期刊文献+
共找到795篇文章
< 1 2 40 >
每页显示 20 50 100
Significance of Coal Seam in Recognition of Sequence Boundaries and Systems Tract of the Jurassic in East Fukang Slope, Junggar Basin, China
1
作者 Zhang Qin Zhu Xiaomin Song Gang 《Petroleum Science》 SCIE CAS CSCD 2006年第2期7-13,共7页
The Jurassic in the East Fukang Slope can be divided into six sequences based on sequence stratigraphy by combining logging, core and seismic data. The indicators of sequence boundaries include unconformity, coal seam... The Jurassic in the East Fukang Slope can be divided into six sequences based on sequence stratigraphy by combining logging, core and seismic data. The indicators of sequence boundaries include unconformity, coal seams, change of spore and pollen abundance, scour surfaces and base conglomerate, change of logging curve and sedimentary facies. How to determine the location of the first flooding surfaces and the maximum flooding surface is the key step to divide the systems tract. There occurred a topographic slope break in the East Fukang Slope when the Jurassic was deposited, and therefore we can recognize the location of the first flooding surface and establish the sequence stratigraphic framework with the slope break in the study area. Coal seams regionally distributed are correlatable and isochronic, and record the termination of a depositional event or episode. So, the regional coal seam (more than 60 percent coverage) can be used as the genetic stratigraphic sequence boundary, while locally distributed coal seam (less than 60 percent coverage) can be used as the systems tract boundary. The thick coal seams distributed regionally in the middle of the Badaowan Formation and the lower part of the Xishanyao Formation in the study area act as the sequence boundaries, while the thin and locally distributed coal seam acts as the systems tract boundary, which results in the correlation of the division of sequence stratigraphy of the Jurassic to the whole basin where coal seams are developed extensively. 展开更多
关键词 JURASSIC sequence boundary systems tract coal seam
下载PDF
Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system 被引量:18
2
作者 Pier Alberto Testoni Benedetto Mangiavillano 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第42期6444-6452,共9页
Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar t... Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of tissues.The physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic waves.The in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue surface.In the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal system.OCT imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal system.Esophagus and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively investigated.OCT imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the submucosa.The technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic lesions.OCT imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis between neoplastic and non-neoplastic lesions. 展开更多
关键词 光学相干性 断层摄影术 发育异常 胃肠病
下载PDF
国人胆道三维重建解剖变异应用研究
3
作者 江剑宏 段仁鹏 李晓锋 《中国临床解剖学杂志》 CSCD 北大核心 2024年第1期1-4,共4页
目的通过三维重建国人胆道系统,研究国人胆道走行及其解剖变异特点。方法利用海信计算机辅助手术系统对100例梗阻性胆道疾病患者的腹部CT数据进行三维重建,得到胆道三维模型,观察肝内胆道系统的走形,根据黄氏分型法(右后叶胆管、右前叶... 目的通过三维重建国人胆道系统,研究国人胆道走行及其解剖变异特点。方法利用海信计算机辅助手术系统对100例梗阻性胆道疾病患者的腹部CT数据进行三维重建,得到胆道三维模型,观察肝内胆道系统的走形,根据黄氏分型法(右后叶胆管、右前叶胆管与左肝管的汇入方式)以及是否存在副肝管对胆道进行分型。结果成功重建100例国人的胆道三维模型,观察到胆道有7种类型,54%(54例)拥有典型的胆道解剖结构(Ⅰ型);46%(46例)有解剖变异,其中10%(10例)为Ⅱ型,14%(14例)为Ⅲ型,10%(10例)为Ⅳ型,2%(2例)为Ⅴ型,2%(2例)为Ⅵ型,此外有8%(8例)存在副肝管,其中6例同时伴有其他变异。结论通过三维重建模型,能清晰识别国人胆道系统走形及变异特点,发现新的胆道变异类型,有助于指导临床诊疗。 展开更多
关键词 三维重建 胆道系统 胆道变异
下载PDF
小儿肺炎支原体肺炎并发消化道系统损害的相关影响因素分析
4
作者 钱元原 季卫刚 +1 位作者 陈艳艳 张娟 《中国医学创新》 CAS 2024年第9期143-146,共4页
目的:探讨小儿肺炎支原体肺炎并发消化道系统损害的相关影响因素。方法:回顾性分析2020年1月—2023年3月南通大学附属南通妇幼保健院收治的132例小儿肺炎支原体肺炎患儿临床资料,根据是否并发消化道系统损害分为消化道系统损害组(n=35)... 目的:探讨小儿肺炎支原体肺炎并发消化道系统损害的相关影响因素。方法:回顾性分析2020年1月—2023年3月南通大学附属南通妇幼保健院收治的132例小儿肺炎支原体肺炎患儿临床资料,根据是否并发消化道系统损害分为消化道系统损害组(n=35)、非消化道系统损害组(n=97)。收集患儿一般资料,包括性别、年龄、体重、发热病程、病程、大环内酯类药物开始使用时间、糖皮质激素开始使用时间、红细胞沉降率(ESR)、C反应蛋白(CRP)水平、白细胞(WBC)水平、中性粒细胞百分比。对一般资料进行单因素分析,再对有统计学差异因素的进行多因素logistic回归分析。结果:132例小儿肺炎支原体感染患儿发生35例消化道系统损害,发生率26.52%(35/132)。单因素分析显示,两组性别、体重、病程、糖皮质激素开始使用时间、ESR、WBC、中性粒细胞百分比对比,差异均无统计学意义(P>0.05)。两组年龄、发热病程、大环内酯类药物开始使用时间、CRP水平比较,差异均有统计学意义(P<0.05)。logistic回归分析显示,年龄≤3岁、发热病程≥7 d、大环内酯类药物使用时间<3 d、CRP≥10 mg/L是小儿肺炎支原体感染并发消化道系统损害的独立危险因素(OR>1且P<0.05)。结论:小儿肺炎支原体肺炎患儿并发消化道系统损害与年龄≤3岁、发热病程≥7 d、大环内酯类药物使用时间<3 d、CRP≥10 mg/L有关。 展开更多
关键词 小儿肺炎支原体肺炎 消化道系统损害 影响因素 炎症水平 大环内酯类
下载PDF
玛湖凹陷三叠系百口泉组地层再认识与勘探潜力分析
5
作者 钟厚财 朱俊梅 +5 位作者 林煜 邓勇 刘作强 黄友华 张珊 屈琳 《特种油气藏》 CAS CSCD 北大核心 2024年第2期28-36,共9页
为进一步探索玛中平台区近4000.0 km 2勘探空白区的勘探潜力,扩大玛湖凹陷百口泉组勘探潜力,实现玛湖凹陷整体突破,综合利用地质、钻井、高精度地震等资料,对玛湖凹陷百口泉组地层划分进行了细化,将玛中平台区低位域砂体划分为百口泉组... 为进一步探索玛中平台区近4000.0 km 2勘探空白区的勘探潜力,扩大玛湖凹陷百口泉组勘探潜力,实现玛湖凹陷整体突破,综合利用地质、钻井、高精度地震等资料,对玛湖凹陷百口泉组地层划分进行了细化,将玛中平台区低位域砂体划分为百口泉组零段(百零段)。在此基础上,结合区域沉积、构造背景,从烃源岩条件、疏导体系、沉积体系和成藏条件等方面对玛中平台区低位域百零段油气成藏条件及控制因素展开了综合分析。研究表明:二叠系风城组烃源岩具有碱湖双峰式生油特征,油气资源基础大,百零段更近源,更容易捕获深层油气;玛中平台区印支期走滑断裂直插深层烃源岩,搭接形成了高效的输导体系;百口泉组顶底板条件优越,百零段在大型地层超覆背景下叠置发育多期湖侵退积砂体,形成规模有效的储盖组合;百零段发育四大规模扇体,其扇三角洲平原亚相致密带、扇间泥岩、构造等值线相互配置,形成复合式多面遮挡,为扇三角洲前缘大面积成藏奠定了基础。类比研究认为,中拐扇前缘亚相上倾、侧向遮挡条件好,具有宏观整体成藏基础。该区前缘亚相有利勘探面积大,岩性目标叠置发育,落实程度高,是目前寻求百零段新层系突破的重点勘探目标。百零段的突破有望打开玛中平台区勘探局面,进而实现玛湖凹陷百口泉组整体突破。 展开更多
关键词 扇控大面积成藏 低位域 勘探潜力分析 百口泉组 玛中平台区 玛湖凹陷
下载PDF
丽水凹陷明下段强制海退体系域油气地质意义
6
作者 马文睿 覃军 +2 位作者 董哲 张彦振 焦社宝 《科技创新与应用》 2024年第11期89-94,共6页
丽水凹陷油气勘探思路正逐步转向“近源下洼”,寻找入洼发育的具有优质物性条件的岩性圈闭是获得油气勘探成功的关键之一。通过地球物理、地质分析等方法在丽水凹陷西次凹明月峰组底部识别出一套强制海退体系域沉积,具有储层物性好,易... 丽水凹陷油气勘探思路正逐步转向“近源下洼”,寻找入洼发育的具有优质物性条件的岩性圈闭是获得油气勘探成功的关键之一。通过地球物理、地质分析等方法在丽水凹陷西次凹明月峰组底部识别出一套强制海退体系域沉积,具有储层物性好,易形成岩性圈闭、有利于捕获油气的有利成藏条件,这类圈闭的探索对油气勘探具有重要的地质意义。 展开更多
关键词 丽水凹陷 明下段 强制海退体系域 岩性圈闭 油气
下载PDF
灸法治疗经尿道前列腺切除术后下尿路症候群的meta分析
7
作者 何丽慧 黄惠榕 丁铭 《中国医药科学》 2024年第9期127-130,共4页
目的系统评价灸法治疗经尿道前列腺切除(TURP)术后下尿路症候群(LUTS)的临床效果。方法检索中国知网、维普网、万方数据知识服务平台、中国生物医学文献数据库、the Cochrane Library、PubMed、Embase建库至2023年5月31日有关灸法治疗T... 目的系统评价灸法治疗经尿道前列腺切除(TURP)术后下尿路症候群(LUTS)的临床效果。方法检索中国知网、维普网、万方数据知识服务平台、中国生物医学文献数据库、the Cochrane Library、PubMed、Embase建库至2023年5月31日有关灸法治疗TURP术后LUTS的随机对照试验(RCT)。结果共纳入14篇文献,1225例患者。meta分析结果显示:治疗组总有效率、最大尿流速、IPSS优于对照组[Z=7.55,RR=1.25,95%CI(1.18,1.32),P<0.00001;Z=3.39,MD=3.08,95%CI(1.30,4.86),P<0.05;Z=7.04,MD=-3.47,95%CI(-4.43,-2.50),P<0.00001],差异均有统计学意义(P<0.05);两组均未见不良反应。结论灸法治疗TURP术后LUTS患者效果显著。 展开更多
关键词 灸法 经尿道前列腺切除术 下尿路症候群 系统评价
下载PDF
百蕊颗粒治疗儿童急性上呼吸道感染疗效及安全性系统评价
8
作者 张小龙 闫孝永 +1 位作者 付宏 李静 《临床合理用药杂志》 2024年第14期32-36,共5页
目的系统评价百蕊颗粒治疗儿童急性上呼吸道感染(AURTI)的疗效及安全性。方法通过计算机系统检索中国知网、万方数据与维普网数据库自建库至2022年9月有关百蕊颗粒治疗儿童AURTI的随机对照研究,并按照Cochrane质量评价标准对纳入研究的... 目的系统评价百蕊颗粒治疗儿童急性上呼吸道感染(AURTI)的疗效及安全性。方法通过计算机系统检索中国知网、万方数据与维普网数据库自建库至2022年9月有关百蕊颗粒治疗儿童AURTI的随机对照研究,并按照Cochrane质量评价标准对纳入研究的方法学质量进行评估,运用RevMan 5.4软件进行Meta分析。结果纳入文献10篇,涉及患儿1257例。Meta分析显示百蕊颗粒组总有效率高于对照组(OR=4.26,95%CI:2.94~6.16,P<0.00001)。依据疾病类型、治疗疗程进行亚组分析,结果显示,疱疹性咽峡炎患者与非疱疹性咽峡炎患者百蕊颗粒组总有效率均高于对照组(OR=5.34,95%CI:3.23~8.84,P<0.00001;OR=3.12,95%CI:1.80~5.42,P<0.0001);疗程3~5 d与6~7 d百蕊颗粒组总有效率均高于对照组(OR=5.24,95%CI:3.20~8.59,P<0.00001;OR=3.14,95%CI:1.79~5.52,P<0.0001)。百蕊颗粒组退热时间、咽喉部症状消退时间短于对照组(MD=-1.23,95%CI:-1.78~-0.68,P<0.0001;MD=-1.38,95%CI:-1.65~-1.11,P<0.00001)。百蕊颗粒组与对照组不良反应总发生率比较差异无统计学意义(OR=2.09,95%CI:0.69~6.33,P=0.19)。结论百蕊颗粒治疗儿童AURTI疗效较好,且不会增加不良反应。 展开更多
关键词 急性上呼吸道感染 儿童 百蕊颗粒 系统评价
下载PDF
以奥马哈系统为理论依据的延续性护理在膀胱癌尿路造口患者中的应用效果
9
作者 巫冬梅 黄丽芳 +3 位作者 陆岁花 黄美秋 黄欢 农丽榕 《中国当代医药》 CAS 2024年第12期162-166,共5页
目的探讨在膀胱癌尿路造口患者中采取以奥马哈系统为理论依据的延续性护理的应用效果。方法选取2022年9月至2023年6月右江民族医学院附属医院收治的48例膀胱癌患者作为研究对象,采用随机数字表法将其分为对照组(24例)和观察组(24例)。... 目的探讨在膀胱癌尿路造口患者中采取以奥马哈系统为理论依据的延续性护理的应用效果。方法选取2022年9月至2023年6月右江民族医学院附属医院收治的48例膀胱癌患者作为研究对象,采用随机数字表法将其分为对照组(24例)和观察组(24例)。对照组患者接受常规护理,观察组患者接受以奥马哈系统为理论依据的延续性护理,两组均持续护理观察3个月。比较两组患者心理状态、支持性照顾需求、并发症发生率以及生活质量。结果观察组护理后的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组,差异有统计学意义(P<0.05);观察组护理后的支持性照顾需求量表(SCNS-SF34)评分、生活质量评分均高于对照组,差异有统计学意义(P<0.05);观察组并发症总发生率(8.33%)低于对照组(33.33%),差异有统计学意义(P<0.05)。结论以奥马哈系统为理论依据的延续性护理可为膀胱癌尿路造口患者提供相应的照顾需求,有效减轻患者消极情绪,降低并发症发生率,从而提升患者生活质量。 展开更多
关键词 膀胱癌 尿路造口 奥马哈系统 延续性护理 心理状态 支持性照顾需求 并发症 生活质量
下载PDF
消化道穿孔患者感染性休克早期预警评分系统的构建及诊断效果
10
作者 李炎 朱晓丽 施晓晓 《中国急救复苏与灾害医学杂志》 2024年第4期472-475,479,共5页
目的 调查分析消化道穿孔(DTP)患者感染性休克的发生率和主要危险因素,并构建早期预警评分系统以指导临床实践。方法 回顾性纳入2021年1月—2023年1月南通市肿瘤医院诊断DTP患者共188例,将其分为休克组59例和无休克组129例,比较两组患... 目的 调查分析消化道穿孔(DTP)患者感染性休克的发生率和主要危险因素,并构建早期预警评分系统以指导临床实践。方法 回顾性纳入2021年1月—2023年1月南通市肿瘤医院诊断DTP患者共188例,将其分为休克组59例和无休克组129例,比较两组患者的临床资料,采用单因素与多因素Logistic回归分析筛选休克发生的危险因素。结果 与无休克组比较,休克组入院急性生理与慢性健康评估(APACHEⅡ)、快速序贯器官衰竭评估(qSOFA)和Logistic器官功能障碍评分(LODS)、平均心率、血钾、血乳酸、血肌酐、降钙素原(PCT)、C反应蛋白(CRP)和病死率明显升高,而白蛋白、氧合指数(PaO_(2)/FiO_(2))和pH值显著降低(P<0.05)。单因素与多因素Logistic回归模型均显示,LODS≥11分(β=1.468,OR=3.025,P<0.001)、平均心率≥100次/min(β=0.568,OR=1.568,P<0.001)、乳酸≥5.8 mmol/L(β=0.859,OR=1.958,P<0.001)、PCT≥5.0μg/L(β=1.002,OR=2.124,P<0.001)、CRP≥20.0 mg/L(β=0.685,OR=1.647,P<0.001)是DTP患者感染性休克的危险因素。根据β值分别赋值为3、1、1、2和1分,总分8分。受试者工作曲线(ROC)显示,评分系统预测休克的曲线下面积(AUC)为0.902(95%CI=0.856~0.933,P<0.001),高于APACHEⅡ、qSOFA和LODS的AUC值(Z≥3.526,均P<0.01)。结论 DTP患者有较高的感染性休克发生率,入院LODS、平均心率、乳酸、PCT和CRP升高是休克发生的主要危险因素,根据上述因素建立的新型评分系统对指导临床早期识别休克高危患者具有较好的预警作用,有推广应用的潜力。 展开更多
关键词 消化道穿孔 感染性休克 危险因素 评分系统
下载PDF
ICU意识障碍病人呼吸道感染预防护理质量敏感指标体系的构建与应用
11
作者 王双 刘亚 +1 位作者 黄清月 裴建枫 《循证护理》 2024年第2期304-309,共6页
目的:通过文献分析法、德尔菲法构建重症监护室(ICU)意识障碍病人呼吸道感染预防护理质量敏感指标体系,并经临床应用验证其效果。方法:通过文献分析法筛选ICU意识障碍病人呼吸道感染预防护理质量敏感指标,经德尔菲法专家函询完善指标内... 目的:通过文献分析法、德尔菲法构建重症监护室(ICU)意识障碍病人呼吸道感染预防护理质量敏感指标体系,并经临床应用验证其效果。方法:通过文献分析法筛选ICU意识障碍病人呼吸道感染预防护理质量敏感指标,经德尔菲法专家函询完善指标内容,最终形成ICU意识障碍病人呼吸道感染预防护理质量敏感指标体系。自2022年1月起应用ICU意识障碍病人呼吸道感染预防护理质量敏感指标体系,此前采取常规护理模式,选择我院ICU 2021年1月—12月、2022年1月—12月收治的意识障碍病人,各60例,分别设为对照组、观察组,比较两组病人呼吸道感染发生率及护理质量改进效果。结果:2轮函询有效问卷回收率均为100%,专家权威系数分别为0.875,0.899,肯德尔和谐系数分别为0.328(χ^(2)=32.284,P<0.001)、0.472(χ^(2)=51.093,P<0.001),构建的ICU意识障碍病人呼吸道感染预防护理质量敏感指标体系共有47个指标,其中一级指标3个,二级指标9个,三级指标35个,变异系数为0.07~0.11。指标体系应用结果显示,观察组上呼吸道、下呼吸道感染发生率均低于对照组,差异有统计学意义(P<0.05);观察组护理质量改进效果优于对照组,差异有统计学意义(P<0.05)。结论:基于文献分析法、德尔菲法构建的ICU意识障碍病人呼吸道感染预防护理质量敏感指标体系内容全面,且科学性、可靠性较好,其在临床中的应用能持续评价,改进呼吸道感染预防护理质量,降低呼吸道感染风险。 展开更多
关键词 重症监护室 呼吸道感染 预防护理 指标体系 德尔菲法
下载PDF
Stratigraphic Sequence and Sedimentary Systems in the Middle-Southern Continental Slope of the East China Sea from Seismic Reflection Data: Exploration Prospects of Gas Hydrate 被引量:1
12
作者 LI Deyong CHEN Hongyan +3 位作者 XU Shujuan XING Junhui CHENG Honggang WANG Jinkai 《Journal of Ocean University of China》 SCIE CAS CSCD 2019年第6期1302-1316,共15页
Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mu... Many evidences for gas hydrate bearing sediments had been found in the continental slope of the East China Sea,such as bottom simulating reflections(BSRs),undersea gas springs,pyrite associated with methane leakage,mud diapirs/mud volcanos,bottom-water methane anomalies and so on.In this study,six key stratigraphic interfaces including T_0(seafloor),T_1(LGM,23 kyr B.P.),T_2(2.58 Myr),T_3(5.33 Myr),T_4(11.02 Myr)and T_5(16.12 Myr)were identified,and then five third-order sequences of SQIII1 to SQIII5 were divided.However,T5 in southern continental slope is not found,which shows that the middle-northern Okinawa Trough had begun to rift in the early Miocene,earlier than the southern segment.Four system tracts including lowstand systems tract(LST),transgressive systems tract(TST),highstand systems tract(HST)and falling stage systems tract(FSST)are further divided.The marine erosion interface of 11.02 Myr and regressive unconformity interface of 23 kyr B.P.indicate two large-scale sea level drop events in the research area.Seven typical seismic facies identified in the continental slope are continental shelf-edge deltas,littoral fluvial-delta plains,incised channels or submarine canyons,slope fans,submarine fans or coastal sandbars,littoral-neritic finegrained sediments,mud volcanos and some other geological bodies respectively.The minimum water depth for hydrate occurrence in the Okinawa Trough is 630 m,and the thickness of gas hydrate stability zone in continental slope is between 0 and 590 m.The calculated bottom boundary of hydrate stability zone is slightly deeper than BSRs on the seismic sections.The re-depositional turbidite sand bodies,such as canyon channels,slope fans and submarine fans developed in Quaternary strata,are the predominant hydrate reservoirs.According to developing process,the dynamic accumulation of hydrate systems can be divided into three evolutionary stages including canyon erosion and hydrate stability zone migration stage,sediments destabilizing and methane leakage stage,and channel filling and hydrate re-occurrence stage. 展开更多
关键词 sequence STRATIGRAPHIC architecture systemS tract seismic facies DEPOSITIONAL system submarine CANYON gas HYDRATE stability zone HYDRATE dynamic accumulation continental slope of the East China Sea
下载PDF
Gastrointestinal complications of systemic sclerosis 被引量:2
13
作者 Xin-Ping Tian Xuan Zhang 《World Journal of Gastroenterology》 SCIE CAS 2013年第41期7062-7068,共7页
Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness.Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality;however,the gast... Systemic sclerosis is an autoimmune disease characterized by progressive skin thickening and tightness.Pulmonary interstitial fibrosis and kidney damage are the most important indicators for mortality;however,the gastrointestinal tract is the most commonly damaged system.Virtually all parts of the gastrointestinal(GI)tract can be involved,although the esophagus is the most frequently reported.The mechanisms that cause such extensive damage are generally unclear,but vascular changes,immunological abnormalities,excessive accumulation of collagen in the submucosa,smooth muscle atrophy and neuropathy may participate because these are the most common histological findings in biopsies and autopsies.Most patients with GI tract involvement complain about dyspepsia,nausea,vomiting,abdominal bloating/distension,and fecal incontinence.These symptoms are generally mild during the early stage of the disease and are likely ignored by physicians.As the disease becomes more advanced,however,patient quality of life is markedly influenced,whereby malnutrition and shortened survival are the usual consequences.The diagnosis for systemic sclerosis is based on manometry measurements and an endoscopy examination.Supportive and symptomatic treatment is the main therapeutic strategy;however,an early diagnosis is critical for successful management. 展开更多
关键词 systemIC SCLEROSIS GASTROINTESTINAL tract MANOMETRY ENDOSCOPY Diagnosis Treatment
下载PDF
HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists 被引量:5
14
作者 Nicola Fusco Silvano Bosari 《World Journal of Gastroenterology》 SCIE CAS 2016年第35期7926-7937,共12页
Management of cancers of the digestive system has progressed rapidly into the molecular era. Despite the significant recent achievements in the diagnosis and treatment of these patients, the number of deaths for these... Management of cancers of the digestive system has progressed rapidly into the molecular era. Despite the significant recent achievements in the diagnosis and treatment of these patients, the number of deaths for these tumors has currently plateaued. Many investigations have assessed the role of HER2 in tumors of the digestive system in both prognostic and therapeutic settings, with heterogeneous results. Novel testing and treatment guidelines are emerging, in particular in gastric and colorectal cancers. However, further advances are needed. In this review we provide a comprehensive overview of the current state-ofknowledge of HER2 alterations in the most common tumors of the digestive system and discuss the operational implications of HER2 testing. 展开更多
关键词 HER2 消化系统 胃肠的道 胃的癌症 结肠癌 食道的癌症 Gastroesophageal 连接癌症 胆汁的道癌症 胆囊癌症 肝癌症 胰癌症
下载PDF
E2F transcription factors and digestive system malignancies:How much do we know? 被引量:2
15
作者 Konstantinos Evangelou Sophia Havaki Athanassios Kotsinas 《World Journal of Gastroenterology》 SCIE CAS 2014年第29期10212-10216,共5页
The E2F proteins comprise a family of 8 members that function as transcription factors.They are key targets of the retinoblastoma protein(RB)and were initially divided into groups of activators and repressors.Accumula... The E2F proteins comprise a family of 8 members that function as transcription factors.They are key targets of the retinoblastoma protein(RB)and were initially divided into groups of activators and repressors.Accumulating data suggest that there is no specific role for each individual E2F member.Instead,each E2F can exert a variety of cellular effects,some of which represent opposing ones.For instance,specific E2Fs can activate transcription and repression,promote or hamper cell proliferation,augment or inhibit apoptosis,all being dependent on the cellular context.This complexity reflects the importance that these transcription factors have on a cell’s fate.Thus,delineating the specific role for each E2F member in specific malignancies,although not easy,is a challenging and continuously pursued task,especially in view of potential E2F targeted therapies.Therefore,several reviews are continuously trying to evaluate available data on E2F status in various malignancies.Such reviews have attempted to reach a consensus,often in the simplistic form of oncogenes or tumor suppressor genes for the E2Fs.However they frequently miss spatial and temporal alterations of these factors during tumor development,which should also be considered in conjunction with the status of the regulatory networks that these factors participate in.In the current‘‘Letter to the Editor’’,we comment on the flaws,misinterpretations and omissions in one such review article published recently in the World Journal of Gastroenterology regarding the role of E2Fs in digestive system malignancies. 展开更多
关键词 E2F Hepatocellular carcinoma Pancreatic DUCTAL ade
下载PDF
Intestinal pseudo-obstruction in patients with systemic lupus erythematosus: A real diagnostic challenge 被引量:5
16
作者 Carlos Alberto García López Fernando Laredo-Sánchez +2 位作者 José Malagón-Rangel Miguel G Flores-Padilla Haiko Nellen-Hummel 《World Journal of Gastroenterology》 SCIE CAS 2014年第32期11443-11450,共8页
Intestinal pseudo-obstruction secondary to systemic lupus erythematosus(SLE) is a rare syndrome described in recent decades. There are slightly over 30 published cases in the English language literature, primarily ass... Intestinal pseudo-obstruction secondary to systemic lupus erythematosus(SLE) is a rare syndrome described in recent decades. There are slightly over 30 published cases in the English language literature, primarily associated with renal and hematological disease activity. Its presentation and evolution are a diagnostic challenge for the clinician. We present four cases of intestinal pseudo-obstruction due to lupus in young Mexican females. One patient had a previous diagnosis of SLE and all presented with a urinary tract infection of varying degrees of severity during their evolution. We consider that recognition of the disease is of vital importance because it allows for establishing appropriate management, leading to a better prognosis and avoiding unnecessary surgery and complications. 展开更多
关键词 INTESTINAL PSEUDO-OBSTRUCTION systemIC LUPUS eryth
下载PDF
Integration of Sequence Stratigraphic Analysis and 3D Geostatistical Modeling of Pliocene–Pleistocene Delta,F3 Block,Netherlands
17
作者 Haris Ahmed KHAN Ali Asghar SHAHID +3 位作者 Muhammad Jahangir KHAN Taher ZOUAGHI Maria Dolores ALVAREZ Syed Danial Mehdi NAQVI 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2023年第1期256-268,共13页
This research is focused on the analysis of the sequence stratigraphic units of F3 Block,within a wave-dominated delta of Plio–Pleistocene age.Three wells of F3 block and a 3D seismic data,are utilized in this resear... This research is focused on the analysis of the sequence stratigraphic units of F3 Block,within a wave-dominated delta of Plio–Pleistocene age.Three wells of F3 block and a 3D seismic data,are utilized in this research.The conventional techniques of 3D seismic interpretation were utilized to mark the 11 surfaces on the seismic section.Integration of seismic sequence stratigraphic interpretation,using well logs,and subsequent 3D geostatistical modeling,using seismic data,aided to evaluate the shallow hydrocarbon traps.The resulting models were obtained using System Tract and Facies models,which were generated by using sequential stimulation method and their variograms made by spherical method,moreover,these models are validated via histograms.The CDF curve generated from upscaling of well logs using geometric method,shows a good relation with less percentage of errors(1 to 2 for Facies and 3 to 4 for System Tract models)between upscaled and raw data that complements the resulted models.These approaches help us to delineate the best possible reservoir,lateral extent of system tracts(LST and/or HST)in the respective surface,and distribution of sand and shale in the delta.The clinoform break points alteration observed on seismic sections,also validates the sequence stratigraphic interpretation.The GR log-based Facies model and sequence stratigraphy-based System Tract model of SU-04-2 showed the reservoir characteristics,presence of sand bodies and majorly LST,respectively,mainly adjacent to the main fault of the studied area.Moreover,on the seismic section,SU-04-2 exhibits the presence of gas pockets at the same location that also complements the generated Facies and System Tract models.The generated models can be utilized for any similar kind of study and for the further research in the F3 block reservoir characterization. 展开更多
关键词 sequence stratigraphy facies modeling system tract modeling F3 block North Sea
下载PDF
Changes in Cardiovascular Activity During an Increase in Biliary Tract Pressure in Rabbits
18
作者 郑启昌 叶建宇 +2 位作者 胡佑华 官敏丽 王迪浔 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 1994年第3期181-182,184-185,共4页
In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary... In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary tract pressure was increased.It was found that both the blood pressure and cardiac output evidently decreased (P<0.05) parallelly, and the systolic pressure decreased more markedly than diastolic pressure. At the same time there was fluctuation in heart rate and in central venous pressure; but there was no significant difference between them (P>0. 05), suggesting that in the absence of infective agents,the increased biliary tract pressure can bring about a decrease in cardiac output, which is an important factor contributing to an early blood pressure decrease in acute cholangitis of severe type (ACST). 展开更多
关键词 biliary tract blood pressure cardiovascular system CHOLANGITIS PRESSURE
下载PDF
鄂尔多斯盆地中南部上古生界层序与岩相古地理演化 被引量:3
19
作者 李克永 杨文鹏 +1 位作者 徐帅康 李文厚 《古地理学报》 CAS CSCD 北大核心 2023年第1期75-92,共18页
为明确鄂尔多斯盆地中南部上古生界层序特点与岩相古地理演化规律,利用周缘野外露头和盆地钻井测井相特征,分析层序界面、体系域界面的岩性、古构造及海侵方向变化特征,总结层序发育特点与岩相古地理演化规律。结果表明:不同风化序列的... 为明确鄂尔多斯盆地中南部上古生界层序特点与岩相古地理演化规律,利用周缘野外露头和盆地钻井测井相特征,分析层序界面、体系域界面的岩性、古构造及海侵方向变化特征,总结层序发育特点与岩相古地理演化规律。结果表明:不同风化序列的区域性不整合面及海侵方向转换面为二级层序界面,区域性海退面、下切冲刷面及陆上暴露面为三级层序界面;潮间带砂坪及近岸相海侵含砾砂岩顶为海侵面,最大海侵面发育灰岩、泥页岩及煤层,是海侵体系域与高位体系域分界面;上古生界包括二级层序2个:MSQ1、MSQ2,三级层序6个:SQ1、SQ2、SQ3、SQ4、SQ5、SQ6,其中SQ1—SQ2发育水进体系域与高位体系域,不发育低位体系域,SQ1为潟湖—障壁海岸沉积体系,SQ2为泥炭坪—泥坪相潮坪沉积;SQ3—SQ6发育完整的低位—海侵—高位体系域,SQ3发育区域性海退进积海陆过渡相三角洲沉积,SQ4早期为低位体系域下切冲蚀砂体,晚期沉积古环境由温暖湿润还原环境演变为炎热干燥的氧化环境,SQ5—SQ6早中期为氧化环境三角洲沉积,SQ6晚期为高位体系域具海侵夹层的潮坪相沉积。研究为鄂尔多斯盆地及其他盆地层序与岩相古地理演化提供理论依据。 展开更多
关键词 区域性不整合面 层序地层 体系域 岩相古地理 鄂尔多斯盆地
下载PDF
赵绍琴治疗呼吸系统疾病的用药规律研究 被引量:1
20
作者 曾江楠 熊广 +4 位作者 耿子凯 谢纬 祝庆华 潘蕊 刘玉 《世界中西医结合杂志》 2023年第5期869-875,共7页
目的 基于数据挖掘分析并总结赵绍琴教授治疗呼吸系统疾病的用药规律。方法 收集《赵绍琴临证验案精选》《赵绍琴医案实录》《赵绍琴临床经验辑要》《赵绍琴内科学》《跟名师学临床系列丛书—赵绍琴》《赵绍琴临证400法》中所记载的治... 目的 基于数据挖掘分析并总结赵绍琴教授治疗呼吸系统疾病的用药规律。方法 收集《赵绍琴临证验案精选》《赵绍琴医案实录》《赵绍琴临床经验辑要》《赵绍琴内科学》《跟名师学临床系列丛书—赵绍琴》《赵绍琴临证400法》中所记载的治疗呼吸系统疾病的医案和处方,运用中医传承计算平台(V3.0)中的统计分析、频次分析、关联规则、K-means算法聚类分析模块等分析方法进行数据分析与挖掘,对处方中核心药物的性味归经、核心用药和类方等进行总结分析。结果 共筛选出90首方剂,涉及169种中药。治疗最多的呼吸系统疾病分别为上呼吸道感染、支气管炎和哮喘,将疾病分成这三类进行数据分析。赵绍琴教授治疗上呼吸道感染喜用寒性药物,其次是温性药物和平性药物。药味多为苦味药,其次是辛味药、甘味药。使用频次在前10位的中药分别是前胡、芦根、栀子、杏仁、淡豆豉、连翘、半夏、佩兰、浙贝母、广藿香。药物组合频次前3的是“芦根-前胡”“前胡-栀子”“芦根-栀子”。聚类药物组合3种。治疗支气管炎药物的药性与治疗上呼吸道感染疾病一样,而其药味用得最多的是辛味药。用药频次前8的中药分别是前胡、杏仁、紫苏子、紫苏叶、半夏、枇杷叶、麦芽、莱菔子。药物组合频次前4的是“前胡-杏仁”“前胡-紫苏子”“杏仁-紫苏子”“前胡-杏仁-紫苏子”。生成3个赵绍琴教授治疗支气管炎的类方。治疗哮喘的药物药性以温性药居多,药味以辛味药为主。使用频次前十的药物分别是半夏、杏仁、紫苏子、前胡、紫苏叶、陈皮、枇杷叶、六神曲、麦芽、山楂。用药频次前4的药对分别是“杏仁-紫苏子”“杏仁-紫苏叶”“半夏-陈皮”“杏仁-前胡”。生成3个赵绍琴教授治疗哮喘的类方。结论 赵绍琴教授治疗上呼吸道感染疾病治以辛凉,佐以苦甘,宣降肺气、通畅三焦、注意固护脾胃。治疗支气管炎多将前胡、杏仁、紫苏叶与紫苏子同用,降气祛痰,透热外出。治疗哮喘时不仅用大量温性祛痰之品,还注重饮食的调摄,喜用焦三仙消食导滞。通过调理脏腑,恢复肺的宣发肃降功能从而止咳、祛痰、平喘等。 展开更多
关键词 赵绍琴 呼吸系统疾病 上呼吸道感染 支气管炎 哮喘
下载PDF
上一页 1 2 40 下一页 到第
使用帮助 返回顶部