Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in tra...Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.展开更多
目的:观察四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫的临床疗效。方法:将86例风寒袭络型急性期周围性面瘫患者按照随机数字表法分为对照组和试验组,每组各43例。对照组给予四物牵正散治疗,试验组在对照组治疗的基础上联合针刺...目的:观察四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫的临床疗效。方法:将86例风寒袭络型急性期周围性面瘫患者按照随机数字表法分为对照组和试验组,每组各43例。对照组给予四物牵正散治疗,试验组在对照组治疗的基础上联合针刺疗法。比较两组患者的临床疗效、不良反应发生率及治疗前后面神经功能评分、面部残疾指数躯体功能(facial disability index physical function, FDIP)评分、面部残疾指数社会功能(facial disability index social function, FDIS)评分、中医证候积分、FaCE量表评分、免疫功能水平(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化情况。结果:对照组有效率为81.39%,试验组有效率为93.02%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后面神经功能评分、FDIP评分、FDIS评分高于本组治疗前,中医证候积分较低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后FaCE量表各项评分高于本组治疗前,且治疗后试验组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫患者,能够调节患者免疫功能,改善临床症状,且不良反应较低。展开更多
目的:观察五苓散加味治疗单纯性肥胖合并脂代谢异常的临床治疗。方法:回顾性分析本院门诊2014年1月至2016年6月收治的80例单纯性肥胖合并脂代谢异常患者为研究对象,随机分为治疗组和对照组,每组各40例。对照组给予健康教育、饮食指导及...目的:观察五苓散加味治疗单纯性肥胖合并脂代谢异常的临床治疗。方法:回顾性分析本院门诊2014年1月至2016年6月收治的80例单纯性肥胖合并脂代谢异常患者为研究对象,随机分为治疗组和对照组,每组各40例。对照组给予健康教育、饮食指导及适度有氧运动干预,同时给予辛伐他汀胶囊,治疗组在对照组的基础上加用五苓散加味治疗。观察两组患者的临床疗效,比较两组患者治疗前后体质量指数(body mass index,BMI),采用全自动生化分析仪检测两组患者治疗前后三酰甘油(threeacyl glycerin,TG)、血清总胆固醇(total cholesterol,TC)及高密度脂肪蛋白(high density lipoprotein cholesterol,HDL-C)水平。结果:对照组有效率为75.0%,治疗组有效率为92.5%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后BMI低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后TC、TG、HDL-C水平低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:五苓散加味可以明显改善单纯性肥胖合并脂代谢异常症患者的临床症状,提高临床疗效。展开更多
基金supported by National Basic Research Program of China(No.2013CB531803)
文摘Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling(FL) in traditional Chinese medicine(TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi(FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu(ZM) in TCM, with cold property, as reference drugs, respectively. The appearance score, toe and rectal temperatures of the animals treated were assessed at different time points. Several indices in vivo correlated with substance and energy metabolism(glucokinas, phosphoglycerate kinase, cytochrome c reductase, cytochrome c oxydase, and Na^+-K^+-ATPase), endocrine system(triiodothyronine, thyroxine, and 17-hydroxycorticosteroid), nervous system(acetylcholin esterase), and cyclic nucleotide system were determined. The changes in appearance score and indices in vivo suggested the successful establishment of cold-deficiency and heat-deficiency syndrome models. FZ reversed the decreased levels of indices(substance and energy metabolism and endocrine system) and alleviated the syndrome of cold-deficiency model, and ZM showed obviously therapeutic effect on heat-deficiency syndrome(appearance score, substance and energy metabolism, and endocrine system). FL could alleviate cold-deficiency syndrome and raise the decreased levels of glucokinas, phosphoglycerate kinase, cytochrome c reductase and triiodothyronine in cold-deficiency model, but had no significant effect on heat-deficiency syndrome. Drug property of FL was inferred as trending to "flat and warm", which still need further study. It was advisable to adopt both cold-deficiency and heat-deficiency models to study the drugs with "flat" property.
文摘目的:观察四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫的临床疗效。方法:将86例风寒袭络型急性期周围性面瘫患者按照随机数字表法分为对照组和试验组,每组各43例。对照组给予四物牵正散治疗,试验组在对照组治疗的基础上联合针刺疗法。比较两组患者的临床疗效、不良反应发生率及治疗前后面神经功能评分、面部残疾指数躯体功能(facial disability index physical function, FDIP)评分、面部残疾指数社会功能(facial disability index social function, FDIS)评分、中医证候积分、FaCE量表评分、免疫功能水平(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化情况。结果:对照组有效率为81.39%,试验组有效率为93.02%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后面神经功能评分、FDIP评分、FDIS评分高于本组治疗前,中医证候积分较低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后FaCE量表各项评分高于本组治疗前,且治疗后试验组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫患者,能够调节患者免疫功能,改善临床症状,且不良反应较低。
文摘目的:观察五苓散加味治疗单纯性肥胖合并脂代谢异常的临床治疗。方法:回顾性分析本院门诊2014年1月至2016年6月收治的80例单纯性肥胖合并脂代谢异常患者为研究对象,随机分为治疗组和对照组,每组各40例。对照组给予健康教育、饮食指导及适度有氧运动干预,同时给予辛伐他汀胶囊,治疗组在对照组的基础上加用五苓散加味治疗。观察两组患者的临床疗效,比较两组患者治疗前后体质量指数(body mass index,BMI),采用全自动生化分析仪检测两组患者治疗前后三酰甘油(threeacyl glycerin,TG)、血清总胆固醇(total cholesterol,TC)及高密度脂肪蛋白(high density lipoprotein cholesterol,HDL-C)水平。结果:对照组有效率为75.0%,治疗组有效率为92.5%,两组患者临床疗效比较,差异具有统计学意义(P<0.05)。两组患者治疗后BMI低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后TC、TG、HDL-C水平低于治疗前,且治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:五苓散加味可以明显改善单纯性肥胖合并脂代谢异常症患者的临床症状,提高临床疗效。
