Objectives To find out whether there are also penicillinresistant str eptococcus pneumoniae and the resistant rate in China Methods A surveillance study which is a part of the international surve illance on pneumoco...Objectives To find out whether there are also penicillinresistant str eptococcus pneumoniae and the resistant rate in China Methods A surveillance study which is a part of the international surve illance on pneumococci resistance to penicillin and other antimicrobial agents w as conducted in Beijing, China More than 900 pediatric patients with respirato r y tract infections aged from six months to three years selected from two pediatr ic units were enrolled in the study Perthroat swabs were immediately streaked o nto blood agar plates Isolates were identified as pneumococci by their typical appearance, gram stain, confirmation tests Antibiotic susceptibility was asses s ed by the disk diffusion method and minimal inhibition concentration (MIC) deter mination according to Protocol and National Committee for Clinical Laboratory St andards (NCCLS). Results Of the 51 streptococcus pneumoniae isolates, 5 strains had zone s of inhibition indicative of penicillin resistance, of which two had penicillin MICs01?mg/L and were considered to be relatively or fully resistant to pen i cillin The MICs of two penicillin resistant strains were 2?mg/L and 4?mg/L R esistant rates to ceftriaxone and cefotaxime were 0% and 10% respectively For the othe r ten antimicrobial agents, the resistant rates were as follows: ampicillin 12% , piperacillin 26%, furbenicillin 14%, cefuroxime 6%, erythromycin 54%, clarithr omycin 52%, meleumycin 64%, roxithromycin 52%, chloramphenicol 35%, tetracycline 100% Conclusions The study suggested that penicillin resistant streptococcus pneumoniae strains existed in China and were also resistant to ampicillin, pipe racillin, furbenicillin and cefuroxime Moreover, the resistant rates of penici llin resistant streptococcus pneumoniae to macrolides and tetracycline were high展开更多
文摘Objectives To find out whether there are also penicillinresistant str eptococcus pneumoniae and the resistant rate in China Methods A surveillance study which is a part of the international surve illance on pneumococci resistance to penicillin and other antimicrobial agents w as conducted in Beijing, China More than 900 pediatric patients with respirato r y tract infections aged from six months to three years selected from two pediatr ic units were enrolled in the study Perthroat swabs were immediately streaked o nto blood agar plates Isolates were identified as pneumococci by their typical appearance, gram stain, confirmation tests Antibiotic susceptibility was asses s ed by the disk diffusion method and minimal inhibition concentration (MIC) deter mination according to Protocol and National Committee for Clinical Laboratory St andards (NCCLS). Results Of the 51 streptococcus pneumoniae isolates, 5 strains had zone s of inhibition indicative of penicillin resistance, of which two had penicillin MICs01?mg/L and were considered to be relatively or fully resistant to pen i cillin The MICs of two penicillin resistant strains were 2?mg/L and 4?mg/L R esistant rates to ceftriaxone and cefotaxime were 0% and 10% respectively For the othe r ten antimicrobial agents, the resistant rates were as follows: ampicillin 12% , piperacillin 26%, furbenicillin 14%, cefuroxime 6%, erythromycin 54%, clarithr omycin 52%, meleumycin 64%, roxithromycin 52%, chloramphenicol 35%, tetracycline 100% Conclusions The study suggested that penicillin resistant streptococcus pneumoniae strains existed in China and were also resistant to ampicillin, pipe racillin, furbenicillin and cefuroxime Moreover, the resistant rates of penici llin resistant streptococcus pneumoniae to macrolides and tetracycline were high
