目的评估Solumbra技术和SWIM技术治疗急性缺血性脑卒中(acute ischemic stroke,AIS)的有效性与安全性。方法回顾性分析191例AIS病例资料,根据手术方式分为Solumbra组(n=97)和SWIM组(n=94)。应用倾向性评分匹配法(propensity score match...目的评估Solumbra技术和SWIM技术治疗急性缺血性脑卒中(acute ischemic stroke,AIS)的有效性与安全性。方法回顾性分析191例AIS病例资料,根据手术方式分为Solumbra组(n=97)和SWIM组(n=94)。应用倾向性评分匹配法(propensity score matching,PSM)将两组患者按1∶1配比。对比匹配后两组患者临床相关指标、术后不同时间点美国国立卫生院卒中量表(the National Institutes of Health Stroke Scale,NIHSS)评分、侧支循环改善情况及并发症发生率。结果经PSM匹配,有50对患者匹配成功。Solumbra组患者取栓>2次占比与住院时间均高于SWIM组,预后良好占比低于SWIM组(P<0.05)。Solumbra组患者术后7d及术后2周NIHSS评分均低于SWIM组(P<0.05)。并发症发生率Solumbra组为20.00%,SWIM组为38.00%,Solumbra组低于SWIM组(P<0.05)。结论Solumbra技术和SWIM技术取栓治疗各有优势,临床可充分结合患者实际病情,针对性选择取栓方式。展开更多
The three-dimensional lattice Boltzmann method(LBM)is used to simulate the motion of a spherical squirmer in a square tube,and the steady motion velocity of a squirmer with different Reynolds numbers(Re,ranging from 0...The three-dimensional lattice Boltzmann method(LBM)is used to simulate the motion of a spherical squirmer in a square tube,and the steady motion velocity of a squirmer with different Reynolds numbers(Re,ranging from 0.1 to 2)and swimming types is investigated and analyzed to better understand the swimming characteristics of microorganisms in different environments.First,as the Reynolds number increases,the effect of the inertial forces becomes significant,disrupting the squirmer's ability to maintain its theoretical velocity.Specifically,as the Reynolds number increases,the structure of the flow field around the squirmer changes,affecting its velocity of motion.Notably,the swimming velocity of the squirmer exhibits a quadratic relationship with the type of swimming and the Reynolds number.Second,the narrow tube exerts a significant inhibitory effect on the squirmer motion.In addition,although chirality does not directly affect the swimming velocity of the squirmer,it can indirectly affect the velocity by changing its motion mode.展开更多
广域信息管理SWIM(System Wide Information Management)是下一代空中交通管理系统NGATM的信息共享机制,其主要核心服务之一是信息安全保障。文章根据国际民航组织ICAO制定的相关标准,从SWIM信息安全核心服务入手,研究了SWIM安全架构,...广域信息管理SWIM(System Wide Information Management)是下一代空中交通管理系统NGATM的信息共享机制,其主要核心服务之一是信息安全保障。文章根据国际民航组织ICAO制定的相关标准,从SWIM信息安全核心服务入手,研究了SWIM安全架构,分析了以Web服务安全标准为主的SWIM安全服务和基础设施所应遵循的安全技术标准,对SWIM数据安全和隐私保护具有重要意义。展开更多
目的总结颅内支撑导管辅助Solitaire支架取栓+吸栓技术(Solitaire FR with intracranial support catheter for mechanical thrombectimy,SWIM)治疗大血管闭塞性脑梗死的围手术期护理要点。方法对80例急性大血管闭塞性脑梗死患者采用SWI...目的总结颅内支撑导管辅助Solitaire支架取栓+吸栓技术(Solitaire FR with intracranial support catheter for mechanical thrombectimy,SWIM)治疗大血管闭塞性脑梗死的围手术期护理要点。方法对80例急性大血管闭塞性脑梗死患者采用SWIM技术进行取栓和吸栓相结合开通血管,加强围手术期护理管理。结果 80例患者中,75例血管成功再通,5例血管再通不佳,术中医护配合良好。结论快速有效地完善术前准备、密切观察病情、熟练的术中护理配合、仔细认真的术后护理有利于血管再通治疗顺利完成,改善患者预后。展开更多
We investigated the concentration of trihalomethanes (THMs) in tap water and swimming pool water in the area of the Nakhon Path- om Municipality during the period April 2005-March 2006. The concentrations of total T...We investigated the concentration of trihalomethanes (THMs) in tap water and swimming pool water in the area of the Nakhon Path- om Municipality during the period April 2005-March 2006. The concentrations of total THMs, chloroform, bromodichloromethane, dibromochloromethane and bromoform in tap water were 12.70-41.74, 6.72-29.19, 1.12-11.75, 0.63-3.55 and 0.08-3.40 μg/L, respectively, whereas those in swimming pool water were 26.15-65.09, 9.50-36.97, 8.90-18.01, 5.19-22.78 and ND-6.56 μg/L, respectively. It implied that the concentration of THMs in swimming pool water was higher than those in tap water, particularly, brominated-THMs. Both tap water and swimming pool water contained concentrations of total THMs below the standards of the World Health Organization (WHO), European Union (EU) and the United States Environmental Protection Agency (USEPA) phase Ⅰ, but 1 out of 60 tap water samples and 60 out of 72 swimming pool water samples contained those over the Standard of the USEPA phase Ⅱ. From the two cases of cancer risk assessment including Case Ⅰ Non-Swimmer and Case Ⅱ Swimmer, assessment of cancer risk of nonswimmers from exposure to THMs at the highest and the average concentrations was 4.43×10^-5 and 2.19×10^-5, respectively, which can be classified as acceptable risk according to the Standard of USEPA. Assessment of cancer risk of swimmers from exposure to THMs at the highest and the average concentrations was 1.47×10^-3 and 7.99×10^-4, respectively, which can be classified as unacceptable risk and needs to be improved. Risk of THMs exposure from swimming was 93.9%-94.2% of the total risk. Cancer risk of THMs concluded from various routes in descending order was: skin exposure while swimming, gastro-intestinal exposure from tap water intake, and skin exposure to tap water and gastro-intestinal exposure while swimming. Cancer risk from skin exposure while swimming was 94.18% of the total cancer risk.展开更多
There are many kinds of swimming mode in the fish world, and we investigated two of them, used by cyprinids and bulltrout. In this paper we track the locomotion locus by marks in different flow velocity from 0.2 m...There are many kinds of swimming mode in the fish world, and we investigated two of them, used by cyprinids and bulltrout. In this paper we track the locomotion locus by marks in different flow velocity from 0.2 m·s^-1 to 0.8 m·s^-1. By fit the data above we could find out the locomotion mechanism of the two kinds of fish and generate a mathematical model of fish kine- matics. The cyprinid fish has a greater oscillation period and amplitude compared with the bulltrout, and the bulltrout changes velocity mainly by controlling frequency of oscillation.展开更多
Numerical simulation and control of self- propelled swimming of two- and three-dimensional biomimetic fish school in a viscous flow are investigated. With a parallel computational fluid dynamics package for the two- a...Numerical simulation and control of self- propelled swimming of two- and three-dimensional biomimetic fish school in a viscous flow are investigated. With a parallel computational fluid dynamics package for the two- and three-dimensional moving boundary problem, which combines the adaptive multi-grid finite volume method and the methods of immersed boundary and volume of fluid, it is found that due to the interactions of vortices in the wakes, without proper control, a fish school swim with a given flap- ping rule can not keep the fixed shape of a queue. In order to understand the secret of fish swimming, a new feedback con- trol strategy of fish motion is proposed for the first time, i,e., the locomotion speed is adjusted by the flapping frequency of the caudal, and the direction of swimming is controlled by the swinging of the head of a fish. Results show that with this feedback control strategy, a fish school can keep the good order of a queue in cruising, turning or swimming around circles. This new control strategy, which separates the speed control and direction control, is important in the construction of biomimetic robot fish, with which it greatly simplifies the control devices of a biomimetic robot fish.展开更多
We have studied a biomimetic swimmer based on the motion of bacteria such as Escherichia coli (E. coli) theoretically andexperimentally. The swimmer has an ellipsoidal cell body propelled by a helical filament. The pe...We have studied a biomimetic swimmer based on the motion of bacteria such as Escherichia coli (E. coli) theoretically andexperimentally. The swimmer has an ellipsoidal cell body propelled by a helical filament. The performance of this swimmer wasestimated by modeling the dynamics of a swimmer in viscous fluid. We applied the Resistive Force Theory (RFT) on this modelto calculate the linear swimming speed and the efficiency of the model. A parametric study on linear velocity and efficiency tooptimize the design of this swimmer was demonstrated. In order to validate the theoretical results, a biomimetic swimmer wasfabricated and an experiment setup was prepared to measure the swimming speed and thrust force in silicone oil. The experimentalresults agree well with the theoretical values predicted by RFT. In addition, we studied the flow patterns surrounding thefilament with a finite element simulation with different Reynolds number (Re) to understand the mechanism of propulsion. Thesimulation results provide information on the nature of flow patterns generated by swimming filament. Furthermore, the thrustforces from the simulation were compared with the thrust forces from theory. The simulation results are in good agreement withthe theoretical results.展开更多
A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this...A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats(cold water swimming for 3 minutes at 4℃) spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~+ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.展开更多
文摘目的评估Solumbra技术和SWIM技术治疗急性缺血性脑卒中(acute ischemic stroke,AIS)的有效性与安全性。方法回顾性分析191例AIS病例资料,根据手术方式分为Solumbra组(n=97)和SWIM组(n=94)。应用倾向性评分匹配法(propensity score matching,PSM)将两组患者按1∶1配比。对比匹配后两组患者临床相关指标、术后不同时间点美国国立卫生院卒中量表(the National Institutes of Health Stroke Scale,NIHSS)评分、侧支循环改善情况及并发症发生率。结果经PSM匹配,有50对患者匹配成功。Solumbra组患者取栓>2次占比与住院时间均高于SWIM组,预后良好占比低于SWIM组(P<0.05)。Solumbra组患者术后7d及术后2周NIHSS评分均低于SWIM组(P<0.05)。并发症发生率Solumbra组为20.00%,SWIM组为38.00%,Solumbra组低于SWIM组(P<0.05)。结论Solumbra技术和SWIM技术取栓治疗各有优势,临床可充分结合患者实际病情,针对性选择取栓方式。
基金Project supported by the National Natural Science Foundation of China(Nos.12132015 and 12372251)the Fundamental Research Funds for the Provincial Universities of Zhejiang of China(No.2023YW69)。
文摘The three-dimensional lattice Boltzmann method(LBM)is used to simulate the motion of a spherical squirmer in a square tube,and the steady motion velocity of a squirmer with different Reynolds numbers(Re,ranging from 0.1 to 2)and swimming types is investigated and analyzed to better understand the swimming characteristics of microorganisms in different environments.First,as the Reynolds number increases,the effect of the inertial forces becomes significant,disrupting the squirmer's ability to maintain its theoretical velocity.Specifically,as the Reynolds number increases,the structure of the flow field around the squirmer changes,affecting its velocity of motion.Notably,the swimming velocity of the squirmer exhibits a quadratic relationship with the type of swimming and the Reynolds number.Second,the narrow tube exerts a significant inhibitory effect on the squirmer motion.In addition,although chirality does not directly affect the swimming velocity of the squirmer,it can indirectly affect the velocity by changing its motion mode.
文摘广域信息管理SWIM(System Wide Information Management)是下一代空中交通管理系统NGATM的信息共享机制,其主要核心服务之一是信息安全保障。文章根据国际民航组织ICAO制定的相关标准,从SWIM信息安全核心服务入手,研究了SWIM安全架构,分析了以Web服务安全标准为主的SWIM安全服务和基础设施所应遵循的安全技术标准,对SWIM数据安全和隐私保护具有重要意义。
文摘目的总结颅内支撑导管辅助Solitaire支架取栓+吸栓技术(Solitaire FR with intracranial support catheter for mechanical thrombectimy,SWIM)治疗大血管闭塞性脑梗死的围手术期护理要点。方法对80例急性大血管闭塞性脑梗死患者采用SWIM技术进行取栓和吸栓相结合开通血管,加强围手术期护理管理。结果 80例患者中,75例血管成功再通,5例血管再通不佳,术中医护配合良好。结论快速有效地完善术前准备、密切观察病情、熟练的术中护理配合、仔细认真的术后护理有利于血管再通治疗顺利完成,改善患者预后。
文摘We investigated the concentration of trihalomethanes (THMs) in tap water and swimming pool water in the area of the Nakhon Path- om Municipality during the period April 2005-March 2006. The concentrations of total THMs, chloroform, bromodichloromethane, dibromochloromethane and bromoform in tap water were 12.70-41.74, 6.72-29.19, 1.12-11.75, 0.63-3.55 and 0.08-3.40 μg/L, respectively, whereas those in swimming pool water were 26.15-65.09, 9.50-36.97, 8.90-18.01, 5.19-22.78 and ND-6.56 μg/L, respectively. It implied that the concentration of THMs in swimming pool water was higher than those in tap water, particularly, brominated-THMs. Both tap water and swimming pool water contained concentrations of total THMs below the standards of the World Health Organization (WHO), European Union (EU) and the United States Environmental Protection Agency (USEPA) phase Ⅰ, but 1 out of 60 tap water samples and 60 out of 72 swimming pool water samples contained those over the Standard of the USEPA phase Ⅱ. From the two cases of cancer risk assessment including Case Ⅰ Non-Swimmer and Case Ⅱ Swimmer, assessment of cancer risk of nonswimmers from exposure to THMs at the highest and the average concentrations was 4.43×10^-5 and 2.19×10^-5, respectively, which can be classified as acceptable risk according to the Standard of USEPA. Assessment of cancer risk of swimmers from exposure to THMs at the highest and the average concentrations was 1.47×10^-3 and 7.99×10^-4, respectively, which can be classified as unacceptable risk and needs to be improved. Risk of THMs exposure from swimming was 93.9%-94.2% of the total risk. Cancer risk of THMs concluded from various routes in descending order was: skin exposure while swimming, gastro-intestinal exposure from tap water intake, and skin exposure to tap water and gastro-intestinal exposure while swimming. Cancer risk from skin exposure while swimming was 94.18% of the total cancer risk.
基金the National Natural Science Foundation of China (Grant No. 50579007)
文摘There are many kinds of swimming mode in the fish world, and we investigated two of them, used by cyprinids and bulltrout. In this paper we track the locomotion locus by marks in different flow velocity from 0.2 m·s^-1 to 0.8 m·s^-1. By fit the data above we could find out the locomotion mechanism of the two kinds of fish and generate a mathematical model of fish kine- matics. The cyprinid fish has a greater oscillation period and amplitude compared with the bulltrout, and the bulltrout changes velocity mainly by controlling frequency of oscillation.
基金supported by the National Natural Science Foundation of China(10172095 and 10672183)
文摘Numerical simulation and control of self- propelled swimming of two- and three-dimensional biomimetic fish school in a viscous flow are investigated. With a parallel computational fluid dynamics package for the two- and three-dimensional moving boundary problem, which combines the adaptive multi-grid finite volume method and the methods of immersed boundary and volume of fluid, it is found that due to the interactions of vortices in the wakes, without proper control, a fish school swim with a given flap- ping rule can not keep the fixed shape of a queue. In order to understand the secret of fish swimming, a new feedback con- trol strategy of fish motion is proposed for the first time, i,e., the locomotion speed is adjusted by the flapping frequency of the caudal, and the direction of swimming is controlled by the swinging of the head of a fish. Results show that with this feedback control strategy, a fish school can keep the good order of a queue in cruising, turning or swimming around circles. This new control strategy, which separates the speed control and direction control, is important in the construction of biomimetic robot fish, with which it greatly simplifies the control devices of a biomimetic robot fish.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education Science and Technology(Grant number:2010-0018884)
文摘We have studied a biomimetic swimmer based on the motion of bacteria such as Escherichia coli (E. coli) theoretically andexperimentally. The swimmer has an ellipsoidal cell body propelled by a helical filament. The performance of this swimmer wasestimated by modeling the dynamics of a swimmer in viscous fluid. We applied the Resistive Force Theory (RFT) on this modelto calculate the linear swimming speed and the efficiency of the model. A parametric study on linear velocity and efficiency tooptimize the design of this swimmer was demonstrated. In order to validate the theoretical results, a biomimetic swimmer wasfabricated and an experiment setup was prepared to measure the swimming speed and thrust force in silicone oil. The experimentalresults agree well with the theoretical values predicted by RFT. In addition, we studied the flow patterns surrounding thefilament with a finite element simulation with different Reynolds number (Re) to understand the mechanism of propulsion. Thesimulation results provide information on the nature of flow patterns generated by swimming filament. Furthermore, the thrustforces from the simulation were compared with the thrust forces from theory. The simulation results are in good agreement withthe theoretical results.
基金supported by a grant from the Incubation Project of Natural Science Foundation of Tianjin Medical University General Hospital in China,No.303071901401the Natural Science Foundation of Tianjin of China,No.13JCZDJC30800the National Natural Science Foundation of China,No.81271361 and 81330029
文摘A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats(cold water swimming for 3 minutes at 4℃) spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~+ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.