Enantioselective extraction of hydrophobic clorprenaline （CPE） enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin （SBE-β-CD） as the selector was investigated with insight into a...Enantioselective extraction of hydrophobic clorprenaline （CPE） enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin （SBE-β-CD） as the selector was investigated with insight into a number of important process variables, such as the type of organic solvent, concentration of selector, pH, and temperature. Equilibrium of the extraction system was modeled using a reactive extraction modcl with a homogeneous aqueous phase reaction. The important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic CPE were determined as 0.3 and 8.93, respectively. The equilibrium constants of the complexation reaction with SBE-β-CD were determined as 152 and 110 L/mol for R- and S-CPE, respectively. Results show that the experimental data agree with the model predictions perfectly. Comprehensively considering the experiment and model, the extraction conditions are optimized and the best extraction conditions are： pH of 6.0, SBE-β-CD concentration of 0.04 tool/L, and temperature of 5 ℃, providing the enantioselectivity （a） of 1.25, the fraction of R-CPE （φR） in aqueous phase of 0.71 and performance factor （pf） of 0.025.展开更多
基金Projects(21176262,21071052) supported by the National Natural Science Foundation of ChinaProject supported by the Aid program for Technology Innovative Research Team in Higher Educational Institutions of Hunan Province,China
文摘Enantioselective extraction of hydrophobic clorprenaline （CPE） enantiomers from organic phase to aqueous phases with sulfobutylether-β-cyclodextrin （SBE-β-CD） as the selector was investigated with insight into a number of important process variables, such as the type of organic solvent, concentration of selector, pH, and temperature. Equilibrium of the extraction system was modeled using a reactive extraction modcl with a homogeneous aqueous phase reaction. The important parameters of this model were determined experimentally. The physical distribution coefficients for molecular and ionic CPE were determined as 0.3 and 8.93, respectively. The equilibrium constants of the complexation reaction with SBE-β-CD were determined as 152 and 110 L/mol for R- and S-CPE, respectively. Results show that the experimental data agree with the model predictions perfectly. Comprehensively considering the experiment and model, the extraction conditions are optimized and the best extraction conditions are： pH of 6.0, SBE-β-CD concentration of 0.04 tool/L, and temperature of 5 ℃, providing the enantioselectivity （a） of 1.25, the fraction of R-CPE （φR） in aqueous phase of 0.71 and performance factor （pf） of 0.025.
