The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

目的：明确益气养阴法联合化疗是否较单纯使用化疗治疗肺癌在增效、减毒等方面更有优势.方法：从网络数据库中检索2013年1月至2017年1月期间以中医益气养阴为治法联合化疗方案对比单纯化疗治疗肺癌并且运用了随机对照试验研究的国内外文献,然后采用RevMan5.3.5软件对搜集的文献质量进行评价、筛选.结果：成功筛选符合系统评价的文献10篇,总病例691例,治疗组共369例（益气养阴中药＋化疗）,对照组322例（单纯化疗）.Meta分析结果显示治疗组在改善肺癌临床症状方面具有显著统计学差异（P〈0.001）,在实体瘤情况方面、在生活质量改善情况方面、在不良反应发生情况方面两组对比均有显著统计学差异（P〈0.001）.结论：益气养阴法联合化疗能显著改善中晚期肺癌患者的临床症状,减少因化疗引起的毒副反应,提高患者生活质量.

中药滋阴补阳方剂治疗肾气亏虚型多囊卵巢综合征不孕症对患者超声动态多参数的影响评价

目的评价中药滋阴补阳方剂治疗肾气亏虚型多囊卵巢综合征不孕症对患者超声动态多参数的影响。方法选取2022年1月至2023年1月江西省妇幼保健院收治的80例肾气亏虚型多囊卵巢综合征患者作为研究对象,按照随机数字法将其分为观察组(40例)与对照组(40例)。对照组采用枸橼酸氯米芬片治疗,观察组在对照组方法的基础上联合中药滋阴补阳方剂治疗。比较两组患者的治疗效果、卵泡发育情况、激素水平、子宫动脉血流灌注情况及子宫内膜厚度。结果观察组的有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后的卵泡及优势卵泡数目多于对照组,差异有统计学意义(P<0.05);观察组治疗后的黄体生成素(LH)、促卵泡激素(FSH)、睾酮(T)均低于对照组,雌二醇(E2)高于对照组,差异有统计学意义(P<0.05);观察组治疗后的搏动指数(PI)、阻力指数(RI)均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的子宫内膜厚度高于对照组,差异有统计学意义(P<0.05)。结论将中药滋阴补阳方剂应用于肾气亏虚型多囊卵巢综合征不孕症患者治疗中,可积极改善患者的激素水平及子宫动脉血流灌注情况,同时能够促进卵泡发育,增加子宫内膜厚度,改善症状,值得推广。

益气养阴方对动脉粥样硬化大鼠免疫炎症因子和胸主动脉内、中膜厚度的影响

目的:观察益气养阴方对动脉粥样硬化大鼠治疗前后免疫炎症因子的表达水平及对胸主动脉内、中膜厚度变化的影响。方法:46只4周龄SPF级Wistar雄性大鼠,随机选出10只为空白组,只给予基础饲料,其余36只采用主动脉内膜球囊拉伤术加高脂饲料喂养完成动脉粥样硬化大鼠模型。造模成功后的30只随机分为模型组、益气养阴方组(中药组)和瑞舒伐他汀组(西药组),每组10只。空白组予以基础饲料喂养,中药组给予益气养阴方,西药组给予瑞舒伐他汀钙片。给药6周后胸主动脉剪取粥样斑块留作标本,检测超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、转化生长因子β_(1)(transforming growth factor β_(1),TGF-β_(1))、白细胞介素8(interleukin-8,IL-8)、基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)的表达水平及胸主动脉内、中膜厚度及病理变化。结果:用SNK法两两比较,与模型组比较,中药组、西药组在hs-CRP、TGF-β_(1)、IL-8、MMP-9的表达水平方面均明显降低(P<0.05),胸主动脉内、中膜厚度的变化差异有统计学差异(P<0.05)。益气养阴方组大鼠胸、腹主动脉各层细胞结构的组织修复方面优于模型组,病变明显减轻。结论:益气养阴方对动脉粥样硬化大鼠治疗前后hs-CRP、TGF-β_(1)、IL-8、MMP-9的表达水平及颈动脉内中膜厚度方面均有明显改善作用,为临床对动脉粥样硬化的干预治疗提供一个研究方向。

Effect of Chinese Drugs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Myocardial Perfusion in Patients with Acute Myocardial Infarction after Revascularization

Objective:To observe the effects of Chinese drugs for supplementing qi,nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction(AMI) patients after revascularization.Methods:Eighty patients with anterior or inferior ventricular wall AMI,who had received revascularization by intravenous thrombolysis or coronary bypass,were randomized into the treated group and the control group equally,both treated with conventional Western medical treatment,but combined,resp...

Effect of Chinese Herbal Medicine for Nourishing Yin,Supplementing Qi,and Activating Blood on the Th1/Th2 Immune Balance in Peripheral Blood in Patients with Primary Sjogren's Syndrome

Objective： To observe the effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the expression of interferen- γ （IFN-γ,）/interleukin-4 （IL-4） in peripheral blood and disease activity in primary Sjogren＇s syndrome （pSS） patients, and to study the relationship between the immune balance of Th1/Th2 and the disease activity. Methods： A total of 66 pSS patients were randomized with tossing coins method into two groups： the integrative therapy group （34 cases） and the control group （32 cases）; and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G （IgG）, erythrocyte sedimentation rate （ESR）, IFN-γand IL-4 in peripheral blood were measured before and after treatment. Results： Compared with the normal group, the levels of IgG, ESR, IFN- γ and IL-4 were significantly increased in pSS patients （P〈0.05）. Remarkably, after 3 months of treatment, these levels were dramatically decreased in both the integrative therapy group and the control group, although still higher than the normal group. The levels of IgG, ESR, IFN- and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment （P〈0.05）. The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover, the level of IFN- γ, and the ratio of IFN- γ/IL-4 in the integrative theraphy group were significantly lower than the control group （P〈0.05）. For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Conclusion： Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Effect of Chinese Herbal Medicines for Nourishing Yin,Supplementing Qi,and Activating Blood on Reproductive Endocrine Activity and Immune Functions in Patients with Primary Sjogren's Syndrome

ABSTRACT Objective： To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren＇s syndrome （pSS）. Methods： Seventy pSS patients were randomly assigned to two groups using a randomized digital table： the integrative therapy group （36 cases） and the control group （34 cases）. Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol （E2）, testosterone （T）, luteinizing hormone （LH）, prolactin （PRL） by radioimmunoassay and immunoglobulin （IgG） by immunodiffusion, erythrocyte sedimentation rate （ESR） by Westergren, interferon-γ （IFN-γ） and interleukin-4 （IL-4） by enzyme linked immunosorbent assay were determined. Results： E2 and T levels in all patients were lower than those of normal subjects before treatment （P〈0.05） and were increased significantly after 6-month treatment （P〈0.05）. ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN --γ/IL in the patients were higher than those of normal subjects before the treatments （P〈0.05）, and were reduced significantly after the treatments （P〈0.05）. The T and IFN -γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group （P〈0.05）. However, the PRL levels before and after treatment were not significantly changed in the two groups （P〉0.05）. The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment （P〈0.05）. Conclusions： The ratios of E2/T and IFN - γ/ IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

Protective Effect of Chinese Herbs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Heart Function of Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Objective： To investigate the effects of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome （ACS） after successful percutaneous coronary intervention （PCI）. Methods： One hundred patients with ACS after successful PCI were randomly assigned to a Western medicine （WM） treatment group （WMG） and a combined treatment group （CMG） treated by Chinese herbs for supplementing qi, nourishing yin and activating blood circulation, besides Western medicine treatment, with 50 cases in each group. Both treatment courses were 6 months. The follow- up was scheduled at baseline, 6 months and 1 year after PCI, and New York Heart Association （NYHA） functional class, Chinese medicine （CM） symptom scores, blood stasis syndrome scores, and major adverse cardiovascular events （MACE） were observed, serum levels of N-terminal pro-brain natriuretic peptide （NT-proBNP） and hyper-sensitivity C-reactive protein （Hs-CRP） were measured, an echocardiogram was conducted to examine left ventricular ejection fraction （LVEF）, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV）, inter-ventricular septal thickness （IVST）, left ventricular posterior wall thickness （LVPWT）, and ventricular wall motion index （VWMI）. Results： Compared with the baseline, LVEF significantly increased （P〈0.01）, and CM symptom scores, blood stasis syndrome scores, VWMI, LVEDV, LVESV, NT-proBNP, and Hs-CRP all decreased （P〈0.01） in both groups at 6 months and at 1 year after PCI. There were no significant differences in all the above parameters at 1 year vs those at 6 months after PCI （P〉0.05）. VWMI, LVEDV, LVESV, NT-proBNP, Hs-CRP, LVEF, and CM symptom and blood stasis syndrome scores were all improved obviously in CMG than those in WMG （P〈0.05 or P〈0.01） at 6 months and at 1 year after PCI. There were no significant differences in NYHA functional class between CMG and WMG at different follow-up timepoints; it was notable that P value was 0.054 when comparing the cases of NYHA functional class between the two groups at 1-year follow-up. During the 1-year follow-up, 3 MACE and 11 MACE occurred in CMG and WMG, respectively; the MACE rate in CMG was lower than that in WMG （6% vs 22%, P〈0.05）. Conclusion： Chinese herbs for supplementing qi, nourishing yin and activating blood circulation could improve heart function, reduce the CM symptom scores and blood stasis syndrome scores, and decrease the incidence of MACE in patients with ACS after successful PCI.

Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Objective: To probe the effects of qi-supplementing and yin-nourishing therapy (blood-increasing decoction and blood generating powder) on chronic thrombocytopenia. Methods: Two hundred patients with chronic thrombocytopenia were randomly divided into control (n=100) and test groups (n = 100) with Amino-polypeptide as a basic treatment for both. Test group patients consumed a blood-increasing decoction and blood-generating powder for 1-3 months. Improvements in platelet counts and TCM syndrome were observed. Results: One hundred and sixty-four (80 in the test group and 84 in the control group) of 189 total participants were treated for 3 months. The total effective rate in improving TCM syndrome was 95.00% in the test group and 79.76% in the control group (P<0.05). There was significant difference (P<0.05) in the accumulated score of TCM syndrome between the two groups treated at different time points. The total effective rate of platelet counts was 86.25% in the test group and 59.52% in the control group (P<0.05). There was a significant difference in platelet counts before and after treatment in the two groups (P<0.05). There was no significant differences in platelet count between the two groups treated for 1-2 months; however, a significant difference was found between the two groups after treatment for 3 months (P<0.05). Conclusions: After a 3-month treatment of chronic thrombocytopenia patients with qi-supplementing and yin-nourishing therapy, TCM syndrome was improved and platelet counts increased with no obvious side effects, and the quality of life of the participants was enhanced with noticeable long-term curative effects.

活血通络类方剂治疗糖尿病肾脏疾病的研究进展

糖尿病肾脏疾病(DKD)是导致慢性肾脏病和终末期肾病的首要病因,严重危害人类健康。中医认为血瘀是贯穿DKD全病程的重要病机,多项研究拟定了多个活血通络类方治疗DKD患者,其临床症状好转、蛋白尿减少、肾功能保护、治疗有效率提高和疾病进展延缓等方面均有成效。

基于阴阳平衡探讨运用膏方治疗虚劳

虚劳是“虚损劳伤”的简称,中医认为虚劳是由各种原因引起的以五脏气血阴阳亏损为主要表现的证候,其病机为脏腑气血阴阳虚衰、久虚不复成劳,病位以脾肾为主。各种慢性疑难疾病的后期,皆属于虚劳范畴,可按虚劳病辨治。阴阳理论是古人用以认识自然和解释自然的世界观和方法论,它含有丰富的辩证法思想。古人认为阴阳失调,乃百病之本,一些慢性病、疑难病的发生发展多与人体阴阳失衡相关,故在治疗虚劳病中调和阴阳,使人体恢复阴阳平衡就显得尤为重要。膏作为中药丸、丹、汤、膏、锭等八种剂型之一,具有调补正气、滋养补虚、平调脏腑阴阳、寓治于养之功效,非常适合慢性虚损性、危重病后期以及亚健康状态的调治。因此,文章以阴阳理论为指导,对于虚劳病以膏方论治进行探讨,以期为临床治疗虚损性疾病提供借鉴和思路。

益气养阴活血法治疗2型糖尿病合并慢性心力衰竭患者的疗效观察

目的 探讨中医益气养阴活血法辨证治疗2型糖尿病(Type 2 diabetes, T2DM)合并慢性心力衰竭(Chronic heart failure, CHF)患者的临床疗效。方法 选取2021年1月—2022年1月期间唐山市中医医院内分泌一科收治的T2DM合并CHF患者102例作为研究对象,按随机数字表法分为对照组与治疗组,每组各51例。对照组给予常规西医治疗,治疗组在对照组基础上联合中医益气养阴活血法辨证治疗,均治疗12周。观察比较两组患者西医疗效、中医证候疗效、安全性及治疗前后血糖水平[空腹血糖(Fasting blood glucose, FPG)、餐后2 h血糖(Blood glucose 2 h after a meal, 2 h PG)、糖化血红蛋白(Glycosylated hemoglobin, HbAlc)]、心功能指标[6分钟步行试验距离(6 min walking test, 6MWT)、左室射血分数(Left ventricular ejection fraction, LVEF)、N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor, NT-pro BNP)]、生活质量评分[T2DM生活质量(Quality of life specific scale for diabetes patients, DSQL)、CHF生活质量(Minnesota Living with Heart Failure Questionnaire, MLHFQ)]变化。结果 临床疗效:治疗后治疗组西医疗效总有效率96.08%(49/51)高于对照组82.35%(42/51),差异有统计学意义(P<0.05);治疗组中医证候疗效总有效率92.16%(47/51)高于对照组68.63%(35/51),差异有统计学意义(P<0.05)。血糖水平:治疗后两组患者血糖FPG、2 h PG及HbAlc水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血糖FPG、2 h PG及HbAlc水平均明显低于对照组,差异有统计学意义(P<0.05)。心功能指标:治疗后两组患者心功能6MWT、LVEF水平较治疗前升高,NT-pro BNP水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组6MWT、LVEF水平高于对照组,NT-pro BNP水平低于对照组,差异有统计学意义(P<0.05)。生活质量:治疗后两组患者DSQL、MLHFQ评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组DSQL、MLHFQ评分均明显低于对照组,差异有统计学意义(P<0.05)。安全性:治疗期间,两组患者不良反应均为轻度或一过性,未影响治疗,且不良反应发生率组间比较,差异无统计学意义(P>0.05)。结论 中医益气养阴活血法辨证治疗T2DM合并CHF效果显著、安全性高,有利于控制患者血糖,改善心功能与生活质量。

益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清Vaspin和SCUBE2水平的影响

目的:观察益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)和骨形态发生蛋白1-表皮生长样结构域蛋白2(SCUBE2)水平的影响。方法:选择2021年1月至2022年12月于该院治疗的糖尿病视网膜病变患者102例,以随机数字表法分组。对照组50例患者给予常规西医治疗,观察组52例患者在对照组的基础上给予益气养阴化瘀方治疗。比较两组患者的临床疗效、治疗前后的中医证候评分,检测视野平均敏感度、视力、收缩期血流速度峰值、眼动脉阻力指数(RI)和舒张期血流速度峰值,检测患者Vaspin、低氧诱导因子-1(HIF-1)、可溶性细胞黏附分子(sICAM-1)、SCUBE2、外周血内皮细胞(CEC)和循环祖细胞(CPC)水平。结果:观察组患者总有效率为98.08%(51/52),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05)。治疗后,观察组患者的中医证候评分较对照组降低,差异有统计学意义(P<0.05)。治疗后,观察组患者的RI低于对照组,收缩期血流速度峰值、舒张期血流速度峰值、视野平均敏感度和最佳矫正视力高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的CPC水平较对照组升高,CEC水平较对照组降低,Vaspin、HIF-1、sICAM-1和SCUBE2水平较对照组降低,差异均有统计学意义(P<0.05)。结论:益气养阴化瘀法治疗糖尿病视网膜病变,可改善患者微血管功能、动脉血流、微视野和视力,提高临床疗效。

陈健教授从“伏火”论治儿童周期性发热综合征经验

[目的]总结陈健教授从“伏火”论治儿童周期性发热综合征的临床经验。[方法]通过门诊跟诊学习、病案收集整理及查阅相关文献,探讨儿童周期性发热综合征的病因病机,总结陈教授从“伏火”论治该病的治疗经验,并举验案一则加以验证。[结果]陈教授认为,儿童周期性发热综合征的核心病机为“伏火”,“伏火”为发病之本,痰、毒、瘀既是病理产物,也是贯穿病程始终的重要致病因素,郁为存在于发病全过程的病理状态。治疗上以益气除热或养阴清热与调气之法并行,并以自拟方药为治疗儿童周期性发热综合征的有效验方。所举验案以周期性发热为主要症状,辨为阴虚发热证,投以养阴清热、行气解郁之法,取得了较好的疗效。[结论]陈教授从“伏火”论治儿童周期性发热综合征,疗效显著,具有一定的指导意义,值得临床参考借鉴。

Randomized Double-blinded and Controlled Clinical Trial on Treatment of HIV/AIDS by Zhongyan-4 (中研-4号)

Objective： To assess the efficacy and safety of Zhongyan-4 （中研-4号, ZY-4, a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi, nourishing Yin, clearing heat and detoxication） in treating HIV/AIDS patients in the early or middle stage. Methods： Adopted was randomized double-blinded and placebo-parallel-controlled method, with 72 HIV/AIDS patients randomly divided into the ZY-4 group （36 patients） treated with ZY-4 and the control group （36 patients） treated with placebo. The treatment course was six months. The index of OD4^＋, OD8^＋ counts, body weight, clinical symptom scoring were estimated at 4 time points （0, 1, 3 and 6 month in the course）, and also the viral load before and after treatment. The whole course of observation was completed in 63 patients, 30 in the ZY-4 group and 33 in the control group. Results： OD4^＋ count in the ZY-4 group got elevated by 7.70 4±150.96/mm^3 on average, while that in the control group lowered by 27.33 4±85.28 /mm^3 . Fifteen out of the 30 patients in the ZY-4 group had their OD4^＋ count increased, which was evidently much higher than that in the control group （8/33, P〈0. 05）, suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating OD4^＋ count. Moreover, ZY-4 showed actions in elevating OD45RA^＋ and OD8^＋ count, reducing HIV virus load, improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial. Conclusion： ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage, and also shows effects in lowering viral load, increasing body weight and improving symptoms and signs to a certain degree.

基于数据挖掘分析糖尿病肾病证候及用药规律

目的:应用数据挖掘技术分析总结相关文献中糖尿病肾病的证候及用药规律。方法:运用中国知网(CNKI)、维普资讯中文期刊服务平台,搜集2015年1月1日至2020年12月31日治疗糖尿病肾病的医案,提取用药信息,通过Microsoft Excel 2019建立数据库整理归纳数据,总结糖尿病肾病的证候分布情况、药物治疗分布情况以及药物组合关联规则等。结果:共检索相关文献923篇,根据证候分布情况,病位类证候要素主要为肾、脾、肝、肺、心等;病性类证候要素主要为瘀血、痰浊、阴虚、气虚、浊毒等。根据药物治疗分布情况,四气主要为平、温、寒、微温、微寒,五味多为甘、苦、辛、酸、淡、微苦,且归于肝、脾、肾、肺、心、胃、膀胱、大肠经。核心药物以黄芪、茯苓、山药、山茱萸、丹参等50味中药为主,可归纳为补虚药、活血化瘀药、清热药、利湿药、收涩药;药物组合关联规则显示,丹参、山药、山茱萸、茯苓均与黄芪联系密切。结论:益气养阴、活血通络法为糖尿病肾病主要治法,此为后续进一步开展临床研究提供了数据支撑。

基于“湿火”理论探讨糖尿病合并冠心病的诊治

[目的]基于“湿火”理论探究糖尿病合并冠心病的临床治疗方法。[方法]以“湿火”理论内涵为着手点,基于古今文献,分析论证“湿火”与糖尿病合并冠心病病理过程的关系,总结出从“湿火”治疗糖尿病合并冠心病的原则,并附上一则医案予以佐证。[结果]糖尿病合并冠心病在中医学属于消渴合并胸痹的范畴,“湿火”是其重要病机,中医学以“火热”并谈,然“湿火”“湿热”两异,“湿火”为湿热伤阴,因此应益气养阴以清“湿火”,进而治疗糖尿病合并冠心病。目前临床上鲜有基于“湿火”理论指导糖尿病合并冠心病治疗的报道。所列举医案即为“湿火”所致,以益气养阴为治法,治疗后症状改善明显。[结论]从“湿火”论治糖尿病合并冠心病,并予以临证加减,疗效颇佳,可为医者提供新颖的治疗思路。

益气养阴方联合电针对产后压力性尿失禁大鼠CXCR4/COX-2信号通路的影响

目的:探究益气养阴方联合电针对产后压力性尿失禁(postpartum urinary incontinence,PPUI)大鼠趋化因子受体4(chemokine receptor 4,CXCR4)/环氧合酶2(cyclooxygenase,COX-2)信号通路的作用机制。方法:将大鼠随机分为空白组、PPUI组、益气养阴组和益气养阴+电针组,制备PPUI大鼠模型;检测4组大鼠收缩力/肌重比值、血清乳酸脱氢酶(lactate dehydrogenase,LDH)和心肌酶肌酸激酶(creatine kinase,CK)含量;HE染色检测4组大鼠肛提肌组织病理学变化;蛋白质印迹法检测4组大鼠尿道组织CXCR4和COX-2蛋白表达。结果:与空白组相比,大鼠最大膀胱容量和漏尿压力点PPUI组降低(P<0.05),益气养阴组和益气养阴+电针组升高,益气养阴+电针组升高明显(P<0.05);与空白组相比,收缩力/肌重比值PPUI组降低(P<0.05),益气养阴组和益气养阴+电针组较PPUI组增加,且益气养阴+电针组增加更明显(P<0.05);与空白组相比,LDH和CK含量PPUI组升高(P<0.05),益气养阴组和益气养阴+电针组低于PPUI组(P<0.05)。与空白组相比,PPUI组CXCR4蛋白减少,COX-2蛋白增多(P<0.05),益气养阴组和益气养阴+电针组CXCR4蛋白较PPUI组增多,COX-2蛋白较PPUI组减少(P<0.05),益气养阴+电针组CXCR4蛋白较益气养阴组增加,COX-2蛋白较益气养阴组减少(P<0.05)。结论:益气养阴方联合电针可能通过抑制PPUI大鼠血清LDH和CK表达,增加PPUI大鼠CXCR4表达,抑制COX-2表达,增加盆底肌肌肉收缩功能,治疗PPUI。

益气养阴活血方联合针灸治疗糖尿病肾病临床观察

目的 探讨益气养阴活血方联合针灸治疗糖尿病肾病临床效果。方法 将101例糖尿病肾病患者随机分为对照组和观察组,各50、51例。对照组给予降糖、调脂、降压等基础治疗和口服雷公藤多苷片,观察组于上述治疗基础上加用益气养阴活血方联合针灸治疗,2个月后比较2组疗效、中医症状积分、肾功能指标、炎症因子水平。结果 观察组治疗后临床总有效率高于对照组(P<0.05),尿浊、肢体浮肿、面色晦暗及尿频尿多症状积分均低于对照组(P<0.05),Scr、Cys-C、β_(2)-MG及eGFR水平均低于对照组(P<0.05),IL-6、TNF-ɑ及IL-1β水平均低于对照组(P<0.05)。结论 益气养阴活血方联合针灸疗法对改善糖尿病肾病患者临床症状和肾功能具有积极作用,作用机制可能与减轻炎症反应有关。

从阴阳论治甲状腺功能亢进症

甲状腺功能亢进症(简称甲亢),是甲状腺激素增多导致身体机能亢进的一类内分泌疾病,以心慌手抖、多食易饥、体质量减轻、眼球突出、烦躁易怒为主要临床表现。西医通常选用抗甲状腺药物、甲状腺切除术等方法治疗该病,虽有疗效,但存在需要长期服药、复发率高、手术创伤大、不良反应多等问题。中医将该病归为“瘿病”范畴。贾颖教授具有多年的临床、科研、教学经验,主要运用调和阴阳的方法治疗该病,临床效果显著。文章以阴阳为切入点,通过查阅文献并结合医案分析,浅析贾颖教授治疗“甲亢”过程中的点滴感悟。贾师认为,甲亢主要病机为阴虚阳亢,其中的关键原因为七情郁结,阴虚气弱是基本病变,阴损及阳是转折点。贾师在汲取前人经验及对赵尚华老先生所提出的治疗理念进行全面传承的基础上,对其进行中医辨证分型,分为肝郁痰结、阴虚阳亢、气阴两虚、阴损及阳,并把现代医疗知识融入阴阳之道,在辨证施治的过程中形成了自身的诊疗特色,实现了使患者机体阴阳稳态平衡的治疗目的。

益气养阴散结方对甲状腺癌术后患者免疫功能的影响

目的:探讨益气养阴散结方辅助治疗对甲状腺癌手术(thyroid carcinoma surgery,TCS)后患者免疫功能的影响。方法:将TCS后患者87例采用随机分组方法分为观察组(左甲状腺素钠^(+)益气养阴散结方辅助治疗)45例和对照组(左甲状腺素钠治疗)42例。观察两组患者总有效率、CD3^(+)与CD4^(+)水平及并发症发生率。结果:总有效率观察组为93.33%(42/45),高于对照组的71.43%(30/42)(P<0.05);治疗后观察组CD3^(+)、CD4^(+)水平高于对照组(P<0.05);并发症发生率观察组为6.67%(3/45),低于对照组的23.81%(10/42)(P<0.05)。结论:益气养阴散结方辅助治疗TCS术后患者临床疗效优于左甲状腺素钠,可提高患者免疫功能,降低术后并发症。