In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system （MFS）, providing the resulting ethers in high yield with fewer ...In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system （MFS）, providing the resulting ethers in high yield with fewer side effects. Meanwhile, this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides, giving moderate yields.展开更多
基金financially supported by the National Key Basic Research Program of China(973 Program,Nos.2012CB725204 and 2012CB721104)the National Natural Science Foundation of China(Nos.U1463201,81302632,21522604 and21402240)+1 种基金the youth in Jiangsu Province Natural Science Fund(No.BK20130913)National Science and Technology Major Projects for"Major New Drugs Innovation and Development"(No.2013ZX09103001-004)
文摘In this study, etherification of ginkgolide B and dimethylaminoethyl chloride hydrochloride was investigated as a model reaction in a micro-flow system （MFS）, providing the resulting ethers in high yield with fewer side effects. Meanwhile, this novel process in MFS worked well for other ginkgolides from Ginkgol biloba and halides, giving moderate yields.
