BACKGROUND Bone metastasis has various negative impacts.Activities of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may increase.It is estimated ...BACKGROUND Bone metastasis has various negative impacts.Activities of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may increase.It is estimated that at least 5%cancer patients might be suffering from bone metastases.In 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone Metastasis.Since then,the therapeutic outcomes for patients have gradually improved.As life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be achieved.AIM To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone metastasis.METHODS For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was calculated.The association with survival was determined for each factor.RESULTS Data from 136 patients were obtained.The 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was developed.Other factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced cancer.It is necessary not only to simply extend survival time,but also to maintain ADL and improve QOL.CONCLUSION Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly required.Guidelines and scoring system for prognosis need to be revised promptly.展开更多
In this work, a best answer recommendation model is proposed for a Question Answering (QA) system. A Community Question Answering System was subsequently developed based on the model. The system applies Brouwer Fixed ...In this work, a best answer recommendation model is proposed for a Question Answering (QA) system. A Community Question Answering System was subsequently developed based on the model. The system applies Brouwer Fixed Point Theorem to prove the existence of the desired voter scoring function and Normalized Google Distance (NGD) to show closeness between words before an answer is suggested to users. Answers are ranked according to their Fixed-Point Score (FPS) for each question. Thereafter, the highest scored answer is chosen as the FPS Best Answer (BA). For each question asked by user, the system applies NGD to check if similar or related questions with the best answer had been asked and stored in the database. When similar or related questions with the best answer are not found in the database, Brouwer Fixed point is used to calculate the best answer from the pool of answers on a question then the best answer is stored in the NGD data-table for recommendation purpose. The system was implemented using PHP scripting language, MySQL for database management, JQuery, and Apache. The system was evaluated using standard metrics: Reciprocal Rank, Mean Reciprocal Rank (MRR) and Discounted Cumulative Gain (DCG). The system eliminated longer waiting time faced by askers in a community question answering system. The developed system can be used for research and learning purposes.展开更多
目的:运用频率学网状Meta分析评价耳穴贴压相关疗法干预脑卒中后失眠的临床效果。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、PubMed、EMbase、the Cochrane Library、Web of Science,检索时限为建库...目的:运用频率学网状Meta分析评价耳穴贴压相关疗法干预脑卒中后失眠的临床效果。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献服务系统、PubMed、EMbase、the Cochrane Library、Web of Science,检索时限为建库至2022年8月9日收录的耳穴贴压相关疗法治疗脑卒中后失眠的随机对照试验,按照纳入、排除标准和Cochrane偏倚风险评估工具进行文献筛选和质量评价,采用RevMan 5.4、Stata SE 17进行统计分析。结果:纳入35篇文献,涉及9种干预措施及2780例病人。网状Meta分析显示,临床有效率较高的前4种疗法依次为耳穴贴压联合中药、耳穴贴压联合中药足浴、耳穴贴压联合穴位敷贴、耳穴贴压联合针刺;改善匹兹堡睡眠质量指数(Pittsburgh Sleeping Quality Index,PSQI)评分较好的前4种疗法依次为耳穴贴压联合穴位敷贴、耳穴贴压联合音乐疗法、耳穴贴压联合中药、耳穴贴压联合中药足浴。仅有9篇文献报告不良反应,其中耳穴贴压单用或联合针刺、联合穴位敷贴的不良反应发生率低于西药。结论:现有证据显示,耳穴贴压联合中药、联合穴位敷贴在提高临床有效率、改善PSQI评分方面具有较好的效果;耳穴贴压单用或联合针刺、联合穴位敷贴的不良反应发生率低于西药。但所纳入的研究方法学质量偏低,故该结论有待高质量研究予以验证。展开更多
文摘BACKGROUND Bone metastasis has various negative impacts.Activities of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may increase.It is estimated that at least 5%cancer patients might be suffering from bone metastases.In 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone Metastasis.Since then,the therapeutic outcomes for patients have gradually improved.As life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be achieved.AIM To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone metastasis.METHODS For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was calculated.The association with survival was determined for each factor.RESULTS Data from 136 patients were obtained.The 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was developed.Other factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced cancer.It is necessary not only to simply extend survival time,but also to maintain ADL and improve QOL.CONCLUSION Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly required.Guidelines and scoring system for prognosis need to be revised promptly.
文摘In this work, a best answer recommendation model is proposed for a Question Answering (QA) system. A Community Question Answering System was subsequently developed based on the model. The system applies Brouwer Fixed Point Theorem to prove the existence of the desired voter scoring function and Normalized Google Distance (NGD) to show closeness between words before an answer is suggested to users. Answers are ranked according to their Fixed-Point Score (FPS) for each question. Thereafter, the highest scored answer is chosen as the FPS Best Answer (BA). For each question asked by user, the system applies NGD to check if similar or related questions with the best answer had been asked and stored in the database. When similar or related questions with the best answer are not found in the database, Brouwer Fixed point is used to calculate the best answer from the pool of answers on a question then the best answer is stored in the NGD data-table for recommendation purpose. The system was implemented using PHP scripting language, MySQL for database management, JQuery, and Apache. The system was evaluated using standard metrics: Reciprocal Rank, Mean Reciprocal Rank (MRR) and Discounted Cumulative Gain (DCG). The system eliminated longer waiting time faced by askers in a community question answering system. The developed system can be used for research and learning purposes.
