This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful character...This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful characters,say,Lear,the two daughters and the victims of violence vividly,however,each one of them cannot persist the temptation of the innate sin,resulting in the eventual self-destruction.Despite the sinful behaviors in the daily life or the political world,the goodness of human nature rather than the inborn sinful nature should play an important role to build the peaceful and harmonious society.展开更多
Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infe...Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough infection or vaccination potentially induces a stronger antibody response against the ancestral strain than to subsequent variants, as in the case of influenza. Thus, overcoming OAS is important for the development of future vaccine designs. This review summarizes the recent findings on OAS in the antibody response to SARS-CoV-2 and its variants, with an emphasis on future vaccine designs.展开更多
文摘This thesis attempts to seek the goodness of human nature,which is core of the moral society,analyzing the "Original Sin"——violence,aggression and greed,etc.In Lear,Edward Bond depicts the sinful characters,say,Lear,the two daughters and the victims of violence vividly,however,each one of them cannot persist the temptation of the innate sin,resulting in the eventual self-destruction.Despite the sinful behaviors in the daily life or the political world,the goodness of human nature rather than the inborn sinful nature should play an important role to build the peaceful and harmonious society.
基金supported by the National Science Fund for Distinguished Young Scholars(82025022)the National Science Fund for Outstanding Young Scholars(82322040)+6 种基金the National Natural Science Foundation of China(92169204,82302494)the Guangdong Science and Technology Plan Project-Construction of High-level Biosafety Laboratories(2021B1212030010)the Guangdong Basic and Applied Basic Research Foundation(2021B1515020034,2023A1515011883)the Shenzhen Science and Technology Program(RCYX20200714114700046,ZDSYS20210623091810030)the Shenzhen Natural Science Foundation(JCYJ20220530163405012)the Chinese Academy of Medical Sciences Clinical and Translational Medicine Research Project(2022-I2M-C&T-B-113)the Shenzhen High-level Hospital Construction Fund(23250G1002).
文摘Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the original antigenic sin (OAS), variant breakthrough infection or vaccination potentially induces a stronger antibody response against the ancestral strain than to subsequent variants, as in the case of influenza. Thus, overcoming OAS is important for the development of future vaccine designs. This review summarizes the recent findings on OAS in the antibody response to SARS-CoV-2 and its variants, with an emphasis on future vaccine designs.
