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Multi-Component Resource Recycling from Waste Light-Emitting Diode Under Hydrothermal Condition:Plastic Package Degradation,Speciation of Nano-TiO_(2),and Environmental Impact Assessment
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作者 Yongliang Zhang Lu Zhan Zhenming Xu 《Engineering》 SCIE EI CAS CSCD 2024年第8期253-261,共9页
Light emitting diodes(LEDs)have accounted for most of the lighting market as the technology matures and costs continue to reduce.As a new type of e-waste,LED is a double-edged sword,as it contains not only precious an... Light emitting diodes(LEDs)have accounted for most of the lighting market as the technology matures and costs continue to reduce.As a new type of e-waste,LED is a double-edged sword,as it contains not only precious and rare metals but also organic packaging materials.In previous studies,LED recycling focused on recovering precious and strategic metals while ignoring harmful substances such as organic packaging materials.Unlike crushing and other traditional methods,hydrothermal treatment can provide an environment-friendly process for decomposing packaging materials.This work developed a closed reaction vessel,where the degradation rate of plastic polyphthalamide(PPA)was close to 100%,with nano-TiO_(2)encapsulated in plastic PPA being efficiently recovered,while metals contained in LED were also recycled efficiently.Besides,the role of water in plastic PPA degradation that has been overlooked in current studies was explored and speculated in detail in this work.Environmental impact assessment revealed that the proposed recycling route for waste LED could significantly reduce the overall environmental impact compared to the currently published processes.Especially the developed method could reduce more than half the impact of global warming.Furthermore,this research provides a theoretical basis and a promising method for recycling other plastic-packaged e-waste devices,such as integrated circuits. 展开更多
关键词 Waste LED Hydrothermal treatment RECYCLinG Plastic PPA degradation Packaging materials
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DSN-BR-Based Online Inspection Method and Application for Surface Defects of Pharmaceutical Products in Aluminum-Plastic Blister Packages
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作者 Mingzhou Liu Yu Gong +2 位作者 Xiaoqiao Wang Conghu Liu Jing Hu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第4期194-214,共21页
Ensuring high product quality is of paramount importance in pharmaceutical drug manufacturing,as it is subject to rigorous regulatory practices.This study presents a research focused on the development of an on-line d... Ensuring high product quality is of paramount importance in pharmaceutical drug manufacturing,as it is subject to rigorous regulatory practices.This study presents a research focused on the development of an on-line detection method and system for identifying surface defects in pharmaceutical products packaged in aluminum-plastic blisters.Firstly,the aluminum-plastic blister packages exhibit multi-scale features and inter-class indistinction.To address this,the deep semantic network with boundary refinement(DSN-BR)model is proposed,which leverages semantic segmentation domain knowledge,to accurately segment the defects in pixel level.Additionally,a specialized image acquisition module that minimizes the impact of ambient light is established,ensuring high-quality image capture.Finally,the image acquisition module,image detection module,and data management module are designed to construct a comprehensive online surface defect detection system.To validate the effectiveness of our approach,we employ a real dataset for instance verification on the implemented system.The experimental results substantiate the outstanding performance of the DSN-BR,achieving the mean intersection over union(MIoU)of 90.5%.Furthermore,the proposed system achieves an inference speed of up to 14.12 f/s,while attaining an F1-Score of 98.25%.These results demonstrate that the system meets the actual needs of the enterprise and provides theoretical and methodological support for intelligent inspection of product surface quality.By standardizing the control process of pharmaceutical manufacturing and improving the management capability of the manufacturing process,our approach holds significant market application prospects. 展开更多
关键词 Surface defect detection system Deep learning Semantic segmentation Aluminum-plastic blister packages identification
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基于递归认证测试的SIP协议形式化分析
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作者 姚萌萌 王宇 洪瑜平 《信息网络安全》 CSCD 北大核心 2024年第10期1586-1594,共9页
文章以形式化分析方法证明协议安全为研究目的,以具有灵活性、开放性、可伸缩性等特性的SIP协议为研究对象,运用基于串空间理论改进的递归认证测试形式化分析方法,分析了一种BAN逻辑证明安全的SIP身份认证协商协议,发现了该协议执行过... 文章以形式化分析方法证明协议安全为研究目的,以具有灵活性、开放性、可伸缩性等特性的SIP协议为研究对象,运用基于串空间理论改进的递归认证测试形式化分析方法,分析了一种BAN逻辑证明安全的SIP身份认证协商协议,发现了该协议执行过程中协议格式不准确、易受中间人攻击的缺陷,并提出了针对该协议缺陷的改进方案。结果表明,文章所提出的递归认证测试形式化分析方法比BAN逻辑更适用、更有效,同时改进方案也增强了SIP身份认证协商协议的安全性。 展开更多
关键词 sip协议 递归认证测试 串空间 形式化分析方法
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基于SIP的应急通信调度台设计
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作者 李文峰 金进 +3 位作者 董家麟 王宁 冯杰 薛严博 《煤矿安全》 CAS 北大核心 2024年第6期206-210,共5页
针对各应急救援场景中通信网络复杂多样,普通调度台的指挥通信系统相互独立等问题,提出一款基于SIP的应急通信调度台的构建方案;详细介绍了调度台的各硬件模块构成,阐述了SIP软交换技术在方案中的应用。调度台支持接入数字和模拟通信网... 针对各应急救援场景中通信网络复杂多样,普通调度台的指挥通信系统相互独立等问题,提出一款基于SIP的应急通信调度台的构建方案;详细介绍了调度台的各硬件模块构成,阐述了SIP软交换技术在方案中的应用。调度台支持接入数字和模拟通信网络以实现语音通信并通过有线和无线的多种宽带通信方式实现多媒体视频通信;基于SIP软交换技术,针对不同应急救援场景下的应急通信需求,提出了全融合通信概念,完成统一指挥调度。 展开更多
关键词 应急通信 通信调度台 全融合通信 sip 软交换
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微型组合导航SIP芯片的PDN电热协同仿真与优化
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作者 陈明 余未 +1 位作者 倪屹 时广轶 《空天预警研究学报》 CSCD 2024年第3期226-230,234,共6页
随着SIP芯片逐步小型化和集成化,导致芯片对PDN的直流压降、电流密度以及系统的温升控制要求越来越高.本文通过改变载流导体的面积来改善直流压降和电流密度过高的问题,同时针对芯片温升研究通过合理优化热过孔阵列的孔径、过孔数量以... 随着SIP芯片逐步小型化和集成化,导致芯片对PDN的直流压降、电流密度以及系统的温升控制要求越来越高.本文通过改变载流导体的面积来改善直流压降和电流密度过高的问题,同时针对芯片温升研究通过合理优化热过孔阵列的孔径、过孔数量以及镀铜厚度来减小热阻以达到控制芯片温升的目的.仿真结果表明,增加载流导体的面积能有效降低直流压降和电流密度,且还留有很大的裕量;而热过孔阵列的合理布局能有效控制芯片温升,从而提升了芯片的功能和可靠性. 展开更多
关键词 微型组合导航 sip芯片 直流压降 热分布 电热协同仿真
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基于SIPS理论模型的美食短视频传播城市形象策略研究
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作者 胡志超 《鞍山师范学院学报》 2024年第1期100-104,共5页
智能媒体时代,短视频为大众主动参与城市形象的建构与传播提供了新的视角和实践。美食因其独特魅力,成为城市独有的特殊符号和城市形象传播的重要载体。以短视频垂直细分领域下的美食短视频作为切入点,解析美食短视频在城市形象传播上... 智能媒体时代,短视频为大众主动参与城市形象的建构与传播提供了新的视角和实践。美食因其独特魅力,成为城市独有的特殊符号和城市形象传播的重要载体。以短视频垂直细分领域下的美食短视频作为切入点,解析美食短视频在城市形象传播上的重要性,厘清其在传播城市形象过程中存在的问题,结合SIPS模式,分别从共鸣、确认、参与、共享四个阶段,提出优化美食短视频传播城市形象的策略。 展开更多
关键词 sipS模式 美食 短视频 城市形象
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Bisphenol A (BPA) Contamination in Whole Milk Marketed in Different Packages 被引量:1
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作者 Patrícia dos Santos Souza Thomas Manfred Krauss +1 位作者 André Victor Sartori Shirley de Mello Pereira Abrantes 《Journal of Environmental Protection》 2023年第9期711-724,共14页
Bisphenol A (BPA), an important endocrine disruptor, is used in the manufacturing of various materials, including food packaging. Ingestion of contaminated foodstuffs is, in fact, the most relevant form of exposure to... Bisphenol A (BPA), an important endocrine disruptor, is used in the manufacturing of various materials, including food packaging. Ingestion of contaminated foodstuffs is, in fact, the most relevant form of exposure to this substance. However, scarce data on the presence of this contaminant in milk, or whether different types of food packaging influence food contamination are available in Brazil. This study, therefore, aimed to evaluate the BPA contamination of whole milk (fluid and powder) samples packaged in different types of packaging (Tetra Pak?;PET: Poly (ethylene terephthalate;Metallic can (epoxy resin);Polyethylene (PE) and poly (vinylidene chloride) (PVDC);Laminated Film - Metallized Polyester-Polyethylene and glass) and marketed metropolitan region of Rio de Janeiro, Brazil. An analytical method for the BPA determination in milk was optimized for both fluid (pasteurized and ultra-high temperature) and powdered milk samples. A modified QuEChERS method was applied, and BPA determinations were conducted by ultra-performance liquid chromatography coupled with sequential mass spectrometry (HPLC-MS/MS). The validated method was then applied to 51 milk samples, where BPA was detected in five samples (9.8%) and quantified in two (3.8%). 展开更多
关键词 Bisphenol A. Packaging MIGRATION MILK Endocrine Disruptors
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基于SIP技术的固态硬盘电路设计
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作者 杨楚玮 张梅娟 沈庆 《电子技术应用》 2024年第3期36-41,共6页
存储系统小型化、高性能需求与日俱增,为此设计了一款基于SiP技术的固态硬盘电路,用于验证存储系统SiP电路的可行性。该SiP电路内部以SSD控制模块为核心处理单元,集成了用于数据存储的NAND颗粒、用于固件存储的SPI Flash以及电源管理等... 存储系统小型化、高性能需求与日俱增,为此设计了一款基于SiP技术的固态硬盘电路,用于验证存储系统SiP电路的可行性。该SiP电路内部以SSD控制模块为核心处理单元,集成了用于数据存储的NAND颗粒、用于固件存储的SPI Flash以及电源管理等元器件。在搭建的软硬件平台上进行底层ATA指令验证以及与传统分离式存储系统的对比性能测试,证明了应用SiP技术的存储系统具备高性能、小型化、低功耗等诸多优势,为后续SiP存储系统的设计和验证奠定了一定的技术基础。 展开更多
关键词 系统级封装(sip) 存储系统 SSD控制模块 小型化
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基于硅基堆叠SIP技术的超宽带T/R组件 被引量:1
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作者 刘卫强 万涛 +2 位作者 吕苗 倪涛 史千一 《微波学报》 CSCD 北大核心 2024年第2期74-78,共5页
传统的超宽带T/R组件采用的是两维砖块式结构,体积和重量已不适应目前小型化、低剖面、易共形的相控阵天线要求。文中提出的基于硅基堆叠系统级封装(SIP)技术,将四通道的射频芯片高度集成在硅基介质基板上,将多层介质基板厚金压合,实现... 传统的超宽带T/R组件采用的是两维砖块式结构,体积和重量已不适应目前小型化、低剖面、易共形的相控阵天线要求。文中提出的基于硅基堆叠系统级封装(SIP)技术,将四通道的射频芯片高度集成在硅基介质基板上,将多层介质基板厚金压合,实现多层堆叠的三维封装。通过采用芯片多功能集成技术和超宽带射频信号的垂直互连技术,设计出三维堆叠的四通道超宽带T/R组件。T/R组件带宽为6 GHz~18 GHz,单通道的发射功率优于23 dBm,接收增益优于20 dB,可实现6位数控衰减及6位数控移相,尺寸仅有13.0 mm×13.0 mm×3.4 mm。该技术可以实现多通道超宽带T/R组件的SIP封装,有利于工程应用。 展开更多
关键词 T/R组件 超宽带 硅基 系统级封装 堆叠
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A Novel Multiple DBC-staked units Package to Parallel More Chips for SiC Power Module 被引量:1
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作者 Xiaoshuang Hui Puqi Ning +4 位作者 Tao Fan Yuhui Kang Kai Wang Yunhui Mei Guangyin Lei 《CES Transactions on Electrical Machines and Systems》 EI CSCD 2024年第1期72-79,共8页
Silicon carbide(SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple stake... Silicon carbide(SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple staked direct bonded copper(DBC) unit based power module packaging method to parallel more chips. This method utilizes mutual inductance cancellation effect to reduce parasitic inductance. Because the conduction area in the new package is doubled, the overall area of power module can be reduced. Entire power module is divided into smaller units to enhance manufacture yield, and improve design freedom. This paper provides a detailed design, analysis and fabrication procedure for the proposed package structure. Additionally, this paper offers several feasible solutions for the connection between power terminals and DBC untis. With the structure, 18dies were paralleled for each phase-leg in a econodual size power module. Both simulation and double pulse test results demonstrate that, compared to conventional layouts, the proposed package method has 74.8% smaller parasitic inductance and 34.9% lower footprint. 展开更多
关键词 Silicon carbide Electric vehicle Power modules package
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基于SIPS模型的短视频二次传播策略研究 被引量:4
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作者 华鲁辉 张智军 井媛 《传媒》 2024年第3期88-90,共3页
伴随着新媒体的崛起,信息的传播方式变得更加多元化。信息接收者与信息传递者之间的界限变得更为模糊,由共享与转发行为形成的二次传播也在信息传递中占据了重要地位。本文对二次传播形成的影响因素进行研究,在内容上首先对研究背景、... 伴随着新媒体的崛起,信息的传播方式变得更加多元化。信息接收者与信息传递者之间的界限变得更为模糊,由共享与转发行为形成的二次传播也在信息传递中占据了重要地位。本文对二次传播形成的影响因素进行研究,在内容上首先对研究背景、相关概念、二次传播对国内短视频发展的影响做了简要叙述,其次通过将SIPS模型带入广告视频的传播中,合理运用SIPS模型的传播特征、兴趣和共鸣的内在规律、双向沟通和及时性响应理论,为短视频的二次传播提供新的思路。 展开更多
关键词 sipS模型 二次传播 短视频
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X波段三维异构片式收发SiP模块设计
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作者 李晓林 刘星 +2 位作者 高艳红 赵宇 许春良 《太赫兹科学与电子信息学报》 2024年第7期758-763,767,共7页
采用硅基三维异构集成技术,在极小的体积内,将多个微波单片集成电路(MMIC)和无源功分网络一体化集成,实现了一种X波段4通道片式收发系统级封装(SiP)。该SiP由2个体硅堆叠封装(PoP)而成,不同封装通过球栅阵列(BGA)方式互连,单层封装的内... 采用硅基三维异构集成技术,在极小的体积内,将多个微波单片集成电路(MMIC)和无源功分网络一体化集成,实现了一种X波段4通道片式收发系统级封装(SiP)。该SiP由2个体硅堆叠封装(PoP)而成,不同封装通过球栅阵列(BGA)方式互连,单层封装的内部腔体上下面均贴装芯片,封装内部采用硅通孔技术(TSV)实现垂直互连,SiP尺寸为14 mm×14 mm×3.2 mm。测试结果表明,在8~12 GHz内,SIP 4个通道的发射饱和输出功率≥30.5 dBm,接收增益≥24.5 dB,噪声系数≤3 dB,接收输入P-1≥-26 dBm,同时具备6位数控移相和6位数控衰减功能,重量约1 g,可广泛用于微波收发系统。 展开更多
关键词 三维异构集成 堆叠封装 高集成 片式 系统级封装
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Distribution of 26 Metals in the Waters of the Aquatic Ecosystems of the Cotonou Channel and Lake Nokoué, Benin
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作者 Alassane Youssao Abdou Karim Acakpo Nonvignon Magloire Gbaguidi +7 位作者 Kpessou Martin Vitus Mickael Saizonou Léonce Firmin Dovonon Gabin Laly Abdoul Kader Alassane Moussa Emmanuel Azokpota Fabienne Seby Olivier Donard Houénoukpo Henri Soclo 《Journal of Materials Science and Chemical Engineering》 CAS 2023年第2期13-28,共16页
Metallic elements have various origins: natural and anthropogenic sources as geochemical, marine and atmospheric sources resulting from the fallout of pollutants emitted or dust raised and which are transported by wat... Metallic elements have various origins: natural and anthropogenic sources as geochemical, marine and atmospheric sources resulting from the fallout of pollutants emitted or dust raised and which are transported by water and air currents. Thus marine, brackish and fresh continental waters may have high metal concentrations. In addition, some essential metals can become toxic above certain concentration values in aquatic environments. The aquatic ecosystems of Cotonou channel and lake Nokoué receive the pollutants charges from the town cities of Cotonou, Abomey-Calavi and town hall of So Ava. The aim of this study is to analyze waters from Eighteen (18) stations identified in the two ecosystems (nine by ecosystem). The concentrations of magnesium (Mg), calcium (Ca), vanadium (V), chromium (Cr), manganese (Mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), beryllium (Be), aluminum (Al), strontium (Sr), molybdenum (Mo), silver (Ag), tin (Sn), barium (Ba), platinum (Pt), mercury (Hg), thallium (Tl), lead (Pb), thorium (Th) and uranium (U) were measured after acid digestion of the water samples using the inductively coupled plasma source mass spectrometer (ICP-MS). The results of the analyses indicate an unequal distribution of metals in the different ecosystems. However, atypical concentrations were observed at some stations of the lake and the channel. Magnesium, calcium and manganese have very high values in Lake Nokoué respectively at Ganvié market station GAN_M (2990 ± 105 mg/L), Ganvié center, station GAN_C (4991 ± 177 mg/L) and Lake middle station MLak4 (10662 ± 17.03 μg/L). On the other hand, iron, aluminum and strontium have very high concentrations in the Cotonou Channel respectively at Agbato station AGB (5236 ± 103 and 8289 ± 519 μg/L) and at the estuary station EST (6118 ± 68 μg/L). The concentrations were compared to wells and cborehole waters in sixth neighborhood of Cotonou. We have used statistical analyzers such as MANOVA which have made it possible to classify the waters and metals in the ecosystems studied compared to groundwater and Well water waters. We use hierarchical clustering on principal components to identify similarities between stations based on metal concentration with R software packages “FactoMineR” and “factoextra”. In general, we can conclude that most of the metals have an anthropogenic source except strontium and major elements (Ca and Mg) which could respectively provide from marine waters and geochemical sources. 展开更多
关键词 METALS Water MANOVA R Software packages Nokoué Lake Cotonou Channel
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基于ATE的可编程SiP器件测试
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作者 李鹏 白艳放 +2 位作者 郑松海 赵娜 刘颖 《电子与封装》 2024年第10期51-59,共9页
分析了SiP器件内部数字芯片FPGA和模拟芯片ADC/DAC的主要电气参数及性能参数,明确了SiP器件的测试内容和方法。使用Altium Designer软件设计SiP6117M信号处理器专用测试板,结合测试需求、测试流程以及芯片具体参数提出设计目标,完成原... 分析了SiP器件内部数字芯片FPGA和模拟芯片ADC/DAC的主要电气参数及性能参数,明确了SiP器件的测试内容和方法。使用Altium Designer软件设计SiP6117M信号处理器专用测试板,结合测试需求、测试流程以及芯片具体参数提出设计目标,完成原理图设计、PCB设计、制板和调试工作。基于Ultra Flex测试机台和设计完成的测试板搭建SiP6117M模块的测试平台,运用Verilog语言编写FPGA配置程序及测试程序,并通过JTAG接口对FPGA进行配置。开发Ultra Flex测试程序对测试过程进行控制,实现了对SiP器件主要功能和性能参数的测试。 展开更多
关键词 sip 测试板设计 测试平台 测试数据
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基于SIPS模型的读者参与图书馆文献资源建设策略优化研究
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作者 蒋钟叶 张仕韬 +1 位作者 谢丹琳 李小丽 《技术与市场》 2024年第7期146-149,156,共5页
为优化图书馆荐购服务,提升图书馆服务质量,满足读者多元化需求,实现图书馆的高质量发展,分析读者参与图书馆资源建设的现状与问题,利用在图书馆领域已有实践应用的用户消费模型SIPS模型为研究工具,提出了激发读者共鸣、确认荐购品质、... 为优化图书馆荐购服务,提升图书馆服务质量,满足读者多元化需求,实现图书馆的高质量发展,分析读者参与图书馆资源建设的现状与问题,利用在图书馆领域已有实践应用的用户消费模型SIPS模型为研究工具,提出了激发读者共鸣、确认荐购品质、推动读者参与、读者口碑分享的读者参与图书馆文献资源建设的优化策略。 展开更多
关键词 图书馆 sipS模型 读者荐购 服务质量
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基于SIPS模型的服装品牌短视频营销体系构建
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作者 姜雯静 孙虹 《服装设计师》 2024年第10期122-128,共7页
为探究服装品牌短视频营销中缺乏系统的矩阵规划问题,提出了基于SIPS模型的营销策略。针对服装品牌短视频营销所呈现的不足,将其营销策略划分为内容、形式、引流、传播四个维度。对每个维度进行了分析,归纳总结了服装品牌短视频营销在... 为探究服装品牌短视频营销中缺乏系统的矩阵规划问题,提出了基于SIPS模型的营销策略。针对服装品牌短视频营销所呈现的不足,将其营销策略划分为内容、形式、引流、传播四个维度。对每个维度进行了分析,归纳总结了服装品牌短视频营销在四个维度中适用的方法,并结合SIPS模型调整四个维度的逻辑关系与布局,得到一个完整的营销闭环。解决了服装品牌在短视频营销布局中矩阵混乱的问题,实现了清晰、高效的营销体系构建。 展开更多
关键词 sipS模型 短视频 服装品牌 营销策略
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基于SIPS模型的景德镇手工制瓷非遗技艺营销传播策略研究
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作者 高若桐 黄志坚 《景德镇学院学报》 2024年第2期7-13,共7页
近年来,为推动传统文化的复兴与繁荣,国家不断加大对非遗的宣传力度。在此背景下,景德镇借由兴趣电商平台,实现了陶瓷销售的场景创新,从用户的视角出发,开始注重引导大众触摸景德镇手工制瓷非遗技艺的历史传统和文化内涵。对此,本文旨... 近年来,为推动传统文化的复兴与繁荣,国家不断加大对非遗的宣传力度。在此背景下,景德镇借由兴趣电商平台,实现了陶瓷销售的场景创新,从用户的视角出发,开始注重引导大众触摸景德镇手工制瓷非遗技艺的历史传统和文化内涵。对此,本文旨在打造可提升景德镇手工制瓷非遗技艺的差异化与分众化程度的营销策略,基于SIPS模型和景德镇手工制瓷非遗技艺的特点,从共鸣、确认、参与、共享和扩散四个维度探索景德镇手工制瓷非遗技艺营销传播策略,不仅可以促进景德镇陶瓷制作工艺的宣传和普及,还对推动陶瓷工艺的传承和发展具有重要现实意义。 展开更多
关键词 景德镇手工制瓷技艺 sipS模型 短视频 非物质文化遗产
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基于SiP技术多核处理器微系统设计
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作者 梁涛涛 李岩 刘振华 《电子技术应用》 2024年第9期83-88,共6页
系统级封装SiP(System in a Package)已成为后摩尔时代延续摩尔定律的主要技术路线,电子装备小型化和多功能化的推动,使其在领域具有广阔前景。描述了一种基于SiP技术小型化多核信号处理的实现方案,详细讲述了芯片级设计及封装的具体方... 系统级封装SiP(System in a Package)已成为后摩尔时代延续摩尔定律的主要技术路线,电子装备小型化和多功能化的推动,使其在领域具有广阔前景。描述了一种基于SiP技术小型化多核信号处理的实现方案,详细讲述了芯片级设计及封装的具体方法和思路,提出了一种基于SiP技术的多核处理器微系统设计及实现。 展开更多
关键词 sip 信号处理 DSP FPGA RDL
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基于ROCK-2/Moesin信号通路探究下调SIP1对子宫内膜癌细胞凋亡侵袭迁移的影响
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作者 刘雪洁 李晓妍 张凤 《河北医学》 CAS 2023年第3期364-369,共6页
目的:探究下调SIP1对子宫内膜癌细胞凋亡、迁移、侵袭影响及其作用机制。方法:人子宫内膜癌细胞HEC-1A细胞分为对照组,NC组,SIP1下调组(转染si-SIP1),Y27632组(ROCK抑制剂),SIP1下调组+Y27632组(转染si-SIP1+ROCK抑制剂),通过流式细胞... 目的:探究下调SIP1对子宫内膜癌细胞凋亡、迁移、侵袭影响及其作用机制。方法:人子宫内膜癌细胞HEC-1A细胞分为对照组,NC组,SIP1下调组(转染si-SIP1),Y27632组(ROCK抑制剂),SIP1下调组+Y27632组(转染si-SIP1+ROCK抑制剂),通过流式细胞技术、Transwell实验分别检测各组细胞凋亡、迁移能力和侵袭能力,通过Western blot检测各组细胞凋亡关键蛋白B淋巴细胞瘤-2基因(Bcl-2)、细胞凋亡基因Bcl-2相关蛋白x(Bax)、Caspase家族蛋白3(Caspase3)、Rho相关激酶2(ROCK-2)和Moesin蛋白表达水平。20只SPF级BALB/c小鼠通过皮下荷瘤建立子宫内膜癌荷瘤模型,对照组(n=10)采用人子宫内膜癌HEC-1A细胞荷瘤,SIP1下调组(n=10)小鼠采用下调SIP1的人子宫内膜癌HEC-1A细胞荷瘤,每3天用游标卡尺测量瘤体积,连续测量21d绘制肿瘤生长曲线,实验终点测量每只小鼠肿瘤质量并检测肿瘤组织中ROCK-2及Moesin蛋白表达水平。结果:细胞实验结果表明,与对照组和NC组相比,SIP1下调组、Y27632组、SIP1下调+Y27632组细胞凋亡比例显著上升,细胞迁移数量减少,细胞侵袭数量减少(P<0.01),NC组与对照组没有显著的统计学差异(P>0.05)。Western blot结果表明,与对照组和NC组相比,SIP1下调组、Y27632组、SIP1下调+Y27632组细胞ROCK和Moesin蛋白表达水平有降低趋势(P<0.01)。小鼠实验结果表明,与对照组相比,下调SIP1后小鼠肿瘤生长速度显著降低,肿瘤质量显著降低(P<0.01),肿瘤组织ROCK-2及Moesin蛋白表达水平显著降低(P<0.01)。结论:下调SIP1可导人子宫内膜癌细胞HEC-1A细胞凋亡,抑制其迁移和侵袭能力,介导ROCK-2/Moesin信号通路。 展开更多
关键词 sip1 子宫内膜癌 凋亡 迁移 ROCK-2/Moesin信号通路
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Product family modeling technology for customized cosmetic packaging design based on basic-element theory 被引量:1
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作者 Tao Chen Ding-Bang Luh Jinguang Wang 《Journal of dermatologic science and cosmetic technology》 2024年第1期2-12,共11页
Background:As the market demands change,SMEs(small and medium-sized enterprises)have long faced many design issues,including high costs,lengthy cycles,and insufficient innovation.These issues are especially noticeable... Background:As the market demands change,SMEs(small and medium-sized enterprises)have long faced many design issues,including high costs,lengthy cycles,and insufficient innovation.These issues are especially noticeable in the domain of cosmetic packaging design.Objective:To explore innovative product family modeling methods and configuration design processes to improve the efficiency of enterprise cosmetic packaging design and develop the design for mass customization.Methods:To accomplish this objective,the basic-element theory has been introduced and applied to the design and development system of the product family.Results:By examining the mapping relationships between the demand domain,functional domain,technology domain,and structure domain,four interrelated models have been developed,including the demand model,functional model,technology model,and structure model.Together,these models form the mechanism and methodology of product family modeling,specifically for cosmetic packaging design.Through an analysis of a case study on men’s cosmetic packaging design,the feasibility of the proposed product family modeling technology has been demonstrated in terms of customized cosmetic packaging design,and the design efficiency has been enhanced.Conclusion:The product family modeling technology employs a formalized element as a module configuration design language,permeating throughout the entire development cycle of cosmetic packaging design,thus facilitating a structured and modularized configuration design process for the product family system.The application of the basic-element principle in product family modeling technology contributes to the enrichment of the research field surrounding cosmetic packaging product family configuration design,while also providing valuable methods and references for enterprises aiming to elevate the efficiency of cosmetic packaging design for the mass customization product model. 展开更多
关键词 Packaging design Cosmetic packaging Product family modeling technology Basic-element theory Design for mass customization
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