The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

Objective： To evaluate whether herbs of supplementing Qi and nourishing Yin combined with chemotherapy （versus chemotherapy alone） improve survival, increase tumor response, improve performance status or reduce chemotherapy toxicity in patients with lung cancer. Methods： Searching the randomized controlled trials （RCT） studies from the databases （China HowNet database, Wan Fang database, VIP database, Master Thesis and Pubmed） between January 2013 and January 2017. RevMan 5.3 software was used to evaluate the quality of these collected papers. Results： Of 48 potentially relevant publications, 10 randomized studies representing 691 patients met inclusion criteria with 369 cases in the supplementing Qi and nourishing Yin plus Chemotherapy group （Herbs ＋ Chem group） and 322 cases in Chemotherapy group （Chem only group）. There were significant differences between Herbs ＋ Chem group and Chem only group in improving the treatment efficacy and reducing the side effects of chemotherapy （P 〈 0.001 for all）. There were also significant differences between the two groups in tumor response and quality of life （P 〈 0.001 for all）. Conclusion： Herbs of supplementing Qi and nourishing Yin may increase chemotherapy effectiveness, reduce chemotherapy toxicity and improve the quality of life of patients with lung cancer when combined with chemotherapy.

Effect of Chinese Drugs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Myocardial Perfusion in Patients with Acute Myocardial Infarction after Revascularization

Objective:To observe the effects of Chinese drugs for supplementing qi,nourishing yin and activating blood circulation on the myocardial perfusion in acute myocardial infarction(AMI) patients after revascularization.Methods:Eighty patients with anterior or inferior ventricular wall AMI,who had received revascularization by intravenous thrombolysis or coronary bypass,were randomized into the treated group and the control group equally,both treated with conventional Western medical treatment,but combined,resp...

Effect of Chinese Herbal Medicine for Nourishing Yin,Supplementing Qi,and Activating Blood on the Th1/Th2 Immune Balance in Peripheral Blood in Patients with Primary Sjogren's Syndrome

Objective： To observe the effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the expression of interferen- γ （IFN-γ,）/interleukin-4 （IL-4） in peripheral blood and disease activity in primary Sjogren＇s syndrome （pSS） patients, and to study the relationship between the immune balance of Th1/Th2 and the disease activity. Methods： A total of 66 pSS patients were randomized with tossing coins method into two groups： the integrative therapy group （34 cases） and the control group （32 cases）; and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G （IgG）, erythrocyte sedimentation rate （ESR）, IFN-γand IL-4 in peripheral blood were measured before and after treatment. Results： Compared with the normal group, the levels of IgG, ESR, IFN- γ and IL-4 were significantly increased in pSS patients （P〈0.05）. Remarkably, after 3 months of treatment, these levels were dramatically decreased in both the integrative therapy group and the control group, although still higher than the normal group. The levels of IgG, ESR, IFN- and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment （P〈0.05）. The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover, the level of IFN- γ, and the ratio of IFN- γ/IL-4 in the integrative theraphy group were significantly lower than the control group （P〈0.05）. For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Conclusion： Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Effect of Chinese Herbal Medicines for Nourishing Yin,Supplementing Qi,and Activating Blood on Reproductive Endocrine Activity and Immune Functions in Patients with Primary Sjogren's Syndrome

ABSTRACT Objective： To investigate the effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on the reproductive endocrine-immune network and its mechanisms in patients with primary Sjogren＇s syndrome （pSS）. Methods： Seventy pSS patients were randomly assigned to two groups using a randomized digital table： the integrative therapy group （36 cases） and the control group （34 cases）. Thirty healthy subjects were taken as a normal group. The control group was treated with hydroxychloroquine sulfate tablets alone, and the integrative therapy group was treated by Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with hydroxychloroquine sulfate tablets. The treatment course was 6 months for both groups. Before and after treatment, serum estradiol （E2）, testosterone （T）, luteinizing hormone （LH）, prolactin （PRL） by radioimmunoassay and immunoglobulin （IgG） by immunodiffusion, erythrocyte sedimentation rate （ESR） by Westergren, interferon-γ （IFN-γ） and interleukin-4 （IL-4） by enzyme linked immunosorbent assay were determined. Results： E2 and T levels in all patients were lower than those of normal subjects before treatment （P〈0.05） and were increased significantly after 6-month treatment （P〈0.05）. ESR, FSH, LH, IgG, IFN - γ, IL - 4 and ratios of E2/T, and IFN --γ/IL in the patients were higher than those of normal subjects before the treatments （P〈0.05）, and were reduced significantly after the treatments （P〈0.05）. The T and IFN -γ levels and E2/T ratio in the patients treated with integrative therapy were reduced significantly compared with the control group （P〈0.05）. However, the PRL levels before and after treatment were not significantly changed in the two groups （P〉0.05）. The ratios of E2/T and IFN -γ/IL-4, and levels of IgG and ESR were positively correlated before and after treatment （P〈0.05）. Conclusions： The ratios of E2/T and IFN - γ/ IL-4 might be used as indicators of pSS activity. Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood combined with Western medicine could improve the therapeutic effect by regulating the reproductive endocrine-immune network in pSS patients.

Protective Effect of Chinese Herbs for Supplementing Qi,Nourishing Yin and Activating Blood Circulation on Heart Function of Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Objective： To investigate the effects of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome （ACS） after successful percutaneous coronary intervention （PCI）. Methods： One hundred patients with ACS after successful PCI were randomly assigned to a Western medicine （WM） treatment group （WMG） and a combined treatment group （CMG） treated by Chinese herbs for supplementing qi, nourishing yin and activating blood circulation, besides Western medicine treatment, with 50 cases in each group. Both treatment courses were 6 months. The follow- up was scheduled at baseline, 6 months and 1 year after PCI, and New York Heart Association （NYHA） functional class, Chinese medicine （CM） symptom scores, blood stasis syndrome scores, and major adverse cardiovascular events （MACE） were observed, serum levels of N-terminal pro-brain natriuretic peptide （NT-proBNP） and hyper-sensitivity C-reactive protein （Hs-CRP） were measured, an echocardiogram was conducted to examine left ventricular ejection fraction （LVEF）, left ventricular end-diastolic volume （LVEDV）, left ventricular end-systolic volume （LVESV）, inter-ventricular septal thickness （IVST）, left ventricular posterior wall thickness （LVPWT）, and ventricular wall motion index （VWMI）. Results： Compared with the baseline, LVEF significantly increased （P〈0.01）, and CM symptom scores, blood stasis syndrome scores, VWMI, LVEDV, LVESV, NT-proBNP, and Hs-CRP all decreased （P〈0.01） in both groups at 6 months and at 1 year after PCI. There were no significant differences in all the above parameters at 1 year vs those at 6 months after PCI （P〉0.05）. VWMI, LVEDV, LVESV, NT-proBNP, Hs-CRP, LVEF, and CM symptom and blood stasis syndrome scores were all improved obviously in CMG than those in WMG （P〈0.05 or P〈0.01） at 6 months and at 1 year after PCI. There were no significant differences in NYHA functional class between CMG and WMG at different follow-up timepoints; it was notable that P value was 0.054 when comparing the cases of NYHA functional class between the two groups at 1-year follow-up. During the 1-year follow-up, 3 MACE and 11 MACE occurred in CMG and WMG, respectively; the MACE rate in CMG was lower than that in WMG （6% vs 22%, P〈0.05）. Conclusion： Chinese herbs for supplementing qi, nourishing yin and activating blood circulation could improve heart function, reduce the CM symptom scores and blood stasis syndrome scores, and decrease the incidence of MACE in patients with ACS after successful PCI.

Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Objective: To probe the effects of qi-supplementing and yin-nourishing therapy (blood-increasing decoction and blood generating powder) on chronic thrombocytopenia. Methods: Two hundred patients with chronic thrombocytopenia were randomly divided into control (n=100) and test groups (n = 100) with Amino-polypeptide as a basic treatment for both. Test group patients consumed a blood-increasing decoction and blood-generating powder for 1-3 months. Improvements in platelet counts and TCM syndrome were observed. Results: One hundred and sixty-four (80 in the test group and 84 in the control group) of 189 total participants were treated for 3 months. The total effective rate in improving TCM syndrome was 95.00% in the test group and 79.76% in the control group (P<0.05). There was significant difference (P<0.05) in the accumulated score of TCM syndrome between the two groups treated at different time points. The total effective rate of platelet counts was 86.25% in the test group and 59.52% in the control group (P<0.05). There was a significant difference in platelet counts before and after treatment in the two groups (P<0.05). There was no significant differences in platelet count between the two groups treated for 1-2 months; however, a significant difference was found between the two groups after treatment for 3 months (P<0.05). Conclusions: After a 3-month treatment of chronic thrombocytopenia patients with qi-supplementing and yin-nourishing therapy, TCM syndrome was improved and platelet counts increased with no obvious side effects, and the quality of life of the participants was enhanced with noticeable long-term curative effects.

Randomized Double-blinded and Controlled Clinical Trial on Treatment of HIV/AIDS by Zhongyan-4 (中研-4号)

Objective： To assess the efficacy and safety of Zhongyan-4 （中研-4号, ZY-4, a Chinese herbal preparation worked out according to the therapeutic principle of supplementing qi, nourishing Yin, clearing heat and detoxication） in treating HIV/AIDS patients in the early or middle stage. Methods： Adopted was randomized double-blinded and placebo-parallel-controlled method, with 72 HIV/AIDS patients randomly divided into the ZY-4 group （36 patients） treated with ZY-4 and the control group （36 patients） treated with placebo. The treatment course was six months. The index of OD4^＋, OD8^＋ counts, body weight, clinical symptom scoring were estimated at 4 time points （0, 1, 3 and 6 month in the course）, and also the viral load before and after treatment. The whole course of observation was completed in 63 patients, 30 in the ZY-4 group and 33 in the control group. Results： OD4^＋ count in the ZY-4 group got elevated by 7.70 4±150.96/mm^3 on average, while that in the control group lowered by 27.33 4±85.28 /mm^3 . Fifteen out of the 30 patients in the ZY-4 group had their OD4^＋ count increased, which was evidently much higher than that in the control group （8/33, P〈0. 05）, suggesting that the efficacy of ZY-4 is superior to that of placebo in elevating OD4^＋ count. Moreover, ZY-4 showed actions in elevating OD45RA^＋ and OD8^＋ count, reducing HIV virus load, improving clinical symptom/sign and increasing body weight of patients. No obvious adverse reaction was found in the clinical trial. Conclusion： ZY-4 has an immunity-protective and/or rebuilding function in HIV/AIDS patients in the early and middle stage, and also shows effects in lowering viral load, increasing body weight and improving symptoms and signs to a certain degree.

基于气阴两虚夹瘀运用五参汤治疗肺癌术后发热浅析

肺癌术后发热有非感染性发热与感染性发热之分,在气虚、阴虚、瘀血阻滞病理状态下形成热蕴状态,是为非感染性发热;而术中感染或外感风寒入里化热则形成感染性发热表现。其基本病机均可概括为气阴两虚夹瘀。五参汤具有益气养阴、清热解毒之功,为证属正气亏虚、外感邪毒者而设,用于肺癌术后发热契合其病机。

朱丹溪四物汤应用特色探析

[目的]探析金元医家朱丹溪临证运用四物汤的经验与特色。[方法]全面收集朱丹溪医著中四物汤医案及医论,对方药部分采用定量频次统计及关联规则分析方法;对医论部分采用定性主题分析方法,用Nvivo 11对病机及治法进行开放式编码、轴心式编码及核心式编码,构建朱丹溪运用四物汤的病机及治法体系。[结果]共收集朱丹溪应用四物汤的医案97则、医论125条,涉及内科杂病40种、妇科疾病6种、外科疾病8种、男科疾病3种、儿科疾病1种。用药频次前10位为:当归、白芍、川芎、熟地黄、白术、人参、陈皮、生甘草、黄芩、黄柏。以四物汤为主方,根据不同病机分别配合养阴(39)、清热(37)、祛风(23)、益气(28)、生血(28)、行血(27)六法。[结论]朱丹溪临证广泛运用四物汤养血法(养血助阴、养血清热、养血祛风)与补血法(补血益气、补血生血、补血行血)治疗由血虚、血实引起的内、妇、外、男、儿科诸病。

基于动静观与阴火理论探讨儿童注意缺陷多动障碍的病机辨治

注意缺陷多动障碍作为儿科常见的神经发育障碍性疾病之一,严重影响广大儿童身心健康与个人发展。中药在改善核心症状、减轻药物不良反应方面具有优势。中国古代动静观认为,疾病生于阴阳动静的失衡,阴火源于脾胃虚损后阳气升发与阴气静藏的动静状态失衡,是一种虚性火热邪气。凡动皆属火,此病理状态与注意缺陷多动障碍患儿神思涣散、行为躁动的表现多有相符之处。王俊宏教授认为,脾胃亏虚、元气不足为注意缺陷多动障碍的发病基础,阴火邸张、动静失衡为其病势动态,湿火闭塞、气机郁结为其病理因素,治疗上应以“除阴火、平动静”为总纲,健运脾胃以伏火、益气养阴以涵动、调和气机以通静,同时遵循儿童体质特点与动静药性配伍规律,附临床验案一则以供参考。

甘温除热法治疗乳腺癌化疗后并发症

乳腺癌的发病以气郁、痰凝、血瘀为因,患之日久,积聚为核,囿于乳络,终耗气伤血,应用化疗药物后,毒邪进入体内最先伤及脾胃,脾胃受损则气血生化无本,输布无源,进而影响其他脏腑生理功能,致正气虚损、气血耗伤。甘温除热法可扶正祛邪、调畅气机、补益气血、安和诸脏,病及于心可用泻火升阳汤,病及于肝可用补中益气汤,病及于肺可用升阳益胃汤,病及于肾可用神圣复气汤。临证时需把握甘温除热法对应证的病机变化,选用方除李东垣著作中所载方外,亦可选黄芪建中汤、人参养荣汤、十全大补汤、七味白术散等符合甘温除热思想之方。

董明国从湿热稽留、阴虚血瘀论治早期肝硬化经验

肝硬化是指由各种病因长期损害肝脏,致肝脏进展成为肝炎、肝纤维化、假小叶形成的病理阶段。中医认为,无论隐源性抑或是继发性肝硬化,均存在明确的病理因素。董明国教授继承以往各名老中医辨治肝硬化的思路,并结合多年临床实践经验,认为早期肝硬化患者的主要病机为湿热稽留、阴虚血瘀,病位主要涉及脾胃与肝胆;对于湿热的治疗,主张采用“轻可去实”之法,运用轻清芳香之品,轻开宣达,醒脾祛湿,分消其势;对于阴虚血瘀,宜施“四面合围”之策,合用养阴益气、活血消癥、清热诸法,常选用新订之何炎燊的二甲调肝汤。通过“轻可去实”“四面合围”方法将病因尽除,分消其病势,以达祛除病因、稳定肝硬化进程的目的,为肝硬化的巩固治疗奠定基础。

楼丽华教授辨治流感大流行后产后缺乳经验浅析

[目的]总结楼丽华教授治疗流感大流行后产后缺乳的临床经验。[方法]通过临床跟师、记录医案及查阅文献,从病因病机、临证施治两方面总结楼师治疗流感大流行后产后缺乳的临床经验,并列举验案加以佐证。[结果]楼师指出,流感大流行后产后缺乳主要与津液灼伤、肺脾两虚密切相关,治疗宜滋阴益气、顾护脾胃、畅达情志,并重建泌乳反射,辅以通络饮食疗。所举医案为流感大流行后产后缺乳,证属肺脾气虚、津液灼伤,采用滋阴补液、益气生津之法,施以“通乳育麟汤”加减,同时注重情志疏导及瘥后饮食调护。经治疗,患者诸证好转,乳汁充盈且通畅。[结论]楼师在治疗流感大流行后产后缺乳方面经验丰富,以滋阴益气、顾护脾胃、畅达情志为法,临床效果显著,颇具借鉴价值。

益气养阴方治疗气阴两虚型慢性心力衰竭临床观察

目的:观察益气养阴方治疗气阴两虚型慢性心力衰竭(chronic heart failure,CHF)的临床疗效。方法:选取2022年8月至2023年8月郑州市第九人民医院诊治的CHF患者80例,按照随机数字表法分为对照组和治疗组,每组40例。对照组给予常规抗心力衰竭治疗,治疗组在对照组治疗的基础上给予益气养阴方治疗。观察两组患者临床症状(下肢水肿、呼吸困难、全身乏力)消退时间、心率(heart rate,HR)、6min行走试验(6-minute walking test,6MWT)、明尼苏达州心功能不全生存质量量表(Minnesota living with heart failure questionnaire,MLHFQ)评分、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)、左室收缩末期内径(left ventricular end systolic diameter,LVESD)及左室射血分数(left ventricular ejection fraction,LVEF)变化情况。结果:治疗组有效率为92.5%,对照组有效率为75.0%,治疗组有效率高于对照组,差异具有统计学意义(P<0.05);治疗组呼吸困难、乏力、下肢水肿等临床症状消退时间短于对照组,差异具有统计学意义(P<0.05);治疗组治疗后6MWT长于对照组,MLHFQ评分、心率低于对照组,差异具有统计学意义(P<0.05);治疗组治疗后LVEDD、LVESD低于对照组,LVEF高于对照组,差异具有统计学意义(P<0.05)。结论:益气养阴方能改善气阴两虚型慢性心力衰竭患者心功能,提高左心室舒张能力、生活质量。

益气养阴活血法治疗2型糖尿病合并慢性心力衰竭患者的疗效观察

目的 探讨中医益气养阴活血法辨证治疗2型糖尿病(Type 2 diabetes, T2DM)合并慢性心力衰竭(Chronic heart failure, CHF)患者的临床疗效。方法 选取2021年1月—2022年1月期间唐山市中医医院内分泌一科收治的T2DM合并CHF患者102例作为研究对象,按随机数字表法分为对照组与治疗组,每组各51例。对照组给予常规西医治疗,治疗组在对照组基础上联合中医益气养阴活血法辨证治疗,均治疗12周。观察比较两组患者西医疗效、中医证候疗效、安全性及治疗前后血糖水平[空腹血糖(Fasting blood glucose, FPG)、餐后2 h血糖(Blood glucose 2 h after a meal, 2 h PG)、糖化血红蛋白(Glycosylated hemoglobin, HbAlc)]、心功能指标[6分钟步行试验距离(6 min walking test, 6MWT)、左室射血分数(Left ventricular ejection fraction, LVEF)、N末端B型脑钠肽前体(N-terminal B-type brain natriuretic peptide precursor, NT-pro BNP)]、生活质量评分[T2DM生活质量(Quality of life specific scale for diabetes patients, DSQL)、CHF生活质量(Minnesota Living with Heart Failure Questionnaire, MLHFQ)]变化。结果 临床疗效:治疗后治疗组西医疗效总有效率96.08%(49/51)高于对照组82.35%(42/51),差异有统计学意义(P<0.05);治疗组中医证候疗效总有效率92.16%(47/51)高于对照组68.63%(35/51),差异有统计学意义(P<0.05)。血糖水平:治疗后两组患者血糖FPG、2 h PG及HbAlc水平均较治疗前降低,差异有统计学意义(P<0.05);且治疗组血糖FPG、2 h PG及HbAlc水平均明显低于对照组,差异有统计学意义(P<0.05)。心功能指标:治疗后两组患者心功能6MWT、LVEF水平较治疗前升高,NT-pro BNP水平较治疗前降低,差异有统计学意义(P<0.05);且治疗组6MWT、LVEF水平高于对照组,NT-pro BNP水平低于对照组,差异有统计学意义(P<0.05)。生活质量:治疗后两组患者DSQL、MLHFQ评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组DSQL、MLHFQ评分均明显低于对照组,差异有统计学意义(P<0.05)。安全性:治疗期间,两组患者不良反应均为轻度或一过性,未影响治疗,且不良反应发生率组间比较,差异无统计学意义(P>0.05)。结论 中医益气养阴活血法辨证治疗T2DM合并CHF效果显著、安全性高,有利于控制患者血糖,改善心功能与生活质量。

益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清Vaspin和SCUBE2水平的影响

目的:观察益气养阴化瘀法对糖尿病视网膜病变患者微血管功能、动脉血流、微视野及血清脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)和骨形态发生蛋白1-表皮生长样结构域蛋白2(SCUBE2)水平的影响。方法:选择2021年1月至2022年12月于该院治疗的糖尿病视网膜病变患者102例,以随机数字表法分组。对照组50例患者给予常规西医治疗,观察组52例患者在对照组的基础上给予益气养阴化瘀方治疗。比较两组患者的临床疗效、治疗前后的中医证候评分,检测视野平均敏感度、视力、收缩期血流速度峰值、眼动脉阻力指数(RI)和舒张期血流速度峰值,检测患者Vaspin、低氧诱导因子-1(HIF-1)、可溶性细胞黏附分子(sICAM-1)、SCUBE2、外周血内皮细胞(CEC)和循环祖细胞(CPC)水平。结果:观察组患者总有效率为98.08%(51/52),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05)。治疗后,观察组患者的中医证候评分较对照组降低,差异有统计学意义(P<0.05)。治疗后,观察组患者的RI低于对照组,收缩期血流速度峰值、舒张期血流速度峰值、视野平均敏感度和最佳矫正视力高于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者的CPC水平较对照组升高,CEC水平较对照组降低,Vaspin、HIF-1、sICAM-1和SCUBE2水平较对照组降低,差异均有统计学意义(P<0.05)。结论:益气养阴化瘀法治疗糖尿病视网膜病变,可改善患者微血管功能、动脉血流、微视野和视力,提高临床疗效。

陈健教授从“伏火”论治儿童周期性发热综合征经验

[目的]总结陈健教授从“伏火”论治儿童周期性发热综合征的临床经验。[方法]通过门诊跟诊学习、病案收集整理及查阅相关文献,探讨儿童周期性发热综合征的病因病机,总结陈教授从“伏火”论治该病的治疗经验,并举验案一则加以验证。[结果]陈教授认为,儿童周期性发热综合征的核心病机为“伏火”,“伏火”为发病之本,痰、毒、瘀既是病理产物,也是贯穿病程始终的重要致病因素,郁为存在于发病全过程的病理状态。治疗上以益气除热或养阴清热与调气之法并行,并以自拟方药为治疗儿童周期性发热综合征的有效验方。所举验案以周期性发热为主要症状,辨为阴虚发热证,投以养阴清热、行气解郁之法,取得了较好的疗效。[结论]陈教授从“伏火”论治儿童周期性发热综合征,疗效显著,具有一定的指导意义,值得临床参考借鉴。

补气养阴通便汤配合多点柱状缝扎术治疗直肠前突临床观察

目的:观察补气养阴通便汤配合多点柱状缝扎术治疗直肠前突的临床疗效。方法:选取符合纳入标准的直肠前突住院患者50例作为研究对象,按随机数字表法分为对照组和观察组各25例。对照组采取多点柱状缝扎术治疗,观察组在对照组的基础上给予补气养阴通便汤治疗。比较两组术后疼痛评分、便秘患者症状自评量表评分、临床疗效、术后并发症发生情况。结果:对照组术后24、48、72 h疼痛评分高于观察组(P<0.05)。对照组治疗后便秘患者症状自评量表总分高于观察组(P<0.05)。总有效率观察组为96.00%(24/25),高于对照组的76.00%(19/25)(P<0.05)。术后并发症发生率对照组为16.00%(4/25)高于观察组的4.00%(1/25),但差异无统计学意义(P>0.05)。结论:补气养阴通便汤配合多点柱状缝扎术,可有效降低直肠前突患者术后痛感、减轻便秘程度,提高临床疗效。

中西医结合治疗肥胖型糖尿病前期的临床效果

目的分析在肥胖型糖尿病前期的治疗中应用中西医结合方式的效果。方法选取2022年3月—2023年3月在本院就诊的肥胖型糖尿病前期患者60例为研究对象,根据治疗方式将其分为两组,每组30例。对照组采取西医治疗,观察组采取中西医结合治疗,比较两组治疗效果。结果观察组治疗有效率明显优于对照组(P<0.05)。治疗前,两组患者的空腹血糖和餐后2h血糖水平比较,无显著差异(P>0.05);治疗后,两组空腹血糖和餐后2h血糖水平均下降,且观察组低于对照组(P<0.05)。治疗前,两组患者的血脂水平差异并不明显(P>0.05);治疗后,两组患者的血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]均降低,且观察组低于对照组(P<0.05);治疗后,两组高密度脂蛋白胆固醇(HDL-C)水平均升高,且观察组高于对照组(P<0.05)。治疗前,两组患者的血液流变学指标水平比较,无显著差异(P>0.05);治疗后,两组血液流变学指标水平均降低,且观察组低于对照组(P<0.05)。结论在肥胖性糖尿病的临床实践中,采用中医和西药相结合的方法,能使患者各个时间段的血糖浓度得到明显控制,值得推广应用。

益气固本汤联合运动干预对糖尿病模型大鼠血糖的调节

目的探究益气固本汤对糖尿病模型大鼠的血糖调节作用,并进一步研究其对血糖调节激素水平的影响。方法使用高脂饲料及链脲霉素建立糖尿病大鼠模型,实验设置运动组、益气固本汤组及益气固本汤+运动组,观察运动组、益气固本汤+运动组对糖尿病大鼠一般情况、空腹血糖(FBG)、空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平的影响。结果与模型组比较,运动组、益气固本汤组及益气固本汤+运动组大鼠FBG,血清胰高血糖素、皮质醇水平降低显著,差异具有统计学意义(P<0.01,P<0.05);空腹胰岛素及肝糖原水平升高,差异具有统计学意义(P<0.01,P<0.05),益气固本汤+运动组对大鼠FBG,空腹胰岛素水平、胰高血糖素水平、皮质醇及肝糖原水平改变有协同作用(P<0.05)。结论益气固本汤联合运动干预可有效改善糖尿病大鼠其一般状态,降低糖尿病大鼠血糖并维持其血糖稳态,对糖尿病大鼠胰岛功能具有恢复作用。这可能与益气固本汤增加胰岛素分泌、降低及调节血清胰高血糖素和皮质醇分泌、增加肝糖原含量有关。