SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse array...SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse arrayof biological processes, including controlling gene transcription[1;2], maintaining genome integrity[3;4], regulating cellcycle progression[5;6], and mediating DNA damage and repair[7;8]. In addition to targeting H4K20, SET8 is alsoreported in methylating the tumor suppressor p53 at lysine residue 382 (p53K382me1) and repressing p53-mediatedtranscriptional activation of target genes. In response to ionizing radiation, p53 regulates the transcription of genesin a diverse set of pathways including DNA repair, cell cycle arrest, and apoptosis[9]. Thus, we hypothesis thatSET8 may affect the cellular response to ionizing radiation by interacting with p53.展开更多
C/EBPβ (CCAAT/enhancer-binding protein β) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBPβ protein results in cellular growth arr...C/EBPβ (CCAAT/enhancer-binding protein β) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBPβ protein results in cellular growth arrest and apoptosis. Using a nonviral liposome as carrier, we delivered the full-length C/EBPβ expression plasmid, pCN, into nude mice bearing CW-2 human colon cancer tumors via tail vein. Southern blots revealed that the major organs and tumors were transfected. Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN- treated mice, and such suppression was due to the overexpression of C/EBPβ, leading to the increased apoptosis in tumors of pCN-treated mice. No apparent toxic effects of pCN/liposome complex were observed in the animals. Thus, C/EBPβ has tumor suppression effect in vivo and may be used in gene therapy for cancers.展开更多
Radio Frequency Interference (RFI) suppression is an important technique in the ultra-wideband synthetic aperture radar (UWB SAR). In this paper, we mainly analyze the performance of a notch filter for RFI sup-pressio...Radio Frequency Interference (RFI) suppression is an important technique in the ultra-wideband synthetic aperture radar (UWB SAR). In this paper, we mainly analyze the performance of a notch filter for RFI sup-pression. The theoretical output from notch filter is presented based on RFI signal’s narrowband property. The research conclusion shows that the notch filter has significant effect on sidelobes of the system response, which might be considered to be false targets, however it has little effect on the resolution of the system re-sponse. The theoretical result is verified by simulation and experimental data processing both in one dimen-sion (range dimension) and in two dimensions (range and azimuth dimension).展开更多
文摘SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse arrayof biological processes, including controlling gene transcription[1;2], maintaining genome integrity[3;4], regulating cellcycle progression[5;6], and mediating DNA damage and repair[7;8]. In addition to targeting H4K20, SET8 is alsoreported in methylating the tumor suppressor p53 at lysine residue 382 (p53K382me1) and repressing p53-mediatedtranscriptional activation of target genes. In response to ionizing radiation, p53 regulates the transcription of genesin a diverse set of pathways including DNA repair, cell cycle arrest, and apoptosis[9]. Thus, we hypothesis thatSET8 may affect the cellular response to ionizing radiation by interacting with p53.
文摘C/EBPβ (CCAAT/enhancer-binding protein β) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBPβ protein results in cellular growth arrest and apoptosis. Using a nonviral liposome as carrier, we delivered the full-length C/EBPβ expression plasmid, pCN, into nude mice bearing CW-2 human colon cancer tumors via tail vein. Southern blots revealed that the major organs and tumors were transfected. Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN- treated mice, and such suppression was due to the overexpression of C/EBPβ, leading to the increased apoptosis in tumors of pCN-treated mice. No apparent toxic effects of pCN/liposome complex were observed in the animals. Thus, C/EBPβ has tumor suppression effect in vivo and may be used in gene therapy for cancers.
文摘Radio Frequency Interference (RFI) suppression is an important technique in the ultra-wideband synthetic aperture radar (UWB SAR). In this paper, we mainly analyze the performance of a notch filter for RFI sup-pression. The theoretical output from notch filter is presented based on RFI signal’s narrowband property. The research conclusion shows that the notch filter has significant effect on sidelobes of the system response, which might be considered to be false targets, however it has little effect on the resolution of the system re-sponse. The theoretical result is verified by simulation and experimental data processing both in one dimen-sion (range dimension) and in two dimensions (range and azimuth dimension).
