An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-（hydroxymethyl）-...An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-（hydroxymethyl）- 1-（4-sulfobutyl）pyrrolidinium hydrogen sulfate （[HYSBPI]·HSO4） is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines （A-549 and MCF-7）, and the results showed that these compounds had weak-to-good antitumor activities and their IC50 ranged from 0.05 to more than 100 μmol.L-1.展开更多
基金We thank the National Basic Research Program of China （973 Program） （No. 2003CB 114400） and the Na- tional Natural Science Foundation of China （Nos. 20476098 and 20676123） for financial support.
文摘An efficient synthesis of novel coumarin derivatives via a three-component condensation of 4-hydroxycoumarin, aldehydes and aromatic amines catalyzed by sulfonic acid functionalized ionic liquid L-2-（hydroxymethyl）- 1-（4-sulfobutyl）pyrrolidinium hydrogen sulfate （[HYSBPI]·HSO4） is reported. The condensed product was obtained with excellent yields in water under microwave irradiation condition. The antitumor activities of all the synthesized compounds were assessed on two different human cancer cell lines （A-549 and MCF-7）, and the results showed that these compounds had weak-to-good antitumor activities and their IC50 ranged from 0.05 to more than 100 μmol.L-1.
