<span style="font-family:Verdana;">The article provides a theoretical analysis of the velocity distribution and distribution in the cross section of the pipe during the transportation of cotton. It stu...<span style="font-family:Verdana;">The article provides a theoretical analysis of the velocity distribution and distribution in the cross section of the pipe during the transportation of cotton. It studied the factors that move air and transport material in a </span><span style="font-family:Verdana;">pneumatic pipeline, developed a mathematical model and built graphs. The effect of pressure on the ease of construction of pipes for air transportation of raw cotton and the speed distribution in the process of transporting cotton, as well as the factors that cause pressure loss in the shells of pipes were studied.</span><span style="font-family:""> </span><span style="font-family:Verdana;">So, i</span><span style="font-family:Verdana;">f the expansion after the air </span><span style="font-family:Verdana;">pipe</span><span style="font-family:""><span style="font-family:Verdana;"> is expanded </span><img src="Edit_111b42e7-ead7-4f9b-8a57-0a3b41fff1a6.png" alt="" /></span><span style="font-family:""></span><span style="font-family:Verdana;"> (5), we will</span><span style="font-family:""><span style="font-family:Verdana;"> introduce </span><i><span style="font-family:Verdana;">K</span></i><sub><span style="font-family:Verdana;">1</span></sub><span style="font-family:Verdana;"> = 0 and the beating coefficient </span></span><span style="font-family:""></span><span style="font-family:Verdana;">. If the current narrows before</span><span style="font-family:""><span style="font-family:Verdana;"> burdening, then we enter </span><i><span style="font-family:Verdana;">K</span></i><sub><span style="font-family:Verdana;">1</span></sub><span style="font-family:Verdana;"> = 1 and the input </span></span><span style="font-family:Verdana;">soften</span><span style="font-family:Verdana;"> rate from the formula </span><span style="font-family:""></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> The air flow is moving upwards below the slope and the longer the pipe is the air flow is so significant (strong). The flow of air is divided into laminar and turbulent streams according to leakage. The procedure for transportation of raw cotton using air will move the turbulent the sidelines, interacts with the layers. If the turbulent passes in a well-round smooth passenger-pipes, the number of critical Reynolds can be delivered to 200,000. The process of transporting cotton in pnevmotransport is far from the laminary regime in far away and stronger mode.</span>展开更多
Acid-sensing ion channels(ASICs),the main H^(+)receptors in the central nervous system,sense extracellular pH fluctuations and mediate cation influx.ASIC1a,the major subunit responsible for acid-activated current,is w...Acid-sensing ion channels(ASICs),the main H^(+)receptors in the central nervous system,sense extracellular pH fluctuations and mediate cation influx.ASIC1a,the major subunit responsible for acid-activated current,is widely expressed in brain neurons,where it plays pivotal roles in diverse functions including synaptic transmission and plasticity.However,the underlying molecular mechanisms for these functions remain mysterious.Using extracellular epitope tagging and a novel antibody recognizing the hASIC1a ectodomain,we examined the membrane targeting and dynamic trafficking of hASIC1a in cultured cortical neurons.Surface hASIC1a was distributed throughout somata and dendrites,clustered in spine heads,and co-localized with postsynaptic markers.By extracellular pHluorin tagging and fluorescence recovery after photobleaching,we detected movement of hASIC1a in synaptic spine heads.Single-particle tracking along with use of the anti-hASIC1a ectodomain antibody revealed long-distance migration and local movement of surface hASIC1a puncta on dendrites.Importantly,enhancing synaptic activity with brain-derived neurotrophic factor accelerated the trafficking and lateral mobility of hASIC1a.With this newly-developed toolbox,our data demonstrate the synaptic location and high dynamics of functionallyrelevant hASIC1a on the surface of excitatory synapses,supporting its involvement in synaptic functions.展开更多
文摘<span style="font-family:Verdana;">The article provides a theoretical analysis of the velocity distribution and distribution in the cross section of the pipe during the transportation of cotton. It studied the factors that move air and transport material in a </span><span style="font-family:Verdana;">pneumatic pipeline, developed a mathematical model and built graphs. The effect of pressure on the ease of construction of pipes for air transportation of raw cotton and the speed distribution in the process of transporting cotton, as well as the factors that cause pressure loss in the shells of pipes were studied.</span><span style="font-family:""> </span><span style="font-family:Verdana;">So, i</span><span style="font-family:Verdana;">f the expansion after the air </span><span style="font-family:Verdana;">pipe</span><span style="font-family:""><span style="font-family:Verdana;"> is expanded </span><img src="Edit_111b42e7-ead7-4f9b-8a57-0a3b41fff1a6.png" alt="" /></span><span style="font-family:""></span><span style="font-family:Verdana;"> (5), we will</span><span style="font-family:""><span style="font-family:Verdana;"> introduce </span><i><span style="font-family:Verdana;">K</span></i><sub><span style="font-family:Verdana;">1</span></sub><span style="font-family:Verdana;"> = 0 and the beating coefficient </span></span><span style="font-family:""></span><span style="font-family:Verdana;">. If the current narrows before</span><span style="font-family:""><span style="font-family:Verdana;"> burdening, then we enter </span><i><span style="font-family:Verdana;">K</span></i><sub><span style="font-family:Verdana;">1</span></sub><span style="font-family:Verdana;"> = 1 and the input </span></span><span style="font-family:Verdana;">soften</span><span style="font-family:Verdana;"> rate from the formula </span><span style="font-family:""></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> The air flow is moving upwards below the slope and the longer the pipe is the air flow is so significant (strong). The flow of air is divided into laminar and turbulent streams according to leakage. The procedure for transportation of raw cotton using air will move the turbulent the sidelines, interacts with the layers. If the turbulent passes in a well-round smooth passenger-pipes, the number of critical Reynolds can be delivered to 200,000. The process of transporting cotton in pnevmotransport is far from the laminary regime in far away and stronger mode.</span>
基金This work was supported by grants from the National Natural Science Foundation of China(81961128024 and 81730095)the Innovative Research Team of High-level Local Universities in Shanghai+2 种基金the Science and Technology Commission of Shanghai Municipality(18JC1420302)the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05)the US National Institutes of Health(NS114716).
文摘Acid-sensing ion channels(ASICs),the main H^(+)receptors in the central nervous system,sense extracellular pH fluctuations and mediate cation influx.ASIC1a,the major subunit responsible for acid-activated current,is widely expressed in brain neurons,where it plays pivotal roles in diverse functions including synaptic transmission and plasticity.However,the underlying molecular mechanisms for these functions remain mysterious.Using extracellular epitope tagging and a novel antibody recognizing the hASIC1a ectodomain,we examined the membrane targeting and dynamic trafficking of hASIC1a in cultured cortical neurons.Surface hASIC1a was distributed throughout somata and dendrites,clustered in spine heads,and co-localized with postsynaptic markers.By extracellular pHluorin tagging and fluorescence recovery after photobleaching,we detected movement of hASIC1a in synaptic spine heads.Single-particle tracking along with use of the anti-hASIC1a ectodomain antibody revealed long-distance migration and local movement of surface hASIC1a puncta on dendrites.Importantly,enhancing synaptic activity with brain-derived neurotrophic factor accelerated the trafficking and lateral mobility of hASIC1a.With this newly-developed toolbox,our data demonstrate the synaptic location and high dynamics of functionallyrelevant hASIC1a on the surface of excitatory synapses,supporting its involvement in synaptic functions.