The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurolog...The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation（i LTP） of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.展开更多
Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persist...Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persistent,however,chronic inflammation leads to overproduction of noxious mediators that contribute to cell dysfunction and death.展开更多
Sleep is a universal biological process occurring in almost every species of animal,and the loss of sleep has detrimental effects,especially impairments in cognition[1,2].Yet,the neuronal function of sleep is still on...Sleep is a universal biological process occurring in almost every species of animal,and the loss of sleep has detrimental effects,especially impairments in cognition[1,2].Yet,the neuronal function of sleep is still one of the greatest mysteries.One prominent idea,known as the synaptic homeostasis hypothesis,展开更多
基金supported by German Israeli Foundation(G-1317-418.13/2015 to AV and NM)
文摘The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation（i LTP） of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.
基金supported by grants from the Canadian Institutes of Health Research and the Fonds de recherche du Québec-Santé (FRQS)National Chercheur Boursier award from FRQS
文摘Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to re-establish tissue homeostasis.When the injury is persistent,however,chronic inflammation leads to overproduction of noxious mediators that contribute to cell dysfunction and death.
文摘Sleep is a universal biological process occurring in almost every species of animal,and the loss of sleep has detrimental effects,especially impairments in cognition[1,2].Yet,the neuronal function of sleep is still one of the greatest mysteries.One prominent idea,known as the synaptic homeostasis hypothesis,
