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Dip2a regulates stress susceptibility in the basolateral amygdala
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作者 Jing Li Zixuan He +4 位作者 Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu 《Neural Regeneration Research》 SCIE CAS 2025年第6期1735-1748,共14页
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types... Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders. 展开更多
关键词 5-HYDROXYTRYPTAMINE acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics NEUROTRANSMITTERS principal component analysis stress susceptibility TRYPTOPHAN
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The Relationship between Parental Stress and Child Conformity:The Mediating Role of Resilience
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作者 Houyan Li Guandong Song Bin Xiao 《International Journal of Mental Health Promotion》 2024年第9期767-776,共10页
Background:In today’s society,parental stress has become a prevalent and significant issue,impacting not only parents’mental health but also potentially profoundly affecting children’s growth and education.This top... Background:In today’s society,parental stress has become a prevalent and significant issue,impacting not only parents’mental health but also potentially profoundly affecting children’s growth and education.This topic has garnered continuous attention from scholars.The present study aims to delve into the relationship between parental stress and children’s behavior,particularly focusing on children’s conformity and discipline development during crucial stages.This study aims to explore the relationship between parental stress,child conformity,and resilience,and further examines the mediating role of resilience in the relationship between parental stress and child conformity.Methods:We used three scales:the Parental Stress Scale,the Child Conformity Scale,and the Resilience Scale,to survey 890 elementary school students(aged 6–12)and their parents in the Beijing-Tianjin-Hebei region of China.We employed SPSS 26.0 software for data analysis,conducting descriptive statistics,correlation analysis,and mediation effect tests sequentially.In the mediation effect tests,we utilized structural equation modeling(SEM)and regression analysis to examine the mediation effects,ensuring the accuracy and scientific nature of our analysis.Results:Through descriptive statistics,correlation analysis,regression models,and mediation effect tests,we found that parental stress significantly negatively predicts child conformity,while resilience shows a significant positive prediction.Further mediation analysis indicates that resilience plays a partial mediating role between parental stress and child conformity,with the mediation effect accounting for 36.67%.Conclusion:These findings highlight the importance of the family environment on child behavior and provide valuable insights and recommendations for family education practices in the Beijing-Tianjin-Hebei region.Therefore,we suggest future research should further explore the complex relationships among parental stress,child conformity,and resilience,and examine regional differences to better promote children’s overall development. 展开更多
关键词 Parental stress child conformity resilience mediating variable family education
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Transcriptomic and genetic approaches reveal that low-light-induced disease susceptibility is related to cellular oxidative stress in tomato
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作者 Qian Luo Jiao Wang +7 位作者 Ping Wang Xiao Liang Jianxin Li Changqi Wu Hanmo Fang Shuting Ding Shujun Shao Kai Shi 《Horticulture Research》 SCIE CSCD 2023年第10期64-73,共10页
The impact of low light intensities on plant disease outbreaks represents a major challenge for global crop security,as it frequently results in significant yield losses.However,the underlying mechanisms of the effect... The impact of low light intensities on plant disease outbreaks represents a major challenge for global crop security,as it frequently results in significant yield losses.However,the underlying mechanisms of the effect of low light on plant defense are still poorly understood.Here,using an RNA-seq approach,we found that the susceptibility of tomato to Pseudomonas syringae pv.tomato DC3000(Pst DC3000)under low light was associated with the oxidation-reduction process.Low light conditions exacerbated Pst DC3000-induced reactive oxygen species(ROS)accumulation and protein oxidation.Analysis of gene expression and enzyme activity of ascorbate peroxidase 2(APX2)and other antioxidant enzymes revealed that these defense responses were significantly induced by Pst DC3000 inoculation under normal light,whereas these genes and their associated enzyme activities were not responsive to pathogen inocula-tion under low light.Additionally,the reduced ascorbate to dehydroascorbate(AsA/DHA)ratio was lower under low light compared with normal light conditions upon Pst DC3000 inoculation.Furthermore,the apx2 mutants generated by a CRISPR-Cas9 gene-editing approach were more susceptible to Pst DC3000 under low light conditions.Notably,this increased susceptibility could be significantly reduced by exogenous AsA treatment.Collectively,our findings suggest that low-light-induced disease susceptibility is associated with increased cellular oxidative stress in tomato plants.This study sheds light on the intricate relationship between light conditions,oxidative stress,and plant defense responses,and may pave the way for improved crop protection strategies in low light environments. 展开更多
关键词 susceptibility OXIDATIVE stress
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Stress,Burnout,and Resilience:Are Teachers at Risk?
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作者 JoséLuis Moreno-Lucas Juan Pedro Martínez-Ramón +2 位作者 Francisco Manuel Morales-Rodríguez Cecilia Ruiz-Esteban e Inmaculada Méndez 《International Journal of Mental Health Promotion》 2023年第2期207-222,共16页
It is increasingly common to find alarming news related to tragic events occurring in schools around the world.Being able to deal with these situations without getting hurt is a task not suitable for everyone.In gener... It is increasingly common to find alarming news related to tragic events occurring in schools around the world.Being able to deal with these situations without getting hurt is a task not suitable for everyone.In general,teachers are the ones who must deal with this type of situation in addition to other daily problems that appear in any classroom that make the level of stress to which they are subjected can become dangerous.This research aims to know the current situation of teachers in a region of southeastern Spain in terms of their level of work stress,resilience,and other associated variables,for which an ex post facto quantitative approach study was designed.For this purpose,an ad hoc sociodemographic questionnaire,and questions based on the Teaching and Learning International Survey of the Organization for Economic Co-Operation and Development,the Maslach Burnout Inventory,and the Brief Resilient Coping Scale were applied.The participating sample consisted of 470 teachers.The main findings were that 6%of teachers had burnout(high emotional exhaustion,high cynicism,and low professional effectiveness simultaneously).Resilience correlated inversely with stress,emotional exhaustion,cynicism,excessive teaching,and difficulty maintaining classroom discipline.In conclusion,knowing the needs of teachers allows us to reflect on what kind of prevention and intervention programs are necessary to improve the well-being of teachers and thus improve the quality of education. 展开更多
关键词 BURNOUT COPING resilience stress TEACHER
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Effect of pre-deformation on the stress corrosion cracking susceptibility of aluminum alloy 2519 被引量:15
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作者 LI Huizhong ZHANG Xinming CHEN Mingan LI Yanfang LIANG Xiaopeng 《Rare Metals》 SCIE EI CAS CSCD 2007年第4期385-390,共6页
The effects of pre-deformation and strain rate on the stress corrosion cracking (SCC) behavior of aluminum alloy 2519 in air and in 3.5% NaCI water solution were investigated by means of slow strain rate tension (S... The effects of pre-deformation and strain rate on the stress corrosion cracking (SCC) behavior of aluminum alloy 2519 in air and in 3.5% NaCI water solution were investigated by means of slow strain rate tension (SSRT), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The results indicate that the alloy is susceptible to SCC in 3.5% NaCI water solution and not in air. At the same pre-deformation, the alloy is more susceptible to SCC at 1.33 × 10^-5 s^-1 than at 6.66 × 10^-5 s^-1. Moreover, it is more susceptible to SCC at free pre-deformation than at 10% pre-deformation at the same strain rate. The number of 0 precipitated along the grain boundaries is reduced and distributed discontinuously, at the same time, the precipitate-free zones (PFZ) become narrow and the susceptibility to stress corrosion cracking is reduced after 10% pre-deformation. 展开更多
关键词 2519 aluminum alloy PRE-DEFORMATION slow strain rate tension susceptibility to stress corrosion cracking
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Correspondence between Susceptibility to SCC of 7050 Aluminum Alloy and Passive Film-induced Stress at Various pH Values 被引量:4
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作者 祁星 宋仁国 +4 位作者 QI Wenjuan JIN Jirong WANG Chao LI Hai SUN Bin 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2017年第1期173-178,共6页
The passive film-induced stress and the susceptibility to SCC of 7050 aluminum alloy in 3.5%sodium chloride solution at various pH values were investigated by slow strain rate testing(SSRT) and flowing stress differ... The passive film-induced stress and the susceptibility to SCC of 7050 aluminum alloy in 3.5%sodium chloride solution at various pH values were investigated by slow strain rate testing(SSRT) and flowing stress differential method.The results showed that the passive film-induced stress and the susceptibility to SCC decreased with increasing pH values when pH≤7,while they increased with increasing pH values when pH7.However,the corrosion type was interpreted as exfoliation corrosion when pH=l and 14,and there was no film formed on the surface of the specimens.The whole variation plots of film-induced stress and the SCC susceptibility with pH values were both presented as a valley shape.The symbol and amount of the film-induced stress were related to the compositions of the passive film,which were analyzed using X-ray photoelectron spectroscopy(XPS). 展开更多
关键词 7050 aluminum alloy susceptibility to SCC pH value passive film-induced stress
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Effects of College Students’ Perceived Stress on Anxiety in the Time of COVID-19: The Chain Mediation Role of Psychological Resilience and Regulatory Emotional Self-Efficacy 被引量:3
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作者 Ting Li Qiang Xie 《International Journal of Mental Health Promotion》 2022年第2期263-276,共14页
COVID-19 has changed the way of learning and life of college students.The purpose is to explore the relationship between perceived stress and anxiety,and the mediating effect of resilience and regulatory emotional sel... COVID-19 has changed the way of learning and life of college students.The purpose is to explore the relationship between perceived stress and anxiety,and the mediating effect of resilience and regulatory emotional self-efficacy in college students during COVID-19.309 students from three colleges were selected as research participants(average age 19.79±1.11 years).SPSS was used to measure the correlation between variables.Amos was used to test the path coefficient and mediating effect of the hypothetical model.The results show that:Firstly,perceived stress has a significantly and positively predictive effect on anxiety.Secondly,psychological resilience and regu-latory emotional self-efficacy independently played a significant and partially mediating effect between perceived stress and anxiety.Among them,perceived stress had a negative predictive effect on psychological resilience and regulatory emotional self-efficacy.Psychological resilience and regulatory emotional self-efficacy had a negative predictive effect on anxiety.Thirdly,psychological resilience and regulatory emotional self-efficacy play a chain mediation role between psychological stress and anxiety.Regulatory emotional self-efficacy cannot only directly predict the level of anxiety,but also indirectly predict the level of anxiety by regulating psychological resilience.This study reveals the relationship between college students’perceived stress and anxiety,and the mediating effect of psychological resilience and regulatory emotional self-efficacy in the new time of COVID-19.The chain mediation role of psychological resilience and regulatory emotional self-efficacy reminds college mental health educators that improving students’regulatory emotional self-efficacy is an important way to promote students’mental health. 展开更多
关键词 Perceived stress regulatory emotional self-efficacy psychological resilience ANXIETY
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Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders 被引量:2
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作者 Koichi Inoue 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第10期2153-2156,共4页
Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could b... Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could be a major factor of future therapeutic strategies for neurological disorders.Microglia,derived from myelogenous cells,respond to a number of stimuli and make immune responses,resulting in a prominent role as cells that act on inflammation in the central nervous system.Fractalkine(FKN or CX3CL1)signaling is an important factor that influences the inflammatory response of microglia.The receptor for FKN,CX3CR1,is usually expressed in microglia in the brain,and therefore the inflammatory response of microglia is modified by FKN.Reportedly,FKN often suppresses inflammatory responses in microglia and activation of its receptor may be effective in the treatment of inflammatory neurological disorders.However,it has also been suggested that inflammatory responses facilitated by FKN signaling aggravate neurological disorders.Thus,further studies are still required to resolve the conflicting interpretation of the protective or deleterious contribution of microglial FKN signaling.Yet notably,regulation of FKN signaling has recently been shown to be beneficial in the treatment of human diseases,although not neurological diseases.In addition,a CX3CR1 inhibitor has been developed and successfully tested in animal models,and it is expected to be in human clinical trials in the future.In this review,I describe the potential therapeutic consideration of microglial CX3CR1 dynamics through altered FKN signaling. 展开更多
关键词 Alzheimer’s disease CX3CR1 FRACTALKINE inflammation knockout mice MICROGLIA resilience SARS-CoV-2 stress stroke
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Self-compassion and resilience mediate the relationship between childhood exposure to domestic violence and posttraumatic growth/stress disorder during COVID-19 pandemic 被引量:1
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作者 Xin-Li Chi Qiao-Min Huang +7 位作者 Xiao-Feng Liu Liu-Yue Huang Meng-Jian Hu Zhi-Jing Chen Can Jiao Brendon Stubbs M Mahbub Hossain Li-Ye Zou 《World Journal of Psychiatry》 SCIE 2021年第11期1106-1115,共10页
BACKGROUND Studies have indicated that childhood exposure to domestic violence is a common factor in posttraumatic growth(PTG)and posttraumatic stress disorder(PTSD),but it is unclear whether PTG and PTSD share a comm... BACKGROUND Studies have indicated that childhood exposure to domestic violence is a common factor in posttraumatic growth(PTG)and posttraumatic stress disorder(PTSD),but it is unclear whether PTG and PTSD share a common/different underlying mechanism.AIM To explore the common/different underlying mechanism of PTG and PTSD.METHODS Between February 12 and 17,2020,a nationwide cross-sectional online survey was conducted in China among 2038 university students,and a self-administered questionnaire was used for the data collection.The data included demographic characteristics,such as age,gender,and subjective social economic status,and childhood exposure to domestic violence scale that was selected from the Chinese version of revised Adverse Childhood Experiences Question,Self-compassion Scale,Connor–Davidson Resilience Scale,Posttraumatic Growth Inventory,and the Abbreviated PTSD Checklist-Civilian version.A structural equation model was used to test the hypotheses.RESULTS Exposure to domestic violence was significantly associated with PTG and PTSD via a 1-step indirect path of self-compassion(PTG:β=-0.023,95%CI:-0.44 to-0.007;PTSD:β=0.008,95%CI:0.002,0.014)and via a 2-step indirect path from self-compassion to resilience(PTG:β=-0.008,95%CI:-0.018 to-0.002;PTSD:β=0.013,95%CI:0.004-0.024).However,resilience did not mediate the relationship between exposure to domestic violence and PTG and PTSD.CONCLUSION PTG and PTSD are common results of childhood exposure to domestic violence,which may be influenced by self-compassion and resilience. 展开更多
关键词 SELF-COMPASSION resilience Domestic violence Posttraumatic growth Posttraumatic stress disorder COVID-19
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Longevity of animals under reactive oxygen species stress and disease susceptibility due to global warming
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作者 Biswaranjan Paital Sumana Kumari Panda +4 位作者 Akshaya Kumar Hati Bobllina Mohanty Manoj Kumar Mohapatra Shyama Kanungo Gagan Bihari Nityananda Chainy 《World Journal of Biological Chemistry》 CAS 2016年第1期110-127,共18页
The world is projected to experience an approximate doubling of atmospheric CO_2 concentration in the next decades. Rise in atmospheric CO_2 level as one of the most important reasons is expected to contribute to rais... The world is projected to experience an approximate doubling of atmospheric CO_2 concentration in the next decades. Rise in atmospheric CO_2 level as one of the most important reasons is expected to contribute to raise the mean global temperature 1.4 ℃-5.8 ℃ by that time. A survey from 128 countries speculates that global warming is primarily due to increase in atmospheric CO_2 level that is produced mainly by anthropogenic activities. Exposure of animals to high environmental temperatures is mostly accompanied by unwanted acceleration of certain biochemical pathways in their cells. One of such examples is augmentation in generation of reactive oxygen species(ROS) and subsequent increase in oxidation of lipids, proteins and nucleic acids by ROS. Increase in oxidation of biomolecules leads to a state called as oxidative stress(OS). Finally, the increase in OS condition induces abnormality in physiology of animals under elevated temperature. Exposure of animals to rise in habitat temperature is found to boost the metabolism of animals and a very strong and positive correlation exists between metabolism and levels of ROS and OS. Continuous induction of OS is negatively correlated with survivability and longevity and positively correlated with ageing in animals. Thus, it can be predicted that continuous exposure of animals to acute or gradual rise in habitat temperature due to global warming may induce OS, reduced survivability and longevity in animals in general and poikilotherms in particular. A positive correlation between metabolism and temperature in general and altered O_2 consumption at elevated temperature in particular could also increase the risk of experiencing OS in homeotherms. Effects of global warming on longevity of animals through increased risk of protein misfolding and disease susceptibility due to OS as the cause or effects or both also cannot be ignored. Therefore, understanding the physiological impacts of global warming in relation to longevity of animals will become very crucial challenge to biologists of the present millennium. 展开更多
关键词 Reactive oxygen species Redox regulation Oxidative stress SURVIVABILITY Climate change Disease susceptibility Global WARMING LONGEVITY Thermal stress
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A new anti-influenza animal model for Traditional Chinese Medicine, restraint stress induces influenza susceptibility by regulating mitochondrial antiviral signaling pathway
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《中国药理学通报》 CAS CSCD 北大核心 2015年第B11期48-48,共1页
There are many kinds of Chinese patent medicine used to fight against influenza efficiently in clinical practice. However, little experimental data confirmed the anti-influenza the activities since non-suitable animal... There are many kinds of Chinese patent medicine used to fight against influenza efficiently in clinical practice. However, little experimental data confirmed the anti-influenza the activities since non-suitable animal model and in vitro antiviral experiments. This paradox can be explained by host factors are important in the patho- genesis and outcome of influenza infection. Accordingly, we set up a mouse model by using restraint stress plus vi- ral infection, which is more conducive to simulate the clinical features of susceptible population and evaluate the activities of Chinese herbal medicine. Our results demonstrated that stress-induced corticosterone (CORT) , a stres- sor sensor, increased the morbidity and the mortality of virus infected mice loaded with restraint stress. CORT also increased expression of Mfn2, and accordingly decreased mitochondrial antiviral signaling (MAVS) aggregates in the host cells. Mfn2 overexpression increased NP and decreased IFN-β and IFITM3 protein expressions in influenza virus infected A549 cells. These findings suggested that the mechanism of restraint stress increased the susceptibili- ty due to CORT induces activation of Mfn2 mediated MAVS pathway. 展开更多
关键词 restrain stress MITOCHONDRIAL ANTIVIRAL signaling INFLUENZA CORTICOSTERONE Mfn2 susceptibility
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The impact of acceptance of disability and psychological resilience on post-traumatic stress disorders in burn patients
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作者 Zhe-Yuan Xia Yue Kong +3 位作者 Ting-Ting Yin Su-Hua Shi Rong Huang Yu-Hong Cheng 《International Journal of Nursing Sciences》 2014年第4期371-375,共5页
Objective:To investigate the impact of acceptance of disability and psychological resilience on post-traumatic stress disorders(PTSD)in patients with burns.Methods:A total of 127 patients with burns were asked to comp... Objective:To investigate the impact of acceptance of disability and psychological resilience on post-traumatic stress disorders(PTSD)in patients with burns.Methods:A total of 127 patients with burns were asked to complete PTSD Checklist-Civilian Version,Acceptance of Disability Scale and ConnoreDavidson Resilience Scale questionnaires.Results were evaluated using correlational and regression analyses.Results:The incidence of PTSD in burn patients was 37.80%(48/127),with an overall average checklist score of 45.78±15.29 points.PTSD was negatively correlated with the level of disability acceptance and psychological resilience(p<0.05).Multiple regression analysis showed that the depth of burn,marital status,degree of subordination,self-value and selfimprovement were factors influencing the incidence PTSD.Conclusion:Nurses should screen and identify patients with PTSD as early as possible and provide proper psychological interventions to help them accept the reality of disability and improve the level of psychological resilience。 展开更多
关键词 Acceptance of disability BURNS POST-TRAUMATIC Psychological resilience stress disorders
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Vulnerability and Resilience to Stress and Immune and Neuroendocrine Function in Portuguese Subjects with Psychic Anomaly (Anxiety and Depression)
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作者 Eduardo Goncalves Saul Neves de Jesus 《Open Journal of Psychiatry》 2015年第4期362-373,共12页
The present study aimed to investigate the impact of chronic psychosocial stress and resilience, including at a biological level (immune and neuroendocrine function) in Portuguese citizens with psychic anomaly/mental ... The present study aimed to investigate the impact of chronic psychosocial stress and resilience, including at a biological level (immune and neuroendocrine function) in Portuguese citizens with psychic anomaly/mental disorder. The sample aggregated 69 participants. It has been used the following psychometric instruments: 21-item depression, anxiety and stress scales (DASS-21), in the Portuguese validated version;measuring state resilience (MSR), in the Portuguese validated version;the Portuguese scale of 23 questions on vulnerability to stress. Serum levels of cortisol, dehydroepiandrosterone sulfate, antibodies anti-viral capsid antigen of Epstein-Barr virus, triglycerides, high density lipoprotein-cholesterol and body mass index have been measured. It has been concluded that factors of vulnerability to stress and chronic stress, of social nature (lack of social support, adverse living conditions), correlate positively with depression, anxiety and stress, and, through alostatic load, are involved in a greater propensity for immune and neuroendocrine dysfunction in this population. 展开更多
关键词 VULNERABILITY to stress stress Coping resilience Alostatic Load Anxiety Depression Cortisol DEHYDROEPIANDROSTERONE EPSTEIN-BARR Virus TRIGLYCERIDES High Density Lipoprotein-Cholesterol Body Mass Index
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Proteomic Profiling and Protein-Protein Interaction Network Reveal the Molecular Mechanisms of Susceptibility to Drought Stress in Canola(Brassica napus L.)
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作者 Reza Shokri-Gharelo Ali Bandehagh Mohammad Anwar Hossain 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第7期1403-1417,共15页
Drought stress is one of the most important abiotic stresses that plants face frequently in nature.Under drought conditions,many morphological,physiological,and molecular aspects of plants are changed and as a result ... Drought stress is one of the most important abiotic stresses that plants face frequently in nature.Under drought conditions,many morphological,physiological,and molecular aspects of plants are changed and as a result plants experience a remarkable reduction in growth,yield,and reproduction.To expand our understanding of the molecular basis of the plant response to drought stress,the proteomic profile and protein-protein network of canola(Brassica napus L.)were studied.The focus was to show molecular mechanisms related to canola susceptibility to drought stress.The experiment used a completely randomized design,implemented in a hydroponic system under greenhouse conditions.To impose drought stress,plants were exposed to Hoagland’s solution supplemented with polyethylene glycol(PEG)6000 for 7 days.The drought stress resulted in 161reproducible protein spots in twodimensional electrophoresis of canola leaves.The t-student test showed 21 differentially abundant proteins(DAP),of which 2 and 19 were up and down accumulated,respectively.Two spots identified as 1-aminocyclopropane-1-carboxylate oxidase and D-2-hydroxyglutarate dehydrogenase showed an increased abundance of 2.11 and 1.77,respectively.The extended protein-protein interaction of differentially abundant proteins and KEGG analysis showed 47 pathways directly and indirectly associated with canola response to drought stress.DAPs with increased abundance were associated with amino acid and signaling processes,whereas DAPs with decreased abundance were mostly connected with pathways responsible for energy production.The results of the study will help to elucidate further the molecular events associated with the susceptibility to drought stress in canola. 展开更多
关键词 Abiotic stress differentially abundant protein molecular function PROTEOMICS susceptibility
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Relationship of Stress Coping Behaviors and Changes in Resilience during an Integrated Nursing Practicum
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作者 Etsuko Imoto Emi Yoshioka Sayuri Kaneko 《Open Journal of Nursing》 2020年第11期1026-1037,共12页
This study aims to clarify what kinds of resilience and coping strategies students employ to successfully complete their clinical practicum and provide suggestions for instruction that will allow students to carry out... This study aims to clarify what kinds of resilience and coping strategies students employ to successfully complete their clinical practicum and provide suggestions for instruction that will allow students to carry out effective learning activities. The study subjects were 86 students enrolled at Nursing University A for the 2019 school year and planning to take the integrated nursing practicum. The survey was conducted using an anonymous, self-administered questionnaire. The Wilcoxon signed-rank test was used to determine the amount of change in resilience factors from the surveys before and after the practicum. Subsequently, multiple regression analysis was carried out with stress coping behaviors that were significantly associated with resilience factors in univariate analysis as independent variables and the amount of change in resilience factors before and after the practicum as dependent variables. A total of 56 responses were received (response rate 65.8%) from the 85 survey subjects. Innate resilience factors increased significantly from 41 pre-practicums to 44 post-practicums. Acquired resilience factors also increased significantly from 32 pre-practicums to 35 post-practicums (p < 0.01). The results of multiple regression analysis found that the stress coping behavior of “changing point of view” (β = 0.361, p < 0.01) and pre-practicum innate resilience factors (β = <span style="white-space:nowrap;">&#8722;</span>0.456, p < 0.01) were significantly associated with innate resilience factors. Examining the relationship between the amount of change in student resilience and stress coping behaviors revealed that the stress coping behavior of “changing point of view” was associated with innate resilience. This finding suggests that resilience may be increased by changing one’s perspective on an event by taking on a new way of thinking. The results suggested that helping students transform realizations made during reflection into learning and create a sense of meaning may lead to fostering innate resilience during integrated nursing practicums. 展开更多
关键词 stress Coping Behaviors resilience Integrated Nursing Practicum Nursing Students
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Resilience to the effects of social stress on vulnerability to developing drug addiction
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作者 Claudia Calpe-López Maria A Martínez-Caballero +1 位作者 Maria P García-Pardo Maria A Aguilar 《World Journal of Psychiatry》 SCIE 2022年第1期24-58,共35页
We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse.We define the concept of resilience and how it is applied to the field of d... We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse.We define the concept of resilience and how it is applied to the field of drug addiction research.We also describe the internal and external protective factors associated with resilience,such as individual behavioral traits and social support.We then explain the physiological response to stress and how it is modulated by resilience factors.In the subsequent section,we describe the animal models commonly used in the study of resilience to social stress,and we focus on the effects of chronic social defeat(SD),a kind of stress induced by repeated experience of defeat in an agonistic encounter,on different animal behaviors(depression-and anxiety-like behavior,cognitive impairment and addiction-like symptoms).We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depressionand anxiety-related behaviors in rodents.Finally,we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse,describing the current state of knowledge and suggesting future research directions. 展开更多
关键词 resilience stress DEPRESSION Drug addiction Animal models Social defeat
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Shiqi herbal tea reduces the susceptibility to H1N1 influenza virus in stressed mice
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作者 Guo Xie Zhuo Luo +7 位作者 Lu-Ping Tang Li-Hang Zhang Li-Hua Peng Ling Jin Hiroshi Kurihara Jin-Le Cheng Yi-Fang Li Rong-Rong He 《TMR Modern Herbal Medicine》 2021年第1期44-52,共9页
Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibili... Objective:It is well known that stress plays a critical role in immune response and susceptibility to diseases.Among many stressors,restraint stress has been shown to suppress immune function and increase susceptibility to infections.In this study,we employed a restraint-mouse model to investigate the effect and preliminary mechanism of ShiQi herbal tea(SQHT),a traditional Chinese medicine,on H1N1 virus infection.Methods:Mice were exposed to restraint stress and infected with H1N1 influenza virus by intranasal inoculation.SQHT(936 and 1872 mg/kg/d)was orally administrated to mice for 7 days from the first day of restraint stress.The survival rate of mice in each group was monitored daily for 21 days.Histopathological changes,inflammatory cells infiltration,and virus titer in lungs were examined.For the study of mechanisms,we investigated whether SQHT could promote interferon-β(IFN-β)generation and interferon stimulated genes(ISG)expression.Results:Our results suggested that SQHT(936 mg/kg/d)significantly reduced H1N1-induced mortality,the level of complement C5a and lung tissue inflammation,and viral replication in restraint-stressed mice.Further results revealed that in restraint-stressed mice model,SQHT(936 mg/kg/d)administration markedly improved IFN-βgeneration,and increased MX1 and IFITM3 gene expression.Conclusion:Our study demonstrates that SQHT reduces restraint stress-induced susceptibility to H1N1 infection via improving IFN-βantiviral pathway,which provides a certain basis for the clinical use of SQHT to treat H1N1 infection. 展开更多
关键词 ShiQi herbal tea Restraint stress H1N1 virus C5A INTERFERON-Β susceptibility
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Stress corrosion cracking susceptibility of 7A52 aluminum alloy
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作者 赵军军 王卫欣 +1 位作者 蔡志海 张平 《中国有色金属学会会刊:英文版》 CSCD 2006年第A03期1523-1527,共5页
The stress corrosion sensitivity of 7A52 aluminum alloy was investigated in the artificial sea water through slow stain rate test(SSRT). The stress corrosion cracking(SCC) susceptibility was estimated with the loss of... The stress corrosion sensitivity of 7A52 aluminum alloy was investigated in the artificial sea water through slow stain rate test(SSRT). The stress corrosion cracking(SCC) susceptibility was estimated with the loss of elongation and stress corrosion sensitivity index. The results show that the susceptibility of 7A52 aluminum alloy is always high when the strain rate is in the range of 10-5-10-7s-1.It reaches the maximum at the strain rate of 8.7×10-7s-1,and the sensitivity index reaches 0.346. The characteristics of stress corrosion can be observed clearly on the fracture of tensile specimen. The process of SCC is depicted according to the fracture morphology. The SCC initiates at the edge of the specimen. Then the SCC grows rapidly because of the anode dissolving and stress concentration. When the area of specimen cannot support the tensile stress, it ruptures suddenly. The secondary cracks and quasi-cleavage surface can be found on the fracture morphology. 展开更多
关键词 金属腐蚀 应力腐蚀 铝合金 强度
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Testing the Proposed Municipality Resilience Index to Climate Change Shocks and Stresses in Mbale Municipality in Eastern Uganda
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作者 George Oriangi Yazidhi Bamutaze +3 位作者 Paul Isolo Mukwaya Paul Musali Giuliano Di Baldassarre Petter Pilesjo 《American Journal of Climate Change》 2019年第4期520-543,共24页
Since climate change shocks and stresses cannot be fully prevented, building resilient urban areas is gaining more attention in the global community. By building resilience, the negative impacts of climate change shoc... Since climate change shocks and stresses cannot be fully prevented, building resilient urban areas is gaining more attention in the global community. By building resilience, the negative impacts of climate change shocks and stresses can be alleviated. Several indices have been developed to measure urban resilience. Yet, most of these indices focus more on objective methods which require robust bio-physical and socio-economic data sets which are generally lacking in many developing countries. To reduce this challenge, the use of subjective methods has recently been suggested. This study proposed and tested a Municipality Resilience Index (MRI) which employed a subjective method to assess the resilience of Mbale municipality in Eastern Uganda against climate change shocks and stresses. The proposed MRI includes 46 variables describing the physical, social, economic and institutional dimensions. The MRI can be applied in any municipality in developing countries facing climate related shocks and stresses and with limited survey data. The application of this index to Mbale municipality shows that the municipality has a low resilience index of 0.2. Similarly, most variables in the four dimensions of resilience reflected very low resilience scores with other divisions being more resilient than the others. Furthermore, the social dimension has the lowest score as compared to the physical, economic and institutional dimensions. The findings indicate a spatial variability in the contribution of the resilience dimensions within this small geographic confine. Moreover, the findings show the strengths and weaknesses in the different dimensions of the proposed MRI. This can act as a guide for policy and practitioners on which sectors to target in order to enhance the resilience of Mbale municipality. 展开更多
关键词 URBAN resilience Index Climate Change Shocks and stresses
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Stress Resilience as a Tool to Combat the COVID-19 Pandemic
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作者 Samachi Sharma 《Journal of Psychological Research》 2022年第3期26-32,共7页
The COVID-19 pandemic has not only affected the world in terms of their physical health but has also been a strain on our mental well-being.Individuals who have showcased the tendency to bounce back from this situatio... The COVID-19 pandemic has not only affected the world in terms of their physical health but has also been a strain on our mental well-being.Individuals who have showcased the tendency to bounce back from this situation have been real survivors of this pandemic.With this background in mind,this research aimed to study the gender differences and age differences in stress resilience.The Stress Resiliency Profile by Thomas and Tymon(1992),Jr.was used for this purpose.An equal number of males and females(n=60;N=120)were evaluated for the study.To assess the age differences,the participants were divided into two age groups:15-22 years and 22-30 years of age.There were an equal number of individuals in each group(n=60,N=120).The subjects were assessed on the three dimensions of Stress Resiliency Profile-Necessitating,Skill Recognition and Deficiency Focusing.Results indicated significant differences in the Deficiency Focusing dimension among males and females.In the age difference evaluation,significant differences were found in the Skill Recognition dimension.The findings have been discussed within the framework of previous research.The current research findings have significant implications for the study of stress and resilience. 展开更多
关键词 PANDEMIC stress resilience Gender difference Age difference
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