Systemic lupus erythematosus with multicentric reticulohistiocytosis: A case report

BACKGROUND Multicentric reticulohistiocytosis(MRH)/systemic lupus erythematosus(SLE) overlap syndrome is an uncommon disease in the clinic and is diagnosed through characteristic clinical manifestations, histopathology, and immunopathology. Here, we report the case of a 30-year-old woman with SLE who developed MRH.CASE SUMMARY A 30-year-old woman with a history of polyarthritis for the past 12 years had multiple skin nodules on her body for 10 years, including the sacrococcygeal area, dorsum of the hands, interphalangeal joint of the feet and sternoclavicular joint. The histopathology of a biopsy of the distal interphalangeal joint of the hands revealed granulomatous inflammation, fibrous hyperplasia with ground-glass degeneration, inflammatory cell exudation and focal necrosis. The immunohistochemical stains showed positive staining for CD68 and negative staining for S100 and acid-fast staining. The patient was diagnosed with SLE with MRH. Her symptoms were improved after a combined treatment of prednisone, hydroxychloroquine and cyclophosphamide.CONCLUSION MRH/SLE overlap syndrome is difficult to diagnose and treat. Cyclophosphamide may be an alternative choice for the treatment of MRH.

Ergodicity recovery of random walk in heterogeneous disordered media

Significant and persistent trajectory-to-trajectory variance are commonly observed in particle tracking experiments,which have become a major challenge for the experimental data analysis.In this theoretical paper we investigate the ergodicity recovery behavior,which helps clarify the origin and the convergence of trajectory-to-trajectory fluctuation in various heterogeneous disordered media.The concepts of self-averaging and ergodicity are revisited in the context of trajectory analysis.The slow ergodicity recovery and the non-Gaussian diffusion in the annealed disordered media are shown as the consequences of the central limit theorem in different situations.The strange ergodicity recovery behavior is reported in the quenched disordered case,which arises from a localization mechanism.The first-passage approach is introduced to the ergodicity analysis for this case,of which the central limit theorem can be employed and the ergodicity is recovered in the length scale of diffusivity correlation.

Direct current hopping conductance in one-dimensional diagonal disordered systems

Based on a tight-binding disordered model describing a single electron band, we establish a direct current （de） electronic hopping transport conductance model of one-dimensional diagonal disordered systems, and also derive a dc conductance formula. By calculating the dc conductivity, the relationships between electric field and conductivity and between temperature and conductivity are analysed, and the role played by the degree of disorder in electronic transport is studied. The results indicate the conductivity of systems decreasing with the increase of the degree of disorder, characteristics of negative differential dependence of resistance on temperature at, low temperatures in diagonal disordered systems, and the conductivity of systems decreasing with the increase of electric field, featuring the non-Ohm＇s law conductivity.

Three Lemmas on Dynamic Cavity Method

We study the dynamic cavity method for dilute kinetic Ising models with synchronous update rules. For the parallel update rule we find for fully asymmetric models that the dynamic cavity equations reduce to a Markovian dynamics of the (time-dependent) marginal probabilities. For the random sequential update rule, also an instantiation of a synchronous update rule, we find on the other hand that the dynamic cavity equations do not reduce to a Markovian dynamics, unless an additional assumption of time factorization is introduced. For symmetric models we show that a fixed point of ordinary Belief propagation is also a fixed point of the dynamic cavity equations in the time factorized approximation. For clarity, the conclusions of the paper are formulated as three lemmas.

Full counting statistics of phonon transport in disordered systems

The coherent potential approximation(CPA)within full counting statistics(FCS)formalism is shown to be a suitable method to investigate average electric conductance,shot noise as well as higher order cumulants in disordered systems.We develop a similar FCS-CPA formalism for phonon transport through disordered systems.As a byproduct,we derive relations among coefficients of different phonon current cumulants.We apply the FCS-CPA method to investigate phonon transport properties of graphene systems in the presence of disorders.For binary disorders as well as Anderson disorders,we calculate up to the 8-th phonon transmission moments and demonstrate that the numerical results of the FCS-CPA method agree very well with that of the brute force method.The benchmark shows that the FCS-CPA method achieves 20 times more speedup ratio.Collective features of phonon current cumulants are also revealed.