Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sS...Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.展开更多
BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy recepto...BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy receptor for interleukin(IL)-33 to prevent IL-33/suppression of tumorigenicity 2L(ST2L)-pathwaymediated T helper(Th)2 immune responses.AIM To investigate the role of sST2 in AP.METHODS We assessed the association between sST2 and severity of AP in 123 patients enrolled in this study.The serum levels of sST2,C-reactive protein(CRP)and Th1-and Th2-related cytokines,including interferon(IFN)-γ,tumor necrosis factor(TNF)-α,IL-2,IL-4,IL-5 and IL-13,were measured by highly sensitive ELISA,and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria.RESULTS Serum sST2 levels were significantly increased in AP patients,and further,these levels were significantly elevated in severe AP(SAP)patients compared to moderately severe AP(MSAP)and mild AP(MAP)patients.Logistic regression showed sST2 was a predictor of SAP[odds ratio(OR):1.003(1.001–1.006),P=0.000].sST2 cutoff point was 1190 pg/mL,and sST2 above this cutoff was associated with SAP.sST2 was also a predictor of any organ failure and mortality during AP[OR:1.006(1.003–1.009),P=0.000,OR:1.002(1.001–1.004),P=0.012,respectively].Additionally,the Th1-related cytokines IFN-γand TNF-αin the SAP group were higher and the Th2-related cytokine IL-4 in the SAP group was significantly lower than those in MSAP and MAP groups.CONCLUSION sST2 may be used as a novel inflammatory marker in predicting AP severity and may regulate the function and differentiation of IL-33/ST2-mediated Th1 and Th2 Lymphocytes in AP homeostasis.展开更多
目的探讨心力衰竭患者血浆补体C1q肿瘤坏死因子相关蛋白3(C1q tumor necrosis factor related proteins-3,CTRP3)、血管生成素样蛋白2(angiopoietin like protein 2,angptl2)、可溶性致癌抑制因子2(soluble suppression of tumorigenici...目的探讨心力衰竭患者血浆补体C1q肿瘤坏死因子相关蛋白3(C1q tumor necrosis factor related proteins-3,CTRP3)、血管生成素样蛋白2(angiopoietin like protein 2,angptl2)、可溶性致癌抑制因子2(soluble suppression of tumorigenicity 2,sST2)的浓度及预后价值。方法选择2014年8月到2018年2月在北京市垂杨柳医院心内科收治的心力衰竭患者122例作为心力衰竭组,并分为收缩性心力衰竭组62例和舒张性心力衰竭组60例两个亚组;对照组为非心力衰竭人群122例。采用酶联免疫吸附法检测混杂血浆CTRP3、angptl2、sST2浓度,随访调查患者的预后并进行相关性分析与预测价值分析。结果心力衰竭组的左心室射血分数(left ventricular ejection fraction,LVEF)低于对照组,左心室舒张末期内径(left ventricular end diastolic dimension,LVEDD)及血尿素、肌酐浓度高于对照组,差异有统计学意义(P<0.05)。两组总胆固醇、低密度脂蛋白胆固醇浓度比较,差异无统计学意义(P>0.05)。两亚组心功能与生化指标比较,差异无统计学意义(P>0.05)。心力衰竭组的血浆angptl2、sST2浓度高于对照组,CTRP3浓度低于对照组,差异有统计学意义(P<0.05);两亚组CTRP3、angptl2、s ST2浓度比较,差异无统计学意义(P>0.05)。随访至今,心力衰竭组患者中预后不良16例,发生率为13.1%。Pearson相关分析结果显示CTRP3、angptl2、sST2、LVEF、LVEDD、尿素、肌酐都与心力衰竭患者预后显著相关(P<0.05)。Cox回归模型分析显示CTRP3、angptl2、sST2为影响心力衰竭患者预后的主要因素(P<0.05)。结论心力衰竭患者血清CTRP3、angptl2、sST2浓度呈现异常表达情况,具有预测预后不良的价值,是心力衰竭预后评估的生物学标志物。展开更多
文摘Suppression of Tumorigenicity 2 （ST2） is a member of the interleukin （IL）-1 receptor family The ST2 receptor exists in two isoforms - ST2 ligand （ST2L） and soluble ST2 （sST2）.ST2L is a membrane receptor and sST2 is a trun- cated receptor which is soluble in the blood, allowing it to be detected in serum. IL-33 is a member of the IL-1 family of ligand and is the fimctional ligand of ST2L receptor. It binds to the ST2L, thereby mediating its immune function.
基金Supported by Henan Province Education Department for Henan Province University Key Scientific Research Project,No.20A320018 and No.20A320064。
文摘BACKGROUND Acute pancreatitis(AP)is an inflammatory disease in which the regulatory pathway is complex and not well understood.Soluble suppression of tumorigenicity 2(sST2)protein receptor functions as a decoy receptor for interleukin(IL)-33 to prevent IL-33/suppression of tumorigenicity 2L(ST2L)-pathwaymediated T helper(Th)2 immune responses.AIM To investigate the role of sST2 in AP.METHODS We assessed the association between sST2 and severity of AP in 123 patients enrolled in this study.The serum levels of sST2,C-reactive protein(CRP)and Th1-and Th2-related cytokines,including interferon(IFN)-γ,tumor necrosis factor(TNF)-α,IL-2,IL-4,IL-5 and IL-13,were measured by highly sensitive ELISA,and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria.RESULTS Serum sST2 levels were significantly increased in AP patients,and further,these levels were significantly elevated in severe AP(SAP)patients compared to moderately severe AP(MSAP)and mild AP(MAP)patients.Logistic regression showed sST2 was a predictor of SAP[odds ratio(OR):1.003(1.001–1.006),P=0.000].sST2 cutoff point was 1190 pg/mL,and sST2 above this cutoff was associated with SAP.sST2 was also a predictor of any organ failure and mortality during AP[OR:1.006(1.003–1.009),P=0.000,OR:1.002(1.001–1.004),P=0.012,respectively].Additionally,the Th1-related cytokines IFN-γand TNF-αin the SAP group were higher and the Th2-related cytokine IL-4 in the SAP group was significantly lower than those in MSAP and MAP groups.CONCLUSION sST2 may be used as a novel inflammatory marker in predicting AP severity and may regulate the function and differentiation of IL-33/ST2-mediated Th1 and Th2 Lymphocytes in AP homeostasis.
文摘目的探讨心力衰竭患者血浆补体C1q肿瘤坏死因子相关蛋白3(C1q tumor necrosis factor related proteins-3,CTRP3)、血管生成素样蛋白2(angiopoietin like protein 2,angptl2)、可溶性致癌抑制因子2(soluble suppression of tumorigenicity 2,sST2)的浓度及预后价值。方法选择2014年8月到2018年2月在北京市垂杨柳医院心内科收治的心力衰竭患者122例作为心力衰竭组,并分为收缩性心力衰竭组62例和舒张性心力衰竭组60例两个亚组;对照组为非心力衰竭人群122例。采用酶联免疫吸附法检测混杂血浆CTRP3、angptl2、sST2浓度,随访调查患者的预后并进行相关性分析与预测价值分析。结果心力衰竭组的左心室射血分数(left ventricular ejection fraction,LVEF)低于对照组,左心室舒张末期内径(left ventricular end diastolic dimension,LVEDD)及血尿素、肌酐浓度高于对照组,差异有统计学意义(P<0.05)。两组总胆固醇、低密度脂蛋白胆固醇浓度比较,差异无统计学意义(P>0.05)。两亚组心功能与生化指标比较,差异无统计学意义(P>0.05)。心力衰竭组的血浆angptl2、sST2浓度高于对照组,CTRP3浓度低于对照组,差异有统计学意义(P<0.05);两亚组CTRP3、angptl2、s ST2浓度比较,差异无统计学意义(P>0.05)。随访至今,心力衰竭组患者中预后不良16例,发生率为13.1%。Pearson相关分析结果显示CTRP3、angptl2、sST2、LVEF、LVEDD、尿素、肌酐都与心力衰竭患者预后显著相关(P<0.05)。Cox回归模型分析显示CTRP3、angptl2、sST2为影响心力衰竭患者预后的主要因素(P<0.05)。结论心力衰竭患者血清CTRP3、angptl2、sST2浓度呈现异常表达情况,具有预测预后不良的价值,是心力衰竭预后评估的生物学标志物。
