The surface accuracy of a radio telescope is directly related to its operational efficiency and detection sensitivity.This is crucial under high-frequency observation conditions,where surface shape errors need to be c...The surface accuracy of a radio telescope is directly related to its operational efficiency and detection sensitivity.This is crucial under high-frequency observation conditions,where surface shape errors need to be controlled to within 1/16 of the working wavelength.In addition,the primary reflector of large radio telescopes is subject to dynamic deformation,caused by factors such as gravity and thermal effects.This paper presents a method for detecting the surface shape of radio telescopes using radio interferometry techniques combined with active reflector adjustment technology.This enables accurate assessment and correction of surface errors,ensuring the electrical performance of the radio telescope.This study investigates the practical applications of high-precision measurement techniques,such as microwave holography,out-of-focus holography,and wavefront distortion methods at the Tianma 65 m radio telescope(TMRT).Furthermore,the study presents the construction method of gravity models at different elevation angles and demonstrates the efficacy of the active reflector model.The results of the measurements indicate that the application of these methods to the TMRT has led to a notable enhancement of the accuracy of the primary reflector and a substantial improvement in efficiency in the Q-band.Through a process of iterative measurements and adjustments,the surface shape error is ultimately reduced to 0.28 mm root mean square(RMS).展开更多
The surface undulating shapes of rock joints have been described qualitatively or experimental quantitatively for a long time. The non determined describing method can not fit quantitative evaluation of mechani...The surface undulating shapes of rock joints have been described qualitatively or experimental quantitatively for a long time. The non determined describing method can not fit quantitative evaluation of mechanical parameters of rock joints in engineering. In this paper, relative amplitude ( R A) is chosen as a quantitative describing index of surface measurement of 1 023 surface undulating curves which conducted by profile curve device(PCD). We discuss the nonuniformity,anisotropy and unhomogeneity of surface undulating shapes of joints. A new method that analyzes the complexity of surface undulating shapes of rock joints directional statistically in various rock joints is also put forward.展开更多
A shape hardening function is developed that improves the predictive capabilities of the generalized bounding surface model for cohesive soils, especially when applied to overconsolidated specimens. This improvement i...A shape hardening function is developed that improves the predictive capabilities of the generalized bounding surface model for cohesive soils, especially when applied to overconsolidated specimens. This improvement is realized without any changes to the simple elliptical shape of the bounding surface, and actually reduces the number of parameters associated with the model by one.展开更多
An exact-designed mesh shape with favorable surface accuracy is of practical significance to the performance of large cable-network antenna reflectors. In this study, a novel design approach that could guide the gener...An exact-designed mesh shape with favorable surface accuracy is of practical significance to the performance of large cable-network antenna reflectors. In this study, a novel design approach that could guide the generation of exact spatial parabolic mesh configurations of such reflector was proposed. By incorporating the traditional force density method with the standard finite element method, this proposed approach had taken the deformation effects of flexible ring truss supports into consideration, and searched for the desired mesh shapes that can satisfy the requirement that all the free nodes are exactly located on the objective paraboloid. Compared with the conventional design method,a remarkable improvement of surface accuracy in the obtained mesh shapes had been demonstrated by numerical examples. The present work would provide a helpful technical reference for the mesh shape design of such cable-network antenna reflector in engineering practice.展开更多
According to the characteristics of a complex cover panel, its geometry shape is described by the NURBS surface with great description capability. With the reference to the surface classification determined by Gauss c...According to the characteristics of a complex cover panel, its geometry shape is described by the NURBS surface with great description capability. With the reference to the surface classification determined by Gauss curvature, the proportion of the mid-surface area between before and after being developed is derived from the displacement variation of the mid-surface in the normal vector direction of the sheet metal during the sheet metal forming process. Hereby, based on the curve development theory in differential geometry, a novel diagonal point by point surface development method is put forward to estimate a complex cover panel's blank contour efficiently. By comparing the sample's development result of diagonal point by point surface development method with that of available one-step method, the validity of the proposed surface development method is verified.展开更多
Based on the three-dimensional model of TIG weld pool established,the effect of the arc force on liquid surface was investigated.The simulation was carried out with finite elements software Surface Evolver.The influen...Based on the three-dimensional model of TIG weld pool established,the effect of the arc force on liquid surface was investigated.The simulation was carried out with finite elements software Surface Evolver.The influence of the arc force on the weld pool shape was also studied.According to the results,the variation of the weld shape and the parameters with different arc force strength was obtained.Compared with the back weld pool,the top weld pool was influenced more strongly by the arc force.These results provide an effective basis for further study of the TIG weld pool.展开更多
In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization...In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization and modification of complexity structure without going back to CAD for reconstruction of geometric models or to finite element analysis( FEA) for remodeling. Design of experiments( DOE) and response surface method( RSM) are applied to approximate the constitutive parameters of a machine gun system based on experimental tests. Further FEA,secondary development technique and genetic algorithm( GA) are introduced to find all the optimal solutions in one go and the optimal design of the demonstrated machine gun system is obtained. Results of the rigid-flexible coupling dynamic analysis and exterior ballistics calculation validate the proposed methodology,which is relatively time-saving,reliable and has the potential to solve similar problems.展开更多
The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surf...The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surface shape”for short) data is analysed. This technique in- cludes these concrete methods and principles such as data smoothing, fitting, reconstructing ,elimi- nating and so on. The example and result about computer processing of 3- D surface shape data are given .展开更多
To improve the grinding quality of robotic belt grinding systems for the workpieces with complex shaped surfaces, new concepts of the dexterity grinding point and the dexterity grinding space are proposed and their ma...To improve the grinding quality of robotic belt grinding systems for the workpieces with complex shaped surfaces, new concepts of the dexterity grinding point and the dexterity grinding space are proposed and their mathematical descriptions are defined. Factors influencing the dexterity grinding space are analyzed. And a method to determine the necessary dexterity grinding space is suggested. Based on particle swarm optimization (PSO) method, a strategy to optimize the grinding robot structural dimensions and position with respect to the grinding wheel is put forward to obtain the necessary dexterity grinding space. Finally, to grind an aerial engine blade, a dedicated PPPRRR (P: prismatic R: rotary) grinding robot structural dimensions and position with respect to the grinding wheel are optimized using the above strategy. According to simulation results, if the blade is placed within the dexterity grinding space, only one gripper and one grinding machine are needed to grind its complex shaped surfaces.展开更多
In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussi...In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussian surface function is constructed first by the measurements, and it is used to define the GSM via a mapping function. We then integrate the GSM with the probability hypothesis density(PHD) filter, the Bayesian recursion formulas of GSM-PHD are derived and the Gaussian mixture implementation is employed to obtain the closed-form solutions. Moreover, the estimated shapes are designed to guide the measurement set sub-partition, which can cope with the problem of the spatially close target tracking. Simulation results show that the proposed algorithm can effectively estimate irregular target shapes and exhibit good robustness in cross extended target tracking.展开更多
The surface shape of liquid water is well controlled during nanosecond pulse laser ablation plasma propulsion. In this study, we measured the effect of the shape on the coupling coefficient and the specific impulse. W...The surface shape of liquid water is well controlled during nanosecond pulse laser ablation plasma propulsion. In this study, we measured the effect of the shape on the coupling coefficient and the specific impulse. We found that the coupling coefficient and specific impulse could be optimized by varying the surface convexity. Based on the analysis of the surface radius curvature, we demonstrate that the convex surface changes the laser focal positions to achieve high efficiency.展开更多
Two-dimensional scalar equation for the displacement of steady cross-plane shear (SH) waves in homogeneous and transversely isotropic media like unidirectional fibrous com-posites is given. Then, thrbugh a simple coor...Two-dimensional scalar equation for the displacement of steady cross-plane shear (SH) waves in homogeneous and transversely isotropic media like unidirectional fibrous com-posites is given. Then, thrbugh a simple coordinate system transform, the scalar equation is standardized into a Helmholtz equation. Corresponding integral equations are derived for the scattering problems and boundary element method (BEM) is used to calculate the scattered fields of arbitrarily shaped obstacles with both soft and rigid boudary conditions numerically.A discussion is given on the numerical results which is mainly focused on the influence of the a-nisotropy of the media to the directivity of the scattered fields by circular cylindrical voids.展开更多
Screening is a technique that is extensively adopted for the separation of discrete materials according to particle characteristics such as size and shape.Wide application of the discrete element method has sparked mu...Screening is a technique that is extensively adopted for the separation of discrete materials according to particle characteristics such as size and shape.Wide application of the discrete element method has sparked much research on the vibrating screen,which is a screening apparatus having a specific vibration mode.The shape of the screen surface is a critical factor affecting the sieving performance of the vibrating screen.In this paper,a stepwise optimization method is employed to optimize the screen surface shape of the vibrating screen in discrete element modeling to obtain a high screening efficiency and large processing capacity simultaneously.Adopting this optimization method,a new curved screen with five decks having various inclination angles is presented.Numerical simulations and prototype experiments are conducted to verify the superior sieving performance of the new curved screen.Experimental results clearly show that the new curved screen greatly outperforms three commonly used screens in terms of sieving performance.The conclusions and methodologies of this work will benefit the design and improvement of vibrating screens.展开更多
Protein design has become a powerful method to expand the number of natural proteins and design customized proteins according to demands.Domain-based protein design spares the need to create novel elements from scratc...Protein design has become a powerful method to expand the number of natural proteins and design customized proteins according to demands.Domain-based protein design spares the need to create novel elements from scratch,which makes it a more efficient strategy than scratch-based protein design in designing multi-domain proteins,protein complexes and biomaterials.As the surface shape plays a central role in domain-domain and protein-protein interactions,a global map of the surface shapes of all domains should be very beneficial for domain-based protein design.Therefore,in this study,we characterized the surface shapes of protein domains,collected from CATH and SCOP databases,with their 3D-Zernike descriptors(3DZDs).Then similarities of domain shape features were identified,and all domains were classified accordingly.The preferences of the combinations of domains between different clusters were analyzed in natural proteins from the Protein Data Bank.A user-friendly website,termed CPD3DS,was also developed for storage,retrieval,analyses and visualization of our results.This work not only provides an overall view of protein domain shapes by showing their variety and similarities,but also opens up a new avenue to understand the properties of protein structural domains,and design principles of protein architectures.展开更多
Double-spindle triple-workstation(DSTW) ultra precision grinders are mainly used in production lines for manufacturing and back thinning large diameter(≥300 mm) silicon wafers for integrated circuits.It is import...Double-spindle triple-workstation(DSTW) ultra precision grinders are mainly used in production lines for manufacturing and back thinning large diameter(≥300 mm) silicon wafers for integrated circuits.It is important, but insufficiently studied,to control the wafer shape ground on a DSTW grinder by adjusting the inclination angles of the spindles and work tables.In this paper,the requirements of the inclination angle adjustment of the grinding spindles and work tables in DSTW wafer grinders are analyzed.A reasonable configuration of the grinding spindles and work tables in DSTW wafer grinders are proposed.Based on the proposed configuration,an adjustment method of the inclination angle of grinding spindles and work tables for DSTW wafer grinders is put forward. The mathematical models of wafer shape with the adjustment amount of inclination angles for both fine and rough grinding spindles are derived.The proposed grinder configuration and adjustment method will provide helpful instruction for DSTW wafer grinder design.展开更多
The structure and rheological properties of carbon-based particle suspensions, i.e., carbon black(CB), multi-wall carbon nanotube(MWNT), graphene and hollow carbon sphere(HCS) suspended in polydimethylsiloxane(...The structure and rheological properties of carbon-based particle suspensions, i.e., carbon black(CB), multi-wall carbon nanotube(MWNT), graphene and hollow carbon sphere(HCS) suspended in polydimethylsiloxane(PDMS), are investigated. In order to study the effect of particle shape on the structure and rheological properties of suspensions, the content of surface oxygen-containing functional groups of carbon-based particles is controlled to be similar. Original spherical-like CB(fractal filler), rod-like MWNT and sheet-like graphene form large agglomerates in PDMS, while spherical HCS particles disperse relatively well in PDMS. The dispersion state of carbon-based particles affects the critical concentration of forming a rheological percolation network. Under weak shear, negative normal stress differences(ΔN) are observed in CB, MWNT and graphene suspensions, while ΔN is nearly zero for HCS suspensions. It is concluded that the vorticity alignment of CB, MWNT and graphene agglomerates under shear results in the negative ΔN. However, no obvious structural change is observed in HCS suspension under weak shear, and accordingly, the ΔN is almost zero.展开更多
In this paper, various strategies of spiral irradiating scheme for the flame forming of a bowl shaped surface are investigated experimentally and numerically. Experimental work is performed using a flame torch integra...In this paper, various strategies of spiral irradiating scheme for the flame forming of a bowl shaped surface are investigated experimentally and numerically. Experimental work is performed using a flame torch integrated with a 2-axis CNC workstation. The ABAQUS implicit solver is used in the numerical simulation. Three different strategies of the spiral irradiating scheme are investigated for the flame forming of a bowl shaped surface. The first strategy is the Simple spi- ral irradiating scheme, the second is the Rotational spiral irradiating scheme, and the third is the Symmetrical-Rotational spiral irradiating scheme. The results show that using the Symmetrical- Rotational spiral irradiating scheme, a bowl shaped surface with the maximum deformation can be produced, followed by using the Rotational scheme, and the Simple spiral scheme. It is also concluded from the results that the spiral irradiating scheme with Symmetrical-Rotational, Rota- tional and Simple spiral schemes lead to the maximum symmetries in the produced bowl shaped surface, respectively. All the numerical results are in good agreement with the experimental ob- servations.展开更多
Gold nanoparticles,owing to their unique physicochemical and optical properties,well-established synthetic methods and easy modifications,have been widely used in biomedical science.Therefore,for their safe and effici...Gold nanoparticles,owing to their unique physicochemical and optical properties,well-established synthetic methods and easy modifications,have been widely used in biomedical science.Therefore,for their safe and efficient applications,much attention has been given to the toxicological evaluations of gold nanoparticles in biological systems.A large number of studies focusing on this problem have been carried out during the past years.However,the researches on gold nanoparticles toxicity still remain fragmentary and even contradictory with each other.This may be caused by the variety in experimental conditions.In this review,we aim to provide a better understanding about the in vitro and in vivo toxicity of gold nanoparticles by reviewing and describing the up to date literatures related to this problem and we mainly focused on these properties such as the particle size and shape,the surface charge and modification.Besides,we also summarized the adverse effect of gold nanoparticles on immune systems and analyzed the origin of the toxicity.展开更多
基金supported by the National Key R&D Program of China(2018YFA0404702,2019YFA0708904,2021YFC2203501)Shanghai Key Laboratory of Space Navigation and Positioning Techniques,the National Natural Science Foundation of China(12273097,11903068).
文摘The surface accuracy of a radio telescope is directly related to its operational efficiency and detection sensitivity.This is crucial under high-frequency observation conditions,where surface shape errors need to be controlled to within 1/16 of the working wavelength.In addition,the primary reflector of large radio telescopes is subject to dynamic deformation,caused by factors such as gravity and thermal effects.This paper presents a method for detecting the surface shape of radio telescopes using radio interferometry techniques combined with active reflector adjustment technology.This enables accurate assessment and correction of surface errors,ensuring the electrical performance of the radio telescope.This study investigates the practical applications of high-precision measurement techniques,such as microwave holography,out-of-focus holography,and wavefront distortion methods at the Tianma 65 m radio telescope(TMRT).Furthermore,the study presents the construction method of gravity models at different elevation angles and demonstrates the efficacy of the active reflector model.The results of the measurements indicate that the application of these methods to the TMRT has led to a notable enhancement of the accuracy of the primary reflector and a substantial improvement in efficiency in the Q-band.Through a process of iterative measurements and adjustments,the surface shape error is ultimately reduced to 0.28 mm root mean square(RMS).
文摘The surface undulating shapes of rock joints have been described qualitatively or experimental quantitatively for a long time. The non determined describing method can not fit quantitative evaluation of mechanical parameters of rock joints in engineering. In this paper, relative amplitude ( R A) is chosen as a quantitative describing index of surface measurement of 1 023 surface undulating curves which conducted by profile curve device(PCD). We discuss the nonuniformity,anisotropy and unhomogeneity of surface undulating shapes of joints. A new method that analyzes the complexity of surface undulating shapes of rock joints directional statistically in various rock joints is also put forward.
基金supported by the Fulbright Colombia-Colciencias Scholarship and Universidad Militar Nueva Granada
文摘A shape hardening function is developed that improves the predictive capabilities of the generalized bounding surface model for cohesive soils, especially when applied to overconsolidated specimens. This improvement is realized without any changes to the simple elliptical shape of the bounding surface, and actually reduces the number of parameters associated with the model by one.
文摘An exact-designed mesh shape with favorable surface accuracy is of practical significance to the performance of large cable-network antenna reflectors. In this study, a novel design approach that could guide the generation of exact spatial parabolic mesh configurations of such reflector was proposed. By incorporating the traditional force density method with the standard finite element method, this proposed approach had taken the deformation effects of flexible ring truss supports into consideration, and searched for the desired mesh shapes that can satisfy the requirement that all the free nodes are exactly located on the objective paraboloid. Compared with the conventional design method,a remarkable improvement of surface accuracy in the obtained mesh shapes had been demonstrated by numerical examples. The present work would provide a helpful technical reference for the mesh shape design of such cable-network antenna reflector in engineering practice.
文摘According to the characteristics of a complex cover panel, its geometry shape is described by the NURBS surface with great description capability. With the reference to the surface classification determined by Gauss curvature, the proportion of the mid-surface area between before and after being developed is derived from the displacement variation of the mid-surface in the normal vector direction of the sheet metal during the sheet metal forming process. Hereby, based on the curve development theory in differential geometry, a novel diagonal point by point surface development method is put forward to estimate a complex cover panel's blank contour efficiently. By comparing the sample's development result of diagonal point by point surface development method with that of available one-step method, the validity of the proposed surface development method is verified.
文摘Based on the three-dimensional model of TIG weld pool established,the effect of the arc force on liquid surface was investigated.The simulation was carried out with finite elements software Surface Evolver.The influence of the arc force on the weld pool shape was also studied.According to the results,the variation of the weld shape and the parameters with different arc force strength was obtained.Compared with the back weld pool,the top weld pool was influenced more strongly by the arc force.These results provide an effective basis for further study of the TIG weld pool.
基金Supported by the National Natural Science Foundation of China(51376090,51676099)
文摘In this paper,size and shape optimization problem of a machine gun system is addressed with an efficient hybrid method,in which a novel and flexible mesh morphing technique is employed to achieve fast parameterization and modification of complexity structure without going back to CAD for reconstruction of geometric models or to finite element analysis( FEA) for remodeling. Design of experiments( DOE) and response surface method( RSM) are applied to approximate the constitutive parameters of a machine gun system based on experimental tests. Further FEA,secondary development technique and genetic algorithm( GA) are introduced to find all the optimal solutions in one go and the optimal design of the demonstrated machine gun system is obtained. Results of the rigid-flexible coupling dynamic analysis and exterior ballistics calculation validate the proposed methodology,which is relatively time-saving,reliable and has the potential to solve similar problems.
文摘The laser scanning and CCD image-transmitting measurement method and principle on acquiring 3-D curved surface shape data are discussed. Computer processing technique of 3-D curved surface shape(be called“ 3 - D surface shape”for short) data is analysed. This technique in- cludes these concrete methods and principles such as data smoothing, fitting, reconstructing ,elimi- nating and so on. The example and result about computer processing of 3- D surface shape data are given .
基金National Natural Science Foundation of China (51075013) Beijing Natural Science Foundation (4102035)+1 种基金 Fundamental Research Funds for the Central Universities (YWF-10-01-A09) Research Foundation of State Key Laboratory for Manufacturing Systems Engineering (Xi'an Jiaotong University)
文摘To improve the grinding quality of robotic belt grinding systems for the workpieces with complex shaped surfaces, new concepts of the dexterity grinding point and the dexterity grinding space are proposed and their mathematical descriptions are defined. Factors influencing the dexterity grinding space are analyzed. And a method to determine the necessary dexterity grinding space is suggested. Based on particle swarm optimization (PSO) method, a strategy to optimize the grinding robot structural dimensions and position with respect to the grinding wheel is put forward to obtain the necessary dexterity grinding space. Finally, to grind an aerial engine blade, a dedicated PPPRRR (P: prismatic R: rotary) grinding robot structural dimensions and position with respect to the grinding wheel are optimized using the above strategy. According to simulation results, if the blade is placed within the dexterity grinding space, only one gripper and one grinding machine are needed to grind its complex shaped surfaces.
基金supported by the National Natural Science Foundation of China(6130501761304264+1 种基金61402203)the Natural Science Foundation of Jiangsu Province(BK20130154)
文摘In this paper, we consider the problem of irregular shapes tracking for multiple extended targets by introducing the Gaussian surface matrix(GSM) into the framework of the random finite set(RFS) theory. The Gaussian surface function is constructed first by the measurements, and it is used to define the GSM via a mapping function. We then integrate the GSM with the probability hypothesis density(PHD) filter, the Bayesian recursion formulas of GSM-PHD are derived and the Gaussian mixture implementation is employed to obtain the closed-form solutions. Moreover, the estimated shapes are designed to guide the measurement set sub-partition, which can cope with the problem of the spatially close target tracking. Simulation results show that the proposed algorithm can effectively estimate irregular target shapes and exhibit good robustness in cross extended target tracking.
基金supported by National Natural Science Foundation of China(No.10905049)Fundamental Research Funds for the Central Universities of China(Nos.53200859165,2562010050)
文摘The surface shape of liquid water is well controlled during nanosecond pulse laser ablation plasma propulsion. In this study, we measured the effect of the shape on the coupling coefficient and the specific impulse. We found that the coupling coefficient and specific impulse could be optimized by varying the surface convexity. Based on the analysis of the surface radius curvature, we demonstrate that the convex surface changes the laser focal positions to achieve high efficiency.
文摘Two-dimensional scalar equation for the displacement of steady cross-plane shear (SH) waves in homogeneous and transversely isotropic media like unidirectional fibrous com-posites is given. Then, thrbugh a simple coordinate system transform, the scalar equation is standardized into a Helmholtz equation. Corresponding integral equations are derived for the scattering problems and boundary element method (BEM) is used to calculate the scattered fields of arbitrarily shaped obstacles with both soft and rigid boudary conditions numerically.A discussion is given on the numerical results which is mainly focused on the influence of the a-nisotropy of the media to the directivity of the scattered fields by circular cylindrical voids.
基金financially supported by the Natural Science Foundation of Jiangxi Province(grant No.20192BAB206023)National Natural Science Foundation of China(grant No.51775113)+3 种基金Natural Science Foundation of Fujian Province(grant No.2017J01675)Key Projects of Fujian Provincial Youth Natural Fund(grant No.JZ160460)51st Scientific Research Fund Program of Fujian University of Technology(grant No.GY-Z160139)Subsidized Project for Postgraduates' Innovative Fund in Scientific Research of Huaqiao University(grant Nos.1601103005 and 17013080007).
文摘Screening is a technique that is extensively adopted for the separation of discrete materials according to particle characteristics such as size and shape.Wide application of the discrete element method has sparked much research on the vibrating screen,which is a screening apparatus having a specific vibration mode.The shape of the screen surface is a critical factor affecting the sieving performance of the vibrating screen.In this paper,a stepwise optimization method is employed to optimize the screen surface shape of the vibrating screen in discrete element modeling to obtain a high screening efficiency and large processing capacity simultaneously.Adopting this optimization method,a new curved screen with five decks having various inclination angles is presented.Numerical simulations and prototype experiments are conducted to verify the superior sieving performance of the new curved screen.Experimental results clearly show that the new curved screen greatly outperforms three commonly used screens in terms of sieving performance.The conclusions and methodologies of this work will benefit the design and improvement of vibrating screens.
基金supported by the National Natural Science Foundation of China(No.31971176 and 31800616)the Fundamental Research Funds for the Central Universities(No.A03018023601045).
文摘Protein design has become a powerful method to expand the number of natural proteins and design customized proteins according to demands.Domain-based protein design spares the need to create novel elements from scratch,which makes it a more efficient strategy than scratch-based protein design in designing multi-domain proteins,protein complexes and biomaterials.As the surface shape plays a central role in domain-domain and protein-protein interactions,a global map of the surface shapes of all domains should be very beneficial for domain-based protein design.Therefore,in this study,we characterized the surface shapes of protein domains,collected from CATH and SCOP databases,with their 3D-Zernike descriptors(3DZDs).Then similarities of domain shape features were identified,and all domains were classified accordingly.The preferences of the combinations of domains between different clusters were analyzed in natural proteins from the Protein Data Bank.A user-friendly website,termed CPD3DS,was also developed for storage,retrieval,analyses and visualization of our results.This work not only provides an overall view of protein domain shapes by showing their variety and similarities,but also opens up a new avenue to understand the properties of protein structural domains,and design principles of protein architectures.
基金Project supported by the National High Technology Research and Development Program of China(No.2008AA042505)the National Science and Technology Key Project Program(No.2009ZX02011)the Natural Science Foundation of Guangdong Province,China (No.U0734008)
文摘Double-spindle triple-workstation(DSTW) ultra precision grinders are mainly used in production lines for manufacturing and back thinning large diameter(≥300 mm) silicon wafers for integrated circuits.It is important, but insufficiently studied,to control the wafer shape ground on a DSTW grinder by adjusting the inclination angles of the spindles and work tables.In this paper,the requirements of the inclination angle adjustment of the grinding spindles and work tables in DSTW wafer grinders are analyzed.A reasonable configuration of the grinding spindles and work tables in DSTW wafer grinders are proposed.Based on the proposed configuration,an adjustment method of the inclination angle of grinding spindles and work tables for DSTW wafer grinders is put forward. The mathematical models of wafer shape with the adjustment amount of inclination angles for both fine and rough grinding spindles are derived.The proposed grinder configuration and adjustment method will provide helpful instruction for DSTW wafer grinder design.
基金financially supported by the National Natural Science Foundation of China(Nos.21474111,21222407 and 21274152)subsidized by the National Basic Research Program of China(973 Program,2012CB821500)
文摘The structure and rheological properties of carbon-based particle suspensions, i.e., carbon black(CB), multi-wall carbon nanotube(MWNT), graphene and hollow carbon sphere(HCS) suspended in polydimethylsiloxane(PDMS), are investigated. In order to study the effect of particle shape on the structure and rheological properties of suspensions, the content of surface oxygen-containing functional groups of carbon-based particles is controlled to be similar. Original spherical-like CB(fractal filler), rod-like MWNT and sheet-like graphene form large agglomerates in PDMS, while spherical HCS particles disperse relatively well in PDMS. The dispersion state of carbon-based particles affects the critical concentration of forming a rheological percolation network. Under weak shear, negative normal stress differences(ΔN) are observed in CB, MWNT and graphene suspensions, while ΔN is nearly zero for HCS suspensions. It is concluded that the vorticity alignment of CB, MWNT and graphene agglomerates under shear results in the negative ΔN. However, no obvious structural change is observed in HCS suspension under weak shear, and accordingly, the ΔN is almost zero.
文摘In this paper, various strategies of spiral irradiating scheme for the flame forming of a bowl shaped surface are investigated experimentally and numerically. Experimental work is performed using a flame torch integrated with a 2-axis CNC workstation. The ABAQUS implicit solver is used in the numerical simulation. Three different strategies of the spiral irradiating scheme are investigated for the flame forming of a bowl shaped surface. The first strategy is the Simple spi- ral irradiating scheme, the second is the Rotational spiral irradiating scheme, and the third is the Symmetrical-Rotational spiral irradiating scheme. The results show that using the Symmetrical- Rotational spiral irradiating scheme, a bowl shaped surface with the maximum deformation can be produced, followed by using the Rotational scheme, and the Simple spiral scheme. It is also concluded from the results that the spiral irradiating scheme with Symmetrical-Rotational, Rota- tional and Simple spiral schemes lead to the maximum symmetries in the produced bowl shaped surface, respectively. All the numerical results are in good agreement with the experimental ob- servations.
基金financially supported by the National Natural Science Foundation of China(No.31525009)Sichuan Innovative Research Team Program for Young Scientists(No.2016TD0004)
文摘Gold nanoparticles,owing to their unique physicochemical and optical properties,well-established synthetic methods and easy modifications,have been widely used in biomedical science.Therefore,for their safe and efficient applications,much attention has been given to the toxicological evaluations of gold nanoparticles in biological systems.A large number of studies focusing on this problem have been carried out during the past years.However,the researches on gold nanoparticles toxicity still remain fragmentary and even contradictory with each other.This may be caused by the variety in experimental conditions.In this review,we aim to provide a better understanding about the in vitro and in vivo toxicity of gold nanoparticles by reviewing and describing the up to date literatures related to this problem and we mainly focused on these properties such as the particle size and shape,the surface charge and modification.Besides,we also summarized the adverse effect of gold nanoparticles on immune systems and analyzed the origin of the toxicity.