During the past decades,the rapidly-evolving cancer is hard to be thoroughly eliminated even though the radiotherapy and chemotherapy do exhibit efficacy in some degree.However,a breakthrough appeared when the adoptiv...During the past decades,the rapidly-evolving cancer is hard to be thoroughly eliminated even though the radiotherapy and chemotherapy do exhibit efficacy in some degree.However,a breakthrough appeared when the adoptive cancer therapy[1]was developed,especially T cells armed with chimeric antigen receptors(CARs)showed great potential in tumor clinical trials recently.CAR-T cells successfully elevated the efficiency and specificity of cytotoxicity.In this review,we will talk about the design of CAR and CAR-included combinatory therapeutic applications in the principles of systems and synthetic immunology.展开更多
基金National Key Basic Research Program of China 2015CB910300National Natural Science Foundation of China 31470819,31622022.
文摘During the past decades,the rapidly-evolving cancer is hard to be thoroughly eliminated even though the radiotherapy and chemotherapy do exhibit efficacy in some degree.However,a breakthrough appeared when the adoptive cancer therapy[1]was developed,especially T cells armed with chimeric antigen receptors(CARs)showed great potential in tumor clinical trials recently.CAR-T cells successfully elevated the efficiency and specificity of cytotoxicity.In this review,we will talk about the design of CAR and CAR-included combinatory therapeutic applications in the principles of systems and synthetic immunology.
