The latest Association Fran?aise pour l'Etude du Foie-French Association for Study of the Liver(AFEF) and European Association for the Study of the Liver(EASL) recommendations announce a change of paradigm, for th...The latest Association Fran?aise pour l'Etude du Foie-French Association for Study of the Liver(AFEF) and European Association for the Study of the Liver(EASL) recommendations announce a change of paradigm, for the management of patients infected with hepatitis C virus(HCV). The AFEF recommendations focus on the elimination of HCV infection on a national level by preventing reinfection, in less than ten years. This goal involves the facilitation of patients' management in a simplified pathway by increasing screening procedures and access to pangenotypic treatments mainly in the "reservoir" population of people who inject drugs and migrants. Even in the complex pathway of patients with previous comorbidities, AFEF takes the option of a therapeutic simplification. The EASL guidelines position themselves on the state of the art with a precise description of all therapeutic options available, without separating simplified and complex pathways even if they take into account the epidemiological evolution of difficult-to-treat populations.展开更多
Hepatitis C virus(HCV)/human immunodeficiency virus(HIV)co-infection still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,according to World Health Organization.People living wit...Hepatitis C virus(HCV)/human immunodeficiency virus(HIV)co-infection still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,according to World Health Organization.People living with HIV(PLWH)are six times greater affected by HCV,compared to HIV negative ones;the greater prevalence is encountered among people who inject drugs and men who have sex with men:the risk of HCV transmission through sexual contact in this setting can be increased by HIV infection.These patients experience a high rate of chronic hepatitis,which if left untreated progresses to end-stage liver disease and hepato-cellular carcinoma(HCC)HIV infection increases the risk of mother to child vertical transmission of HCV.No vaccination against both infections is still available.There is an interplay between HIV and HCV infections.Treatment of HCV is nowadays based on direct acting antivirals(DAAs),HCV treatment plays a key role in limiting the progression of liver disease and reducing the risk of HCC development in mono-and coinfected individuals,especially when used at an early stage of fibrosis,reducing liver disease mortality and morbidity.Since the sustained virological response at week 12 rates were observed in PLWH after HCV eradication,the AASLD has revised its simplified HCV treatment algorithm to also include individuals living with HIV.HCV eradication can determine dyslipidemia,since HCV promotes changes in serum lipid profiles and may influence lipid metabolism.In addition to these apparent detrimental effects on the lipid profile,the efficacy of DAA in HCV/HIV patients needs to be considered in light of its effects on glucose metabolism mediated by improvements in liver function.The aim of the present editorial is to describe the advancement in HCV treatment among PLWH.展开更多
Due to the pressure gain combustion characteristics,the rotating detonation combustor(RDC)can enhance thermodynamic cycle efficiency.Therefore,the performance of gas-turbine engine can be further improved with this co...Due to the pressure gain combustion characteristics,the rotating detonation combustor(RDC)can enhance thermodynamic cycle efficiency.Therefore,the performance of gas-turbine engine can be further improved with this combustion technology.In the present study,the RDC operation performance with a turbine guide vane(TGV)is experimentally investigated.Hydrogen and air are used as propellants while hydrogen and air mass flow rate are about 16.1 g/s and 500 g/s and the equivalence ratio is about 1.0.A pre-detonator is used to ignite the mixture.High-frequency dynamic pressure transducers and silicon pressure sensors are employed to measure pressure oscillations and static pressure in the combustion chamber.The experimental results show that the steady propagation of rotating detonation wave(RDW)is observed in the combustion chamber and the mean propagation velocity is above 1650 m/s,reaching over 84%of theoretical Chapman-Jouguet detonation velocity.Clockwise and counterclockwise propagation directions of RDW are obtained.For clockwise propagation direction,the static pressure is about 15%higher in the combustor compared with counterclockwise propagation direction,but the RDW dominant frequency is lower.When the oblique shock wave propagates across the TGV,the pressure oscillations reduces significantly.In addition,as the detonation products flow through the TGV,the static pressure drops up to 32%and 43%for clockwise and counterclockwise propagation process respectively.展开更多
Effective technology for wind direction forecasting can be realized using the recent advances in machine learning.Consequently,the stability and safety of power systems are expected to be significantly improved.Howeve...Effective technology for wind direction forecasting can be realized using the recent advances in machine learning.Consequently,the stability and safety of power systems are expected to be significantly improved.However,the unstable and unpredictable qualities of the wind predict the wind direction a challenging problem.This paper proposes a practical forecasting approach based on the weighted ensemble of machine learning models.This weighted ensemble is optimized using a whale optimization algorithm guided by particle swarm optimization(PSO-Guided WOA).The proposed optimized weighted ensemble predicts the wind direction given a set of input features.The conducted experiments employed the wind power forecasting dataset,freely available on Kaggle and developed to predict the regular power generation at seven wind farms over forty-eight hours.The recorded results of the conducted experiments emphasize the effectiveness of the proposed ensemble in achieving accurate predictions of the wind direction.In addition,a comparison is established between the proposed optimized ensemble and other competing optimized ensembles to prove its superiority.Moreover,statistical analysis using one-way analysis of variance(ANOVA)and Wilcoxon’s rank-sum are provided based on the recorded results to confirm the excellent accuracy achieved by the proposed optimized weighted ensemble.展开更多
The equivalent refractive index(ERI) method is employed to analyze the function of the strip waveguide directional coupling modulator(SWM). Through deducing the diagnostic equation of the Exmn mode of the four-lay...The equivalent refractive index(ERI) method is employed to analyze the function of the strip waveguide directional coupling modulator(SWM). Through deducing the diagnostic equation of the Exmn mode of the four-layer media film waveguide equivalent to the SWM,the transmission constant of the symmetrical mode of the positive phase and negative one and the coupling length of powerful transference are obtained. The veracity of ERI is validated with the example of Ex11 basal mode under conditions of comparing the three results of ERI,EIM and Marcatili.展开更多
在静态栅格地图中,针对传统蚁群算法进行AGV(Automated Guided Vehicle,自动引导车)路径规划收敛慢且搜索结果容易陷入局部最优的问题,提出一种融合跳点搜索(Jump Point Search,JPS)和双向并行蚁群搜索的改进算法.首先,对实际研究环境...在静态栅格地图中,针对传统蚁群算法进行AGV(Automated Guided Vehicle,自动引导车)路径规划收敛慢且搜索结果容易陷入局部最优的问题,提出一种融合跳点搜索(Jump Point Search,JPS)和双向并行蚁群搜索的改进算法.首先,对实际研究环境进行栅格化建模,使用改进的跳点搜索算法生成双向搜索的初始次优路径,为双向蚁群搜索提供初始搜索方向参考.其次,在双向并行蚁群搜索过程中采用改进的转移概率启发函数,该函数在确定下一个转移节点时考虑了避免AGV与障碍物碰撞的因素,同时通过设计信息素共享机制并结合改进的信息素增量及浓度两种融合模型,共享和更新全局信息素浓度,以更好地探索和优化路径,保证双向路径连结.最后,与传统蚁群算法进行实验结果对比,验证了改进算法的全局搜索能力、效率和安全性.展开更多
文摘The latest Association Fran?aise pour l'Etude du Foie-French Association for Study of the Liver(AFEF) and European Association for the Study of the Liver(EASL) recommendations announce a change of paradigm, for the management of patients infected with hepatitis C virus(HCV). The AFEF recommendations focus on the elimination of HCV infection on a national level by preventing reinfection, in less than ten years. This goal involves the facilitation of patients' management in a simplified pathway by increasing screening procedures and access to pangenotypic treatments mainly in the "reservoir" population of people who inject drugs and migrants. Even in the complex pathway of patients with previous comorbidities, AFEF takes the option of a therapeutic simplification. The EASL guidelines position themselves on the state of the art with a precise description of all therapeutic options available, without separating simplified and complex pathways even if they take into account the epidemiological evolution of difficult-to-treat populations.
文摘Hepatitis C virus(HCV)/human immunodeficiency virus(HIV)co-infection still involves 2.3 million patients worldwide of the estimated 37.7 million living with HIV,according to World Health Organization.People living with HIV(PLWH)are six times greater affected by HCV,compared to HIV negative ones;the greater prevalence is encountered among people who inject drugs and men who have sex with men:the risk of HCV transmission through sexual contact in this setting can be increased by HIV infection.These patients experience a high rate of chronic hepatitis,which if left untreated progresses to end-stage liver disease and hepato-cellular carcinoma(HCC)HIV infection increases the risk of mother to child vertical transmission of HCV.No vaccination against both infections is still available.There is an interplay between HIV and HCV infections.Treatment of HCV is nowadays based on direct acting antivirals(DAAs),HCV treatment plays a key role in limiting the progression of liver disease and reducing the risk of HCC development in mono-and coinfected individuals,especially when used at an early stage of fibrosis,reducing liver disease mortality and morbidity.Since the sustained virological response at week 12 rates were observed in PLWH after HCV eradication,the AASLD has revised its simplified HCV treatment algorithm to also include individuals living with HIV.HCV eradication can determine dyslipidemia,since HCV promotes changes in serum lipid profiles and may influence lipid metabolism.In addition to these apparent detrimental effects on the lipid profile,the efficacy of DAA in HCV/HIV patients needs to be considered in light of its effects on glucose metabolism mediated by improvements in liver function.The aim of the present editorial is to describe the advancement in HCV treatment among PLWH.
基金the National Natural Science Foundation of China(No.11702143 and 11802137)the Fundamental Research Funds for the Central Universities(No.30918011343 and 30919011259).
文摘Due to the pressure gain combustion characteristics,the rotating detonation combustor(RDC)can enhance thermodynamic cycle efficiency.Therefore,the performance of gas-turbine engine can be further improved with this combustion technology.In the present study,the RDC operation performance with a turbine guide vane(TGV)is experimentally investigated.Hydrogen and air are used as propellants while hydrogen and air mass flow rate are about 16.1 g/s and 500 g/s and the equivalence ratio is about 1.0.A pre-detonator is used to ignite the mixture.High-frequency dynamic pressure transducers and silicon pressure sensors are employed to measure pressure oscillations and static pressure in the combustion chamber.The experimental results show that the steady propagation of rotating detonation wave(RDW)is observed in the combustion chamber and the mean propagation velocity is above 1650 m/s,reaching over 84%of theoretical Chapman-Jouguet detonation velocity.Clockwise and counterclockwise propagation directions of RDW are obtained.For clockwise propagation direction,the static pressure is about 15%higher in the combustor compared with counterclockwise propagation direction,but the RDW dominant frequency is lower.When the oblique shock wave propagates across the TGV,the pressure oscillations reduces significantly.In addition,as the detonation products flow through the TGV,the static pressure drops up to 32%and 43%for clockwise and counterclockwise propagation process respectively.
文摘Effective technology for wind direction forecasting can be realized using the recent advances in machine learning.Consequently,the stability and safety of power systems are expected to be significantly improved.However,the unstable and unpredictable qualities of the wind predict the wind direction a challenging problem.This paper proposes a practical forecasting approach based on the weighted ensemble of machine learning models.This weighted ensemble is optimized using a whale optimization algorithm guided by particle swarm optimization(PSO-Guided WOA).The proposed optimized weighted ensemble predicts the wind direction given a set of input features.The conducted experiments employed the wind power forecasting dataset,freely available on Kaggle and developed to predict the regular power generation at seven wind farms over forty-eight hours.The recorded results of the conducted experiments emphasize the effectiveness of the proposed ensemble in achieving accurate predictions of the wind direction.In addition,a comparison is established between the proposed optimized ensemble and other competing optimized ensembles to prove its superiority.Moreover,statistical analysis using one-way analysis of variance(ANOVA)and Wilcoxon’s rank-sum are provided based on the recorded results to confirm the excellent accuracy achieved by the proposed optimized weighted ensemble.
文摘The equivalent refractive index(ERI) method is employed to analyze the function of the strip waveguide directional coupling modulator(SWM). Through deducing the diagnostic equation of the Exmn mode of the four-layer media film waveguide equivalent to the SWM,the transmission constant of the symmetrical mode of the positive phase and negative one and the coupling length of powerful transference are obtained. The veracity of ERI is validated with the example of Ex11 basal mode under conditions of comparing the three results of ERI,EIM and Marcatili.
文摘在静态栅格地图中,针对传统蚁群算法进行AGV(Automated Guided Vehicle,自动引导车)路径规划收敛慢且搜索结果容易陷入局部最优的问题,提出一种融合跳点搜索(Jump Point Search,JPS)和双向并行蚁群搜索的改进算法.首先,对实际研究环境进行栅格化建模,使用改进的跳点搜索算法生成双向搜索的初始次优路径,为双向蚁群搜索提供初始搜索方向参考.其次,在双向并行蚁群搜索过程中采用改进的转移概率启发函数,该函数在确定下一个转移节点时考虑了避免AGV与障碍物碰撞的因素,同时通过设计信息素共享机制并结合改进的信息素增量及浓度两种融合模型,共享和更新全局信息素浓度,以更好地探索和优化路径,保证双向路径连结.最后,与传统蚁群算法进行实验结果对比,验证了改进算法的全局搜索能力、效率和安全性.