The aim of the present controlled clinical study was to compare the clinical response of grafting superporous hydroxyapatite (HAp) granules to superporous HAp blocks in the treatment of human intrabony periodontal def...The aim of the present controlled clinical study was to compare the clinical response of grafting superporous hydroxyapatite (HAp) granules to superporous HAp blocks in the treatment of human intrabony periodontal defects. Twenty interproximal intrabony os-seous defects in 20 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. These twenty subjects were randomly assigned to either the HAp granule or the HAp block groups. Clinical and radiographic measurements were determined at baseline, 3, 6, 9 and 12-month post-surgical evaluation time periods. When compared to baseline, the 12-month results indicated both treatment procedures resulted in statistically significant favorable changes in probing depth (mean value: 3.5 mm versus 3.5 mm), clinical attachment level gain (3.2 mm versus 2.3 mm) and radiographic infrabony defect depth decrease (2.9 mm versus 2.5 mm) for HAp granule and HAp block grafting respectively. At 3- and 6-months, the granule group, when compared to the block group, exhibited a statistically significantly more favorable clinical response in clinical attachment level (4.1 mm versus 5.9 mm, p < 0.05 at 3-months;4.3 mm versus 6.5 mm, p < 0.01 at 6- months). The present study demonstrated that both grafting of superporous HAp granules and grafting of HAp blocks were similarly successful in the treatment of human intrabony periodontal defects.展开更多
Anion-exchange superporous cellulose(DEAE-SC)and microporous cellulose(DEAE-MC)adsorbents were packed in an electrochromatographic column,and the effect of external electric field(eEF)on the dynamic adsorption was inv...Anion-exchange superporous cellulose(DEAE-SC)and microporous cellulose(DEAE-MC)adsorbents were packed in an electrochromatographic column,and the effect of external electric field(eEF)on the dynamic adsorption was investigated.The column was designed to provide longitudinal,transverse or 2-dimensional(2D)eEF.It was found that the electro-kinetic effect caused by the introduction of an electric field played an important role in the dynamic adsorption of bovine serum albumin to the adsorbents.The dynamic binding capacity(DBC)in the presence of 2D eEF was higher than in the presence of a one-dimensional eEF.The effect of flow velocity on the DBC of the two adsorbents was also demonstrated.It was found that the effect of electric field on the DEAE-MC column was more remarkable than that on the DEAE-SC column at the same flow rate,whereas the DEAE-SC column showed higher DBC and adsorption efficiency(AE)than the DEAE-MC column.With increasing flow rate,the DEAE-SC column could still offer high DBC and AE in the presence of the 2D eEF.For example,a DBC of 21.4mg/mL and an AE of 57.7%were obtained even at a flow rate as high as 900cm/h.The results indicate that the 2D electrochromatography packed with the superporous cellulose adsorbent is promising for high-speed protein chromatography.展开更多
文摘The aim of the present controlled clinical study was to compare the clinical response of grafting superporous hydroxyapatite (HAp) granules to superporous HAp blocks in the treatment of human intrabony periodontal defects. Twenty interproximal intrabony os-seous defects in 20 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. These twenty subjects were randomly assigned to either the HAp granule or the HAp block groups. Clinical and radiographic measurements were determined at baseline, 3, 6, 9 and 12-month post-surgical evaluation time periods. When compared to baseline, the 12-month results indicated both treatment procedures resulted in statistically significant favorable changes in probing depth (mean value: 3.5 mm versus 3.5 mm), clinical attachment level gain (3.2 mm versus 2.3 mm) and radiographic infrabony defect depth decrease (2.9 mm versus 2.5 mm) for HAp granule and HAp block grafting respectively. At 3- and 6-months, the granule group, when compared to the block group, exhibited a statistically significantly more favorable clinical response in clinical attachment level (4.1 mm versus 5.9 mm, p < 0.05 at 3-months;4.3 mm versus 6.5 mm, p < 0.01 at 6- months). The present study demonstrated that both grafting of superporous HAp granules and grafting of HAp blocks were similarly successful in the treatment of human intrabony periodontal defects.
基金This work was supported by the Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission(Grant No.08JCZDJC17100).
文摘Anion-exchange superporous cellulose(DEAE-SC)and microporous cellulose(DEAE-MC)adsorbents were packed in an electrochromatographic column,and the effect of external electric field(eEF)on the dynamic adsorption was investigated.The column was designed to provide longitudinal,transverse or 2-dimensional(2D)eEF.It was found that the electro-kinetic effect caused by the introduction of an electric field played an important role in the dynamic adsorption of bovine serum albumin to the adsorbents.The dynamic binding capacity(DBC)in the presence of 2D eEF was higher than in the presence of a one-dimensional eEF.The effect of flow velocity on the DBC of the two adsorbents was also demonstrated.It was found that the effect of electric field on the DEAE-MC column was more remarkable than that on the DEAE-SC column at the same flow rate,whereas the DEAE-SC column showed higher DBC and adsorption efficiency(AE)than the DEAE-MC column.With increasing flow rate,the DEAE-SC column could still offer high DBC and AE in the presence of the 2D eEF.For example,a DBC of 21.4mg/mL and an AE of 57.7%were obtained even at a flow rate as high as 900cm/h.The results indicate that the 2D electrochromatography packed with the superporous cellulose adsorbent is promising for high-speed protein chromatography.
