Investigation and Analysis of Lung Cancer Risk Factors in the Health Check-Up Population

Objective: To investigate and analyze the risk factors of lung cancer in the population of health checkups. Methods: A total of 500 cases of the health check-up population were selected for data study. Surveyed showed that 19 cases of lung cancer were grouped as the lung cancer group and the remaining 481 cases made up the control group, and the risk factors were analyzed. Results: Among men, there was a significant proportion of individuals aged 60-69 years old, and women aged 30-39 years old. Additionally, individuals aged 60 and above were at increased risk of developing lung cancer. The results of the multifactorial analysis were that the risk factors affecting the detection of lung cancer in healthy people were smoking history, family history of lung cancer, secondhand smoke, history of respiratory diseases, psychosomatic factors, living environment, and kitchen fumes. Conclusion: People over 60 years of age were prone to early lung cancer, followed by individuals aged 30-39 years. It is important to identify the risk factors of lung cancer to strengthen the screening of high-risk groups for early detection and treatment.

Analysis of the Prevalence Characteristics of Lung Nodules and Their Influencing Factors in The Health Check-Up Population

Objective: To study the prevalence characteristics of pulmonary nodules and their influencing factors in the health check-up population. Methods: A total of 500 cases of health checkups were selected for the data study to analyze the detection and prevalence characteristics of pulmonary nodules. The influencing factors between the pulmonary nodules group and the no pulmonary nodules group were analyzed. Results: A total of 209 cases were detected, of which there were more males than females, and for female patients, the detection rate increased with age (P < 0.05). The distribution of gender, age, smoking, respiratory symptoms, and exposure to kitchen fumes between the two groups was compared (P < 0.05). The multifactorial analysis concluded that risk factors include, respiratory symptoms, older age, exposure to kitchen fumes, and smoking. In addition, patients who exercised more had a lower risk of developing lung nodules. Conclusion: The detection rate of pulmonary nodules was high in the health check-up population and the influencing factors analyzed involved the presence of respiratory symptoms, older age, kitchen fume exposure, and smoking, while the positive influencing factor was increased exercise.

Systematic Review of Community Type 2 Diabetes Structured Health Education (CT2DSHE)

Aim: This paper aims to evaluate disparities of type 2 diabetes structured health education programmes that is utilised within the communities. Design: systematic review, (a type of secondary research design) aiming to summarize the results of prior primary research studies on available evidence Community type 2 diabetes structured education (CT2DSHE). Methods: Research question: Type 2 diabetic structured health education within a community how effective is it? Qualitative Systematic review, defined as a way to get reliable and objective picture of current available evidence on the specific topic—(CT2DSHE), (Denscombe, 2021) through reflexivity synthesis of available data as an example. This is valuable in time constraints such as project assignments that must be met within specific time and also to bring together available evidence together [1]. Results: This review has shown that CT2DSHE is effective with seven out of the eleven authors supporting, three authors against and one was neutral, further showed that knowledge and skills acquired can last longer with patient activation improved among T2DM patients ideal for sustaining their self-management of T2DM. Conclusion: This research provides suggestive answers to the research question: “Type 2 diabetic structured health education within a community how effective is it?”, This has demonstrated CT2DSHE effectiveness in knowledge acquisition and improving T2DM awareness among T2DM patients, whilst evidencing long effects beyond the study times of 3 - 9 months period in relation to patient activation. Also Identified diabetes education self-management on newly diagnosed (DESMOND) patient as CT2DSHE program for recommendation. Patient or Public Contribution: This work aspires to contribute to CT2DSHE in these areas;Influencing policy decision-making for community diabetes care within the UK and world at large., Contributing to already vast knowledge on diabetes self-management and reasons why?, Influencing educators on how CT2DSHEP are designed, delivered by putting the patient at the Centre and bringing different perspectives on CT2DSHEP in one place that is serving users time of having to consult several resources especially busy clinicians [2] [3].

金匮肾气丸联用cART对HIV-1感染者的疗效及不良反应分析

获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)的主要治疗方法为联合抗逆转录病毒治疗(combined antiretroviral therapy,cART),但部分患者由于免疫功能重建不全和不良反应,可能出现药物性肝损伤、消化功能下降、神经系统毒性和代谢紊乱等,严重影响了抗病毒疗效和患者生存质量,已成为AIDS治疗领域的瓶颈[1]。部分国家资助的中医药防治AIDS科研课题提出正虚(主要为肾虚)是AIDS发生发展的内在病理基础,以肾气与肾阴肾阳的功能下降为主要特征[2-3]。补肾制剂可能是缓解人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染患者病情和不良反应的可靠方式。金匮肾气丸是由地黄、山药、茯苓、牡丹皮、山茱萸、牛膝、泽泻等多味中药制成的综合制剂[4],具有温补肾阳、化气行水的作用。本研究首次采用金匮肾气丸与cART联用治疗HIV-1感染者,比较了金匮肾气丸与cART联用、单用cART对HIV-1感染者抗病毒疗效和不良反应的差异,试图为探索HIV-1感染者治疗的新途径提供参考。

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological mechanisms.Methods Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by ELISA.Results Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 expression.Similarly, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 levels.Conclusion This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

Examination of the Illness Representations among Children with T1DM in Relation to Mental Health Factors

The most common comorbid psychiatric disorders in children with type 1 diabetes mellitus(T1DM)are depression,anxiety and behavioral disorders.Patients with comorbid psychopathology are less capable of psychically adjusting to the new life situation resulting from T1DM,which may negatively affect glycemic control and adherence related to the treatment.We aimed to investigate the association between mental health and type 1 diabetes including illness representation.115 children and adolescents with T1DM were recruited through the outpatient clinic in Debrecen,Hungary.Measures:PRISM-D,Child Depression Inventory(CDI),Cantril Ladder and Self-Rated Health,Glycosylaeted haemoglobin(HbA1C)were measured.Children having depressive symptoms drew fewer circles with less area.Children not drawing any important relationships possessed more depressive symptoms.Those diagnosed at a younger age displayed smaller distance between the Self-and Illness-circles.The PRISM-D test can be a promising tool to analyse emotional and cognitive representations and the psychological burden of T1DM.

T淋巴细胞、免疫球蛋白水平联合预测重症肺炎患者院内死亡的价值

目的分析T淋巴细胞、免疫球蛋白水平联合预测重症肺炎患者院内死亡的价值。方法回顾性分析2021年5月—2022年5月在成都中医药大学附属医院接受治疗的80例重症肺炎患者的临床资料,依据患者入院后1个月的存活情况分为死亡组(26例)和存活组(54例)。比较两组基线资料,以及T淋巴细胞[白细胞分化抗原3(CD3^(+))、白细胞分化抗原4(CD4^(+))、白细胞分化抗原8(CD8^(+))]、免疫球蛋白[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]水平。绘制受试者工作特征(ROC)曲线分析入院时急性生理和慢性健康状况Ⅱ(APACHEⅡ)评分,以及T淋巴细胞、免疫球蛋白水平联合预测重症肺炎患者院内死亡的价值。采用多因素逐步Logistic回归分析重症肺炎患者院内死亡的危险因素。结果两组年龄、性别、体质量指数、合并症及呼吸频率比较,差异均无统计学意义(P>0.05)。死亡组APACHEⅡ评分高于存活组(P<0.05),CD3^(+)、CD4^(+)、CD8^(+)、IgA、IgM及IgG水平低于存活组(P<0.05)。ROC曲线分析结果显示,T淋巴细胞、免疫球蛋白水平联合检测重症肺炎患者院内死亡的敏感性为90.3%(95%CI:0.757,0.954),特异性为78.8%(95%CI:0.654,0.819),曲线下面积(AUC)为0.854(95%CI:0.678,0.912)。入院时APACHEⅡ评分检测重症肺炎患者院内死亡的敏感性为71.1%(95%CI:0.657,0.873),特异性为96.2%(95%CI:0.751,0.984),AUC为0.801(95%CI:0.707,0.894)。多因素逐步Logistic回归分析结果显示,入院时APACHEⅡ评分高[OR=1.536(95%CI:1.118,2.110)]、CD3^(+)[OR=1.797(95%CI:1.122,2.878)]、CD4^(+)[OR=1.751(95%CI:1.121,2.735)]、CD8^(+)[OR=1.886(95%CI:1.075,3.309)]、IgA[OR=1.967(95%CI:1.142,3.388)]、IgM[OR=1.945(95%CI:1.145,3.304)]及IgG[OR=2.132(95%CI:1.176,3.865)]均为重症肺炎患者院内死亡的影响因素(P<0.05)。结论入院时APACHEⅡ评分、T淋巴细胞及免疫球蛋白水平预测重症肺炎患者院内死亡的价值较高,且T淋巴细胞、免疫球蛋白水平联合预测时具有更高的敏感性,可有效提高检测效率,另入院时APACHEⅡ评分高、CD3^(+)、CD4^(+)、CD8^(+)、IgA、IgM及IgG均为重症肺炎患者院内死亡的影响因素,临床应结合以上指标对重症肺炎患者进行重点筛查,及时采取干预措施,降低病死率。

Lower Incidence of Positive Gynecological Cancers in Examinees of a Unique Health Check-Up Institute, Ningen Dock in Japan, 2011-2016

The present study aims to determine the gynecologic health status of asymptomatic women at a unique Japanese Health Check-up Institute, Ningen Dock. Medical records of Japanese women, who underwent gynecological medical (health) examinations between January 2011 and December 2016, were retrospectively reviewed. Of the cervical smears from 8927 women aged 18 - 85 years, 50 (0.6%) were classified as dysplastic and malignant changes: 18 of low-grade squamous intraepithelial lesion, 10 high-grade squamous intraepithelial lesion, 21 atypical squamous cells of undetermined significance and 1 cervical squamous cell carcinoma. No case of cervical adenocarcinoma was found. Ultrasonographic examination detected uterus enlargements and ovary tumors in 2.0% and 0.9% of cases, respectively. Most of participants (95.6%) revealed no gynecologic abnormalities. The present study based on the records of Ningen Dock, where asymptomatic participants undergo a medical examination at their own expense, showed very low incidence of abnormal cytologic and/or ultrasonographic findings.

Trends in age distribution of participants in a self-covered and a public expense-covered health check-up programs in Japan

Objective: In Japan, there are unique facilities (namely Ningen Dock) of health check-up, where asymptomatic participants undergo a medical examination at their own expense. The earlier occurrence of cervical cancer and the concern on screening prompted us compare to the age distribution in the self-covered system with that of free physical check-up programs at public expense. Methods: We analyzed medical records of Japanese women, who underwent gynecological examinations at self-covered expense and at public expense between for the periods 2002-2011 and 2005-2009, respectively, restricting examinee’s age group. Results: For self-covered system, approximately 80% of the overall examinee population was occupied with three age groups 30-39, 40-49 and 50-59. The participants was extremely fewer in the over 60 years age group accounting for 10%, compared to those for the public expense-covered system, the over 60 years age group being 25%. Participant under the age of 30 years seemed to increase in chronological order in both systems. Conclusion: The level of knowledge on sexually transmitted infections may contribute to screening promotion for the younger women, while the elderly over 60 years’ attitudes toward screening may be mainly related to social-economic status and/or public expense support.

基于模块化保健型老年T恤衫个性化定制研究

针对老年人对服装理疗保健的功能需求,以保健型老年T恤衫为研究对象,运用模块化设计理论,对保健型老年T恤衫的个性化定制进行研究。首先从老年顾客的需求出发,提出保健型老年T恤衫的理念。基于老年T恤衫常见款式特征,对保健型老年T恤衫进行模块划分,同时建立了2级模块库。然后对保健型老年T恤衫进行模块的合理划分和编码,确立了模块配置规则,并形成了一套模块化设计方案。最后通过用户实际体验,验证了该方案的合理性和可行性。研究发现该方案的提出对服装企业满足老年人市场需求,实现保健型老年T恤衫的个性化定制生产具有指导意义。

基于t-SSA-BP的煤矿噪声职业健康损害预测

为精准预测煤矿接噪人员职业健康损害情况,基于分位图法选取健康损害数据影响因素,依据噪声职业健康损害评估方法,以自适应t分布变异因子和麻雀搜索算法(SSA)作为参数优化算法,建立t-SSA-BP煤矿噪声职业健康损害预测模型,利用基准函数测试算法寻优性能,并以陕北地区10个煤矿为研究对象,采用现场调查、理论分析和Matlab仿真模拟方法验证煤矿噪声职业健康损害预测模型。结果表明:噪声暴露强度、个体年龄、接噪工龄和接噪岗位4个指标是煤矿噪声健康损害的影响因素;t-SSA较SSA在4种基准函数上整体精度提升660%,5种噪声健康损害神经网络预测模型预测精度从高到低依次为:t-SSA-BP>SSA-BP>PSO-BP>CFA-PSO-RBF>PSO-GRNN,t-SSA-BP预测模型的平均绝对误差(MAE)、平均绝对百分误差(MAPE)相比SSA-BP分别降低681%、667%,决定系数(R2)达0999,预测精度明显提升,且收敛速度更快。

Impact of Doctoral Student Training Process Fit on Doctoral Students’ Mental Health

Background:Doctoral students have much higher risk of anxiety or depression than general population.Doctoral students worldwide are facing varying degrees of mental health risks.Method:Based on the survey data of 6,812 doctoral students worldwide in Nature in 2019,Probit and Logit models are used to explore the correlation between thefit of doctoral education and training process and the mental health of doctoral students.Results:(1)The training environmentfit of doctoral students has a significant positive impact on their mental health.(2)The academic professionfit of doctoral students has a significant positive impact on their mental health.(3)The orga-nizational culturefit of doctoral students has a significant positive impact on their mental health.(4)Thefinancial supportfit of doctoral students has a significant positive impact on their mental health.Conclusion:The higher the degree of doctoral students’training environmentfit,academic professionfit,organizational culturefit,andfinancial supportfit,the lower the possibility of anxiety or depression among doctoral students.The current research results can help reveal extensive factors that affect the mental health of doctoral students,facilitate the planning and development of effective intervention measures by universities,improve thefit of the doctoral education and training process,improve the mental health of doctoral students,and boost academic excellence.

血液恶性肿瘤CAR-T治疗后患者报告结局的范围综述

目的 对血液恶性肿瘤嵌合抗原受体T细胞(CAR-T)治疗的急性、亚急性及长期随访期间患者报告结局研究进行范围综述,为临床早期判断和实施干预提供参考。方法 检索中英文数据库中血液恶性肿瘤CAR-T治疗后患者报告结局的相关研究,检索时限为建库至2023年3月20日。对纳入文献进行筛选及汇总分析。结果 共纳入16篇文献。现有研究共使用18种评价工具测量CAR-T治疗后患者报告结局,测量范围包括症状、功能性及心理状态评估。CAR-T治疗后急性期患者突出报告症状领域恶化;亚急性患者突出报告社会及角色功能的持续限制以及疲劳、疼痛、睡眠障碍症状;长期随访患者报告神经系统症状或焦虑、抑郁情绪。结论 不同时期CAR-T治疗患者报告结局存在差异,提示医护人员应长期监测。未来可开发CAR-T治疗血液恶性肿瘤患者特异性评价工具,利用电子化患者报告结局建立数字健康监测系统。

路径化密室逃脱教育在多发性骨髓瘤病人CAR-T治疗中的应用

目的:探究路径化密室逃脱教育在多发性骨髓瘤CAR-T治疗病人中的应用效果。方法:选取我院2019年1月—2022年1月收治的多发性骨髓瘤CAR-T治疗病人98例,按随机数字表法分为对照组和观察组,各49例。对照组采取常规健康教育,观察组在常规健康教育基础上增加路径化密室逃脱教育,比较两组病人疾病知识掌握程度、自我效能与生存质量。结果:观察组病人疾病知识掌握程度评分[(51.34±2.41)分]高于对照组[(40.56±2.35)分],差异有统计学意义(P<0.05);观察组病人自我效能水平评分[(32.45±4.18)分]高于对照组[(28.30±3.54)分],差异有统计学意义(P<0.05);观察组病人生存质量QLQ-C30量表4个功能领域评分均高于对照组,差异有统计学意义(P<0.05)。结论:路径化密室逃脱教育在多发性骨髓瘤CAR-T治疗病人中的应用能强化病人对疾病、自我保护知识的了解、掌握,可提升其自我效能水平,有助于改善生存质量。

心理干预对青光眼患者情绪和 T 细胞亚群的影响

目的:观察心理干预对青光眼患者焦虑情绪和外周血T 细胞亚群的影响。方法:将人选的60例青光眼住院病人随机分为心理干预组和对照组,两组病人给予常规降低眼压和青光眼手术治疗,干预组同时实施支持性心理干预和放松训练等心理治疗,观察治疗前后两组病人的焦虑情绪和外周血T 细胞亚群的变化情况。结果:干预组干预前后SAS 得分无显著差异,T 细胞亚群CD_4及CD_4/CD_8比值干预后较干预前上升(52.70±6.79vs48.72±6.87.t=2.739,P<0.01;1.69±0.33 vs1.50±0.36.t=2.470,P<0.05),CD_3值升高,CD_8值降低, 但无显著性差异。对照组手术后较手术前SAS 得分高(42.1±7.2vs39.0±5.9,t=-2.21,P<0.05),T 细胞亚群CD_3、CD_4及CD_4/CD_8比值手术后较手术前下降,CD_8值增高,但差异无显著性。手术后住院时间干预组7.5±3.8天, 对照组9.4±3.8天,明显少于对照组(t=1.96,P<0.05)。结论:心理干预可降低手术引起的青光眼患者情绪焦虑和提高外周血T 细胞亚群的功能,促进青光眼的好转。

复合材料T型接头损伤监测的概率成像方法

T型接头是复合材料典型的结构形式和重要的损伤监测部位,但其存在变厚度、内填充以及材料各向异性等复杂结构特性,导致依赖于信号传播速度的延迟-累加等基于压电传感器阵列和Lamb波的结构健康监测成像方法难以实现其损伤的准确监测。针对此问题,研究了一种与信号传播速度无关的损伤概率成像方法。该方法利用压电激励-传感网络通道的损伤因子,通过椭圆轨迹法确定各通道损伤因子的有效影响区域,然后对各通道损伤因子的椭圆影响区域合成进行成像,实现了复合材料T型接头损伤的准确监测,并使用超声C扫描进行了验证。实验结果表明,利用损伤因子可以在线监测复合材料T型接头的健康状态并实现损伤预警,在此基础上利用损伤概率成像方法可以实现损伤位置的判别。

正常人Tp-Te间期和Tp-Te/QT比率的研究

目的测定正常人标准心电图Tp-Te间期和Tp-Te/QT比率并探讨其临床意义。方法随机抽取100例正常人标准心电图,分别测量12个导联的Q-T间期、Q-Tp间期,按(Q-T间期)-(Q-Tp间期)的差值计算Tp-Te间期,按Tp-Te间期/Q-T间期计算其比率,并比较12个导联的测定值。结果 (1)Tp-Te/QT比率和Tp-Te间期均为V2最长(分别为0.24±0.04,93.20±16.07ms),avL最短(分别为0.16±0.03,58.06±13.70ms)。(2)Tp-Te间期在Ⅱ、Ⅲ、avR、V2～V6导联男性比女性长(P<0.05);Tp-Te/QT比率在Ⅱ、Ⅲ、avR、avF、V2～V6导联也是男性比女性长(P<0.05)。(3)全体V2导联Tp-Te间期和Tp-Te/QT比率的95%可信区间分别为(90.01,96.39)(ms)和(0.23,0.25)(ms)。男女V2导联Tp-Te间期的95%可信区间分别为(93.67,103.07)(ms)和(85.13,93.46)(ms)。男女V2导联Tp-Te/QT比率的95%可信区间分别为(0.24,0.26)(ms)和(0.21,0.24)(ms)。结论提供正常人Tp-Te间期值和Tp-Te/QT比率可供临床参考。

健康足月分娩母亲与新生儿T细胞亚群和NK细胞水平

目的:探讨健康足月分娩母亲、新生儿T细胞亚群、NK细胞的水平,为围产期母亲及新生儿系统保健提供基础免疫数据。方法:无菌采集健康足月分娩母亲静脉血、肝素抗凝、出生5min新生儿脐静脉及3天新生儿股静脉血、肝素抗凝。由美国RD有限公司提供试剂,采用间接免疫荧光技术和S.P法测定T细胞亚群及NK细胞的水平。结果:①健康足月分娩出生5min及3天新生儿与母亲的T细胞亚群、NK细胞水平差异均无显著性(P>0.05)。②出生3天新生儿CD4与正常参考值比较差异有显著性(P<0.02);出生5min新生儿CD3、CD4/CD8及母亲的CD3、CD4、CD4/CD8与正常参考值比较差异均有非常显著性(P<0.01)。③出生5min新生儿NKCD16、NKCD57,出生3天新生儿及母亲的NKCD16与正常参考值比较差异均有非常显著性(P<0.01)。结论:明确了深圳健康足月分娩母亲、新生儿T细胞亚群、NK细胞表达水平;为围产期的母亲、新生儿系统保健提供基础免疫数据。

大剂量多抗甲素对急性白血病患者T细胞亚群及健康状况的影响

目的 探讨大剂量多抗甲素对急性白血病患者免疫功能及健康状况的影响。方法 分组为化疗加多抗甲素组 (用药组 )和单纯化疗组 (对照组 ) ,用药组于化疗同时每日静脉滴注多抗甲素 30mg ,连续 1 4～ 2 1d后检测T淋巴细胞亚群及患者健康状况的变化。结果 用药组化疗后CD3、CD4和CD56阳性百分率及CD4/CD8比值均明显高于本组化疗前和对照组化疗后水平。用药组患者的健康状况也比本组化疗前和对照组化疗后的健康状况好。

动态监测脓毒症患者辅助性T淋巴细胞亚群变化及其临床意义

目的通过监测脓毒症患者外周静脉血中辅助性T淋巴细胞(Th)亚群的动态变化,评价患者的免疫状态及其与疾病的严重程度和预后的关系。方法在患者被诊断为脓毒症后的第1、4、7、14、28天或出重症监护病房(ICU)及死亡前(将第28天或出ICU或死亡前作为最后一次)抽取外周静脉血,应用流式细胞仪检测细胞表面分子标记为CD3+和CD8-的T淋巴细胞中的白细胞介素(IL)-4和干扰素(IFN)-γ的含量,计算Th1、Th2百分率和Th1/Th2比值,判断外周血中的Th1/Th2漂移现象,并记录当天的急性生理和慢性健康状况评分Ⅱ(APACHEⅡ评分)。结果根据2011年美国危重病学会/欧洲危重病医学会/美国胸科医师协会/美国胸科协会/美国外科学会联席会议提出的脓毒症和重度脓毒症的诊断标准,本组22例患者中,脓毒症组9例,重度脓毒症组13例。重度脓毒症组总体的Th1百分率、Th1/Th2比值分别为(8.5±6.8)%、0.7±0.3,显著低于脓毒症组的(14.9±2.7)%、1.9±0.5(P值均<0.01);Th2百分率为(20.1±13.0)%,显著高于脓毒症组的(8.1±5.9)%(P<0.01)。APACHEⅡ评分与Th1百分率(r=-0.458,P<0.01)、Th1/Th2比值(r=-0.439,P<0.01)呈负相关。重度脓毒症组患者入院第4天起Th1百分率及Th1/Th2比值随时间迁延呈下降趋势,Th2百分率呈上升趋势,与脓毒症组间的差异有统计学意义(P值均<0.01)。结论重度脓毒症患者存在明显的Th1/Th2漂移现象。