AIM: To compare the wavefront aberrations and corneal surface regularity between dry eye(DE) patients and normal subjects and assess its diagnostic performance for DE measured with OPD Scan-Ⅲ.METHODS: Fifty right eye...AIM: To compare the wavefront aberrations and corneal surface regularity between dry eye(DE) patients and normal subjects and assess its diagnostic performance for DE measured with OPD Scan-Ⅲ.METHODS: Fifty right eyes of 50 DE patients and 31 right eyes of normal subjects were included.The examinations for ocular surface including logarithm of the minimum angle of resolution best-corrected distance visual acuity(logMAR BCVA) the ocular surface disease index(OSDI), tear film break-up time(TBUT) and corneal fluorescein staining(CFS).OPD Scan-Ⅲ was used to measure anterior corneal aberrations including total corneal aberrations, high order aberration(HOA), coma, trefoil, spherical aberration(SA), standard deviation of corneal power(SDP), surface regularity index(SRI) and surface asymmetry index(SAI).Statistical analysis were assessed with nonparametric tests and Spearman’s correlations.All parameters were also analyzed for sensitivity, specificity, and receiver operating characteristics(ROC) curves.RESULTS: Wavefront aberrations parameters including total corneal aberrations, HOA, coma, trefoil, and SA in DE group were significantly higher than those in normal group(P<0.001).Corneal surface regularity parameters including SRI and SAI in DE group were significantly higher than both in normal group(P<0.05).All the wavefront aberrations parameters had significant correlations with ocular surface parameters(P<0.05).The logMAR BCVA had positive correlations with SAI and SRI(all P<0.001).CFS scores had positive correlations with SAI and SRI(all P<0.001).All the wavefront aberrations parameters showed good diagnosis sensitivity and specificity, however, the corneal regularity parameters showed only good specificity but poor sensitivity.The cut-off value selected for trefoil in diagnosis DE showed the highest area under the curve(AUC, 0.921) values as compared to the other parameters with sensitivity of 0.955 and specificity of 0.867.CONCLUSION: Wavefront aberrations and corneal surface regularity are increased in DE patients and also correlated with ocular surface parameters.Wavefront aberrations parameters have potential to be indicators to diagnosis and monitor DE.展开更多
Hydrous magnesium oxide coated fly ash （MFA） has environmental remediation potential by providing a sub- strate for the adsorption of aqueous Cr（Ⅲ）. Aqueous Cr（Ⅲ） adsorption onto MFA was examined as a function...Hydrous magnesium oxide coated fly ash （MFA） has environmental remediation potential by providing a sub- strate for the adsorption of aqueous Cr（Ⅲ）. Aqueous Cr（Ⅲ） adsorption onto MFA was examined as a function of MFA dosage, pH and initial Cr（Ⅲ） concentration with the Box-Behnken approach used for experimental design and optimization using response surface methodology （RSM）. pH and dosage （dosage and concentration） have significant interactive effects on Cr（Ⅲ） adsorption efficiency. Analysis of variance shows that the response surface quadratic model is highly significant and can effectively predict the experimental outcomes. Cr（Ⅲ） removal effi- ciency of 98% was obtained using optimized conditions of MFA dosage, pH and initial Cr（Ⅲ） concentration of 1,5 7 g. L- 1, 4.11 and 126 mg. L- 1, respectively. Cr（Ⅲ） adsorption onto MFA is mainly attributed to the interaction between Or（Ⅲ） and the functional group --OH of the hydrous magnesium oxide, in all probability caused by chemisorptions. The results of this study can conduce to reveal the interactions between Cr（Ⅲ） pollutant and MFA characteristics, posing important implications for the cost-effective alternative adsorption technology in the treatment of heavy metal containing wastewater.展开更多
Loess has unique compositions and structural characteristics and can be used for environmental protection.Differences between the surface characteristics of the Malan loess from the suburbs of Taiyuan,Shanxi Province ...Loess has unique compositions and structural characteristics and can be used for environmental protection.Differences between the surface characteristics of the Malan loess from the suburbs of Taiyuan,Shanxi Province before and after reaction with Cr(Ⅲ) solution were studied by SEM/EDS,IR and XRD.The results showed that the Malan loess has a strong ability to remove Cr(Ⅲ) from the solution.The surface characteristics of loess include an effect on Cr(Ⅲ) in solution,as supported by the strong test evidence including the disappearance of Cr peak in the EDS spectrum,the disappearance of carbonate characteristic peaks in the infrared spectrogram,and the positive correlation between Fe and Cr peaks.展开更多
AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patient...AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patients with non-metastatic rectal cancer from March 2004 to November 2008 were analyzed retrospectively at our institute.The mRNA expressions of VEGFR1 and TUBB3 were detected by multiplex branched DNA liquid-chip technology.The Cutoff Finder application was applied to determine cutoff point of mRNA expression.SPSS software version 22.0was used for analysis.RESULTS The median follow-up was 102.7 mo(range,6-153.6).Theχ~2 and Fisher’s exact tests showed that VEGFR1expression was related to lymph node metastasis(P=0.013),while no relationships between TUBB3 and clinicopathological features were observed.Univariate analysis showed that T stage,lymph node metastasis,tumor differentiation,VEGFR1 and TUBB3 mRNA expression were correlated to overall survival(OS)(P=0.048,P=0.003,P=0.052,P=0.003 and P=0.015,respectively).Also,lymph node metastasis and VEGFR1expression independently influenced OS by multivariate analysis(P=0.027 and P=0.033).VEGFR1 expression was positively correlated with TUBB3(P=0.024).The patients with low expression of both TUBB3 and VEGFR1 presented a better OS(P=0.003).In addition,the receiver operating characteristic analysis suggested that the combination of lymph node metastasis and VEGFR1 had a more favorable prognostic value(P<0.001).CONCLUSION VEGFR1 expression and lymph node metastasis independently and jointly affect survival.Moreover,low expression of VEGFR1 and TUBB3 presented a better OS in patients with non-metastatic rectal cancer,which might serve as a potential prognostic factor.展开更多
This paper further extends the generalized covari ant derivative from the first covariant derivative to the sec ond one on curved surfaces. Through the linear transforma tion between the first generalized covariant de...This paper further extends the generalized covari ant derivative from the first covariant derivative to the sec ond one on curved surfaces. Through the linear transforma tion between the first generalized covariant derivative and the second one, the second covariant differential transformation group is set up. Under this transformation group, the sec ond class of differential invariants and integral invariants on curved surfaces is made clear. Besides, the symmetric struc ture of the tensor analysis on curved surfaces are revealed.展开更多
文摘AIM: To compare the wavefront aberrations and corneal surface regularity between dry eye(DE) patients and normal subjects and assess its diagnostic performance for DE measured with OPD Scan-Ⅲ.METHODS: Fifty right eyes of 50 DE patients and 31 right eyes of normal subjects were included.The examinations for ocular surface including logarithm of the minimum angle of resolution best-corrected distance visual acuity(logMAR BCVA) the ocular surface disease index(OSDI), tear film break-up time(TBUT) and corneal fluorescein staining(CFS).OPD Scan-Ⅲ was used to measure anterior corneal aberrations including total corneal aberrations, high order aberration(HOA), coma, trefoil, spherical aberration(SA), standard deviation of corneal power(SDP), surface regularity index(SRI) and surface asymmetry index(SAI).Statistical analysis were assessed with nonparametric tests and Spearman’s correlations.All parameters were also analyzed for sensitivity, specificity, and receiver operating characteristics(ROC) curves.RESULTS: Wavefront aberrations parameters including total corneal aberrations, HOA, coma, trefoil, and SA in DE group were significantly higher than those in normal group(P<0.001).Corneal surface regularity parameters including SRI and SAI in DE group were significantly higher than both in normal group(P<0.05).All the wavefront aberrations parameters had significant correlations with ocular surface parameters(P<0.05).The logMAR BCVA had positive correlations with SAI and SRI(all P<0.001).CFS scores had positive correlations with SAI and SRI(all P<0.001).All the wavefront aberrations parameters showed good diagnosis sensitivity and specificity, however, the corneal regularity parameters showed only good specificity but poor sensitivity.The cut-off value selected for trefoil in diagnosis DE showed the highest area under the curve(AUC, 0.921) values as compared to the other parameters with sensitivity of 0.955 and specificity of 0.867.CONCLUSION: Wavefront aberrations and corneal surface regularity are increased in DE patients and also correlated with ocular surface parameters.Wavefront aberrations parameters have potential to be indicators to diagnosis and monitor DE.
基金Supported by the State Key Development Program for Basic Research of China(2014CB460601)the International S&T Cooperation Program of China(2014DFE70070)
文摘Hydrous magnesium oxide coated fly ash （MFA） has environmental remediation potential by providing a sub- strate for the adsorption of aqueous Cr（Ⅲ）. Aqueous Cr（Ⅲ） adsorption onto MFA was examined as a function of MFA dosage, pH and initial Cr（Ⅲ） concentration with the Box-Behnken approach used for experimental design and optimization using response surface methodology （RSM）. pH and dosage （dosage and concentration） have significant interactive effects on Cr（Ⅲ） adsorption efficiency. Analysis of variance shows that the response surface quadratic model is highly significant and can effectively predict the experimental outcomes. Cr（Ⅲ） removal effi- ciency of 98% was obtained using optimized conditions of MFA dosage, pH and initial Cr（Ⅲ） concentration of 1,5 7 g. L- 1, 4.11 and 126 mg. L- 1, respectively. Cr（Ⅲ） adsorption onto MFA is mainly attributed to the interaction between Or（Ⅲ） and the functional group --OH of the hydrous magnesium oxide, in all probability caused by chemisorptions. The results of this study can conduce to reveal the interactions between Cr（Ⅲ） pollutant and MFA characteristics, posing important implications for the cost-effective alternative adsorption technology in the treatment of heavy metal containing wastewater.
基金supported by the National Natural Science Foundation of China (Nos. 40402021 and 40830748)the China-Russia International Cooperation and Exchange Project of NSFC-RFBR (No. 40711120189)+4 种基金the Key Project of Chinese Ministry of Education (No. 104038)Program for New Century Excellent Talents in University (NCET-07-0773)the Aid Project of Science and Technology Ministry of China to Developing Countries (2008041012)National High Technology Research and Development Program 863 (2007AA06Z337)the Excellent Young Teachers Program of China University of Geosciences (CUGQNL0303)
文摘Loess has unique compositions and structural characteristics and can be used for environmental protection.Differences between the surface characteristics of the Malan loess from the suburbs of Taiyuan,Shanxi Province before and after reaction with Cr(Ⅲ) solution were studied by SEM/EDS,IR and XRD.The results showed that the Malan loess has a strong ability to remove Cr(Ⅲ) from the solution.The surface characteristics of loess include an effect on Cr(Ⅲ) in solution,as supported by the strong test evidence including the disappearance of Cr peak in the EDS spectrum,the disappearance of carbonate characteristic peaks in the infrared spectrogram,and the positive correlation between Fe and Cr peaks.
基金Supported by Fujian Province Natural Science Foundation,Nos.2016J01437,2017J01260 and 2018J01266the Fujian Medical Innovation Project,No.2015-CX-8+1 种基金the Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research,Ministry of Education/Beijing(2017 Open Project-9)Joint Funds for the innovation of science and Technology,Fujian Province,No.2017Y9074
文摘AIM To assess the long-term prognostic value of vascular endothelial growth factor receptor 1(VEGFR1)and classⅢβ-tubulin(TUBB3)mRNA expression in nonmetastatic rectal cancer.METHODS A total of 75 consecutive patients with non-metastatic rectal cancer from March 2004 to November 2008 were analyzed retrospectively at our institute.The mRNA expressions of VEGFR1 and TUBB3 were detected by multiplex branched DNA liquid-chip technology.The Cutoff Finder application was applied to determine cutoff point of mRNA expression.SPSS software version 22.0was used for analysis.RESULTS The median follow-up was 102.7 mo(range,6-153.6).Theχ~2 and Fisher’s exact tests showed that VEGFR1expression was related to lymph node metastasis(P=0.013),while no relationships between TUBB3 and clinicopathological features were observed.Univariate analysis showed that T stage,lymph node metastasis,tumor differentiation,VEGFR1 and TUBB3 mRNA expression were correlated to overall survival(OS)(P=0.048,P=0.003,P=0.052,P=0.003 and P=0.015,respectively).Also,lymph node metastasis and VEGFR1expression independently influenced OS by multivariate analysis(P=0.027 and P=0.033).VEGFR1 expression was positively correlated with TUBB3(P=0.024).The patients with low expression of both TUBB3 and VEGFR1 presented a better OS(P=0.003).In addition,the receiver operating characteristic analysis suggested that the combination of lymph node metastasis and VEGFR1 had a more favorable prognostic value(P<0.001).CONCLUSION VEGFR1 expression and lymph node metastasis independently and jointly affect survival.Moreover,low expression of VEGFR1 and TUBB3 presented a better OS in patients with non-metastatic rectal cancer,which might serve as a potential prognostic factor.
基金supported by the NSFC(11072125 and 11272175)the NSF of Jiangsu Province(SBK201140044)the Specialized Research Fund for Doctoral Program of Higher Education(20130002110044)
文摘This paper further extends the generalized covari ant derivative from the first covariant derivative to the sec ond one on curved surfaces. Through the linear transforma tion between the first generalized covariant derivative and the second one, the second covariant differential transformation group is set up. Under this transformation group, the sec ond class of differential invariants and integral invariants on curved surfaces is made clear. Besides, the symmetric struc ture of the tensor analysis on curved surfaces are revealed.
