A large part of our daily lives is spent with audio information. Massive obstacles are frequently presented by the colossal amounts of acoustic information and the incredibly quick processing times. This results in th...A large part of our daily lives is spent with audio information. Massive obstacles are frequently presented by the colossal amounts of acoustic information and the incredibly quick processing times. This results in the need for applications and methodologies that are capable of automatically analyzing these contents. These technologies can be applied in automatic contentanalysis and emergency response systems. Breaks in manual communication usually occur in emergencies leading to accidents and equipment damage. The audio signal does a good job by sending a signal underground, which warrants action from an emergency management team at the surface. This paper, therefore, seeks to design and simulate an audio signal alerting and automatic control system using Unity Pro XL to substitute manual communication of emergencies and manual control of equipment. Sound data were trained using the neural network technique of machine learning. The metrics used are Fast Fourier transform magnitude, zero crossing rate, root mean square, and percentage error. Sounds were detected with an error of approximately 17%;thus, the system can detect sounds with an accuracy of 83%. With more data training, the system can detect sounds with minimal or no error. The paper, therefore, has critical policy implications about communication, safety, and health for underground mine.展开更多
A state machine can make program designing quicker,simpler and more efficient. This paper describes in detail the model for a state machine and the idea for its designing and gives the design process of the state mach...A state machine can make program designing quicker,simpler and more efficient. This paper describes in detail the model for a state machine and the idea for its designing and gives the design process of the state machine through an example of audio signal generator system based on Labview. The result shows that the introduction of the state machine can make complex design processes more clear and the revision of programs easier.展开更多
In this editorial we introduce the research paradigms of signal processing in the era of systems biology.Signal processing is a field of science traditionally focused on modeling electronic and communications systems,...In this editorial we introduce the research paradigms of signal processing in the era of systems biology.Signal processing is a field of science traditionally focused on modeling electronic and communications systems,but recently it has turned to biological applications with astounding results.The essence of signal processing is to describe the natural world by mathematical models and then,based on these models,develop efficient computational tools for solving engineering problems.Here,we underline,with examples,the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers.Based on this approach,a new field has emerged,called cancer systems biology.Despite its short history,cancer systems biology has already produced several success stories tackling previously impracticable problems.Perhaps most importantly,it has been accepted as an integral part of the major endeavors of cancer research,such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas(TCGA) project.Finally,we show that signal processing and cancer research,two fields that are seemingly distant from each other,have merged into a field that is indeed more than the sum of its parts.展开更多
---Double data rate synchronous dynamic random access memory (DDR3) has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integri...---Double data rate synchronous dynamic random access memory (DDR3) has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integrity (SI) simulation flow for the DDR3 interface, two system-level SI simulation methodologies, which are board-level S-parameter extraction in the frequency-domain and system-level simulation assumptions in the time domain, are introduced in this paper. By comparing the flow of Speed2000 and PowerSI/Hspice, PowerSI is chosen for the printed circuit board (PCB) board-level S-parameter extraction, while Tektronix oscilloscope (TDS7404) is used for the DDR3 waveform measurement. The lab measurement shows good agreement between simulation and measurement. The study shows that the combination of PowerSI and Hspice is recommended for quick system-level DDR3 SI simulation.展开更多
Systemic acquired resistance (SAR), known as the broad-spectrum, inducible plant immunity, is a defense response triggered by pathogen infection. The response starts from the recognition of plant resistance (R) with t...Systemic acquired resistance (SAR), known as the broad-spectrum, inducible plant immunity, is a defense response triggered by pathogen infection. The response starts from the recognition of plant resistance (R) with the corresponding avirulence (avr) gene from the pathogen. There are some genes for convergence of signals downstream of different R/avr interacting partners into a single signaling pathway. Salicylic acid (SA) is required for the induction of SAR and involved in transducing the signal in target tissues. The SA signal is transduced through NPR1, a nuclear-localized protein that interacts with transcription factors that are involved in regulating SA-mediated gene expression. Some chemicals that mimic natural signaling compounds can also activate SAR. The application of biochemical activators to agriculture for plant protection is a novel idea for developing green chemical pesticide.展开更多
The new type of embedded signal processing system based on the packet switched network is achieved. According to the application field and the-characteristics of signal processing system, the RapidIO protocol is used ...The new type of embedded signal processing system based on the packet switched network is achieved. According to the application field and the-characteristics of signal processing system, the RapidIO protocol is used to solve the high-speed interconnection of multi-digital signal processor (DSP). Based on this protocol, a kind of crossbar switch module which is used to interconnect multi-DSP in the system is introduced. A route strategy, some flow control rules and error control rules, which adapt to different RapidIO network topology are also introduced. Crossbar switch performance is analyzed in detail by the probability module. By researching the technique of crossbar switch and analyzing the system performance, it has a significant meaning for building the general signal processing system.展开更多
In this paper, a chaos system and proportional differential control are both used to detect the frequency of an unknown signal. In traditional methods the useful signal is obtained through the Duffing equation or othe...In this paper, a chaos system and proportional differential control are both used to detect the frequency of an unknown signal. In traditional methods the useful signal is obtained through the Duffing equation or other chaotic oscillators. But these methods are too complex because of using a lot of chaos oscillators. In this paper a new method is presented that uses the Rossler equation and proportional differential control to detect a weak signal frequency. Substituting the detected signal frequency into the RSssler equation leads the Rossler phase state to be considerably changed. The chaos state can be controlled through the proportional differential method. Through its phase diagram and spectrum analysis, the unknown frequency is obtained. The simulation results verify that the presented method is feasible and that the detection accuracy is higher than those of other methods.展开更多
Stochastic resonance(SR) is studied in an under-damped bistable system driven by the harmonic mixing signal and Gaussian white noise. Using the linear response theory(LRT), the expressions of the spectral amplific...Stochastic resonance(SR) is studied in an under-damped bistable system driven by the harmonic mixing signal and Gaussian white noise. Using the linear response theory(LRT), the expressions of the spectral amplification at fundamental and higher-order harmonic are obtained. The effects of damping coefficient, noise intensity, signal amplitude, and frequency on spectral amplifications are explored. Meanwhile, the power spectral density(PSD) and signal-to-noise ratio(SNR) are calculated to quantify SR and verify the theoretical results. The SNRs at the first and second harmonics exhibit a minimum first and a maximum later with increasing noise intensity. That is, both of the noise-induced suppression and resonance can be observed by choosing proper system parameters. Especially, when the ratio of the second harmonic amplitude to the fundamental one takes a large value, the SNR at the fundamental harmonic is a monotonic function of noise intensity and the SR phenomenon disappears.展开更多
In order to realize the real-time and precise test for a weapon system of a certain type of fighter,a signal classification method according to attributes is proposed,common input channels for multiple signals are con...In order to realize the real-time and precise test for a weapon system of a certain type of fighter,a signal classification method according to attributes is proposed,common input channels for multiple signals are configured optimally,and a test adapter and an adaptive signal conditioning module is designed. The hardware of conditioning module can be configured flexibly and the programmable test range can be adjusted owing to programmable multiplexer. An FPGA adaptive filter is designed by the calculated filter coefficient vectors with LMS method to solve the problem of parallel test of fighter weapon system in electromagnetic interference environment. The adaptive signal conditioning technology is characterized by high efficiency,precision and integration. Its application makes the test system successful to conduct real-time and parallel test for a weapon system,which is developed based on VXI bus and virtual-instrument technology.展开更多
From the actual perspective of working principle of localizer beacon subsystem of Instrument Landing System (ILS), consideration of the distance information from localizer antenna to field monitor antenna and wide ape...From the actual perspective of working principle of localizer beacon subsystem of Instrument Landing System (ILS), consideration of the distance information from localizer antenna to field monitor antenna and wide aperture effect of localizer antenna, broke through the limitation of signals synthesized only far-field (FF), established the near-field (NF) model. The three-dimensional mathematical model of localizer beacon was designed, and the signals at both near-field and far-field were analyzed qualitatively. At the environment of Antenna Fault as well as Antenna Distribution Unit (ADU) phase shifter simulation, the characteristics of near-field and far-field were also compared. The simulation results showed that the model met the requirement of theory of localizer beacon, and the gap between two models was so evident, which resulted from the broken geometric symmetry in NF area. The model could provide valuable theoretical basis for performance evaluation and maintenance of the ILS, and meanwhile, provide reference for the further analysis of localizer beacon.展开更多
This analysis focuses on PIM interference under multi-band multi-signal input in mobile communication system.Unlike single band system that only odd order PIM(especially 3rd order) should be concerned,in multi-band mu...This analysis focuses on PIM interference under multi-band multi-signal input in mobile communication system.Unlike single band system that only odd order PIM(especially 3rd order) should be concerned,in multi-band multi-signal case,both odd and even order PIM could be interference source because of more complicated intermodulation,more IMPs generated and more receive bands.Especially,the 2nd order PIM may interfere more serious to receiving channel for its strong magnitude.In duplex indoor distribute system,the PIM interference is a potential problem to GSM900,DCS1800,CDMA,and even 3G system wireless services,because the PIM frequencies may fall in receive bands and interfere to the receiving channels.In radio system design and wireless channel assignment,precautions must be taken to minimize the PIM level and to avoid interfere to receiving channels.For practical use,the lower order possible PIM interference to 2G and 3G systems is calculated.展开更多
Multiple cellular components, including neuronal, glial and endothelial ceils, are involved in the sophis- ticated pathological processes following central nervous system injury. The pathological process cannot reduce...Multiple cellular components, including neuronal, glial and endothelial ceils, are involved in the sophis- ticated pathological processes following central nervous system injury. The pathological process cannot reduce damage or improve functional recovery by merely targeting the molecular mechanisms of neuronal cell death after central nerve system injuries. Eph receptors and ephrin ligands have drawn wide attention since the discovery of their extensive distribution and unique bidirectional signaling between astrocytes and neurons. The roles of Eph/ephrin bidirectional signaling in the developmental processes have been re- ported in previous research. Recent observations suggest that Eph/ephrin bidirectional signaling continues to be expressed in most regions and cell types in the adult central nervous system, playing diverse roles. The Eph/ephrin complex mediates neurogenesis and angiogenesis, promotes glial scar formation, regulates endocrine levels, inhibits myelin formation and aggravates inflammation and nerve pain caused by injury. ~lhe interaction between Eph and ephrin is also considered to be the key to angiogenesis. This review focus- es on the roles of Eph/ephrin bidirectional signaling in the repair of central nervous system injuries.展开更多
The central problem of genetics is gene interaction since genes in the course of individual organism development interact with other genes, that’s why their effects may change. Studies for the last 100 years managed ...The central problem of genetics is gene interaction since genes in the course of individual organism development interact with other genes, that’s why their effects may change. Studies for the last 100 years managed to discover that the entire diversity of inter-gene interactions is presented in four major forms: complementarity, epistasis, polymery, and modifying effect of genes. However, gene interaction mechanism which is reflected on the segregation nature of variously crossed hybrids has not been sufficiently studied. Exclusive of molecular genetics, biochemistry and physiology, a genetic analysis of inheritance of characteristics in gene interaction taken by itself cannot reveal nature of this interaction. Lately, molecular-genetic and physiological studies on A. thaliana mutants have enabled to isolate and sequence a wide range of genes controlling certain links of the signalling chain. At the same time, effect of the plant development regulation signalling system on interaction of these genes in inheritance of characteristics of Arabidopsis root system haven’t been studied so far which was a cause for our studies. Gene interaction problem is closely related to the plant development regulation signalling system. Mechanism involved in gene interaction may be explained based on current idea of molecular principles of biological response. Affected by mutations occurring in various genes that control certain links of the signalling chain, signalling path to the cell nucleus and response are blocked partially or in full which leads to distortion in expression of the characteristic on the plant level in general or its organ level. Such phenomenon is observed in realization of many characteristics in animals and plants, including in A. thaliana. In inheritance of such characteristics, as a rule, both allelic, and non-allelic gene interactions are observed. Results of a study of the plant signalling system interconnection and gene interaction in inheritance of characteristics of Arabidopsis root system are presented. It is established that complementary interaction of genes RHD3 and SAR1 is observed in the second crossing generation for plants of rhd3-1 × sar-1 mutant lines. When gpa1-3 × slr-1 mutant-line plants are crossed, recessive epistasis (slr-1 slr-1 > GPA1_) occurs in F<sub>2</sub> generation. Polymeric interaction of genes SHY2 and MSG1 is observed in F<sub>2</sub> in crossing of shy2-2 × msg1-2 mutant-line plants.展开更多
A novel flocking control approach is proposed for multi-agent systems by integrating the variables of velocities, motion directions, and positions of agents. A received signal strength indicator (RSSI) is applied as...A novel flocking control approach is proposed for multi-agent systems by integrating the variables of velocities, motion directions, and positions of agents. A received signal strength indicator (RSSI) is applied as a variable to estimate the inter-distance between agents. A key parameter that contains the local information of agents is defined, and a multi-variable controller is proposed based on the parameter. For the position control of agents, the RSSI is introduced to substitute the distance as a control variable in the systems. The advantages of RSSI include that the relative distance between every two agents can be adjusted through the communication quality under different environments, and it can shun the shortage of the limit of sensors. Simulation studies demonstrate the effectiveness of the proposed control approach.展开更多
The regulatory mechanisms in cellular signaling systems have been studied intensively from the viewpoint that the malfunction of the regulation is thought to be one of the substantial causes of cancer formation. On th...The regulatory mechanisms in cellular signaling systems have been studied intensively from the viewpoint that the malfunction of the regulation is thought to be one of the substantial causes of cancer formation. On the other hand, it is rather difficult to develop the theoretical framework for investigation of the regulatory mechanisms due to their complexity and nonlinearity. In this study, more general approach is proposed for elucidation of characteristics of the stability in cellular signaling systems by construction of mathematical models for a class of cellular signaling systems and stability analysis of the models over variation of the network architectures and the parameter values. The model system is formulated as regulatory network in which every node represents a phosphorylation-dephosphorylation cyclic reaction for respective constituent enzyme. The analysis is performed for all variations of the regulatory networks comprised of two nodes with multiple feedback regulation loops. It is revealed from the analysis that the regulatory networks become mono-stable, bi-stable, tri-stable, or oscillatory and that the negative mutual feedback or positive mutual feedback is favorable for multi-stability, which is augmented by a negatively regulated node with a positive auto-regulation. Furthermore, the multi-stability or the oscillation is more likely to emerge in the case of low value of the Michaelis constant than in the case of high value, implying that the condition of higher saturation levels induces stronger nonlinearity in the networks. The analysis for the parameter regions yielding the multi-stability and the oscillation clarified that the stronger regulation shifts the systems toward multi-stability.展开更多
Relerrlng to contlnuous-Ume claaotlc systems, tills paper presents a new projective syncnromzatlon scheme, wnlcn enables each drive system state to be synchronized with a linear combination of response system states f...Relerrlng to contlnuous-Ume claaotlc systems, tills paper presents a new projective syncnromzatlon scheme, wnlcn enables each drive system state to be synchronized with a linear combination of response system states for any arbitrary scaling matrix. The proposed method, based on a structural condition related to the uncontrollable eigenvalues of the error system, can be applied to a wide class of continuous-time chaotic (hyperchaotic) systems and represents a general framework that includes any type of synchronization defined to date. An example involving a hyperchaotic oscillator is reported, with the aim of showing how a response system attractor is arbitrarily shaped using a scalar synchronizing signal only. Finally, it is shown that the recently introduced dislocated synchronization can be readily achieved using the conceived scheme.展开更多
A low-power complementary metal oxide semiconductor(CMOS) operational amplifier (op-amp) for real-time signal processing of micro air vehicle (MAV) is designed in this paper.Traditional folded cascode architectu...A low-power complementary metal oxide semiconductor(CMOS) operational amplifier (op-amp) for real-time signal processing of micro air vehicle (MAV) is designed in this paper.Traditional folded cascode architecture with positive channel metal oxide semiconductor(PMOS) differential input transistors and sub-threshold technology are applied under the low supply voltage.Simulation results show that this amplifier has significantly low power,while maintaining almost the same gain,bandwidth and other key performances.The power required is only 0.12 mW,which is applicable to low-power and low-voltage real-time signal acquisition and processing system.展开更多
文摘A large part of our daily lives is spent with audio information. Massive obstacles are frequently presented by the colossal amounts of acoustic information and the incredibly quick processing times. This results in the need for applications and methodologies that are capable of automatically analyzing these contents. These technologies can be applied in automatic contentanalysis and emergency response systems. Breaks in manual communication usually occur in emergencies leading to accidents and equipment damage. The audio signal does a good job by sending a signal underground, which warrants action from an emergency management team at the surface. This paper, therefore, seeks to design and simulate an audio signal alerting and automatic control system using Unity Pro XL to substitute manual communication of emergencies and manual control of equipment. Sound data were trained using the neural network technique of machine learning. The metrics used are Fast Fourier transform magnitude, zero crossing rate, root mean square, and percentage error. Sounds were detected with an error of approximately 17%;thus, the system can detect sounds with an accuracy of 83%. With more data training, the system can detect sounds with minimal or no error. The paper, therefore, has critical policy implications about communication, safety, and health for underground mine.
文摘A state machine can make program designing quicker,simpler and more efficient. This paper describes in detail the model for a state machine and the idea for its designing and gives the design process of the state machine through an example of audio signal generator system based on Labview. The result shows that the introduction of the state machine can make complex design processes more clear and the revision of programs easier.
文摘In this editorial we introduce the research paradigms of signal processing in the era of systems biology.Signal processing is a field of science traditionally focused on modeling electronic and communications systems,but recently it has turned to biological applications with astounding results.The essence of signal processing is to describe the natural world by mathematical models and then,based on these models,develop efficient computational tools for solving engineering problems.Here,we underline,with examples,the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers.Based on this approach,a new field has emerged,called cancer systems biology.Despite its short history,cancer systems biology has already produced several success stories tackling previously impracticable problems.Perhaps most importantly,it has been accepted as an integral part of the major endeavors of cancer research,such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas(TCGA) project.Finally,we show that signal processing and cancer research,two fields that are seemingly distant from each other,have merged into a field that is indeed more than the sum of its parts.
基金supported by the National Natural Science Foundation of China under Grant No.61161001
文摘---Double data rate synchronous dynamic random access memory (DDR3) has become one of the most mainstream applications in current server and computer systems. In order to quickly set up a system-level signal integrity (SI) simulation flow for the DDR3 interface, two system-level SI simulation methodologies, which are board-level S-parameter extraction in the frequency-domain and system-level simulation assumptions in the time domain, are introduced in this paper. By comparing the flow of Speed2000 and PowerSI/Hspice, PowerSI is chosen for the printed circuit board (PCB) board-level S-parameter extraction, while Tektronix oscilloscope (TDS7404) is used for the DDR3 waveform measurement. The lab measurement shows good agreement between simulation and measurement. The study shows that the combination of PowerSI and Hspice is recommended for quick system-level DDR3 SI simulation.
基金supported by National Natural Science Foundation of China(30000112)Shanxi Province Natural Science Foundation(20001037).
文摘Systemic acquired resistance (SAR), known as the broad-spectrum, inducible plant immunity, is a defense response triggered by pathogen infection. The response starts from the recognition of plant resistance (R) with the corresponding avirulence (avr) gene from the pathogen. There are some genes for convergence of signals downstream of different R/avr interacting partners into a single signaling pathway. Salicylic acid (SA) is required for the induction of SAR and involved in transducing the signal in target tissues. The SA signal is transduced through NPR1, a nuclear-localized protein that interacts with transcription factors that are involved in regulating SA-mediated gene expression. Some chemicals that mimic natural signaling compounds can also activate SAR. The application of biochemical activators to agriculture for plant protection is a novel idea for developing green chemical pesticide.
文摘The new type of embedded signal processing system based on the packet switched network is achieved. According to the application field and the-characteristics of signal processing system, the RapidIO protocol is used to solve the high-speed interconnection of multi-digital signal processor (DSP). Based on this protocol, a kind of crossbar switch module which is used to interconnect multi-DSP in the system is introduced. A route strategy, some flow control rules and error control rules, which adapt to different RapidIO network topology are also introduced. Crossbar switch performance is analyzed in detail by the probability module. By researching the technique of crossbar switch and analyzing the system performance, it has a significant meaning for building the general signal processing system.
基金Project supported by the National Natural Science Foundation of China (Grant No. 60877065)Science and Technology Innovation Talents Special Funds of Harbin,China (Grant No. RC2008XK009004)the Heilongjiang Provincial Education Department,China (Grant No. 11544035)
文摘In this paper, a chaos system and proportional differential control are both used to detect the frequency of an unknown signal. In traditional methods the useful signal is obtained through the Duffing equation or other chaotic oscillators. But these methods are too complex because of using a lot of chaos oscillators. In this paper a new method is presented that uses the Rossler equation and proportional differential control to detect a weak signal frequency. Substituting the detected signal frequency into the RSssler equation leads the Rossler phase state to be considerably changed. The chaos state can be controlled through the proportional differential method. Through its phase diagram and spectrum analysis, the unknown frequency is obtained. The simulation results verify that the presented method is feasible and that the detection accuracy is higher than those of other methods.
基金Project supported by the National Natural Science Foundation of China(Grant No.11772048)
文摘Stochastic resonance(SR) is studied in an under-damped bistable system driven by the harmonic mixing signal and Gaussian white noise. Using the linear response theory(LRT), the expressions of the spectral amplification at fundamental and higher-order harmonic are obtained. The effects of damping coefficient, noise intensity, signal amplitude, and frequency on spectral amplifications are explored. Meanwhile, the power spectral density(PSD) and signal-to-noise ratio(SNR) are calculated to quantify SR and verify the theoretical results. The SNRs at the first and second harmonics exhibit a minimum first and a maximum later with increasing noise intensity. That is, both of the noise-induced suppression and resonance can be observed by choosing proper system parameters. Especially, when the ratio of the second harmonic amplitude to the fundamental one takes a large value, the SNR at the fundamental harmonic is a monotonic function of noise intensity and the SR phenomenon disappears.
基金Sponsored by the Key Equipment Research Project of Air Force of China (KJZ06119)
文摘In order to realize the real-time and precise test for a weapon system of a certain type of fighter,a signal classification method according to attributes is proposed,common input channels for multiple signals are configured optimally,and a test adapter and an adaptive signal conditioning module is designed. The hardware of conditioning module can be configured flexibly and the programmable test range can be adjusted owing to programmable multiplexer. An FPGA adaptive filter is designed by the calculated filter coefficient vectors with LMS method to solve the problem of parallel test of fighter weapon system in electromagnetic interference environment. The adaptive signal conditioning technology is characterized by high efficiency,precision and integration. Its application makes the test system successful to conduct real-time and parallel test for a weapon system,which is developed based on VXI bus and virtual-instrument technology.
文摘From the actual perspective of working principle of localizer beacon subsystem of Instrument Landing System (ILS), consideration of the distance information from localizer antenna to field monitor antenna and wide aperture effect of localizer antenna, broke through the limitation of signals synthesized only far-field (FF), established the near-field (NF) model. The three-dimensional mathematical model of localizer beacon was designed, and the signals at both near-field and far-field were analyzed qualitatively. At the environment of Antenna Fault as well as Antenna Distribution Unit (ADU) phase shifter simulation, the characteristics of near-field and far-field were also compared. The simulation results showed that the model met the requirement of theory of localizer beacon, and the gap between two models was so evident, which resulted from the broken geometric symmetry in NF area. The model could provide valuable theoretical basis for performance evaluation and maintenance of the ILS, and meanwhile, provide reference for the further analysis of localizer beacon.
文摘This analysis focuses on PIM interference under multi-band multi-signal input in mobile communication system.Unlike single band system that only odd order PIM(especially 3rd order) should be concerned,in multi-band multi-signal case,both odd and even order PIM could be interference source because of more complicated intermodulation,more IMPs generated and more receive bands.Especially,the 2nd order PIM may interfere more serious to receiving channel for its strong magnitude.In duplex indoor distribute system,the PIM interference is a potential problem to GSM900,DCS1800,CDMA,and even 3G system wireless services,because the PIM frequencies may fall in receive bands and interfere to the receiving channels.In radio system design and wireless channel assignment,precautions must be taken to minimize the PIM level and to avoid interfere to receiving channels.For practical use,the lower order possible PIM interference to 2G and 3G systems is calculated.
基金supported by the National Natural Science Foundation of China,No.81371312,81030021the National Basic Research Development Program of China(973 Program),No.2011CB504403
文摘Multiple cellular components, including neuronal, glial and endothelial ceils, are involved in the sophis- ticated pathological processes following central nervous system injury. The pathological process cannot reduce damage or improve functional recovery by merely targeting the molecular mechanisms of neuronal cell death after central nerve system injuries. Eph receptors and ephrin ligands have drawn wide attention since the discovery of their extensive distribution and unique bidirectional signaling between astrocytes and neurons. The roles of Eph/ephrin bidirectional signaling in the developmental processes have been re- ported in previous research. Recent observations suggest that Eph/ephrin bidirectional signaling continues to be expressed in most regions and cell types in the adult central nervous system, playing diverse roles. The Eph/ephrin complex mediates neurogenesis and angiogenesis, promotes glial scar formation, regulates endocrine levels, inhibits myelin formation and aggravates inflammation and nerve pain caused by injury. ~lhe interaction between Eph and ephrin is also considered to be the key to angiogenesis. This review focus- es on the roles of Eph/ephrin bidirectional signaling in the repair of central nervous system injuries.
文摘The central problem of genetics is gene interaction since genes in the course of individual organism development interact with other genes, that’s why their effects may change. Studies for the last 100 years managed to discover that the entire diversity of inter-gene interactions is presented in four major forms: complementarity, epistasis, polymery, and modifying effect of genes. However, gene interaction mechanism which is reflected on the segregation nature of variously crossed hybrids has not been sufficiently studied. Exclusive of molecular genetics, biochemistry and physiology, a genetic analysis of inheritance of characteristics in gene interaction taken by itself cannot reveal nature of this interaction. Lately, molecular-genetic and physiological studies on A. thaliana mutants have enabled to isolate and sequence a wide range of genes controlling certain links of the signalling chain. At the same time, effect of the plant development regulation signalling system on interaction of these genes in inheritance of characteristics of Arabidopsis root system haven’t been studied so far which was a cause for our studies. Gene interaction problem is closely related to the plant development regulation signalling system. Mechanism involved in gene interaction may be explained based on current idea of molecular principles of biological response. Affected by mutations occurring in various genes that control certain links of the signalling chain, signalling path to the cell nucleus and response are blocked partially or in full which leads to distortion in expression of the characteristic on the plant level in general or its organ level. Such phenomenon is observed in realization of many characteristics in animals and plants, including in A. thaliana. In inheritance of such characteristics, as a rule, both allelic, and non-allelic gene interactions are observed. Results of a study of the plant signalling system interconnection and gene interaction in inheritance of characteristics of Arabidopsis root system are presented. It is established that complementary interaction of genes RHD3 and SAR1 is observed in the second crossing generation for plants of rhd3-1 × sar-1 mutant lines. When gpa1-3 × slr-1 mutant-line plants are crossed, recessive epistasis (slr-1 slr-1 > GPA1_) occurs in F<sub>2</sub> generation. Polymeric interaction of genes SHY2 and MSG1 is observed in F<sub>2</sub> in crossing of shy2-2 × msg1-2 mutant-line plants.
基金supported by the National Basic Research Program of China (973Program) under Grant No. 2010CB731800the National Natural Science Foundation of China under Grant No. 60934003 and 61074065the Key Project for Natural Science Research of Hebei Education Departmentunder Grant No. ZD200908
文摘A novel flocking control approach is proposed for multi-agent systems by integrating the variables of velocities, motion directions, and positions of agents. A received signal strength indicator (RSSI) is applied as a variable to estimate the inter-distance between agents. A key parameter that contains the local information of agents is defined, and a multi-variable controller is proposed based on the parameter. For the position control of agents, the RSSI is introduced to substitute the distance as a control variable in the systems. The advantages of RSSI include that the relative distance between every two agents can be adjusted through the communication quality under different environments, and it can shun the shortage of the limit of sensors. Simulation studies demonstrate the effectiveness of the proposed control approach.
基金supported by National Natural Science Foundation of China(61502405,61300039)Provincial Science Foundation of Hunan Province(14JJ3130)+1 种基金Fujian Educational Bureau(JA15368)Xiamen University of Technology(YKJ13024R,XYK201437)
文摘The regulatory mechanisms in cellular signaling systems have been studied intensively from the viewpoint that the malfunction of the regulation is thought to be one of the substantial causes of cancer formation. On the other hand, it is rather difficult to develop the theoretical framework for investigation of the regulatory mechanisms due to their complexity and nonlinearity. In this study, more general approach is proposed for elucidation of characteristics of the stability in cellular signaling systems by construction of mathematical models for a class of cellular signaling systems and stability analysis of the models over variation of the network architectures and the parameter values. The model system is formulated as regulatory network in which every node represents a phosphorylation-dephosphorylation cyclic reaction for respective constituent enzyme. The analysis is performed for all variations of the regulatory networks comprised of two nodes with multiple feedback regulation loops. It is revealed from the analysis that the regulatory networks become mono-stable, bi-stable, tri-stable, or oscillatory and that the negative mutual feedback or positive mutual feedback is favorable for multi-stability, which is augmented by a negatively regulated node with a positive auto-regulation. Furthermore, the multi-stability or the oscillation is more likely to emerge in the case of low value of the Michaelis constant than in the case of high value, implying that the condition of higher saturation levels induces stronger nonlinearity in the networks. The analysis for the parameter regions yielding the multi-stability and the oscillation clarified that the stronger regulation shifts the systems toward multi-stability.
文摘Relerrlng to contlnuous-Ume claaotlc systems, tills paper presents a new projective syncnromzatlon scheme, wnlcn enables each drive system state to be synchronized with a linear combination of response system states for any arbitrary scaling matrix. The proposed method, based on a structural condition related to the uncontrollable eigenvalues of the error system, can be applied to a wide class of continuous-time chaotic (hyperchaotic) systems and represents a general framework that includes any type of synchronization defined to date. An example involving a hyperchaotic oscillator is reported, with the aim of showing how a response system attractor is arbitrarily shaped using a scalar synchronizing signal only. Finally, it is shown that the recently introduced dislocated synchronization can be readily achieved using the conceived scheme.
基金Sponsored by the National Natural Science Foundation of China (60843005)the Basic Research Foundation of Beijing Institute of Technology(20070142018)
文摘A low-power complementary metal oxide semiconductor(CMOS) operational amplifier (op-amp) for real-time signal processing of micro air vehicle (MAV) is designed in this paper.Traditional folded cascode architecture with positive channel metal oxide semiconductor(PMOS) differential input transistors and sub-threshold technology are applied under the low supply voltage.Simulation results show that this amplifier has significantly low power,while maintaining almost the same gain,bandwidth and other key performances.The power required is only 0.12 mW,which is applicable to low-power and low-voltage real-time signal acquisition and processing system.