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人类卵母细胞及植入前胚胎中母性效应基因Mater mRNA的表达 被引量:2
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作者 张莹 刘平 +3 位作者 张秋芳 黄锦 乔杰 张小为 《现代妇产科进展》 CSCD 北大核心 2009年第5期321-325,共5页
目的:了解母性效应基因Mater表达与人类卵母细胞及早期胚胎发育不同阶段的关系。方法:用巢式逆转录多聚酶链式反应(single cell nested RT-PCR)方法检测人类卵子和植入前各阶段胚胎的母性效应基因Mater mRNA的表达。结果:Mater在人类卵... 目的:了解母性效应基因Mater表达与人类卵母细胞及早期胚胎发育不同阶段的关系。方法:用巢式逆转录多聚酶链式反应(single cell nested RT-PCR)方法检测人类卵子和植入前各阶段胚胎的母性效应基因Mater mRNA的表达。结果:Mater在人类卵母细胞GV、MⅠ、MⅡ都有表达,植入前胚胎1、2、4、6细胞期表达量逐渐下降,到8细胞期、囊胚、孵出囊胚期均未检测到Mater mRNA表达。结论:人类卵母细胞和植入前胚胎Mater基因的表达量随发育时间的改变而变化,对卵子生长和胚胎发育有重要意义,与母性效应基因在小鼠等其他哺乳动物中的表达模式相似。 展开更多
关键词 母性效应基因 mater 卵母细胞 胚胎 植入前 巢式RT-PCR
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小鼠Mater基因选择性剪接变异体的鉴定和分析
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作者 程慧 张晓娟 +3 位作者 刘海波 张毅 黄朝峰 马润林 《Acta Genetica Sinica》 SCIE CAS CSCD 北大核心 2004年第8期795-800,共6页
位于小鼠第 7号常染色体的Mater (Maternalantigenthatembryosrequire)编码一个卵母细胞特异的自身抗原 ,与小鼠自免疫性卵巢退化疾病密切相关。在发现Mater基因存在选择性前切现象的基础上 ,通过RT PCR技术 ,在 3个近交品系小鼠 (CBA/J... 位于小鼠第 7号常染色体的Mater (Maternalantigenthatembryosrequire)编码一个卵母细胞特异的自身抗原 ,与小鼠自免疫性卵巢退化疾病密切相关。在发现Mater基因存在选择性前切现象的基础上 ,通过RT PCR技术 ,在 3个近交品系小鼠 (CBA/J、SWR/J、B6 )中发现并初步验证了Mater基因mRNA的 4种选择性剪接变异体 ,分别命名为B、E、F、G型。其中B型与以前报道的一致 ,具有MatermRNA的全部外显子 ,E、F、G为新发现的剪接变异体 ,其选择性剪接位点都位于阅读框内。E变异体缺失了外显子 6 ,F变异体保留了部分内含子 8并且缺失了外显子 10 ,G变异体缺失了部分外显子 14 ,它们所有的内含子与外显子结合处的DNA序列都遵循“GT AG”剪接规则。B、E、F在B6、CBA/J和SWR/J小鼠品系中均存在 ,G仅存在于SWR/J。根据新发现的 3种剪接变异体的cDNA序列推导出对应的预期蛋白异形体的氨基酸序列 。 展开更多
关键词 自免疫性卵巢退化 mater RT-PCR 选择性剪接
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Efficacy of Spinal Pia Mater Incision and Laminoplasty Combined with Internal Fixation for Old Spinal Cord Injury 被引量:4
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作者 Gen-long Jiao Zhi-zhong Li +2 位作者 Ming Tan Yong-qin Pan Zhi-gang Zhou 《Chinese Medical Sciences Journal》 CAS CSCD 2012年第3期134-140,共7页
Objective To evaluate the clinical efficacy of incising spinal pia mater to relieve pressure and unilateral open-door laminoplasty with internal screw fixation for treatment of the dated spinal cord injury. Methods Fr... Objective To evaluate the clinical efficacy of incising spinal pia mater to relieve pressure and unilateral open-door laminoplasty with internal screw fixation for treatment of the dated spinal cord injury. Methods From March, 2009 to July, 2010, 16 cases with chronic cervical cord injury underwent spinal dura mater incision and unilateral open-door laminoplasty with internal screw fixation. Nerve functions of preand postoperation were evaluated by Frankel classification and the Japanese Orthopaedic Association (JOA) scale. The improvement rate of JOA score at the indicated time was recorded. Results Postoperative Frankel classification rating of 16 patients improved obviously. JOA scores at the 1st month, 3rd month, 6th month, and 12th month after surgery were 7.9±2.3, 8.5±1.6, 8.9±2.1, and 12.4±2.5, respectively, and significantly increased compared with that prior to surgery (5.5±0.6). At the end of follow-up period, JOA score was significantly higher than that of pre-treatment (P<0.05). The recovery was relatively rapid during the first 3 months following the surgery, then entered a platform period. Conclusion It is effective for patients with dated spinal cord injury to undergo spinal decompression and laminoplasty. 展开更多
关键词 spinal pia mater DECOMPRESSION LAMINOPLASTY old spinal cord injury
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Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain 被引量:1
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作者 Ho-Sung Lee Dai-In Kang +5 位作者 Seung Zhoo Yoon Yeon Hee Ryu Inhyung Lee Hoon-Gi Kim Byung-Cheon Lee Ki Bog Lee 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第7期1101-1106,共6页
With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained t... With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-weekold rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix. 展开更多
关键词 nerve regeneration dura mater chromium-hematoxylin staining fascia primo vascular system brain hormone neural regeneration
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Dura Mater: Anatomy and Clinical Implication
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作者 Mehmet Ünal Ahmet Burak Sezgin 《Journal of Behavioral and Brain Science》 2021年第10期239-247,共9页
The dura mater is of similar embryological origin to the fascial organ. It contains several fibroblasts which make the dura mater a flexible structure. Dura mater is the outermost of the three layers of meninges, a th... The dura mater is of similar embryological origin to the fascial organ. It contains several fibroblasts which make the dura mater a flexible structure. Dura mater is the outermost of the three layers of meninges, a thick and rigid inelastic membrane that covers the brain and spinal cord and that is impermeable to the cerebrospinal fluid. The cranial dura mater in certain respects differs anatomically from the dura material in the spinal cord, and it is important to classify them separately. This article reviews the anatomical structure of spinal and cranial dura mater and its anatomy with muscle, fascia, bone structure and ligaments. Dura mater is a structure in the body that is connected with systemic functions. 展开更多
关键词 Dura mater OSTEOPATHY PHYSIOTHERAPY
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Viscosity Dependence of Solid-State CD Peaks of Chiral Schiff Base Ni(ll) and Cu(ll) Complexes in PMMA Soft Mater Matrices
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作者 Yu Okamoto Takashiro Akitsu 《Journal of Chemistry and Chemical Engineering》 2013年第6期487-494,共8页
Two new chiral Schiff base acacen-derivative nickel(II) and copper(II) complexes have been prepared and characterized with IR, electronic, and CD spectra and X-ray crystallography. So-called artifact peaks of soli... Two new chiral Schiff base acacen-derivative nickel(II) and copper(II) complexes have been prepared and characterized with IR, electronic, and CD spectra and X-ray crystallography. So-called artifact peaks of solid-state CD spectra due to restricted to rotate freely of molecules appeared at about 334 and 460 nm for nickel(II) and copper(II) complexes. Changes of intensity of the peaks have been investigated in different matrices such as solid-state (microcrystals or KBr pellets), PMMA cast films and acetone solutions of various concentrations and pure acetone solutions. Although restricted orientation of molecules in rigid matrices leads to increase the peak intensity toward negative and positive optical rotation for nickel(II) and copper(II) complexes, respectively, the degree of increasing intensity depends on not concentration but viscosity of polymer solutions. Therefore, the artifact CD peaks of solid-state can act as an indicator of environmental viscosity of soft mater matrices. 展开更多
关键词 CHIRALITY solid-state circular dichroism soft mater Schiffbase nickel(II) copper(II).
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华南师范大学大学李伟善Adv.Mater.:从前驱体形貌转化浅淡金属基多级多孔结构的合成及应用
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《储能科学与技术》 CAS CSCD 2017年第4期654-654,674,695,700,775,781,798,805,共8页
1引言 多级多孔结构材料因其具有如下特点被广泛地应用于能源存储与转换领域:(1)可有效地避免纳米颗粒间的团聚,降低材料界面的界面张力;(2)相较于大颗粒团聚体可提供更多的反应活性位点,减少离子的迁移距离;(3)有利于电解液的... 1引言 多级多孔结构材料因其具有如下特点被广泛地应用于能源存储与转换领域:(1)可有效地避免纳米颗粒间的团聚,降低材料界面的界面张力;(2)相较于大颗粒团聚体可提供更多的反应活性位点,减少离子的迁移距离;(3)有利于电解液的浸润,提供更多的体积膨胀缓冲空间;(4)加强光散色。 展开更多
关键词 Adv.mater 金属基 多孔材料 次级颗粒 多孔结构材料 华南师范大学 材料界面 活性位点 迁移距离 团聚体
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MAGNETOSTRICTIVE MATERIAL RESEARCH
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《China Rare Earth Information》 1992年第1期3-4,共2页
Rare earth-containing magneto-strictive material has caught theworld attention in recent yearsbecause of its amazing performan-ces:high magnetostrictive ratio,rapid response to mechanical be-havior,high rate of energy... Rare earth-containing magneto-strictive material has caught theworld attention in recent yearsbecause of its amazing performan-ces:high magnetostrictive ratio,rapid response to mechanical be-havior,high rate of energy tran-sformation,etc.,which are vitalto sonar transducers,performersand brakes which,in turn,play 展开更多
关键词 SONAR AMAZING transducers MAGNETO CATCH mater
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Mater Painter undo Qamba
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《China's Tibet》 1995年第4期29-29,共1页
MaterPainterundoQambaLENBENCERINGandERMAOAndoQambawasbornin1925intothefamilyofafarmerandlivestockbreederinJi... MaterPainterundoQambaLENBENCERINGandERMAOAndoQambawasbornin1925intothefamilyofafarmerandlivestockbreederinJianzhaCounty,Qingh... 展开更多
关键词 PAINTER mater Painter undo Qamba
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儿童和青少年的超重与行为问题是否有关:来自Mater大学有关妊娠及其转归研究的结果
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作者 Lawlor D.A. Mamun A.A. +1 位作者 O'Callaghan M.J. 郭战宏 《世界核心医学期刊文摘(儿科学分册)》 2005年第10期22-23,共2页
Aims: To examine the associations between being overweight and behavioural pro blems at ages 5 and 14. Methods: Birth cohort study of 2875 individuals who were born in Brisbane between 1981 and 1984 and who were follo... Aims: To examine the associations between being overweight and behavioural pro blems at ages 5 and 14. Methods: Birth cohort study of 2875 individuals who were born in Brisbane between 1981 and 1984 and who were followed up at ages 5 and 1 4 years. Behavioural problems were defined as scoring above the 90th centile on Achenbach’s child behavioural checklist. Results: In cross-sectional analyses there was no association between being overweight and behavioural problems in ei ther females at age 5. At age 14 females who were overweight were more likely th an those who were normal weight to experience behavioural problems. However, the re was no association between being overweight and behavioural problems at age 1 4 among males. The prevalence of behavioural problems increased linearly across the di stribution of body mass index in females at age 14. In prospective analyses, amo ng participants who had no behavioural problems at age 5, there was no associati on between being overweight at age 5 and behavioural problems at age 14 in eithe r sex. Females who were overweight at age 5 and normal weight at age 14 had redu ced odds of behavioural problems at age 14. Conclusions: Among adolescent female s there is a positive linear association between body size and behavioural probl ems. However, no such association was found in adolescent males, or in either se x at age 5 years, and in prospective analyses being overweight at age 5 was not associated with behavioural problems in either sex at age 14. 展开更多
关键词 mater 正常体重者 儿童行为量表 布里斯班 队列研究 中体型 线性分布
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耳内镜下鼓膜修补术后穿孔再修补的疗效分析
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作者 王干 陈志凌 《中国内镜杂志》 2024年第5期69-74,共6页
目的 探讨人工硬脑膜和表皮生长因子在耳内镜下鼓膜修补术后鼓膜穿孔再修补中的临床疗效。方法 选择该院耳内镜下鼓膜修补术后复查时仍有鼓膜穿孔未愈合的患者58例,随机分为A组和B组,各29例。A组采用明胶海绵修补鼓膜穿孔,B组采用人工... 目的 探讨人工硬脑膜和表皮生长因子在耳内镜下鼓膜修补术后鼓膜穿孔再修补中的临床疗效。方法 选择该院耳内镜下鼓膜修补术后复查时仍有鼓膜穿孔未愈合的患者58例,随机分为A组和B组,各29例。A组采用明胶海绵修补鼓膜穿孔,B组采用人工硬脑膜和表皮生长因子修补鼓膜穿孔,每个月复查鼓膜愈合情况,3个月后复查纯间测听。结果 A组修补成功率为34.48%(10/29),B组修补成功率为75.86%(22/29),两组患者比较,差异有统计学意义(P <0.05);A组气骨导差改善(7.32±2.68) dB HL,B组气骨导差改善(21.77±4.65)dB HL,两组患者比较,差异有统计学意义(P <0.05)。结论 人工硬脑膜是合适的鼓膜再生支架,表皮生长因子可促进鼓膜穿孔愈合,两者结合使用是鼓膜再修补的一种可行的治疗方案。 展开更多
关键词 鼓膜修补术后 鼓膜穿孔 耳内镜 再修补 人工硬脑膜 表皮生长因子
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硬脑膜修复生物膜的大鼠原位脑植入局部神经毒性评价方法
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作者 邵安良 王小蕾 +2 位作者 张勇杰 陈亮 李静莉 《北京生物医学工程》 2024年第5期458-463,共6页
目的采用大鼠原位脑植入模型评价硬脑膜修复生物膜的局部神经毒性,旨在建立脑部原位植入局部神经毒性评价方法。方法选择硬脑膜修复生物膜为研究对象,以上市同类产品为对照品,经大鼠原位脑植入,获取包含颅骨、硬脑膜、植入材料及其周围... 目的采用大鼠原位脑植入模型评价硬脑膜修复生物膜的局部神经毒性,旨在建立脑部原位植入局部神经毒性评价方法。方法选择硬脑膜修复生物膜为研究对象,以上市同类产品为对照品,经大鼠原位脑植入,获取包含颅骨、硬脑膜、植入材料及其周围大脑组织的标本。采用苏木精-伊红(hematoxylin-eosin,HE)染色、Fluoro-Jade C(FJC)特殊染色与胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)免疫荧光考察植入物周围脑组织的局部组织学反应、神经元降解退行性变与星形胶质细胞增生来综合评价植入物的潜在神经毒性风险。结果植入4周、13周、26周后,与对照品相比,供试品的局部组织学反应均为无刺激反应;FJC染色单位面积阳性细胞数量不存在显著性差异(P>0.05),提示供试品的神经元降解程度与对照组相比不存在显著性差异;GFAP染色单位面积阳性细胞数量不存在显著性差异(P>0.05),提示供试品的星形胶质细胞增生程度与对照组相比不存在显著性差异。结论可以采用HE染色、FJC特殊染色与GFAP免疫荧光染色联合评价硬脑膜修复生物膜经大鼠原位脑植入后的局部神经毒性。 展开更多
关键词 硬脑膜修复生物膜 大鼠原位脑植入 局部神经毒性 苏木精-伊红染色 Fluoro-Jade C特殊染色 胶质纤维酸性蛋白免疫荧光染色
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EFFECTS OF ELECTRO ACUPUNCTURE AND TWIRLING REINFORCING-REDUCING MANIPULATIONS ON VOLUME OF MICROCIRCULATORY BLOOD FLOW IN CEREBRAL PIA MATER
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作者 史仁华 姬广臣 +2 位作者 赵鲁鸣 王世军 董军 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 1998年第3期220-224,共5页
Effects of electroacupuncture (EA) and routine acupuncture with twirling reinforcing and reducing manipulation of the needle (RA) both at Zusanli point (St 36) on volume of microcirculatory blood flow in the cerebral ... Effects of electroacupuncture (EA) and routine acupuncture with twirling reinforcing and reducing manipulation of the needle (RA) both at Zusanli point (St 36) on volume of microcirculatory blood flow in the cerebral pia mater were observed by fenestration of the cranial bone and laser Doppler microcirculatory blood flow analyser. Results showed that both RA and EA could increase the volume of microcirculatory blood flow in the cerebral pia mater; and that the increase in the EA group was superior to that in RA group. This suggests that a moderate and effective stimulation is a key to the production of a regulative effect on the organism. 展开更多
关键词 ELECTROACUPUNCTURE Acupuncture Therapy Animals Blood Flow Velocity Comparative Study Female Male MICROCIRCULATION Pia mater RABBITS Research Support Non-U.S. Gov't
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9个中国选育油橄榄品种母系来源多样性研究
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作者 马宏博 王桢莹 +2 位作者 赵海云 张建国 曾艳飞 《西北植物学报》 CAS CSCD 北大核心 2024年第11期1760-1768,共9页
【目的】比较中国选育油橄榄品种与地中海油橄榄叶绿体基因组的多样性和亲缘关系,评估中国选育品种母系来源多样性,为中国油橄榄种质开发提供依据。【方法】基于本研究所测的9个中国选育油橄榄品种、7个伊朗种质和下载的52个地中海油橄... 【目的】比较中国选育油橄榄品种与地中海油橄榄叶绿体基因组的多样性和亲缘关系,评估中国选育品种母系来源多样性,为中国油橄榄种质开发提供依据。【方法】基于本研究所测的9个中国选育油橄榄品种、7个伊朗种质和下载的52个地中海油橄榄种质的重测序数据,用NOVOPlasty组装叶绿体基因组,计算序列多态性;用GPA和RAxML-NG、Network 5.0等软件分别构建叶绿体基因组图谱、系统发育和单倍型网络关系。【结果】油橄榄叶绿体基因组在其四分体结构、基因数量上具有一致性;共检测到17个叶绿体单倍型,其中,中国选育油橄榄品种仅有1个单倍型,其多数为地中海栽培油橄榄共享;野生油橄榄序列多态性最高,其次为地中海栽培油橄榄和伊朗种质,而9个中国选育品种的多样性为0。系统发育和单倍型网络关系结果一致,中国选育品种与多数地中海栽培油橄榄、伊朗种质聚为一支。【结论】中国选育油橄榄品种母系来源多样性极低,后期需从更全面的油橄榄种质谱系选育适应中国生境的油橄榄品种。 展开更多
关键词 油橄榄 叶绿体基因组 品种选育 系统发育 母系来源
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颅缝发育与颅缝早闭的分子机制
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作者 叶剑青 胡雪峰 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2024年第2期151-159,共9页
颅骨的发育依赖于颅缝(cranial suture)正常的骨供给,期间颅缝的间充质干细胞经历系统地增殖和成骨分化以保证骨的正常生长。遗传因素或外界干扰则可能引起干细胞的过度成骨分化,导致颅骨的过早闭合,称为颅缝早闭。颅缝细胞与细胞外基... 颅骨的发育依赖于颅缝(cranial suture)正常的骨供给,期间颅缝的间充质干细胞经历系统地增殖和成骨分化以保证骨的正常生长。遗传因素或外界干扰则可能引起干细胞的过度成骨分化,导致颅骨的过早闭合,称为颅缝早闭。颅缝细胞与细胞外基质、骨膜以及脑膜共同构成颅缝微环境(niche)。它们相互调节以保证颅缝的正常发育。临床研究发现,绝大多数颅缝早闭(craniosynostosis)患者都伴有硬脑膜和细胞外基质(extracellular matrixc,ECM)的异常。许多研究也发现,作用于颅缝的异常外界机械刺激也可能导致颅缝发育的异常。考虑到颅缝发育受多方面因素影响,本篇综述将介绍近年来有关颅缝微环境异常,以及机械力在调控颅缝发育中的研究进展,总结颅缝早闭发生的分子机制和目前研究方向,旨在为该病的诊断治疗提供新的思路。 展开更多
关键词 颅缝早闭 硬脑膜 细胞外基质 机械力
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大鼠硬脑膜对颅骨成骨增强的影响
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作者 安冉 邵国 张春阳 《中国组织工程研究》 CAS 北大核心 2024年第22期3478-3483,共6页
背景:硬脑膜与颅骨在结构和功能上联系密切,原代提取硬脑膜和颅骨细胞并将二者共培养的研究几乎没有,利用原代细胞探究硬脑膜对颅骨的影响具有创新性,有望为临床治疗提供理论依据。目的:原代提取大鼠硬脑膜和颅骨细胞,观察硬脑膜对颅骨... 背景:硬脑膜与颅骨在结构和功能上联系密切,原代提取硬脑膜和颅骨细胞并将二者共培养的研究几乎没有,利用原代细胞探究硬脑膜对颅骨的影响具有创新性,有望为临床治疗提供理论依据。目的:原代提取大鼠硬脑膜和颅骨细胞,观察硬脑膜对颅骨增殖和分化能力的影响,初步了解Twist1在其中的作用。方法:利用酶解法与组织块法相结合的方法原代提取出生3 d内大鼠硬脑膜细胞和颅骨细胞,免疫荧光染色鉴定所提取细胞,茜素红染色鉴定与评估颅骨细胞及其矿化能力,real-time PCR检测硬脑膜细胞与颅骨细胞共培养后,颅骨细胞增殖与成骨相关基因表达及Twist1的表达。结果与结论:①形态学:所提取硬脑膜细胞形态特征与成纤维细胞一致,成骨细胞呈纺锤形。②细胞鉴定:免疫荧光染色显示,所提取硬脑膜细胞表达高水平的波形蛋白,颅骨细胞表达高水平的碱性磷酸酶;成骨诱导28 d颅骨细胞茜素红染色观察到明显的矿化结节。③real-time PCR检测显示,与对照组比较,共培养组PCNA、碱性磷酸酶、RUNX2 mRNA表达升高(P<0.01);Twist1 mRNA表达降低(P<0.01)。④结果表明,原代提取的颅骨细胞具有较强的矿化能力,硬脑膜是促进颅骨的生长发育与成骨分化的重要因素,且Twist1在该过程中发挥重要作用。 展开更多
关键词 原代细胞 硬脑膜 颅骨 成骨 TWIST1 成骨分化
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硬脑膜/颅缝间充质干细胞对颅骨发育的影响
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作者 安冉 刘赞(综述) +2 位作者 邵国 张春阳 孙志刚(审校) 《安徽医科大学学报》 CAS 北大核心 2024年第9期1675-1680,共6页
颅缝复合体由具有间充质的纤维组织、成骨前沿、下面的硬脑膜和上覆的骨膜组成。硬脑膜是一层保护大脑和脊髓的纤维结缔组织,拥有血管和淋巴管,对早期发育过程中颅骨成骨的进展,后期颅骨的形态和颅缝状态十分重要。颅缝间充质干细胞主... 颅缝复合体由具有间充质的纤维组织、成骨前沿、下面的硬脑膜和上覆的骨膜组成。硬脑膜是一层保护大脑和脊髓的纤维结缔组织,拥有血管和淋巴管,对早期发育过程中颅骨成骨的进展,后期颅骨的形态和颅缝状态十分重要。颅缝间充质干细胞主要存在于颅缝中,具有增殖、分化为成骨细胞、生成颅骨和增强颅骨损伤后修复的能力。了解颅缝间充质干细胞与硬脑膜的作用机制,对颅骨生长发育和颅脑疾病的治疗非常重要。该文对硬脑膜和颅缝间充质干细胞在颅骨发育中的机制进行综述。 展开更多
关键词 硬脑膜 颅缝间充质干细胞 发育 颅缝 颅骨 成骨
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硬脊膜动静脉瘘的多序列MRI特征与临床
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作者 蔡崧 崔兴宇 孟祥鸿 《医学影像学杂志》 2024年第10期138-141,共4页
目的探讨多序列MRI在硬脊膜动静脉瘘(SDAVF)诊断中的价值。方法选取22例SDAVF患者进行多序列MRI检查,其中14例接受外科手术治疗,8例实施选择性脊髓动脉造影及血管内栓塞治疗;以病变定性诊断及供血动脉、瘘口、引流静脉的显示情况作为评... 目的探讨多序列MRI在硬脊膜动静脉瘘(SDAVF)诊断中的价值。方法选取22例SDAVF患者进行多序列MRI检查,其中14例接受外科手术治疗,8例实施选择性脊髓动脉造影及血管内栓塞治疗;以病变定性诊断及供血动脉、瘘口、引流静脉的显示情况作为评价指标,将多序列MRI与数字减影血管造影(DSA)及手术结果进行对比分析。结果22例SDAVF患者均存在长节段脊髓病变,在矢状位可见T2WI呈“铅笔样”;18例MRI平扫在髓周可见“串珠状”、“虫蚀样”的多发流空血管影;8例MRI增强后髓周可见迂曲扩张的冠状静脉丛,脊髓内病变斑片状强化。22例经多序列MRI检查均明确显示脊髓异常血管及病变范围,3例三维动态增强磁共振血管成像(3D-DCE-MRA)很好的显示供血动脉和引流静脉,对定位瘘口有一定的帮助。结论多序列MRI是诊断SDAVF的主要影像学方法,对早期诊断有着重要的临床意义。 展开更多
关键词 脊髓疾病 硬脊膜 动静脉瘘 磁共振成像
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骨形态发生蛋白2在小儿颅骨缺损自行修复中的作用
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作者 李政堂 郭雅鑫 +1 位作者 邵国 张春阳 《国际神经病学神经外科学杂志》 2024年第2期85-90,共6页
颅脑外伤在小儿各类外伤中占据首位。去骨瓣减压术为神经外科常见减少颅内压的手术方式,颅骨缺失会导致患儿脑组织缺少颅骨保护,颅骨作为脑组织最直接的保护屏障,若缺损不及时修补会因体位、情绪和腹压等会导致脑组织在颅内发生移动,从... 颅脑外伤在小儿各类外伤中占据首位。去骨瓣减压术为神经外科常见减少颅内压的手术方式,颅骨缺失会导致患儿脑组织缺少颅骨保护,颅骨作为脑组织最直接的保护屏障,若缺损不及时修补会因体位、情绪和腹压等会导致脑组织在颅内发生移动,从而造成脑穿通性畸形、癫痫发作和脑变性萎缩等疾病。小儿有好动、依从性差、自我保护能力差等特点,更容易形成二次伤害。小儿处于生长发育期,缺乏颅骨的保护,颅脑容易受到二次伤害,还会影响患儿神经系统的正常发育,造成患儿智力低下,神经系统发育不完善等相关并发症,所以重建颅骨的完整对患儿的生长发育至关重要。未成熟硬脑膜对颅骨的发育和缺损修复有重要作用,2岁以下的儿童能够修复巨大的颅骨缺损,而成年人则缺乏这种内源性能力。幼龄动物骨缺损中骨形态发生蛋白2(BMP2)上调,表明BMP2在骨组织再生中具有重要作用。许多生物调节因子可调控BMP2的活性。该综述就BMP2在小儿颅骨缺损修复中的研究现状做总结。 展开更多
关键词 颅骨 缺损修复 骨形态发生蛋白2 硬脑膜
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Combined application of organic fertilizer and chemical fertilizer alleviates the kernel position effect in summer maize by promoting post-silking nitrogen uptake and dry matter accumulation
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作者 Lichao Zhai Lihua Zhang +7 位作者 Yongzeng Cui Lifang Zhai Mengjing Zheng Yanrong Yao Jingting Zhang Wanbin Hou Liyong Wu Xiuling Jia 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1179-1194,共16页
Adjusting agronomic measures to alleviate the kernel position effect in maize is important for ensuring high yields.In order to clarify whether the combined application of organic fertilizer and chemical fertilizer(CA... Adjusting agronomic measures to alleviate the kernel position effect in maize is important for ensuring high yields.In order to clarify whether the combined application of organic fertilizer and chemical fertilizer(CAOFCF)can alleviate the kernel position effect of summer maize,field experiments were conducted during the 2019 and 2020 growing seasons,and five treatments were assessed:CF,100%chemical fertilizer;OFCF1,15%organic fertilizer+85%chemical fertilizer;OFCF2,30%organic fertilizer+70%chemical fertilizer;OFCF3,45%organic fertilizer+55%chemical fertilizer;and OFCF4,60%organic fertilizer+40%chemical fertilizer.Compared with the CF treatment,the OFCF1 and OFCF2 treatments significantly alleviated the kernel position effect by increasing the weight ratio of inferior kernels to superior kernels and reducing the weight gap between the superior and inferior kernels.These effects were largely due to the improved filling and starch accumulation of inferior kernels.However,there were no obvious differences in the kernel position effect among plants treated with CF,OFCF3,or OFCF4 in most cases.Leaf area indexes,post-silking photosynthetic rates,and net assimilation rates were higher in plants treated with OFCF1 or OFCF2 than in those treated with CF,reflecting an enhanced photosynthetic capacity and improved postsilking dry matter accumulation(DMA)in the plants treated with OFCF1 or OFCF2.Compared with the CF treatment,the OFCF1 and OFCF2 treatments increased post-silking N uptake by 66.3 and 75.5%,respectively,which was the major factor driving post-silking photosynthetic capacity and DMA.Moreover,the increases in root DMA and zeatin riboside content observed following the OFCF1 and OFCF2 treatments resulted in reduced root senescence,which is associated with an increased post-silking N uptake.Analyses showed that post-silking N uptake,DMA,and grain yield in summer maize were negatively correlated with the kernel position effect.In conclusion,the combined application of 15-30%organic fertilizer and 70-85%chemical fertilizer alleviated the kernel position effect in summer maize by improving post-silking N uptake and DMA.These results provide new insights into how CAOFCF can be used to improve maize productivity. 展开更多
关键词 chemical fertilizer dry mater accumulation kernel position effect N uptake organic fertilizer
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