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微滴数字PCR和Super-ARMS检测晚期肺腺癌患者血浆循环肿瘤DNA表皮生长因子受体基因突变的临床价值研究 被引量:15
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作者 曹喆 王静 +11 位作者 秦娜 李琨 吕嘉林 王敬慧 杨新杰 李曦 张卉 张权 龙洪清 舒诚荣 马丽 张树才 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第2期84-90,共7页
背景与目的晚期肺腺癌患者在选择靶向药物时需以肿瘤表皮生长因子受体(epidermal growth factor receptor, EGFR)基因突变类型作为依据,然而晚期肺腺癌肿瘤组织取材较难,有专家共识指出外周血可替代肿瘤组织作为检测标本。本文旨在探讨... 背景与目的晚期肺腺癌患者在选择靶向药物时需以肿瘤表皮生长因子受体(epidermal growth factor receptor, EGFR)基因突变类型作为依据,然而晚期肺腺癌肿瘤组织取材较难,有专家共识指出外周血可替代肿瘤组织作为检测标本。本文旨在探讨微滴数字聚合酶链反应法(droplet digital polymerase chain reaction, ddPCR)和超级扩增阻滞突变系统(super-amplification refractory mutation system, super-ARMS)这两种方法检测晚期肺腺癌患者外周血中血浆循环肿瘤脱氧核糖核酸(circulating tumor DNA, ctDNA)中EGFR基因突变的临床价值。方法收集2016年2月-2019年2月首都医科大学附属北京胸科医院确诊的初治晚期肺腺癌共119例纳入研究,比较ddPCR和Super-ARMS技术检测血浆ctDNA EGFR基因突变的敏感度、特异度。部分EGFR基因经典突变阳性患者接受一线EGFR酪氨酸激酶抑制剂(EGFR tyrosine kinase inhibitors, EGFR-TKI)口服治疗,将患者按检测结果分亚组,组1为ddPCR及Super-ARMS检测EGFR基因突变结果均为阳性,21例。组2为ddPCR及Super-ARMS检测EGFR基因突变结果均为阴性,16例。组3为ddPCR检测结果为阳性而Super-ARMS检测结果为阴性,5例。组4为ddPCR检测结果为阴性而Super-ARMS检测结果阳性,因组4患者个数为0,不纳入统计。以客观缓解率(objective response rate, ORR)及疾病控制率(disease control rate, DCR)评估近期疗效,并用生存分析比较组间无进展生存时间(progression-free survival, PFS)以评估远期疗效。结果 119例晚期肺腺癌组织样本中,共检测到58例(48.7%)EGFR基因突变。ddPCR技术检测与肿瘤组织EGFR基因突变结果的符合率为82.4%(Kappa=0.647, P<0.001),灵敏度为74.1%,特异度为90.2%。而Super-ARMS检测与组织检测的符合度为71.4%,灵敏度仅为58.6%,特异度为83.6%。组3的ORR与DCR值低于组1、2,但组间ORR相比均无统计学意义(P>0.05)。生存分析显示,三组患者PFS比较,差异无统计学意义(χ~2=2.221, P=0.329)。结论 ddPCR作为一种高敏感度及特异度的液体基因检测方法,可以作为检测晚期肺腺癌患者血浆ctDNA EGFR基因突变的一种较为可靠的方法。血浆基因检测结果同样可作为EGFR-TKIs药物对患者的疗效预测的依据。 展开更多
关键词 肺肿瘤 微滴数字聚合酶链反应 表皮生长因子受体 基因突变 循环肿瘤脱氧核糖核酸 突变扩增系统 super-突变扩增系统
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Super-2000 SCADA在配电通信系统中的应用
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作者 杨晓辉 张丽君 蒋伟 《科技广场》 2008年第7期77-78,共2页
本文介绍了SUPER-2000系统在配电系统中的应用,它是在深入剖析了传统SCADA系统存在的缺陷和局限的基础上,采用全新思想、全新技术和全新策略开发完成的。本系统具有完备的SCADA功能,完全满足调度自动化设计技术规范和实用化验收功能技... 本文介绍了SUPER-2000系统在配电系统中的应用,它是在深入剖析了传统SCADA系统存在的缺陷和局限的基础上,采用全新思想、全新技术和全新策略开发完成的。本系统具有完备的SCADA功能,完全满足调度自动化设计技术规范和实用化验收功能技术规范,适应控制无人值守变电所运行的技术要求,配备完整的配电网自动化功能。 展开更多
关键词 super-2000 配电自动化 SCADA系统
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The Effect of SiO_2 Additive on Super-hydrophilic Property of TiO_2-SiO_2 Thin Film by Sol-gel Method 被引量:1
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作者 陈文梅 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2001年第3期30-33,共4页
TiO2-SiO2 thin films have been prepared on slide glass substrates by sol-gel method, and the effect of SiO2 additive on photo-generated hydrophilicity of TiO2 thin film was investigated by measuring the contact angle ... TiO2-SiO2 thin films have been prepared on slide glass substrates by sol-gel method, and the effect of SiO2 additive on photo-generated hydrophilicity of TiO2 thin film was investigated by measuring the contact angle of water, the microstructure, the transmittance, the photocatalytic activity and the specific surface area . The results showed that 10mol% of SiO2 additive was the most effective for decreasing contact angle of water. The SiO2 additive of less than 30mol% has a suppressive effect on the crystal growth of anatase in calcinations, resulting in a large surface area. Consequently, the super-hydrophilicity was improved. 展开更多
关键词 sol-gel TiO2-SiO2 thin films super- hydrophilicity PHOTOCATALYSIS BET
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最大边连通和super-边连通超图的充分条件
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作者 赵静 单而芳 赵加贵 《运筹学学报》 CSCD 北大核心 2021年第1期123-131,共9页
设H是连通超图。若超图H的边连通度等于其最小度,则称H是最大边连通的。若超图H的每个最小边割总是由关联于某个最小度顶点的边集所构成,则称H是super-边连通的。首先给出一致线性超图是最大边连通超图的度序列条件。其次,给出一致线性... 设H是连通超图。若超图H的边连通度等于其最小度,则称H是最大边连通的。若超图H的每个最小边割总是由关联于某个最小度顶点的边集所构成,则称H是super-边连通的。首先给出一致线性超图是最大边连通超图的度序列条件。其次,给出一致线性超图是super-边连通超图的度条件。这些结果分别推广了D ankelmann和Volkmann(1997)以及Hellwig和Volkmann(2005)在图上的相关结论。 展开更多
关键词 超图 边连通度 最大边连通超图 super-边连通 度序列最小度
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森田SUPER-90PLUSX线自动洗相机的使用及故障处理
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作者 孙凯 张增林 《中国航天工业医药》 1999年第B12期84-85,共2页
随着科学技术的发展和改革开放的深入.X线自动冼相机在医院放射科得到广泛使用,不但能为临床医生提供高质量的X线影像,还大幅度减轻了投照技术人员的负担,提高了工作效率。我院放射科自1993年开始使用由ELK公司生产的森田SUPER-帅PL... 随着科学技术的发展和改革开放的深入.X线自动冼相机在医院放射科得到广泛使用,不但能为临床医生提供高质量的X线影像,还大幅度减轻了投照技术人员的负担,提高了工作效率。我院放射科自1993年开始使用由ELK公司生产的森田SUPER-帅PLUSX线自动洗相机,通过有效进行暗室技术质量控制和管理,对洗相机出现的故障进行了分析处理.现总结如下。 展开更多
关键词 森田super-90PLUSX线自动洗相机 故障检修 传感器 X线照片
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的研制及其应用
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作者 程建次 蒙平 +3 位作者 兰庭剑 查忠斌 胡文尧 刘润明 《四川生理科学杂志》 1989年第1期9-10,共2页
生物医学中的各类电信号广泛的用于科研、临床及教学实验等领域申。然而这些信号的采集及显示更多的是用示波器、记录仪完成的。由于器件及性能的原因,它们对波形的存储、再显、重叠显示及分析等不能提供更多的帮助。若能利用计算机快... 生物医学中的各类电信号广泛的用于科研、临床及教学实验等领域申。然而这些信号的采集及显示更多的是用示波器、记录仪完成的。由于器件及性能的原因,它们对波形的存储、再显、重叠显示及分析等不能提供更多的帮助。若能利用计算机快速、存储容量大及计算功能强等特点自动的实现这些功能。 展开更多
关键词 生物医学信号 super-1 处理仪 存储容量 计算功能 多路数据采集 接口卡 信号数据 信号放大 光标测量
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ABSOLUTE CONTINUITIES OF EXIT MEASURES AND TOTAL WEIGHTED OCCUPATION TIME MEASURES FOR SUPER-α-STABLE PROCESSES
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作者 张静 任艳霞 《Acta Mathematica Scientia》 SCIE CSCD 2006年第2期358-370,共13页
Suppose X is a super-α-stable process in R^d, (0 〈 α〈 2), whose branching rate function is dr, and branching mechanism is of the form ψ(z) = z^1+β (0 〈0 〈β ≤1). Let Xγ and Yγ denote the exit measur... Suppose X is a super-α-stable process in R^d, (0 〈 α〈 2), whose branching rate function is dr, and branching mechanism is of the form ψ(z) = z^1+β (0 〈0 〈β ≤1). Let Xγ and Yγ denote the exit measure and the total weighted occupation time measure of X in a bounded smooth domain D, respectively. The absolute continuities of Xγ and Yγ are discussed. 展开更多
关键词 super-α-stable process absolute continuity exit measure total weighted occupation time measure
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子式极小的Super-5连通图
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作者 覃城阜 莫芬梅 《理论数学》 2018年第6期730-736,共7页
如果图G可以经过去边,或者去点,或者收缩子图得到子图H,则称H是G的子式。若G是k-连通图且G中不包含另外一个k-连通图作为子式,则称G是子式极小的k-连通图。M. Krisesell证明了子式极小的hyper-5连通图的顶点数至多是12。本文将这个结论... 如果图G可以经过去边,或者去点,或者收缩子图得到子图H,则称H是G的子式。若G是k-连通图且G中不包含另外一个k-连通图作为子式,则称G是子式极小的k-连通图。M. Krisesell证明了子式极小的hyper-5连通图的顶点数至多是12。本文将这个结论推广到Super-5连通图。 展开更多
关键词 super-5连通图 子式 极小 刻画
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上海林海公路新建工程中Super-19沥青混合料的生产质量控制
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作者 王伟 《中国市政工程》 2012年第5期11-13,108,共3页
介绍了上海林海公路新建工程沥青路面中面层上,采用的Super-19沥青混合料的生产质量控制。它采用Superpave方法成型旋转压实试件,进行混合料设计,确定混合料级配和沥青用量。通过对原材料、拌和工艺、混合料旋转试验和马歇尔试验等进行... 介绍了上海林海公路新建工程沥青路面中面层上,采用的Super-19沥青混合料的生产质量控制。它采用Superpave方法成型旋转压实试件,进行混合料设计,确定混合料级配和沥青用量。通过对原材料、拌和工艺、混合料旋转试验和马歇尔试验等进行过程质量控制,有效地改善了沥青混合料的路用性能,提高了林海公路新建工程路面质量。 展开更多
关键词 super-19沥青混合料 拌和工艺 试验 质量控制
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SUPER-100V型X线机短路故障检修1例
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作者 于金科 盖玉斋 《医疗设备信息》 2003年第11期75-75,共1页
关键词 super-100V型 X线机 短路故障 检修 冷高压保护电路
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无向Kautz图的超级限制边连通性(英文) 被引量:1
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作者 王世英 林上为 《数学研究》 CSCD 2006年第4期335-344,共10页
限制边连通度作为边连通度的推广,是计算机互连网络可靠性的一个重要度量.Superλ-′是比限制边连通度更精确的一个网络可靠性指标.一个图是Superλ-′的,如果它的任一最小限制边割都孤立一条有最小边度的边.本文考虑一类重要的网络模型... 限制边连通度作为边连通度的推广,是计算机互连网络可靠性的一个重要度量.Superλ-′是比限制边连通度更精确的一个网络可靠性指标.一个图是Superλ-′的,如果它的任一最小限制边割都孤立一条有最小边度的边.本文考虑一类重要的网络模型-无向K autz图UK(d,n)的限制边连通度λ,′证明了当d 3,n 2时,λ(′UK(d,n))=4d-4,并进一步指出此时的UK(d,n)是Superλ-′的. 展开更多
关键词 无向Kautz图 限制边连通度 super-λ'
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加氢热化学处理对Super-α2合金中O相形成及形态的影响
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作者 廖波 王天生 +2 位作者 杨柯 肖福仁 李依依 《有色金属》 CAS CSCD 1995年第3期79-85,共7页
利用SEM,XRD,TEM研究了加氢热化学处理条件下Super-a2合会的组织变化规律,探讨了合金中O相的形成以及O相形态、分布、数量与氢含量的关系。结果表明:氢的加入不仅明显地调整和细化组织及形态,同时促进了O相的... 利用SEM,XRD,TEM研究了加氢热化学处理条件下Super-a2合会的组织变化规律,探讨了合金中O相的形成以及O相形态、分布、数量与氢含量的关系。结果表明:氢的加入不仅明显地调整和细化组织及形态,同时促进了O相的形成。研究发现,Super-a2台主中的O相由基体Ba相中析出,二者之间具有特定的位相关系。 展开更多
关键词 super-α_2合金 O相 加氢热化学处理
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电机设计专家系统 Super_ES 总体构造
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作者 董毅 陈贤珍 《湖北工学院学报》 1998年第2期24-27,共4页
针对电机设计的特点,分析了专家系统在电机设计过程中的应用,并且提出了电机设计专家系统Super-ES的总体构建方案.
关键词 专家系统 电机 设计 super-ES
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Computational Fluid Dynamics Approach to the Effect of Mixing and Draft Tube on the Precipitation of Barium Sulfate in a Continuous Stirred Tank
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作者 王正 毛在砂 +1 位作者 杨超 沈湘黔 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第6X期713-722,共10页
The effect of mixing on the precipitation of barium sulfate in a continuous stirred tank is simulated nu- merically with different feeding location, feed concentration, impeller speed and residence time through solvin... The effect of mixing on the precipitation of barium sulfate in a continuous stirred tank is simulated nu- merically with different feeding location, feed concentration, impeller speed and residence time through solving the standard momentum and mass transport equations in combination with the moment equations for crystal population balance. The numerical method was validated with the literature data. The simulation results including the distribu- tion of the local supersaturation ratio distribution in the precipitator, mean crystal size and coefficient of variation under different operating conditions compared well with experimental data in the literature. The effect of the pres- ence of a draft tube on precipitation were also investigated, and it is suggested that the installation of a draft tube increased the mean crystal size, in general agreement with experimental work in the literature. 展开更多
关键词 MIXING PRECIPITATION stirred TANK COMPUTATIONAL fluid dynamics (CFD) numerical simulation super- SAT
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A SUPER SENSITIVITY MINICYCLOTRON MASS SPECTROMETER SPECIALIZED FOR CARBON-14 DATING
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作者 陈茂柏 李德明 +3 位作者 张锡麟 徐森林 陈国生 高文照 《Nuclear Science and Techniques》 SCIE CAS CSCD 1990年第Z1期19-23,共5页
The structure consideration of a minicyclotron as super- sensitivity mass spectrometer for carbon -14 dating being constructed at this Institute is described. Some new design ideas and techniques are presented.
关键词 super- sensitivity minicvclotron MASS SPECTROMETER 14C - dating.
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Neutrino energy spectrum and electron capture of Nuclides^(56))Fe,^(56)Co,^(56)Ni,^(56)Mn,^(56)Cr and^(56)V in stellar interiors
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作者 Jing-Jing Liu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第8期971-978,共8页
Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in... Based on the shell-model Monte Carlo method and random phase approximation theory, the neutrino energy spectrum (NES) and the electron capture (EC) of ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V are investigated in presupemova surroundings. The results show that the EC rates are affected greatly at different densities and temperatures. The rates increase greatly and even exceed six orders of magnitude at lower temperature. On the other hand, the NES is very sensitive to stellar temperature and electron energy. The higher the temperature and the lower the electron energy, the larger the influence on NES is. For example, the maxima of NES in the ground state are 9.02, 160, 80, 24.01, 0.44, 1.42 me c^2 for ^56Fe, ^56Co, ^56Ni, ^56Mn, ^56Cr and ^56V respectively at ρ7 = 10.7, Ye = 0.45 and T9 = 15. Furthermore, the influence on NES due to EC for different nuclei has some otherness because of different Qo-values. For example, the spectrum of ^56Co shows a double bump structure. 展开更多
关键词 physical data and processes neutrinos nuclear reactions -- stars super- novae -- stars evolution
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A new study of neutrino energy loss of nuclides ^(53-60)Cr by electron capture in magnetars
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作者 Jing-Jing Liu 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2013年第8期945-951,共7页
Following the theory of relativity, in the presence of an ultrastrong magnetic field (UMF) and utilizing a nuclear shell model, we carry out an estimation of the neutrino energy loss (NEL) rates of nuclides ^53-60... Following the theory of relativity, in the presence of an ultrastrong magnetic field (UMF) and utilizing a nuclear shell model, we carry out an estimation of the neutrino energy loss (NEL) rates of nuclides ^53-60Cr, which occur by electron capture in magnetars. The results show that the NEL rates greatly increase when a UMF is present, and can even exceed nine orders of magnitude at relatively lower density and temperature (e.g. ρ7 = 5.86, Ye = 0.47, T9 = 7.33) in the range from 1013 G to 1018 G. However, the increase in rates was no more than six orders of magnitude at relatively higher density and temperature (e.g.ρ7 = 4.86 × 10^8, Ye = 0.39, T9 = 14.35). 展开更多
关键词 physical data and processes: neutrinos nuclear reactions - stars: super- novae - stars: evolution
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Eeffect of super early comprehensive rehabilitationon neurodevelopmental prognosis of high-risk infants
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作者 Qian-Jun Yue Xiao-Zhen Wang +6 位作者 Ming-Sheng Tang Jia-Ni Li Zhi-Wei Chen Yu-Qiong Zhang Xiao-Ling Huang Chun-Tao Zhang Su-Ping Li 《Journal of Hainan Medical University》 2019年第3期73-77,共5页
Objective: To observe the effect of super-early comprehensive rehabilitation intervention on neurodevelopmental prognosis of premature high-risk infants;Methods: Premature high-risk infantsmet the inclusion criteria w... Objective: To observe the effect of super-early comprehensive rehabilitation intervention on neurodevelopmental prognosis of premature high-risk infants;Methods: Premature high-risk infantsmet the inclusion criteria were divided into control group (n=30) and treatment group (n=30) according to parental willingness. The control group was given routine treatment, while the treatment group was treated with comprehensive rehabilitationon the basis of the control group. The course of treatment for both groups was 10 d. The changes of body weight, milk consumption, NBNA score, GMFM score and Gesell score were observed. Results:After treatment, the body weight and milk consumption of the treatment group increased significantly compared with those before treatment (P<0.01), which was significantly better than that of the control group (P<0.01);the NBNA score of the treatment group was higher than that of the control group at 40 weeks of gestational age (P<0.05), and the abnormal rate of NBNA was lower than that of the control group (P<0.01). The GMFM scores of A-energy and B-energy areas and the five dimensions of social adaptation, big exercise, fine exercise, language and personal social interaction in the treatment group increased significantly in 1 month, 2 months and 3 months after birth,which were significantly better than those in the control group (P<0.05 or P<0.01). Conclusion: Super-early comprehensive rehabilitation can improve the physical quality of high-risk infants and promote the development of the nervous system, with remarkable effect. 展开更多
关键词 super- early comprehensive rehabilitation PREMATURE HIGH-RISK INFANTS NEURODEVELOPMENT PROGNOSIS
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Super-Edge-Connectivity of G(k,d,s)(s≥k/2)
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作者 YANG Zhaolan HUANG Shihua YANG Rong 《Wuhan University Journal of Natural Sciences》 CAS 2014年第3期189-192,共4页
A graph G is super-edge-connected,for short super-λ,if every minimum edge-cut consists of edges adjacent to a vertex of minimum degree.Alphabet overlap graph G(k,d,s)is undirected,simple graph with vertex set V={v... A graph G is super-edge-connected,for short super-λ,if every minimum edge-cut consists of edges adjacent to a vertex of minimum degree.Alphabet overlap graph G(k,d,s)is undirected,simple graph with vertex set V={v|v=1()kv…v;vi∈{1,2,…,d},i=1,…,k}.Two vertices u=(u1…uk)and v=(v1…vk)are adjacent if and only if us+i=vi or vs+i=ui(i=1,…,k-s).In particular G(k,d,1)is just an undirected de Bruijn graph.In this paper,we show that the diameter of G(k,d,s)is k s,the girth is 3.Finally,we prove that G(k,d,s)(s≥k/2)is super-λ. 展开更多
关键词 alphabet overlap digraph de Bruijn graph alphabet overlap graph diameter girth edge connectivity super-λ
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Testing the distance-duality relation with data from galaxy clusters and type Ia supernovae
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作者 Xiang-Yun Fu Pu-Xun Wu +1 位作者 Hong-Wei Yu Zheng-Xiang Li 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2011年第8期895-901,共7页
We test the distance-duality (DD) relation by combining the angular diameter distance DA provided by two galaxy cluster samples compiled by De Filippis et al. (the elliptical β model) and Bonamente et al. (the s... We test the distance-duality (DD) relation by combining the angular diameter distance DA provided by two galaxy cluster samples compiled by De Filippis et al. (the elliptical β model) and Bonamente et al. (the spherical β model), and the luminosity distance DL from Constitution and Union2 type Ia supernova (SNe Ia) datasets. To obtain DL associated with the observed DA at the same redshift, we smooth the noise of the SNe Ia in a model-independent way, obtain the evolutionary curve of DL and, finally, test the DD relation. We find that the elliptical β model, when compared with the SNe Ia from the Constitution compilation, is only consistent with the DD relation at the 3σ confidence level (CL), while the spherical β model is incompatible with the DD relation at the 3σ CL. For the Union2 compilation, the De Filippis and Bonamente samples are marginally compatible with the validity of the DD relation at the 1σ and 2σ CLs, respectively. 展开更多
关键词 galaxies: distances and redshifts -- galaxies: clusters: general -- super- novae: general
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