Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ...Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.展开更多
The authors use data from fight logs during the 2016-2017 regular National Hockey League (NHL) season to test for a difference in the proportion of games with and without fights for each of the thirty NHL teams. Only ...The authors use data from fight logs during the 2016-2017 regular National Hockey League (NHL) season to test for a difference in the proportion of games with and without fights for each of the thirty NHL teams. Only one team (Toronto Maple Leafs) was more likely to be involved in a fight at a home game than at an away game. Teams that fought proportionally more often in the second half of the season made the playoffs;teams that fought significantly less often did not. And, long distance air travel (flights involving more than 1000 miles or trips that required crossing at least one time zone) resulted in disproportionately more games with fights for eight different NHL teams.展开更多
Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confi...Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confidence interval for a binomial proportion,the sample may contain no successes.Such a scenario could be encountered when attempting to estimate the incidence of an extremely rare side effect associated with the administration of a newly developed drug.In this article,we use examples for our experiences working with scientific investigators and describe several scenarios in which there appeared to be no useful data,or data of only limited usefulness.We describe the methods we prefer for analyzing the data in these situations and illustrate their application using the actual data from the investigations we participated in.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82071426,81873784Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(all to DF)。
文摘Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.
文摘The authors use data from fight logs during the 2016-2017 regular National Hockey League (NHL) season to test for a difference in the proportion of games with and without fights for each of the thirty NHL teams. Only one team (Toronto Maple Leafs) was more likely to be involved in a fight at a home game than at an away game. Teams that fought proportionally more often in the second half of the season made the playoffs;teams that fought significantly less often did not. And, long distance air travel (flights involving more than 1000 miles or trips that required crossing at least one time zone) resulted in disproportionately more games with fights for eight different NHL teams.
文摘Applied statisticians are often confronted with statistical inference problems dealing with situations in which there appear to be no data,or data of only limited usefulness.For example,when attempting to find a confidence interval for a binomial proportion,the sample may contain no successes.Such a scenario could be encountered when attempting to estimate the incidence of an extremely rare side effect associated with the administration of a newly developed drug.In this article,we use examples for our experiences working with scientific investigators and describe several scenarios in which there appeared to be no useful data,or data of only limited usefulness.We describe the methods we prefer for analyzing the data in these situations and illustrate their application using the actual data from the investigations we participated in.
