Comparative systems biology between human and animal models based on next-generation sequencing methods

Animal models provide myriad benefits to both experimental and clinical research. Unfortunately, in many situations, they fall short of expected results or provide contradictory results. In part, this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism. To improve the efficacy of animal models, a technological breakthrough is required. The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform. In the present study, we introduce the concept of the comparative systems biology, which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels". Furthermore, we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.

Comparative systems biology between human and animal models based on next-generation sequencing methods

Animal models provide myriad benefits to both experimental and clinical research.Unfortunately,in many situations,they fall short of expected results or provide contradictory results.In part,this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism.To improve the efficacy of animal models,a technological breakthrough is required.The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform.In the present study,we introduce the concept of the comparative systems biology,which we define as“comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels”.Furthermore,we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.

Construction and harmonious development of urban-rural com-paring fi nancial systems based on comparative advantages theory

There exist diferences between urban-rural financial systems,Generally,the development of unban financial industry has absolute advanages compared with rural financial industry.According to the Matthew Effect,the financial resources will flow into cities for higher benefit ,so rural areas are unable to obtain absolute advantages However,relative advantage theory of the comparative advantage theory of the comparative advantage theory provides an lmportant way to observe res[ectove advamtage of both city and country.Therefore,there are comparative advantages for the development of financial industry in both urban and rural areas.The respective comparative advantages of urban-rural financial systems will supply greater efficiency than that in current dual puttern condition.Closely connected with China＇s financial development and reform and the fact of recreation of urban-rural financial system,this paper tries to explain the comparative advantage of the urban-rural financial systems.The anaalysis of the comparative advantage between urban and rural finance is the clue for the bonndary between urban-rural financial systems.This paper analyzes the current situration of urban-rural financial system.Then it proposes some views and suggestions on how to develop and maintain these two systemw as well as how to promote their coordinative development.

The State of Sea Systems and Practices in East and Southern Africa

This paper develops a comparative overview of SEA in Kenya, Tanzania and South Africa regarding legal, institutional and procedural perspectives, in order to assess their effectiveness and unveil main constrains. It is clear from this brief review that SEA is a tool of environmental governance that is of growing importance in East and Southern Africa. With regards to the institutional and legal framework, both Kenya and Tanzania have formal provisions for SEA, but no specific legislation. The main constrains on SEA effectiveness are related to the lack of a clear mandate and institutional framework, guidelines for procedures and public participation. As this analysis and case studies from the three countries examined here reveal, Kenya, Tanzania, and South Africa have expanded their use of SEA as a preventive mechanism for environmental policy and to enhance the efficiency of strategic decisions. While each of these countries has made great strides in developing the SEA process and integrating it into their decision-making processes, much work remains to be done. Ongoing refinement to the SEA process, both within this region and elsewhere in the world, will mean that this important tool integrates sustainable environmental management principles and practices into policies, plans, and programmes and the decision-making process.