectroscopy. The thermally-induced transformation fitted a first-order solid-state kinetic model (R2=0.992), giving a rate constant of 2.43 × 10^- 2 s 1. 展开更多
关键词 Polymorphic transformation SULFANILAMIDE Diffuse reflectance visible spectroscopy Powder X-ray diffraction Differential scanning calorimetry
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Design, Synthesis and Characterization of Novel Sulfonamides Derivatives as Anticancer Agent Targeting EGFR TK, and Development of New Methods of Synthesis by Microwave Irradiation
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作者 Souad Akili Djamila Ben Hadda +2 位作者 Yaser Bitar Amir Balash Mustapha Fawaz Chehna 《International Journal of Organic Chemistry》 CAS 2021年第4期199-223,共25页
Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TM... Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug candidates for treating cancer. Binding free energy was calculated by Molegro virtual docker (MVD) to select the most promising hits. The corresponding docking score values into EGFR (TMLR) of 4b gave the best energy docking -147.213 Kcal/mol. And some of the designed sulfonamide derivatives have been synthesized by conventional method in addition to a microwave-assisted method of synthesis. The reaction of an amino group-containing drug;sulfamethoxazole and sulfanilamide with carbonyl group in benzoyl chloride and phthalic acid in basic media, generated a series of sulfonamide derivatives. The structures of all the synthesized compounds were well characterized by Mass spectrometry (MS), Infrared spectroscopy (IR), <sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">1</span></sup><span style="font-family:Verdana;">H NMR), </span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C nuclear magnetic resonance (</span><sup><span style="font-family:Verdana;">13</span></sup><span style="font-family:Verdana;">C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.</span> 展开更多
关键词 SULFONAMIDE Anticancer EGFR TMLR 5EDQ Molegro Virtual Docker Sul-famethoxazole SULFANILAMIDE Microwave
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Synthesis, Characteristic and Antimicrobial Activity of Some New Spiro[indol-thiazolidon-2,4-diones] and Bis(5-fluorospiro[indoline-3,2’-thiazolidine]-2,4’-dione) Probes
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作者 Abeer N. Al-Romaizan 《International Journal of Organic Chemistry》 2020年第2期77-87,共11页
In a search for new antimicrobial agents, some new spiro[indol-thiazolidon- 2,4-diones] (<strong>6a-c</strong>) were synthesized by condensation of 5-substituted isatins <strong>1 </strong>with... In a search for new antimicrobial agents, some new spiro[indol-thiazolidon- 2,4-diones] (<strong>6a-c</strong>) were synthesized by condensation of 5-substituted isatins <strong>1 </strong>with sulfanilamide in MeOH, followed by aroylation with p-nitrobenzoyl chloride in DMF to get compounds <strong>4a-c</strong>. Cycloaddition of <strong>4a</strong><strong>-c</strong> with thioglycolic acid in a dry non-polar solvent (dioxane) gave the targets <strong>6a-c</strong>. Also, bis(5-fluorospiro[indoline-3,2’-thiazolidine]-2,4’-dione) (<strong>9</strong>) was synthesized by condensation of 5-fluoroindoline-2,3-dione with benzene-1,4-diamine (2:1 by mol) in MeOH, which followed by cycloaddition with thioglycolic acid in dioxane gave compound <strong>8</strong>. Acylation of the later with 2,2,2-trifluoroacetic anhydride in THF has yielded the target <strong>9</strong>. Structures of the products have been deduced from their elemental analysis and spectral data. The <em>in vitro</em> antimicrobial activity of the new systems <strong>6a-c</strong>, and <strong>9</strong> was tested. 展开更多
关键词 SYNTHESIS Spiroindoline-Thiazolidine Mercaptoacetic Acid Antimicrobial 5-Substituted Isatin SULFANILAMIDE
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NitroMAC:An instrument for the measurement of HONO and intercomparison with a long-path absorption photometer
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作者 Charbel Afif Corinne Jambert +6 位作者 Vincent Michoud Aurélie Colomb Gregory Eyglunent Agnès Borbon Véronique Daele Jean-Francois Doussin Pascal Perros 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2016年第2期105-113,共9页
Nitro MAC(French acronym for continuous atmospheric measurements of nitrogenous compounds) is an instrument which has been developed for the semi-continuous measurement of atmospheric nitrous acid(HONO). This inst... Nitro MAC(French acronym for continuous atmospheric measurements of nitrogenous compounds) is an instrument which has been developed for the semi-continuous measurement of atmospheric nitrous acid(HONO). This instrument relies on wet chemical sampling and detection using high performance liquid chromatography(HPLC)-visible absorption at540 nm. Sampling proceeds by dissolution of gaseous HONO in a phosphate buffer solution followed by derivatization with sulfanilamide/N-(1-naphthyl)-ethylenediamine. The performance of this instrument was found to be as follows: a detection limit of around 3 ppt with measurement uncertainty of 10% over an analysis time of 10 min. Intercomparison was made between the instrument and a long-path absorption photometer(LOPAP) during two experiments in different environments. First, air was sampled in a smog chamber with concentrations up to 18 ppb of nitrous acid. Nitro MAC and LOPAP measurements showed very good agreement. Then, in a second experiment, ambient air with HONO concentrations below250 ppt was sampled. While Nitro MAC showed its capability of measuring HONO in moderate and highly polluted environments, the intercomparison results in ambient air highlighted that corrections must be made for minor interferences when low concentrations are measured. 展开更多
关键词 Atmospheric measurements Nitrous acid Sulfanilamide/N-(1-naphthyl)-ethylenediamine Long-path absorption photometer French acronym for continuous atmospheric measurements of nitrogenous compounds(NitroMAC)
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