The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the ...The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.展开更多
Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based c...Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.展开更多
The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key...The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in control.Through six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.展开更多
This paper presents the preliminary design of poloidal field power supply system of HT-7U super-conducting tokamak. With an emphasis on AC/DC power converter, DC circuit breaker, quench protection, harmonic suppressio...This paper presents the preliminary design of poloidal field power supply system of HT-7U super-conducting tokamak. With an emphasis on AC/DC power converter, DC circuit breaker, quench protection, harmonic suppression and static var. compensation, and AC power system, the design principle and features are introduced, the design scheme and R & D progress are described, the simulation studies and laboratory test are presented too.展开更多
Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-b...Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.展开更多
In this paper, the number-phase quantization scheme of the mesoscopic circuit, which consists of a singlequbit structure with superconducting quantum interference device coupled with a super-conducting resonator, is g...In this paper, the number-phase quantization scheme of the mesoscopic circuit, which consists of a singlequbit structure with superconducting quantum interference device coupled with a super-conducting resonator, is given. By introducing a unitary matrix and by means of spectral decomposition, the Hamiltonian operator of the system is exactly formulated in compact forms in spin-l/2 notation. The eigenvalues and the eigenstates of the system are investigated. It is found that using this system the entangled states can not only be prepared, but also be manipulated by tuning the magnetic flux through the super-conducting loop.展开更多
Transport of electron pairs in super-conducting junction with spatial-temporal noise is investigated. We show that the spatial-temporal noise can produce the current of the electron pairs, which stems from a symmetry ...Transport of electron pairs in super-conducting junction with spatial-temporal noise is investigated. We show that the spatial-temporal noise can produce the current of the electron pairs, which stems from a symmetry breaking of the system induced by the correlation of the spatial-temporal noise with the phase difference. It is found that there is a positive current for the electron pairs, exhibiting a peak with increasing the values of some parameters of the noises. The results provide a theoretical foundation for the further investigation of the super-conducting junction.展开更多
Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,de...Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,descriptive study with a convenient sample size using a structured questionnaire among pregnant women attending the gynecology and obstetrics department at Acıbadem Mehmet Ali Aydinlar Hospital,Istanbul,Türkiye.The Health Belief Model scale was used to assess the intention and reluctance to accept a booster dose of the COVID-19 vaccine.Results:A total of 145 participants,with a mean age of(33.5±4.8)years,and a gestational age of(30.9±7.3)weeks,were enrolled in this study.88.8%Received full doses of the Pfizer-BioNTech vaccination.47.8%Participants suffered from vaccine adverse effects.Health Belief Model demonstrated a significant finding of perceived susceptibility(P<0.001),perceived severity of COVID-19 complications(P<0.001),and perceived benefits regarding a booster COVID-19 vaccination(P<0.001).Conclusions:Most pregnant women who received the COVID-19 immunization express a significant intention to receive a booster dose,regardless of the adverse effects experienced from the previous doses.However,a small percentage of the study sample express hesitancy about receiving the booster dose.展开更多
Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received ...Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Methods:We conducted a retrospective analysis of early COVID-19 monovalent vaccine efficacy(i.e.,within 120 days)against COVID-19 related hospitalizations,intensive care unit(ICU)admissions and deaths in older persons(i.e.,aged≥80 years),by accessing official data of the COVID-19 national integrated surveillance program instituted by the Italian National Institute of Health.Vaccine efficacy was compared(odds ratio;OR)among cohorts receiving the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Results:A consistent decline could be seen in the rate of COVID-19 hospitalizations,ICU admissions and deaths with increasing number of monovalent immunizations.Within 120 days of administration,the first and second vaccine boosters had superior efficacy compared to the primary vaccination cycle,reducing the odds of all endpoints between 62%-71%and 69%-84%,respectively.A modestly superior early efficacy could also be noted for the second versus the first monovalent vaccine booster(ORs of all endpoints further reduced by 18%-48%).Conclusion:Since an increasing number of immunizations is associated with a lower risk of unfavourable COVID-19 outcomes,vaccine boosters may be useful for limiting the clinical burden of this infectious disease in elderly populations.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.12005239).
文摘The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.
文摘Objective:To elucidate the relationship among knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status among women with infertility.Methods:This questionnaire-based cross-sectional study was performed online and offline among women with infertility who visited an infertility clinic in Jakarta,Indonesia.We assessed the patient’s knowledge,attitudes,and practices regarding Covid-19 and their relationship with booster vaccination status and sociodemographic profile.Results:A total of 178 subjects participated in this study,and most participants(92.6%)had received booster Covid-19 vaccines.From the questionnaire,74.2%had good knowledge,and 99.4%had good attitudes regarding Covid-19;however,only 57.9%of patients had good practices.A weak positive correlation existed between knowledge and attitudes(r=0.11,P=0.13)and a moderate negative correlation between attitudes and practices(r=-0.44,P=0.56).Participants’knowledge about vaccines and infertility was correlated with booster vaccination status(P=0.04).Academic background(P=0.01)and attitudes(P=0.01)were also correlated with booster vaccination status.The significant determinants of hesitance of receiving Covid-19 booster vaccines were high school education or below(OR=0.08,95%CI 0.02-0.36)and poor practices(OR=0.21,95%CI 0.05-0.95).Conclusions:The majority of the participants had received the Covid-19 booster vaccine and had good knowledge and attitudes but poor practices regarding Covid-19.Most participants had poor knowledge about the relationship between infertility and the Covid-19 vaccine.The general population should be more informed and reminded about practices to prevent Covid-19 and the relationship between vaccination and fertility to increase the number of people who receive Covid-19 booster vaccines.
文摘The role of the rocket attitude control system is to execute the required maneuvers for guidance and ensure the stability of the rocket's flight attitude. Attitude control technology has always been one of the key technologies for ensuring the success of rocket flights and has been a core topic in carrier rocket technology research. The Gravity-1 solid carrier rocket is the first solid rocket bundled rocket developed by China, adopting a configuration with four boosters and a core stage bundled together. During the actual flight process, the four booster engines are ignited first, and then, in the event of insufficient control force from the boosters, the core stage engine is ignited to participate in control. To address thrust asynchrony during the descent of the four boosters, an Extended State Observer(ESO) is employed in the control scheme for this flight segment. This involves real-time estimation and compensation of attitude parameters during flight, identification of thrust asynchrony among the boosters, and simultaneous determination of whether the core stage engine is ignited to participate in control.Through six degrees of freedom simulation analysis and Y1 flight test validation, this method has been proven to be correct and feasible.
文摘This paper presents the preliminary design of poloidal field power supply system of HT-7U super-conducting tokamak. With an emphasis on AC/DC power converter, DC circuit breaker, quench protection, harmonic suppression and static var. compensation, and AC power system, the design principle and features are introduced, the design scheme and R & D progress are described, the simulation studies and laboratory test are presented too.
基金supported by the Science Fund of the Republic of Serbia,#Grant No:7748088。
文摘Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.
基金The project supported by National Natural Science Foundation of China under Grant No.10574060the Natural Science Foundation of Shandong Province under Grant No.Y2004A09
文摘In this paper, the number-phase quantization scheme of the mesoscopic circuit, which consists of a singlequbit structure with superconducting quantum interference device coupled with a super-conducting resonator, is given. By introducing a unitary matrix and by means of spectral decomposition, the Hamiltonian operator of the system is exactly formulated in compact forms in spin-l/2 notation. The eigenvalues and the eigenstates of the system are investigated. It is found that using this system the entangled states can not only be prepared, but also be manipulated by tuning the magnetic flux through the super-conducting loop.
基金The project supported by National Natural Science Foundation of China under Grant No. 10375009, SRF for R0CS, SEM, and by K.C. Wong Magna Fund in Ningbo University of China
文摘Transport of electron pairs in super-conducting junction with spatial-temporal noise is investigated. We show that the spatial-temporal noise can produce the current of the electron pairs, which stems from a symmetry breaking of the system induced by the correlation of the spatial-temporal noise with the phase difference. It is found that there is a positive current for the electron pairs, exhibiting a peak with increasing the values of some parameters of the noises. The results provide a theoretical foundation for the further investigation of the super-conducting junction.
文摘Objective:To examine the pattern of COVID-19 infection and vaccination,and to explore pregnant women’s willingness and reluctance to accept a booster dose of the COVID-19 vaccine.Methods:This was a cross-sectional,descriptive study with a convenient sample size using a structured questionnaire among pregnant women attending the gynecology and obstetrics department at Acıbadem Mehmet Ali Aydinlar Hospital,Istanbul,Türkiye.The Health Belief Model scale was used to assess the intention and reluctance to accept a booster dose of the COVID-19 vaccine.Results:A total of 145 participants,with a mean age of(33.5±4.8)years,and a gestational age of(30.9±7.3)weeks,were enrolled in this study.88.8%Received full doses of the Pfizer-BioNTech vaccination.47.8%Participants suffered from vaccine adverse effects.Health Belief Model demonstrated a significant finding of perceived susceptibility(P<0.001),perceived severity of COVID-19 complications(P<0.001),and perceived benefits regarding a booster COVID-19 vaccination(P<0.001).Conclusions:Most pregnant women who received the COVID-19 immunization express a significant intention to receive a booster dose,regardless of the adverse effects experienced from the previous doses.However,a small percentage of the study sample express hesitancy about receiving the booster dose.
文摘Background:We analysed data garnered during the ongoing Italian nationwide coronavirus disease 2019(COVID-19)vaccination campaign for comparing early COVID-19 monovalent vaccine efficacy in older persons who received the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Methods:We conducted a retrospective analysis of early COVID-19 monovalent vaccine efficacy(i.e.,within 120 days)against COVID-19 related hospitalizations,intensive care unit(ICU)admissions and deaths in older persons(i.e.,aged≥80 years),by accessing official data of the COVID-19 national integrated surveillance program instituted by the Italian National Institute of Health.Vaccine efficacy was compared(odds ratio;OR)among cohorts receiving the primary vaccination cycle,the first vaccine booster,and the second vaccine booster.Results:A consistent decline could be seen in the rate of COVID-19 hospitalizations,ICU admissions and deaths with increasing number of monovalent immunizations.Within 120 days of administration,the first and second vaccine boosters had superior efficacy compared to the primary vaccination cycle,reducing the odds of all endpoints between 62%-71%and 69%-84%,respectively.A modestly superior early efficacy could also be noted for the second versus the first monovalent vaccine booster(ORs of all endpoints further reduced by 18%-48%).Conclusion:Since an increasing number of immunizations is associated with a lower risk of unfavourable COVID-19 outcomes,vaccine boosters may be useful for limiting the clinical burden of this infectious disease in elderly populations.