[Objective] This work was aimed to explore the mechanism of Hg2+ toxicity on plants.[Method]Activities of peroxidase(POD),catalase(CAT)and superoxide dismutase(SOD)were investigated in wheat(Triticum aestivum L.)seedl...[Objective] This work was aimed to explore the mechanism of Hg2+ toxicity on plants.[Method]Activities of peroxidase(POD),catalase(CAT)and superoxide dismutase(SOD)were investigated in wheat(Triticum aestivum L.)seedlings under Hg2+ stress at different concentrations.[Result]① There were no obvious effects on the growth of seedlings when the concentration of Hg2+ was lower than 0.10 mmol/L.However,toxic effects on the growth of seedling were observed when the concentration of Hg2+ was higher than 0.10 mmol/L.② Different tissues showed different resistant ability in response to Hg2+ stress.The leaves and roots of wheat seedlings were more insensitive to Hg2+ toxicity.③ CAT was more sensitive to Hg2+ stress compared to POD and SOD.[Conclusion]The toxic effect was related to the concentration of Hg2+(0.10 mmol/L).The higher concentration of Hg2+ could affect the expression of POD,CAT,and SOD isozymes in the leaves,roots of wheat seedlings and germinated seeds,which further affect the normal metabolism of membrane lipid and inhibit the growth of wheat seedlings at last.展开更多
[ Objective ] The paper was to study the effect of controlled atmosphere stress of carbon dioxide （ CO2 ） on Superoxide dismutase （SOD） activity of in- sect, so as to analyze the biological mechanism of the action...[ Objective ] The paper was to study the effect of controlled atmosphere stress of carbon dioxide （ CO2 ） on Superoxide dismutase （SOD） activity of in- sect, so as to analyze the biological mechanism of the action of controlled atmosphere stress on insect. [ Method] Using nitrotetrazolium blue chloride （NBT） light reduction method, SOD activity of drugstore beetle （ Stegobium panlceum ）, cigarette beetle （ Lasioderma serricorne） and coffee bean beetle （Araecerus fasciculatus） was studied, and the stress response of the enzyme under controlled atmosphere stress of CO2 was analyzed. [ Result ] SOD activity of drugstore beetle, cigarette beetle and coffee bean beetle exposed to controlled atmosphere stress of high concentrations of CO2 for 3 and 6 h had certain degree of increase, and the activity sig- nificantly increased from 2.011±0.954,2.664±0.218 and 1.458±0.718 to 3. 135±0. 105,3.050±0.673 and 2.975±0.229 U/（per pest · 30 min） after treat- ment for 6 h. [ Conclusion] Controlled atmosphere stress of high concentrations of CO2 had certain activation effect on SOD activity of storage pest in Chinese me- dicinal material within the context of sub-lethal events. The results could enrich the insecticidal mechanism of controlled atmosphere and theoretical system of analy- sis on insect resistance to controlled atmosphere.展开更多
A rapid and concentration-dependent generation of superoxide anion （·O2^-）, measured with a superoxide-specific Cypridina luciferin-derived chemiluminescent reagent, was observed when two lanthanide salts （LaC...A rapid and concentration-dependent generation of superoxide anion （·O2^-）, measured with a superoxide-specific Cypridina luciferin-derived chemiluminescent reagent, was observed when two lanthanide salts （LaCl3 and CdCl3 ） were added to tobacco （ Nicotiana tabacum） cell suspension culture. Addition of superoxide dismutase （480 U·ml^-1） and Tiron （5 μmol·L^-1） to cell culture suspension decreases the level of lanthanide cation-induced ·O2^- generation, suggesting that ·O2^- generation is extra-cellular. Pretreatment of the cell culture suspension with diphenyleneiodonium （10 and 50 μmol·L^-1 ）, quinacrine （ 1 and 5 mmol· L^-1 ） and imidazol （ 10 mmol· L^-1 ）, inhibitors of NADPH oxidase, notably inhibits the generation of superoxide induced by lanthanide cation, implying the possible involvement of activation of NADPH oxidase. In addition, addition of SHAM （1 and 5 mmol· L^-1）, azide （0.2 and 1 mmol· L^-1 ）, inhibitor of peroxidase, has no influence on ·O2^- generation.展开更多
目的探讨金匮肾气丸联合维生素D钙片治疗2型糖尿病性骨质疏松症(T2DOP)的临床疗效,以及对患者血清骨转换标志物、白细胞介素-1β(IL-1β)、基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)水平的影响。方法选择该院2021年1月至2022年10...目的探讨金匮肾气丸联合维生素D钙片治疗2型糖尿病性骨质疏松症(T2DOP)的临床疗效,以及对患者血清骨转换标志物、白细胞介素-1β(IL-1β)、基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)水平的影响。方法选择该院2021年1月至2022年10月收治的84例T2DOP患者作为研究对象,按随机数字表法将患者分为观察组(42例)和对照组(42例)。观察组采用金匮肾气丸联合维生素D钙片治疗,对照组单用维生素D钙片治疗,治疗24周后比较两组临床疗效。治疗前后检测两组患者第1~4腰椎(L 1~4)、股骨颈的骨密度(BMD),并对两组患者进行疼痛视觉模拟量表(VAS)评分。治疗前后检测两组患者的糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、血清骨转换标志物{25羟基维生素D[25(OH)D]、β-胶原特殊序列(β-Crosslaps)、总Ⅰ型胶原氨基端延长肽(Total-P1NP)、骨钙素N端中分子片段(N-MID)}以及IL-1β、MMP-9、SOD水平。统计两组不良反应发生情况。结果观察组总有效率为95.24%,明显高于对照组的76.19%(P<0.05)。治疗后,两组L 1~4 BMD以及血清25(OH)D、Total-P1NP、N-MID、SOD水平均高于治疗前(P<0.05),VAS评分、FPG、2 h PG、HbA1c以及血清β-Crosslaps、IL-1β、MMP-9水平均低于治疗前(P<0.05)。治疗后,观察组L 1~4 BMD以及血清25(OH)D、Total-P1NP、N-MID、SOD水平均高于对照组(P<0.05),VAS评分、FPG、2 h PG、HbA1c以及血清β-Crosslaps、IL-1β、MMP-9水平均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论金匮肾气丸联合维生素D钙片治疗T2DOP能有效调节患者血清骨转换标志物、IL-1β、MMP-9、SOD水平,改善糖代谢与骨代谢,提高临床疗效。展开更多
Objective To investigate the correlation between drinking behavior combined with polymorphisms of extracellular superoxide dismutase （EC-SOD） and aldehyde dehydrogenase-2 （ALDH2） genes and pancreatic cancer. Meth...Objective To investigate the correlation between drinking behavior combined with polymorphisms of extracellular superoxide dismutase （EC-SOD） and aldehyde dehydrogenase-2 （ALDH2） genes and pancreatic cancer. Methods The genetic polymorphisms of EC-SOD and ALDH2 were analyzed by polymerase chain reaction restriction fragment length polymorphism in the peripheral blood leukocytes obtained from 680 pancreatic cancer cases and 680 non-cancer controls. Subsequently the frequency of genotype was compared between the pancreatic cancer patients and the healthy controls.The relationship of drinking with pancreatic cancer was analyzed. Results The frequencies of EC-SOD （C/G） and ALDH2 variant genotypes were 37.35% and 68.82% respectively in the pancreatic cancer cases, and were significantly higher than those in the healthy controls （21.03% and 44.56%, all P〈0.01）. People who carried EC-SOD （C/G） （0R=2.24, 95% C1= 1.81-4.03, P〈0.01） or ALDH2 variant genotypes （OR=2.75, 95% CI=1.92-4.47, P〈0.01） had a high risk to develop pancreatic cancer. Those who carried EC-SOD （C/G） genotype combined with ALDH2 variant genotype had a high risk for pancreatic cancer （29.56% vs. 6.76%, 0R=7.69, 95% CI=3.58-10.51, P〈0.01）. The drinking rate of the pancreatic cancer group （64.12%） was significantly higher than that of the control group （40.15%; OR=2.66, 95% CI=1.30-4.42, P〈0.01）. An interaction between drinking and EC-SOD （C/G）/ALDH2 variant genotypes increased the risk of occurrence of pancreatic cancer （OR=25.00, 95% CI= 11.87-35.64, P〈0.01）. Conclusion EC-SOD （C/G）, ALDH2 variant genotypes and drinking might be the risk factors of pancreatic cancer.展开更多
Extensive DFT calculations are performed to optimize the geometric structures of O-rich tungsten oxide clusters, to simulate the PES spectra, and to analyze the chemical bonding. The ground-state structure of W4O14^- ...Extensive DFT calculations are performed to optimize the geometric structures of O-rich tungsten oxide clusters, to simulate the PES spectra, and to analyze the chemical bonding. The ground-state structure of W4O14^- is best considered as W4O12（O2^-）, containing a side-on bound superoxide ligand. The current study indicates that the extra electron in W4O12^- is capable of activating dioxygen by non-dissociative electron transfer （W 5d → O2 π^＊）, and the anionic clusters can be viewed as models for reduced defect sites on tungsten oxide surfaces for the chemisorption of O2.展开更多
Objective To explore the protective effects of N Acetylcysteine (NAC) on exogenous hydrogen peroxide and endogenous superoxide anion induced DNA strand breakage in human spermatozoa by using the single cell gel el...Objective To explore the protective effects of N Acetylcysteine (NAC) on exogenous hydrogen peroxide and endogenous superoxide anion induced DNA strand breakage in human spermatozoa by using the single cell gel electropherosis (SCGE) Methods Sperm cells were exposed to 0.5 mmol/L of H 2O 2 or 5.0 mmol/L of β NADPH with or without 0.1, 0.5, 1.0 mmol/L of NAC. The percentage of sperm comet cells and the comet tail lengths were measured in the treated sperm cells by using SCGE. Results Both percentage of comet sperm nuclei and mean tail length in sperm cells exposed to 0.5 mmol/L hydrogen peroxide with different concentrations of NAC decrease significantly in a dose dependent manner as compared with sperm cells exposed to H 2O 2 without NAC or catalase. Although mean tail length in sperm cells exposed to 5.0 mmol/L of β NADPH with different concentrations of NAC decreases significantly compared with sperm cells exposed to β NADPH without NAC or SOD, there were no significant differences on the percentage of sperm comet cells between sperm cells exposed to 5.0 mmol/L of β NADPH with different concentrations of NAC and sperm cells exposed to 5.0 mmol/L of β NADPH without NAC. Conclusion NAC has a protective effect on exogenous hydrogen peroxide induced DNA damage, while protective effect of NAC against O - 2 induced DNA strand breakage is significant but very weak.展开更多
In this study, the superoxide anion radicals were generated by the auto-oxidation of 1,2,3-trihydroxybenzene and determined by UV spectrophotometry, and the reaction was found to be facilitated by anthraquinone-2-sulf...In this study, the superoxide anion radicals were generated by the auto-oxidation of 1,2,3-trihydroxybenzene and determined by UV spectrophotometry, and the reaction was found to be facilitated by anthraquinone-2-sulfonic acid sodium salt. The bamboo kraft pulps were treated by the 1,2,3-trihydroxybenzene auto-oxidation method or the 1,2,3-trihydroxybenzene auto-oxidation combined with anthraquinone-2-sulfonic acid sodium salt to show the ef-fect of the superoxide anion radicals during the oxygen delignification of bamboo kraft pulp and the enhancing af-fect of anthraquinone compounds as an additive on delignification. The results indicated that the superoxide anion radicals could react with lignin and remove it from pulp with negligible damage on cellulose, and the an-thraquinone-2-sulfonic acid sodium salt could facilitate the generation of superoxide anion radical to enhance delig-nification of pulps. The oxygen delignification selectivity could be improved using the 1,2,3-trihydroxybenzene auto-oxidation system combined with anthraquinone-2-sulfonic acid sodium salt.展开更多
Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons.Symptoms include muscle weakness and atrophy,spasticity,and progressive paralysis.Currently,there is no treatment to r...Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons.Symptoms include muscle weakness and atrophy,spasticity,and progressive paralysis.Currently,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral sclerosis.The only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial effects.The difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis pathogenesis.Among mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious circle.Sharpening the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and inflammation.We here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.展开更多
文摘[Objective] This work was aimed to explore the mechanism of Hg2+ toxicity on plants.[Method]Activities of peroxidase(POD),catalase(CAT)and superoxide dismutase(SOD)were investigated in wheat(Triticum aestivum L.)seedlings under Hg2+ stress at different concentrations.[Result]① There were no obvious effects on the growth of seedlings when the concentration of Hg2+ was lower than 0.10 mmol/L.However,toxic effects on the growth of seedling were observed when the concentration of Hg2+ was higher than 0.10 mmol/L.② Different tissues showed different resistant ability in response to Hg2+ stress.The leaves and roots of wheat seedlings were more insensitive to Hg2+ toxicity.③ CAT was more sensitive to Hg2+ stress compared to POD and SOD.[Conclusion]The toxic effect was related to the concentration of Hg2+(0.10 mmol/L).The higher concentration of Hg2+ could affect the expression of POD,CAT,and SOD isozymes in the leaves,roots of wheat seedlings and germinated seeds,which further affect the normal metabolism of membrane lipid and inhibit the growth of wheat seedlings at last.
基金Supported by Project of Guizhou Provincial Modernization of Chinese Medicine Material Project(QKHYZ[2011]5049Organization Department of CPCGuizhou Committee(TZJF-2009-02)Promotion Project of Key Scientific and Technological Achievements of Guiyang City([2010]1-T-4)~~
文摘[ Objective ] The paper was to study the effect of controlled atmosphere stress of carbon dioxide （ CO2 ） on Superoxide dismutase （SOD） activity of in- sect, so as to analyze the biological mechanism of the action of controlled atmosphere stress on insect. [ Method] Using nitrotetrazolium blue chloride （NBT） light reduction method, SOD activity of drugstore beetle （ Stegobium panlceum ）, cigarette beetle （ Lasioderma serricorne） and coffee bean beetle （Araecerus fasciculatus） was studied, and the stress response of the enzyme under controlled atmosphere stress of CO2 was analyzed. [ Result ] SOD activity of drugstore beetle, cigarette beetle and coffee bean beetle exposed to controlled atmosphere stress of high concentrations of CO2 for 3 and 6 h had certain degree of increase, and the activity sig- nificantly increased from 2.011±0.954,2.664±0.218 and 1.458±0.718 to 3. 135±0. 105,3.050±0.673 and 2.975±0.229 U/（per pest · 30 min） after treat- ment for 6 h. [ Conclusion] Controlled atmosphere stress of high concentrations of CO2 had certain activation effect on SOD activity of storage pest in Chinese me- dicinal material within the context of sub-lethal events. The results could enrich the insecticidal mechanism of controlled atmosphere and theoretical system of analy- sis on insect resistance to controlled atmosphere.
文摘A rapid and concentration-dependent generation of superoxide anion （·O2^-）, measured with a superoxide-specific Cypridina luciferin-derived chemiluminescent reagent, was observed when two lanthanide salts （LaCl3 and CdCl3 ） were added to tobacco （ Nicotiana tabacum） cell suspension culture. Addition of superoxide dismutase （480 U·ml^-1） and Tiron （5 μmol·L^-1） to cell culture suspension decreases the level of lanthanide cation-induced ·O2^- generation, suggesting that ·O2^- generation is extra-cellular. Pretreatment of the cell culture suspension with diphenyleneiodonium （10 and 50 μmol·L^-1 ）, quinacrine （ 1 and 5 mmol· L^-1 ） and imidazol （ 10 mmol· L^-1 ）, inhibitors of NADPH oxidase, notably inhibits the generation of superoxide induced by lanthanide cation, implying the possible involvement of activation of NADPH oxidase. In addition, addition of SHAM （1 and 5 mmol· L^-1）, azide （0.2 and 1 mmol· L^-1 ）, inhibitor of peroxidase, has no influence on ·O2^- generation.
文摘目的探讨金匮肾气丸联合维生素D钙片治疗2型糖尿病性骨质疏松症(T2DOP)的临床疗效,以及对患者血清骨转换标志物、白细胞介素-1β(IL-1β)、基质金属蛋白酶-9(MMP-9)、超氧化物歧化酶(SOD)水平的影响。方法选择该院2021年1月至2022年10月收治的84例T2DOP患者作为研究对象,按随机数字表法将患者分为观察组(42例)和对照组(42例)。观察组采用金匮肾气丸联合维生素D钙片治疗,对照组单用维生素D钙片治疗,治疗24周后比较两组临床疗效。治疗前后检测两组患者第1~4腰椎(L 1~4)、股骨颈的骨密度(BMD),并对两组患者进行疼痛视觉模拟量表(VAS)评分。治疗前后检测两组患者的糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、血清骨转换标志物{25羟基维生素D[25(OH)D]、β-胶原特殊序列(β-Crosslaps)、总Ⅰ型胶原氨基端延长肽(Total-P1NP)、骨钙素N端中分子片段(N-MID)}以及IL-1β、MMP-9、SOD水平。统计两组不良反应发生情况。结果观察组总有效率为95.24%,明显高于对照组的76.19%(P<0.05)。治疗后,两组L 1~4 BMD以及血清25(OH)D、Total-P1NP、N-MID、SOD水平均高于治疗前(P<0.05),VAS评分、FPG、2 h PG、HbA1c以及血清β-Crosslaps、IL-1β、MMP-9水平均低于治疗前(P<0.05)。治疗后,观察组L 1~4 BMD以及血清25(OH)D、Total-P1NP、N-MID、SOD水平均高于对照组(P<0.05),VAS评分、FPG、2 h PG、HbA1c以及血清β-Crosslaps、IL-1β、MMP-9水平均低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论金匮肾气丸联合维生素D钙片治疗T2DOP能有效调节患者血清骨转换标志物、IL-1β、MMP-9、SOD水平,改善糖代谢与骨代谢,提高临床疗效。
文摘Objective To investigate the correlation between drinking behavior combined with polymorphisms of extracellular superoxide dismutase （EC-SOD） and aldehyde dehydrogenase-2 （ALDH2） genes and pancreatic cancer. Methods The genetic polymorphisms of EC-SOD and ALDH2 were analyzed by polymerase chain reaction restriction fragment length polymorphism in the peripheral blood leukocytes obtained from 680 pancreatic cancer cases and 680 non-cancer controls. Subsequently the frequency of genotype was compared between the pancreatic cancer patients and the healthy controls.The relationship of drinking with pancreatic cancer was analyzed. Results The frequencies of EC-SOD （C/G） and ALDH2 variant genotypes were 37.35% and 68.82% respectively in the pancreatic cancer cases, and were significantly higher than those in the healthy controls （21.03% and 44.56%, all P〈0.01）. People who carried EC-SOD （C/G） （0R=2.24, 95% C1= 1.81-4.03, P〈0.01） or ALDH2 variant genotypes （OR=2.75, 95% CI=1.92-4.47, P〈0.01） had a high risk to develop pancreatic cancer. Those who carried EC-SOD （C/G） genotype combined with ALDH2 variant genotype had a high risk for pancreatic cancer （29.56% vs. 6.76%, 0R=7.69, 95% CI=3.58-10.51, P〈0.01）. The drinking rate of the pancreatic cancer group （64.12%） was significantly higher than that of the control group （40.15%; OR=2.66, 95% CI=1.30-4.42, P〈0.01）. An interaction between drinking and EC-SOD （C/G）/ALDH2 variant genotypes increased the risk of occurrence of pancreatic cancer （OR=25.00, 95% CI= 11.87-35.64, P〈0.01）. Conclusion EC-SOD （C/G）, ALDH2 variant genotypes and drinking might be the risk factors of pancreatic cancer.
基金the National Natural Science Foundation of China (20641004, 20771026 and 20773024)the Natural Science Foundation of Fujian Province (No. 2008J0151)
文摘Extensive DFT calculations are performed to optimize the geometric structures of O-rich tungsten oxide clusters, to simulate the PES spectra, and to analyze the chemical bonding. The ground-state structure of W4O14^- is best considered as W4O12（O2^-）, containing a side-on bound superoxide ligand. The current study indicates that the extra electron in W4O12^- is capable of activating dioxygen by non-dissociative electron transfer （W 5d → O2 π^＊）, and the anionic clusters can be viewed as models for reduced defect sites on tungsten oxide surfaces for the chemisorption of O2.
基金China Medical Board ( 980 0 1 ) and Natural Science Foundation ofAnhui Province( 99j1 0 0 95)
文摘Objective To explore the protective effects of N Acetylcysteine (NAC) on exogenous hydrogen peroxide and endogenous superoxide anion induced DNA strand breakage in human spermatozoa by using the single cell gel electropherosis (SCGE) Methods Sperm cells were exposed to 0.5 mmol/L of H 2O 2 or 5.0 mmol/L of β NADPH with or without 0.1, 0.5, 1.0 mmol/L of NAC. The percentage of sperm comet cells and the comet tail lengths were measured in the treated sperm cells by using SCGE. Results Both percentage of comet sperm nuclei and mean tail length in sperm cells exposed to 0.5 mmol/L hydrogen peroxide with different concentrations of NAC decrease significantly in a dose dependent manner as compared with sperm cells exposed to H 2O 2 without NAC or catalase. Although mean tail length in sperm cells exposed to 5.0 mmol/L of β NADPH with different concentrations of NAC decreases significantly compared with sperm cells exposed to β NADPH without NAC or SOD, there were no significant differences on the percentage of sperm comet cells between sperm cells exposed to 5.0 mmol/L of β NADPH with different concentrations of NAC and sperm cells exposed to 5.0 mmol/L of β NADPH without NAC. Conclusion NAC has a protective effect on exogenous hydrogen peroxide induced DNA damage, while protective effect of NAC against O - 2 induced DNA strand breakage is significant but very weak.
基金Supported by the National Natural Science Foundation of China (No.20477046)the Natural Science Foundation of Fujian Prov-ince of China (No.2004HZ03-5)the Young Scientist Innovation Foundation of Fujian Province of China (No.2006F3009).
文摘In this study, the superoxide anion radicals were generated by the auto-oxidation of 1,2,3-trihydroxybenzene and determined by UV spectrophotometry, and the reaction was found to be facilitated by anthraquinone-2-sulfonic acid sodium salt. The bamboo kraft pulps were treated by the 1,2,3-trihydroxybenzene auto-oxidation method or the 1,2,3-trihydroxybenzene auto-oxidation combined with anthraquinone-2-sulfonic acid sodium salt to show the ef-fect of the superoxide anion radicals during the oxygen delignification of bamboo kraft pulp and the enhancing af-fect of anthraquinone compounds as an additive on delignification. The results indicated that the superoxide anion radicals could react with lignin and remove it from pulp with negligible damage on cellulose, and the an-thraquinone-2-sulfonic acid sodium salt could facilitate the generation of superoxide anion radical to enhance delig-nification of pulps. The oxygen delignification selectivity could be improved using the 1,2,3-trihydroxybenzene auto-oxidation system combined with anthraquinone-2-sulfonic acid sodium salt.
基金supported by a grant from the Association Française contre les Myopathies(AFM Téléthongrant 23667,to JCL).
文摘Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons.Symptoms include muscle weakness and atrophy,spasticity,and progressive paralysis.Currently,there is no treatment to reverse damage to motor neurons and cure amyotrophic lateral sclerosis.The only two treatments actually approved,riluzole and edaravone,have shown mitigated beneficial effects.The difficulty to find a cure lies in the complexity and multifaceted pattern of amyotrophic lateral sclerosis pathogenesis.Among mechanisms,abnormal RNA metabolism,nucleocytoplasmic transport defects,accumulation of unfolded protein,and mitochondrial dysfunction would in fine induce oxidative damage and vice versa.A potent therapeutic strategy will be to find molecules that break this vicious circle.Sharpening the nuclear factor erythroid-2 related factor 2 signaling may fulfill this objective since nuclear factor erythroid-2 related factor 2 has a multitarget profile controlling antioxidant defense,mitochondrial functioning,and inflammation.We here discuss the interest of developing nuclear factor erythroid-2 related factor 2-based therapy in regard to the pathophysiological mechanisms and we provide a general overview of the attempted clinical assays in amyotrophic lateral sclerosis.
