A novel chromatographic packing of chlorogenic acid（CGA） molecularly imprinted polymer（MIP） based on the 5.0 ~tm silica was prepared by surface initiated atom transfer radical polymerization（SI-ATRP） with 4-viny...A novel chromatographic packing of chlorogenic acid（CGA） molecularly imprinted polymer（MIP） based on the 5.0 ~tm silica was prepared by surface initiated atom transfer radical polymerization（SI-ATRP） with 4-vinylpyridine（4-VP） as functional monomer, ethyl glycol dimethacrylate（EDMA） as cross-linker in the mixture of methanol and water（7：3, volume ratio） under mild reaction conditions. The characteristics of CGA MIP were investi- gated by elemental analysis, thermogravimetric analysis（TGA）, Fourier transform infrared spectrometry（FTIR） and atomic force microscopy（AFM）. The effects of some chromatographic conditions such as mobile phase composition and temperature on the retention time were investigated. The adsorption capacity of the stationary phase for com- pounds was determined by frontal chromatographic technique. The results show that Freundlich isotherm fits the ex- perimental adsorption isotherm data better than Langmuir model does. The relatively high heterogeneity index values regressed with the Freundlich isotherm suggest the formation of fairly homogeneous MIP. Thermodynamic data（AAH and AAS） obtained by van＇t Hoff plots reveal an entropy-controlled separation. The CGA MIP column was shown to be successful for the separation and purification of chlorogenic acid from the extract of Honeysuckle.展开更多
We introduce a reaction model for use in coarse-grained simulations to study the chemical reactions in polymer systems at mesoscopic level.In this model,we employ an idea of reaction probability in control of the whol...We introduce a reaction model for use in coarse-grained simulations to study the chemical reactions in polymer systems at mesoscopic level.In this model,we employ an idea of reaction probability in control of the whole process of chemical reactions.This model has been successfully applied to the studies of surface initiated polymerization process and the network structure formation of typical epoxy resin systems.It can be further modified to study different kinds of chemical reactions at mesoscopic scale.展开更多
基金Supported by the National Natural Science Foundation of China（No.31271868） and the National Science and Technology Support Project of China（No.2012BAKI7B07）.
文摘A novel chromatographic packing of chlorogenic acid（CGA） molecularly imprinted polymer（MIP） based on the 5.0 ~tm silica was prepared by surface initiated atom transfer radical polymerization（SI-ATRP） with 4-vinylpyridine（4-VP） as functional monomer, ethyl glycol dimethacrylate（EDMA） as cross-linker in the mixture of methanol and water（7：3, volume ratio） under mild reaction conditions. The characteristics of CGA MIP were investi- gated by elemental analysis, thermogravimetric analysis（TGA）, Fourier transform infrared spectrometry（FTIR） and atomic force microscopy（AFM）. The effects of some chromatographic conditions such as mobile phase composition and temperature on the retention time were investigated. The adsorption capacity of the stationary phase for com- pounds was determined by frontal chromatographic technique. The results show that Freundlich isotherm fits the ex- perimental adsorption isotherm data better than Langmuir model does. The relatively high heterogeneity index values regressed with the Freundlich isotherm suggest the formation of fairly homogeneous MIP. Thermodynamic data（AAH and AAS） obtained by van＇t Hoff plots reveal an entropy-controlled separation. The CGA MIP column was shown to be successful for the separation and purification of chlorogenic acid from the extract of Honeysuckle.
基金the support of the National Natural Science Foundation of China(Grant Nos.21025416,20974040,50930001)China Postdoctoral Science Foundation(Grant No.20110491295).
文摘We introduce a reaction model for use in coarse-grained simulations to study the chemical reactions in polymer systems at mesoscopic level.In this model,we employ an idea of reaction probability in control of the whole process of chemical reactions.This model has been successfully applied to the studies of surface initiated polymerization process and the network structure formation of typical epoxy resin systems.It can be further modified to study different kinds of chemical reactions at mesoscopic scale.
