Caveolin-1 is involved in the regulation of synaptic plasticity, but the relationship between its ex-pression and cognitive function during aging remains controversial. To explore the relationship be-tween synaptic pl...Caveolin-1 is involved in the regulation of synaptic plasticity, but the relationship between its ex-pression and cognitive function during aging remains controversial. To explore the relationship be-tween synaptic plasticity in the aging process and changes in learning and memory, we examined caveolin-1 expression in the hippocampus, cortex and cerebellum of rats at different ages. We also examined the relationship between the expression of caveolin-1 and synaptophysin, a marker of synaptic plasticity. Hippocampal caveolin-1 and synaptophysin expression in aged （22-24 month old） rats was significantly lower than that in young （1 month old） and adult （4 months old） rats. Ex- pression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats, and levels were similar between the three age groups in the cerebellum. Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities. Moreover, synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus, cortex and cerebellum. These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity, and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging.展开更多
This study was aimed at improved understanding of the mechanisms of previously reported protective effects of a pneumatic boxing glove. A Motion Capture System was used to obtain velocity data from four different boxi...This study was aimed at improved understanding of the mechanisms of previously reported protective effects of a pneumatic boxing glove. A Motion Capture System was used to obtain velocity data from four different boxing gloves dropped on to a force plate from nine heights ranging from 1 to 5 metres. Two gloves were of the conventional type but differed in mass. The other two were prototype pneumatic gloves. One of these (SBLI) had a sealed bladder while the other (ARLI) incorporated a port allowing air exchange with the external environment. The pneumatic gloves decelerated more slowly than the conventional gloves following impact and compressed through a greater absolute distance. Consequently, they took longer to reach zero velocity. As drop height increased, these trends became more pronounced for the ARLI glove than the SBLI glove. Increase in velocity during rebound was also slower for the pneumatic gloves. The ARLI glove had a lower coefficient of restitution than any of the other gloves at low to moderate drop heights but not at high drop heights. The SBLI glove had a higher coefficient of restitution than the other gloves at all drop heights from 2 metres upwards. This indicated that, overall, the ARLI glove was the most effective, and the SBLI glove the least effective, in dissipating the kinetic energy of impact through conversion to other energy forms. For all gloves at all drop heights, peak positive acceleration at the beginning of rebound was of lower absolute magnitude than peak negative acceleration at the end of compression. The influence of drop height on an index characterising this relationship differed between the conventional and pneumatic gloves, possibly reflecting structural changes to gloves as impact energy increased. The conventional and pneumatic gloves differed regarding temporal alignment between key kinematic and kinetic events, and there were some differences between the two pneumatic gloves in this respect. Nevertheless, peak glove deceleration correlated highly with peak impact force, not only for each glove individually but also when data for all gloves were combined. The findings confirmed the potential practical utility of the ARLI glove and identified air cushion thickness, glove compressibility and capacity for air release and subsequent reuptake as critical aspects of its design.展开更多
The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. ...The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. Be- cause the shape and rolling force distribution are very sensitive to strip thickness transverse distribution% variation, the iterative course is rather unstable and sometimes convergence cannot be achieved. In addition, the calculating speed of results coupling method is low, which restricts its usable range. To solve the problem, a new model cou- pling method is developed, which takes the force distribution between rolls, rolling force distribution and strip＇s exit transverse displacement distribution as basic unknowns, and integrates strip plastic deformation model and rolls elas- tic deformation model as a unified linear equations through their internal relation, so the iterative calculation between the strip plastic deformation model and rolls elastic deformation model can be avoided. To prove the effectiveness of the model coupling method, two examples are calculated by results coupling method and model coupling method re- spectively. The results of front tension stress, back tension stress, strip^s exit gauge, the force between rolls and rolling force distribution calculated by model coupling method coincide very well with results coupling method. How- ever the calculation course of model coupling method is more steady than results coupling method, and its calculating speed is about ten times as much as the maximal speed of results coupling method, which validates its practicability and reliability.展开更多
基金funded by the National Natural Science Foundation of China,No.81071009,31200740,81271412the International S & T Cooperation Project of the Ministry of S & T of China,No.2010DFR30850+1 种基金the People’s Livelihood S & T Project,the Bureau of S & T of Dalian,No.2010E11SF008,2011E12SF030the Doctoral Fund of S & T Department of Liaoning Province,No.20121109
文摘Caveolin-1 is involved in the regulation of synaptic plasticity, but the relationship between its ex-pression and cognitive function during aging remains controversial. To explore the relationship be-tween synaptic plasticity in the aging process and changes in learning and memory, we examined caveolin-1 expression in the hippocampus, cortex and cerebellum of rats at different ages. We also examined the relationship between the expression of caveolin-1 and synaptophysin, a marker of synaptic plasticity. Hippocampal caveolin-1 and synaptophysin expression in aged （22-24 month old） rats was significantly lower than that in young （1 month old） and adult （4 months old） rats. Ex- pression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats, and levels were similar between the three age groups in the cerebellum. Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities. Moreover, synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus, cortex and cerebellum. These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity, and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging.
文摘This study was aimed at improved understanding of the mechanisms of previously reported protective effects of a pneumatic boxing glove. A Motion Capture System was used to obtain velocity data from four different boxing gloves dropped on to a force plate from nine heights ranging from 1 to 5 metres. Two gloves were of the conventional type but differed in mass. The other two were prototype pneumatic gloves. One of these (SBLI) had a sealed bladder while the other (ARLI) incorporated a port allowing air exchange with the external environment. The pneumatic gloves decelerated more slowly than the conventional gloves following impact and compressed through a greater absolute distance. Consequently, they took longer to reach zero velocity. As drop height increased, these trends became more pronounced for the ARLI glove than the SBLI glove. Increase in velocity during rebound was also slower for the pneumatic gloves. The ARLI glove had a lower coefficient of restitution than any of the other gloves at low to moderate drop heights but not at high drop heights. The SBLI glove had a higher coefficient of restitution than the other gloves at all drop heights from 2 metres upwards. This indicated that, overall, the ARLI glove was the most effective, and the SBLI glove the least effective, in dissipating the kinetic energy of impact through conversion to other energy forms. For all gloves at all drop heights, peak positive acceleration at the beginning of rebound was of lower absolute magnitude than peak negative acceleration at the end of compression. The influence of drop height on an index characterising this relationship differed between the conventional and pneumatic gloves, possibly reflecting structural changes to gloves as impact energy increased. The conventional and pneumatic gloves differed regarding temporal alignment between key kinematic and kinetic events, and there were some differences between the two pneumatic gloves in this respect. Nevertheless, peak glove deceleration correlated highly with peak impact force, not only for each glove individually but also when data for all gloves were combined. The findings confirmed the potential practical utility of the ARLI glove and identified air cushion thickness, glove compressibility and capacity for air release and subsequent reuptake as critical aspects of its design.
基金Sponsored by National Science and Technology Support Plan of China (2009AA04Z143)Science and Technology Support Plan of Hebei Province of China (10212101D)Important Natural Science Foundation of Hebei Province of China (E2006001038)
文摘The shape of strip is calculated by iterative method which combines strip plastic deformation model with rolls elastic deformation model through their calculation results, which can be called results coupling method. Be- cause the shape and rolling force distribution are very sensitive to strip thickness transverse distribution% variation, the iterative course is rather unstable and sometimes convergence cannot be achieved. In addition, the calculating speed of results coupling method is low, which restricts its usable range. To solve the problem, a new model cou- pling method is developed, which takes the force distribution between rolls, rolling force distribution and strip＇s exit transverse displacement distribution as basic unknowns, and integrates strip plastic deformation model and rolls elas- tic deformation model as a unified linear equations through their internal relation, so the iterative calculation between the strip plastic deformation model and rolls elastic deformation model can be avoided. To prove the effectiveness of the model coupling method, two examples are calculated by results coupling method and model coupling method re- spectively. The results of front tension stress, back tension stress, strip^s exit gauge, the force between rolls and rolling force distribution calculated by model coupling method coincide very well with results coupling method. How- ever the calculation course of model coupling method is more steady than results coupling method, and its calculating speed is about ten times as much as the maximal speed of results coupling method, which validates its practicability and reliability.
