A Fixed Suppressed Rate Selection Method for Suppressed Fuzzy C-Means Clustering Algorithm

Suppressed fuzzy c-means (S-FCM) clustering algorithm with the intention of combining the higher speed of hard c-means clustering algorithm and the better classification performance of fuzzy c-means clustering algorithm had been studied by many researchers and applied in many fields. In the algorithm, how to select the suppressed rate is a key step. In this paper, we give a method to select the fixed suppressed rate by the structure of the data itself. The experimental results show that the proposed method is a suitable way to select the suppressed rate in suppressed fuzzy c-means clustering algorithm.

Effects of Bortezomib and Dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels

Objective:To investigate the effects of Bortezomib and Dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels.Methods:A total of 80 cases of patients with multiple myeloma treated in our hospital from Oct 2013 to Jul 2015 were selected as investigate subjects. They were randomly divided to be observation group consisted of 43 cases and control group consisted of 37 cases. For observation group, treatment of Bortezomib and Dexamethasone combination was provided. For control group, Vincristine + Epirubicin + Dexamethasone treatment was provided. After three courses, effects on two groups of patients were compared, and immune suppressed factors and immune cell levels before and after treatment in different periods were compared.Results:After three courses of treatment, the total effective rate in observation group was significantly higher than control group. Before treatment, IL-6, IL-17, TGF-β, CD3+CD4+, CD3+CD8+ and CD3+CD4+/CD3+CD8+ between the two group of patients were compared, no significant difference showed;After treatment for 6 weeks, IL-6, IL-17 levels in observation group were significantly decreased comparing with the same group before treatment;After treatment for 12 weeks, IL-6, IL-17 and TGF-β levels in observation group were significantly decreased comparing with the same group before treatment;After treatment, IL-6, IL-17 levels in observation group were significantly lower than control group at the same phase. After treatment for 12 weeks, CD3+CD4+, CD3+CD4+/CD3+CD8+ in observation group were significantly higher than the same group before treatment, and significantly higher than control group at the same phase;CD3+CD8+ in observation group was significantly lower than the same group before treatment, and significantly lower than control group at the same phase. Conclusion:Compared with Vincristine + Epirubicin + Dexamethasone treatment, Bortezomib and Dexamethasone combination on treating senile multiple myeloma had more significant effects, which deserves further clinical researches.

Identification of human genomic DNA from suppressed metastatic phenotype cells of mouse lung adenocarcinoma

Objectives:To isolate tumor metastaticsuppressing genes or relating human DNA sequencesand to study the molecular biological regulatingmechanism of tumor metastasis. Methods: HumanDNA fragments were amplified by Inter Alu PCRtechnique from normal human genomic DNAtransfected mouse tumor cell clones of which themetastatic phenotype had been suppressed. Thehuman origin of the amplified DNA was furtherconfirmed by PCR in situ hybridization. One

Partition region-based suppressed fuzzy C-means algorithm

Aimed at the problem that the traditional suppressed fuzzy C-means clustering algorithms ignore the real needs of different objects, applying the same suppressed parameter for modifying membership degrees of all the objects, a novel partition region-based suppressed fuzzy C-means clustering algorithm with better capacity of adaptability and robustness is proposed in this paper. The model based on the real needs of different objects is built, making it clear to decide whether to proceed with further determination; in addition, the external user-defined suppressed parameter is automatically selected according to the intrinsic structural characteristic of each dataset, making the proposed method become robust to the fluctuations in the incoming dataset and initial conditions. Experimental results show that the proposed method is more robust than its counterparts and overcomes the weakness of the original suppressed clustering algorithm in most cases.

Effects of Heat Clearing and Stasis Resolving Method on PTS,Inflammatory Factors and T-lymphocyte Subsets in Peripheral Blood of URM Patients with Suppressed Internal Heat

[Objectives]To explore the effects of heat clearing and stasis resolving method on prethrombotic state,inflammatory factors and T-lymphocyte subsets in peripheral blood of unexplained recurrent miscarriage(URM)patients with suppressed internal heat.[Methods]Thirty cases of URM patients with suppressed internal heat and 30 normal women were collected,and characteristics of changes in peripheral serum D-dimer(D-D),fibrin degradation product(FDP),fibrinogen(FIB),IL-6,IL-10 and TNF-α,CD,CD,CD,CD,CDlevels were detected.URM patients were treated with traditional Chinese medicine for clearing heat and resolving blood stasis for 3 menstrual cycles,and the changes of indicators before and after treatment were observed.[Results]Compared with normal women,the peripheral serum levels of D-D,IL-6,TNF-αand CDin URM patients with suppressed internal heat were increased(P<0.05),while the IL-10 lymphocyte level was significantly decreased(P<0.05);compared with that before treatment,the contents of D-D,IL-6,TNF-αand CDdecreased after 3 menstrual cycles(P<0.05),while the contents of IL-10 and CDT lymphocytes increased significantly(P<0.05).[Conclusions]The heat clearing heat and stasis resolving method can effectively improve the prethrombotic state of URM,and the action mechanism may be related to the regulation of immune and peripheral blood inflammatory factors.

Stable continuous-wave single-frequency intracavity frequency-doubled laser with intensity noise suppressed in audio frequency region

We demonstrated a continuous wave(cw) single-frequency intracavity frequency-doubled Nd:YVO_4/LBO laser with 532 nm output of 7.5 W and 1.06 μm output of 3.1 W, and low intensity noise in audio frequency region.To suppress the intensity noise of the high power 532 nm laser, a laser frequency locking system and a feedback loop based on a Mach-Zehnder interferometer were designed and used.The influences of the frequency stabilization and the crucial parameters of the MZI, such as the power splitting ratio of the beam splitters and the locking state of the MZI, on the intensity noise of the 532 nm laser were investigated in detail.After the experimental optimizations, the laser intensity noise in the frequency region from 0.4 kHz to 10 kHz was significantly suppressed.

Random-injection-based two-channel chaos with enhanced bandwidth and suppressed time-delay signature by mutually coupled lasers: Proposal and numerical analysis

Simultaneous bandwidth(BW) enhancement and time-delay signature(TDS) suppression of chaotic lasing over a wide range of parameters by mutually coupled semiconductor lasers(MCSLs) with random optical injection are proposed and numerically investigated. The influences of system parameters on TDS suppression(characterized by autocorrelation function(ACF) and permutation entropy(PE) around characteristic time) and chaos BW are investigated. The results show that, with the increasing bias current, the ranges of parameters(detuning and injection strength) for the larger BW(> 20 GHz) are broadened considerably, while the parameter range for optimized TDS(< 0.1) is not shrunk obviously.Under optimized parameters, the system can simultaneously achieve two chaos outputs with enhanced BW(> 20 GHz)and perfect TDS suppression. In addition, the system can generate two-channel high-speed truly physical random number sequences at 200 Gbits/s for each channel.

Effect of Fuzheng Jiedu granule on immunological function and level of immune-related cytokines in immune-suppressed mice

Fuzheng Jiedu granule exhibits a number of health benefits and it is thought that the mechanisms involved in these effects are due to the modulation of immunity. In this article, we studied the effect of Fuzheng Jiedu granule on immunological function and the expression of immune-related cytokines in immune-suppressed mice. 72 mice were randomly divided into six groups, with 12 in each group. The control groups included an untreated group, a negative control group（Cyclophosphamide） and a positive control group（Astragalus polysaccharide）. There were three treated groups, which were given different doses of Fuzheng Jiedu granule： a low dose（100 mg kg^（–1））, a medium dose（400 mg kg^（–1）） and a high dose（600 mg kg^（–1））. With the exception of the untreated control animals, each group received an intraperitoneal injection of Cyclophosphamide（100 mg kg^（–1）） for 3 days to establish the immune-suppressed model. Mice were then treated for 19 consecutive days and, 24 h after the last treatment, blood was taken for the eyeballs and serum separation was performed. Analysis was made of the levels of related cytokines（IgA, IgG, IgM, IL-6, IFN-γ, C3, C4 and TNF-α）, the transformation of lymphocytes and the immune organ indexes. The results showed that Fuzheng Jiedu granule can improve the levels of cytokines, the rate of proliferation of lymphocytes and the immune organ indexes of immune-suppressed mice.

Enhanced or suppressed six-wave mixing in a five-level atomic system

We show the enhancement and suppression of a six-wave mixing （SWM） signal in the electromagnetically induced transparency in a five-level SSRb atomic system. The results show the Autler-Townes splitting and the enhancement or suppression of SWM, which are caused respectively by a self-dressing effect and by an external dressing effect in the presence of mutual dressing between two SWM signals. In addition, we observe the polarization dependence of the enhancement and suppression of the SWM signals.

Colorless WDM-PON Using Single Side Band Carrier Suppressed Signals Mitigating Carrier Rayleigh Backscattering

A new scheme is offered for minimizing carrier Rayleigh backscattering(CRB) in single feeder fiber based wavelength division multiplexed passive optical network(WDM-PON). The proposed scheme is based on single side band carrier suppressed(SSBCS) signal, both at network and receiver sides, used for the first time at optical line terminal(OLT) and optical network unit(ONU) sides. We use dual-drive Mach-zehnder modulator(DD-MZM) for generating SSB-CS signals, which decreases the expense per bit in full transmission. SSB-CS mitigates CRB, both at OLT and ONU sides, because of having no chance of reflections from the carrier. Since no extra dedicated RF or laser source is used at ONU side, we thus achieve cost effective colorless WDM-PON system. Suppressed signals from four channels, each of 10 Gbps, are multiplexed before injecting into the fiber span of 25 km at OLT. At ONU side, half of the downlink power is used for re-modulating the data signal. The simulation results show an errorfree transmission. Moreover, the detailed power budget calculations show that the proposed scheme can be sought out for splitting ratio up to 128. Hence it offers enough system's margin for unseen losses.

IMMUNOREGULATORY EFFECT OF PANAXATRIOL GINSENOSIDE ON IMMUNE FUNCTIONS IN BONE MARROW SUPPRESSED MICE

The effect of Panaxatriol Ginsenoside (PTGS) on Immune functions in bone marrow suppressed mice induced by injection of cyclophosphamide (CY) has been studied. Bone marrow suppressed mice were made by injection of CY (150 mg/kg) parenterally. Subcutaneous injection of PTGS three days earlier partially restored the number and the activity of bone marrow cells, significantly enhanced the production of IL-1, IL- 3 and IL- 6 like substances and promoted the reactivity of murlne spleen cells to Con-A In bone marrow suppressed mice.

High⁃Efficiency Two⁃Port Encapsulated Low⁃Contrast Grating with Suppressed Zeroth Order under Normal Incidence

A two⁃port encapsulated low⁃contrast grating with suppressed zeroth order under normal incidence is described in this paper.Based on such grating configuration,the improved efficiency and spectral bandwidth of the first order for TE and TM polarizations with a designed period of 1860 nm can be obtained.On the one hand,some of the accurate grating parameters were numerically optimized utilizing a rigorous coupled⁃wave analysis;on the other hand,the inherent physical mechanism suppressing the zeroth order through an encapsulated fused⁃silica grating was adequately interpreted on account of a simplified modal method.Encapsulated grating with a cover layer cannot be simply considered as adding a coating on it.Compared with reported surface⁃relief grating,all parameters of encapsulated grating should be re⁃optimized and the optimized performances of encapsulated grating were greatly improved.Therefore,the encapsulated grating can be potentially applied in writing fiber Bragg gratings.

Double-ended passivator enables dark-current-suppressed colloidal quantum dot photodiodes for CMOS-integrated infrared imagers

Lead sulfide(PbS)colloidal quantum dot(CQD)photodiodes integrated with silicon-based readout integrated circuits(ROICs)offer a promising solution for the next-generation short-wave infrared(SWIR)imaging technology.Despite their potential,large-size CQD photodiodes pose a challenge due to high dark currents resulting from surface states on nonpassivated(100)facets and trap states generated by CQD fusion.In this work,we present a novel approach to address this issue by introducing double-ended ligands that supplementally passivate(100)facets of halidecapped large-size CQDs,leading to suppressed bandtail states and reduced defect concentration.Our results demonstrate that the dark current density is highly suppressed by about an order of magnitude to 9.6 nA cm^(2) at -10 mV,which is among the lowest reported for PbS CQD photodiodes.Furthermore,the performance of the photodiodes is exemplary,yielding an external quantum efficiency of 50.8%(which corresponds to a responsivity of 0.532 A W^(-1))and a specific detectivity of 2.5×10^(12) Jones at 1300 nm.By integrating CQD photodiodes with CMOS ROICs,the CQD imager provides high-resolution(640×512)SWIR imaging for infrared penetration and material discrimination.

Wind-Vortex-Induced Vibrations of a Deepwater Jacket Pipe and Vibration Suppression Using a Nonlinear Energy Sink

The purpose of this study is to investigate the suppression effect of a nonlinear energy sink(NES)on the wind-vortex-induced pipe vibration and explore the influence of damping,stiffness,and NES installation position on the suppression effect.In this work,the wind-vortex-induced vibration of an elastic pipe of a deepwater jacket was studied,and vibrations were suppressed by using an NES.A van der Pol wake oscillator was used to simulate vortex-induced force,and the dynamic equation of the pipe considering the NES was established.The Galerkin method was applied to discretize the motion equation,and the vortex-induced vibration(VIV)of the pipe at reduced wind speeds was numerically analyzed.The novelty of this research is that particle swarm optimization was used to optimize the parameters of the NES to improve vibration suppression.The influence of the installation position,nonlinear stiffness,and damping parameters of the NES on vibration suppression was analyzed.Results showed that the optimized parameter combinations of the NES can effectively reduce wind-vortex-induced pipe vibration.The installation position of the NES had a significant effect on vibration suppression,and the midpoint of the pipe was the optimal NES installation position.An increase in stiffness or a 10% decrease in damping may cause vibration suppression failure.The results of this study provide some guidance for VIV suppression in deepwater jacket pipes.

Multi-distortion suppression for neutron radiographic images based on generative adversarial network

Neutron radiography is a crucial nondestructive testing technology widely used in the aerospace,military,and nuclear industries.However,because of the physical limitations of neutron sources and collimators,the resulting neutron radiographic images inevitably exhibit multiple distortions,including noise,geometric unsharpness,and white spots.Furthermore,these distortions are particularly significant in compact neutron radiography systems with low neutron fluxes.Therefore,in this study,we devised a multi-distortion suppression network that employs a modified generative adversarial network to improve the quality of degraded neutron radiographic images.Real neutron radiographic image datasets with various types and levels of distortion were built for the first time as multi-distortion suppression datasets.Thereafter,the coordinate attention mechanism was incorporated into the backbone network to augment the capability of the proposed network to learn the abstract relationship between ideally clear and degraded images.Extensive experiments were performed;the results show that the proposed method can effectively suppress multiple distortions in real neutron radiographic images and achieve state-of-theart perceptual visual quality,thus demonstrating its application potential in neutron radiography.

High Permeability in Broadband of Co-sputtered [Fe-Fe_(20)Ni_(80)/Cr]_(n) Multilayer Films

To achieve high microwave permeability in wide-band for the micron-thick magnetic films,[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer structure was proposed by co-sputtering Fe and FeNi to form the magnetic layers and Cr to form the interlayers.The multilayer structure contributes to the high permeability by reducing the coercivity and diminishing out-of-plane magnetization.The maximum imaginary permeability of[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer film reaches a large value of 800 at 0.52 GHz even though its overall thickness exceeds 1μm.Besides,the magnetic resonance frequency of the multilayer film can be modulated from 0.52 to 1.35 GHz by adjusting the sputtering power of Fe from 0 to 86 W,and its bandwidth for μ’’>200(Δf) is as large as 2.0 GHz.The desirable broad Δf of magnetic permeability,which can be well fitted by the Landau-Lifshitz-Gilbert equations,is due to dual magnetic resonances originated from double magnetic phases of Fe and FeNi that are of different saturation magnetization.The micron-thick multilayer films with high permeability in extended waveband are promising candidate for electromagnetic noise suppression application.

Recent research progress in the mechanism and suppression of fusion welding-induced liquation cracking of nickel based superalloys

Nickel-based superalloys are extensively used in the crucial hot-section components of industrial gas turbines,aeronautics,and astronautics because of their excellent mechanical properties and corrosion resistance at high temperatures.Fusion welding serves as an effective means for joining and repairing these alloys;however,fusion welding-induced liquation cracking has been a challenging issue.This paper comprehensively reviewed recent liquation cracking,discussing the formation mechanisms,cracking criteria,and remedies.In recent investigations,regulating material composition,changing the preweld heat treatment of the base metal,optimizing the welding process parameters,and applying auxiliary control methods are effective strategies for mitigating cracks.To promote the application of nickel-based superalloys,further research on the combination impact of multiple elements on cracking prevention and specific quantitative criteria for liquation cracking is necessary.

Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial filtering.If the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation effect.To cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range dimension.The principle is presented,and the validity is proven by simulation results.

New insights on the high-corrosion resistance of UHP Mg-Ge alloys tested in a simulated physiological environment

UHP Mg-Ge alloys was recently found to provide excellent corrosion resistance.This paper provides new insights on the mechanism of improved corrosion resistance of UHP Mg-Ge alloys in Hanks’solution.The studied UHP Mg-0.5Ge and UHP Mg-1Ge alloys showed superior corrosion resistance compared to UHP Mg and WE43,with the Mg-1Ge exhibiting the best corrosion performance.The exceptional corrosion resistance of the UHP alloy is attributed to(i)Mg_(2)Ge’s ability to suppress cathodic kinetics,(ii)Ge’s capability to accelerate the formation of a highly passive layer,and the(iii)low amounts of corrosion-accelerating impurities.

Progress on Transition Metal Ions Dissolution Suppression Strategies in Prussian Blue Analogs for Aqueous Sodium-/Potassium-Ion Batteries

Aqueous sodium-ion batteries(ASIBs)and aqueous potassium-ion batteries(APIBs)present significant potential for large-scale energy storage due to their cost-effectiveness,safety,and environmental compatibility.Nonetheless,the intricate energy storage mechanisms in aqueous electrolytes place stringent require-ments on the host materials.Prussian blue analogs(PBAs),with their open three-dimensional framework and facile synthesis,stand out as leading candidates for aqueous energy storage.However,PBAs possess a swift capacity fade and limited cycle longevity,for their structural integrity is compromised by the pronounced dis-solution of transition metal(TM)ions in the aqueous milieu.This manuscript provides an exhaustive review of the recent advancements concerning PBAs in ASIBs and APIBs.The dissolution mechanisms of TM ions in PBAs,informed by their structural attributes and redox processes,are thoroughly examined.Moreover,this study delves into innovative design tactics to alleviate the dissolution issue of TM ions.In conclusion,the paper consolidates various strategies for suppressing the dissolution of TM ions in PBAs and posits avenues for prospective exploration of high-safety aqueous sodium-/potassium-ion batteries.