In view of the isosterism of the sulfonyl (-SO2-) and phosphoryl groups [-P(O)(OR)-,R=H, CH3, C2H5, etc], two new types of ureas, N-(N-aryl-O-alkyl phosphoryl)-N'-(4, 6-dimethoxypyrinddin-2-yl) ureas 2 and N-(N-ar...In view of the isosterism of the sulfonyl (-SO2-) and phosphoryl groups [-P(O)(OR)-,R=H, CH3, C2H5, etc], two new types of ureas, N-(N-aryl-O-alkyl phosphoryl)-N'-(4, 6-dimethoxypyrinddin-2-yl) ureas 2 and N-(N-aryl-N-alkyl phosphoryl)-N'-(4, 6-dimethoxy pyrimidin-2-yl)ureas 3, were synthesized by treating N- (arylandnochlorophosphoryl ) - N'- (4, 6-dimethoxypyriAndinyl-2-) ureas 4 with alcohols or amines. Compounds 4 were obtained by reactingdichlorophosphoryl isocyanate with 4,6 - di meth oxy- 2-aminopyrimidine, and then with aromaticamines. The enzyme tests (in vitro) indicated that compounds 2 and 3 were two novel classes ofacetolactate synthase (ALS) inhibitors, which showed that the phosphoryl group, [-P(O)(OR)-], or[-P(O)(NHR)-], was a good bioisostere of the sulfonyl group (-SO2-) in sulfonylurea.展开更多
Utilizing N-[(4-carboxyphenyl)-sulfonyl]glycine (abbreviated as cbsglyH3),a new cobalt complex [Co(cbsglyH)(bipy)2]3H2O (bipy = 2,2'-bipyridine) has been synthesized under mild conditions and characterized ...Utilizing N-[(4-carboxyphenyl)-sulfonyl]glycine (abbreviated as cbsglyH3),a new cobalt complex [Co(cbsglyH)(bipy)2]3H2O (bipy = 2,2'-bipyridine) has been synthesized under mild conditions and characterized by IR,elemental analysis,thermogravimetric analysis and X-ray diffraction analysis. It crystallizes in the monoclinic system,space group C2/c with a = 34.978(3),b = 12.0437(11),c = 20.0041(19) ,β = 122.2990(10)°,V = 7123.0(11) 3,Z = 8,C29H28CoN5O9S,Mr = 681.55,μ = 0.593 mm-1,Dc = 1.271 Kg/m3,F(000) = 2816,the final R = 0.0434 and wR = 0.1351. The title complex is a monomeric compound which is further assembled by intermolecular hydrogen bonds into a 3-D supramolecular network. Thermogravimetric analysis illustrates that this complex begins decomposing at 100 ℃ and decompounding completely at 560 ℃.展开更多
Several new sulfonates and sulfonamides were synthesized with sulfonyl imidazoles as reagents. These compounds were characterized by ^1H NMR. The melting points of all solids synthesized were obtained on Fisher-Johns ...Several new sulfonates and sulfonamides were synthesized with sulfonyl imidazoles as reagents. These compounds were characterized by ^1H NMR. The melting points of all solids synthesized were obtained on Fisher-Johns Melting Point Apparatus.展开更多
This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to ...This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance;therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results;it was possible to make a structure-activity relationship with the obtained results and a comparison between the results.展开更多
The reductive coupling reactions of aryl sulfonyl chloride induced by (TiCl4-Zn) reagent affords diaryl disulfide. However, reaction of aryl sulfonyl chloride with α,β-unsaturated ester under the same condition affo...The reductive coupling reactions of aryl sulfonyl chloride induced by (TiCl4-Zn) reagent affords diaryl disulfide. However, reaction of aryl sulfonyl chloride with α,β-unsaturated ester under the same condition affords β-arylsulfo ester.展开更多
CCl_3SO_2Br used as a 'telogen' reacts with CH_2=CF_2 to give mainly the 'mono- adduct' CCl_3CH_2CF_2Br, together with very small amouats of CCl_3CF_2CH_2Br, CCl_2BrCH_2CF_2Br and the 'di-adduct...CCl_3SO_2Br used as a 'telogen' reacts with CH_2=CF_2 to give mainly the 'mono- adduct' CCl_3CH_2CF_2Br, together with very small amouats of CCl_3CF_2CH_2Br, CCl_2BrCH_2CF_2Br and the 'di-adduct' CCl_3(CH_2CF_2)_2Br. The result indicates that CCl_3SO_2Br can be used as an addendum in trichloromethyl-bromo-addition reactions to olefins.展开更多
Three new coordination networks based on a versatile and unsymmetric building block 3-(sulfonyl-glycine)benzoic acid (HAL) ligand and inorganic Co(Ⅱ) salt, [Co(HL)(bipy)2]. ClO4·1.5H2O (1), [Co3(L...Three new coordination networks based on a versatile and unsymmetric building block 3-(sulfonyl-glycine)benzoic acid (HAL) ligand and inorganic Co(Ⅱ) salt, [Co(HL)(bipy)2]. ClO4·1.5H2O (1), [Co3(L)2(H2O)6]·4H2O (2) and [Co(HL)(bpp)(H2O)2]·2H2O (3) (bipy = 2,2-bipyridine, bpp = 1,3-bi(4-pyridyl)propane), have been synthesized in aqueous media and structurally characterized by single-crystal X-ray diffraction. Reaction of Co salt with H3L afforded a neutral 1D alternating chain, which shows a 3-D supramolecular network through hydrogen bonds. When the auxiliary 2,2-bipyridine is used, a mononuclear unit is constructed; if using auxiliary ligand bpp, a neutral 1-D uniform chain is obtained and further extended into a 3-D supramolecular structure through versatile hydrogen bonds. The H3L ligand in 1 adopts a bidentate chelating coordination mode while that in 2 and 3 assumes a pentadentate bridging and a bis-monodentate bridging modes, respectively. This work and our previous work evidently demonstrate that the structures vary with altering the second ligands.展开更多
Comprehensive Summary The selective oxidative sulfonylation of alkenes with selenium sulfonate depended on the reaction conditions.The electrochemical C—H sulfonylation proceeded smoothly to afford(E)-vinyl sulfones ...Comprehensive Summary The selective oxidative sulfonylation of alkenes with selenium sulfonate depended on the reaction conditions.The electrochemical C—H sulfonylation proceeded smoothly to afford(E)-vinyl sulfones with good selectivity in an undivided cell without external oxidant.While aerobic trifunctionalization of alkenes occurred in the presence of KI in the air,which providesβ-keto selenosulfones via the formation of C—O,C—S,and C—Se bonds in one-pot.Following control experiments,a plausible mechanism is proposed to rationalize the experimental results.展开更多
Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and electrophiles.However,the inclusion of alkylarenes instead of active carbon pronucleophil...Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and electrophiles.However,the inclusion of alkylarenes instead of active carbon pronucleophiles such as aldehydes and ketones in these addition reactions has been a challenge due to the inherent difficulty of benzylic deprotonation.In this study,we present a novel approach for the construction of N-sulfonyl amines via rhodium-catalyzed addition of unbiased benzylic C–H bonds to cyclic N-sulfonyl ketamines throughπ-coordination.This strategy enables the synthesis of a diverse range of N-sulfonyl amines,and subsequent diversification of the addition products showcases the synthetic potential of this protocol.展开更多
A general and straightforward strategy for the synthesis of thioester-substituted oxindoles via a palladium-catalyzed thiocarbonyla-tive cyclization process has been developed.With sulfonyl chlorides as promising sulf...A general and straightforward strategy for the synthesis of thioester-substituted oxindoles via a palladium-catalyzed thiocarbonyla-tive cyclization process has been developed.With sulfonyl chlorides as promising sulfur source,a wide range of thioester-substituted oxindoles were obtained in moderate to high yields.Both aryl and alkyl sulfonyl chlorides were well tolerated,and Mo(CO)6 played a dual role as both a CO source and a reductant in this approach.展开更多
Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluori...Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluoride(SSF)as a near-perfect Michael acceptor for Cys-specific protein bioconjugation.Compared to maleimides,which are predominantly used,SSF exhibited better chemoselectivity,selfstability,and conjugate stability while maintaining comparable reactivity.Using SSF-derived probes,proteins can be readily modified on the Cys residue(s)to install functionalities,for example,fluorescent dyes,toxins,and oligonucleotides,without influencing the activity.Further applications of SSF-derived serum-stable antibody-drug conjugates and PD-L1 nanobody-oligo conjugates demonstrate the great translational value of SSF-based bioconjugation in drug development and single-cell sequencing.展开更多
N,N’-Disulfonylhydrazines have been proven to be the most reactive precursors of the sulfonyl radicals among all types of sulfonyl substituted hydrazines as early as half a century ago.However,the sulfonyl radicals g...N,N’-Disulfonylhydrazines have been proven to be the most reactive precursors of the sulfonyl radicals among all types of sulfonyl substituted hydrazines as early as half a century ago.However,the sulfonyl radicals generated from these compounds have not been used in organic synthesis except the simple selfdimerization synthesis of disulfones controlled by the"solvent-cage-effects".In this article,N,N’-disulfonylhydrazines were introduced as new sulfonylating reagents and their combinations with NIS were disclosed as new iodosulfonylating reagents of allcynes.Finally,a highly efficient method for the synthesis of(E)-β-iodovinyl arenesulfones was developed by mixing an alkyne,a N,N’-disulfonylhydrazine and NIS in aqueous THF at room temperature for 5 min.展开更多
An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal-and oxidant-fre...An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal-and oxidant-free conditions has been developed.The mild reaction conditions,high reaction efficiency,operational simplicity,short reaction time and remarkable functional-group compatibility make the developed protocol very attractive for the preparation of 2-sulfonyl N-heteroaromatic compounds.展开更多
A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and in...A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular cyclization.This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good yields.This reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.展开更多
The selective synthesis of N^(2)-sulfonyl and N^(2)-H 1,2,3-triazoles via organocatalytic annulation of enaminone/enaminoester with sulfonyl azide has been realized. The unconventional selectivity providing N^(2)-sulf...The selective synthesis of N^(2)-sulfonyl and N^(2)-H 1,2,3-triazoles via organocatalytic annulation of enaminone/enaminoester with sulfonyl azide has been realized. The unconventional selectivity providing N^(2)-sulfoyl 1,2,3-triazoles takes place in pure water, wherein the hydrogen bond effect between water and the intermediate resulting from enamine-azide corporation accounts for the novel reaction selectivity. On the other hand, the reactions conducted in DMSO specifically afford N^(2)-H 1,2,3-triazoles in the absence of such hydrogen bond effect.展开更多
Bis[(perfluoroalkyl)sulfonyl]imides [HN(SO2Rf)2, and Rf represents the perfluorinated alkyl group] supported on MCM-41 were synthesized and characterized by XRD, FTIR, SEM, TGA and N2-adsorption techniques. The su...Bis[(perfluoroalkyl)sulfonyl]imides [HN(SO2Rf)2, and Rf represents the perfluorinated alkyl group] supported on MCM-41 were synthesized and characterized by XRD, FTIR, SEM, TGA and N2-adsorption techniques. The supported catalysts, HN(SO2Rf)2/MCM-41, were used as the catalysts for the tert-butylafion of hydroquinone (HQ) with tert-butyl alcohol (TBA) in the liquid phase. A high yield (52.0%) of 2-tert-butyl hydroquinone (TBHQ) could be obtained in the presence of 5 tool% HN(SO2C4F9)2/MCM-41 under the optimized reaction conditions and the heterogeneous catalyst could be recycled at least 6 times without substantial loss of activity.展开更多
文摘In view of the isosterism of the sulfonyl (-SO2-) and phosphoryl groups [-P(O)(OR)-,R=H, CH3, C2H5, etc], two new types of ureas, N-(N-aryl-O-alkyl phosphoryl)-N'-(4, 6-dimethoxypyrinddin-2-yl) ureas 2 and N-(N-aryl-N-alkyl phosphoryl)-N'-(4, 6-dimethoxy pyrimidin-2-yl)ureas 3, were synthesized by treating N- (arylandnochlorophosphoryl ) - N'- (4, 6-dimethoxypyriAndinyl-2-) ureas 4 with alcohols or amines. Compounds 4 were obtained by reactingdichlorophosphoryl isocyanate with 4,6 - di meth oxy- 2-aminopyrimidine, and then with aromaticamines. The enzyme tests (in vitro) indicated that compounds 2 and 3 were two novel classes ofacetolactate synthase (ALS) inhibitors, which showed that the phosphoryl group, [-P(O)(OR)-], or[-P(O)(NHR)-], was a good bioisostere of the sulfonyl group (-SO2-) in sulfonylurea.
基金supported by the National Natural Science Foundation of China (Nos. 20771054 and 20471026)Henan Tackle Key Problem of Science and Technology (Nos. 072102270030 and 072102270034)
文摘Utilizing N-[(4-carboxyphenyl)-sulfonyl]glycine (abbreviated as cbsglyH3),a new cobalt complex [Co(cbsglyH)(bipy)2]3H2O (bipy = 2,2'-bipyridine) has been synthesized under mild conditions and characterized by IR,elemental analysis,thermogravimetric analysis and X-ray diffraction analysis. It crystallizes in the monoclinic system,space group C2/c with a = 34.978(3),b = 12.0437(11),c = 20.0041(19) ,β = 122.2990(10)°,V = 7123.0(11) 3,Z = 8,C29H28CoN5O9S,Mr = 681.55,μ = 0.593 mm-1,Dc = 1.271 Kg/m3,F(000) = 2816,the final R = 0.0434 and wR = 0.1351. The title complex is a monomeric compound which is further assembled by intermolecular hydrogen bonds into a 3-D supramolecular network. Thermogravimetric analysis illustrates that this complex begins decomposing at 100 ℃ and decompounding completely at 560 ℃.
文摘Several new sulfonates and sulfonamides were synthesized with sulfonyl imidazoles as reagents. These compounds were characterized by ^1H NMR. The melting points of all solids synthesized were obtained on Fisher-Johns Melting Point Apparatus.
文摘This work describes the synthesis of seven new sulfonyl hydrazones, which were proposed from the general structure of acyl hydrazones and 2,4-dinitrosulfonamides. Sulfonyl hydrazones are a class of compounds known to exhibit a wide range of biological activity. In this sense, the study of the pharmacokinetic properties of the bioactive molecules is of extreme importance;therefore, in this article the permeability of these compounds with in vitro PAMPA assay mimetizing the permeability through the gastrointestinal tract as well as lipophilicity through miLogP was investigated. All compounds presented good permeability results;it was possible to make a structure-activity relationship with the obtained results and a comparison between the results.
文摘The reductive coupling reactions of aryl sulfonyl chloride induced by (TiCl4-Zn) reagent affords diaryl disulfide. However, reaction of aryl sulfonyl chloride with α,β-unsaturated ester under the same condition affords β-arylsulfo ester.
文摘CCl_3SO_2Br used as a 'telogen' reacts with CH_2=CF_2 to give mainly the 'mono- adduct' CCl_3CH_2CF_2Br, together with very small amouats of CCl_3CF_2CH_2Br, CCl_2BrCH_2CF_2Br and the 'di-adduct' CCl_3(CH_2CF_2)_2Br. The result indicates that CCl_3SO_2Br can be used as an addendum in trichloromethyl-bromo-addition reactions to olefins.
基金Supported by the National Natural Science Foundation of China (Nos. 20471026, 20771054),the Henan Tackle Key Problem of Science and Technology (Nos. 072102270030 and 072102270034)the Foundation of Education Committee of Henan Province (2006150017 and 2008A150018)
文摘Three new coordination networks based on a versatile and unsymmetric building block 3-(sulfonyl-glycine)benzoic acid (HAL) ligand and inorganic Co(Ⅱ) salt, [Co(HL)(bipy)2]. ClO4·1.5H2O (1), [Co3(L)2(H2O)6]·4H2O (2) and [Co(HL)(bpp)(H2O)2]·2H2O (3) (bipy = 2,2-bipyridine, bpp = 1,3-bi(4-pyridyl)propane), have been synthesized in aqueous media and structurally characterized by single-crystal X-ray diffraction. Reaction of Co salt with H3L afforded a neutral 1D alternating chain, which shows a 3-D supramolecular network through hydrogen bonds. When the auxiliary 2,2-bipyridine is used, a mononuclear unit is constructed; if using auxiliary ligand bpp, a neutral 1-D uniform chain is obtained and further extended into a 3-D supramolecular structure through versatile hydrogen bonds. The H3L ligand in 1 adopts a bidentate chelating coordination mode while that in 2 and 3 assumes a pentadentate bridging and a bis-monodentate bridging modes, respectively. This work and our previous work evidently demonstrate that the structures vary with altering the second ligands.
基金supported by a Start-up Grant from Guangdong Pharmaceutical University(Grant Nos.51361303,51361304)the Youth Talent Support Programme of Guangdong Provincial Association for Science and Technology(SKXRC202303).
文摘Comprehensive Summary The selective oxidative sulfonylation of alkenes with selenium sulfonate depended on the reaction conditions.The electrochemical C—H sulfonylation proceeded smoothly to afford(E)-vinyl sulfones with good selectivity in an undivided cell without external oxidant.While aerobic trifunctionalization of alkenes occurred in the presence of KI in the air,which providesβ-keto selenosulfones via the formation of C—O,C—S,and C—Se bonds in one-pot.Following control experiments,a plausible mechanism is proposed to rationalize the experimental results.
基金the National Natural Science Foundation of China(Nos.22271235,22071198)the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(No.2022SDXHDX0006)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2020R01004)for research support。
文摘Mannich-type reactions are a widely used method for the synthesis of amines due to the readily availability of nucleophiles and electrophiles.However,the inclusion of alkylarenes instead of active carbon pronucleophiles such as aldehydes and ketones in these addition reactions has been a challenge due to the inherent difficulty of benzylic deprotonation.In this study,we present a novel approach for the construction of N-sulfonyl amines via rhodium-catalyzed addition of unbiased benzylic C–H bonds to cyclic N-sulfonyl ketamines throughπ-coordination.This strategy enables the synthesis of a diverse range of N-sulfonyl amines,and subsequent diversification of the addition products showcases the synthetic potential of this protocol.
基金We thank the financial supports from the Natural Science Foundationof Zhejiang Province(LY21B020010).
文摘A general and straightforward strategy for the synthesis of thioester-substituted oxindoles via a palladium-catalyzed thiocarbonyla-tive cyclization process has been developed.With sulfonyl chlorides as promising sulfur source,a wide range of thioester-substituted oxindoles were obtained in moderate to high yields.Both aryl and alkyl sulfonyl chlorides were well tolerated,and Mo(CO)6 played a dual role as both a CO source and a reductant in this approach.
基金Financial support from the National Key R&D Program of China(grant no.2019YFA09006600)the National Natural Science Foundation of China(grant nos.21977048 and 92053111)+2 种基金the Natural Science Foundation of Jiangsu Province(grant no.BK20202004)the Beijing National Laboratory for Molecular Sciences(grant no.BNLMS20200)the Jiangsu Specially-Appointed Professor Plan,and the Program for Innovative Talents and Entrepreneur in Jiangsu is gratefully acknowledged.Q.Z.is the Connie and Bob Lurie Fellow of the Damon Runyon Cancer Research Foundation(DRG-2434-21).
文摘Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluoride(SSF)as a near-perfect Michael acceptor for Cys-specific protein bioconjugation.Compared to maleimides,which are predominantly used,SSF exhibited better chemoselectivity,selfstability,and conjugate stability while maintaining comparable reactivity.Using SSF-derived probes,proteins can be readily modified on the Cys residue(s)to install functionalities,for example,fluorescent dyes,toxins,and oligonucleotides,without influencing the activity.Further applications of SSF-derived serum-stable antibody-drug conjugates and PD-L1 nanobody-oligo conjugates demonstrate the great translational value of SSF-based bioconjugation in drug development and single-cell sequencing.
基金the National Natural Science Foundation of China(Nos.21971138 and 21472107)。
文摘N,N’-Disulfonylhydrazines have been proven to be the most reactive precursors of the sulfonyl radicals among all types of sulfonyl substituted hydrazines as early as half a century ago.However,the sulfonyl radicals generated from these compounds have not been used in organic synthesis except the simple selfdimerization synthesis of disulfones controlled by the"solvent-cage-effects".In this article,N,N’-disulfonylhydrazines were introduced as new sulfonylating reagents and their combinations with NIS were disclosed as new iodosulfonylating reagents of allcynes.Finally,a highly efficient method for the synthesis of(E)-β-iodovinyl arenesulfones was developed by mixing an alkyne,a N,N’-disulfonylhydrazine and NIS in aqueous THF at room temperature for 5 min.
基金financial support from the Hunan Provincial Natural Science Foundation of China (No.2019JJ20008)
文摘An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal-and oxidant-free conditions has been developed.The mild reaction conditions,high reaction efficiency,operational simplicity,short reaction time and remarkable functional-group compatibility make the developed protocol very attractive for the preparation of 2-sulfonyl N-heteroaromatic compounds.
基金financial support from the National Natural Science Foundation of China(No.21761132021)Qin Lan Project from Jiangsu Province for J.Han。
文摘A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed,which proceeds via the sequence of reduction of sulfonyl chloride,sulfonylation,and intramolecular cyclization.This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good yields.This reaction is also suitable for gram-scale synthesis,which provides an efficient and green access to multi-substituted tetrahydrocarbazoles.
基金financially supported by the National Natural Science Foundation of China (No.21861019)Natural Science Foundation of Jiangxi Province (No.20202ACBL203006)。
文摘The selective synthesis of N^(2)-sulfonyl and N^(2)-H 1,2,3-triazoles via organocatalytic annulation of enaminone/enaminoester with sulfonyl azide has been realized. The unconventional selectivity providing N^(2)-sulfoyl 1,2,3-triazoles takes place in pure water, wherein the hydrogen bond effect between water and the intermediate resulting from enamine-azide corporation accounts for the novel reaction selectivity. On the other hand, the reactions conducted in DMSO specifically afford N^(2)-H 1,2,3-triazoles in the absence of such hydrogen bond effect.
文摘Bis[(perfluoroalkyl)sulfonyl]imides [HN(SO2Rf)2, and Rf represents the perfluorinated alkyl group] supported on MCM-41 were synthesized and characterized by XRD, FTIR, SEM, TGA and N2-adsorption techniques. The supported catalysts, HN(SO2Rf)2/MCM-41, were used as the catalysts for the tert-butylafion of hydroquinone (HQ) with tert-butyl alcohol (TBA) in the liquid phase. A high yield (52.0%) of 2-tert-butyl hydroquinone (TBHQ) could be obtained in the presence of 5 tool% HN(SO2C4F9)2/MCM-41 under the optimized reaction conditions and the heterogeneous catalyst could be recycled at least 6 times without substantial loss of activity.