β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene ...β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene substrate range.In this study,we present a pioneering two-component approach utilizing readily accessible sulfenamides as efficient difunctionalization reagents.Key to its success is the careful selection of a suitable photosensitizer,which enables precise modulation of sulfenamides by promoting unprecedented energy transfer rather than traditional single-electron oxidation.This novel strategy leads to the concurrent formation of N-and S-radical species,ensuring high regioselectivity for both electronneutral and electron-deficient alkenes.As a result,a wide range of valuableβ-amino sulfides,including those with congested amine groups,can be readily synthesized.These findings highlight the potential of this method for the efficient synthesis of diverse functionalizedβ-amino sulfides.展开更多
基金financial support from the National Natural Science Foundation of China(Nos.22171072,21925103,and22301061)。
文摘β-Amino sulfides hold significant biological importance,motivating the development of several methods for sulfenylamination of alkenes.However,these methods often involve a three-component system with limited alkene substrate range.In this study,we present a pioneering two-component approach utilizing readily accessible sulfenamides as efficient difunctionalization reagents.Key to its success is the careful selection of a suitable photosensitizer,which enables precise modulation of sulfenamides by promoting unprecedented energy transfer rather than traditional single-electron oxidation.This novel strategy leads to the concurrent formation of N-and S-radical species,ensuring high regioselectivity for both electronneutral and electron-deficient alkenes.As a result,a wide range of valuableβ-amino sulfides,including those with congested amine groups,can be readily synthesized.These findings highlight the potential of this method for the efficient synthesis of diverse functionalizedβ-amino sulfides.
