Interaction between high-intensity pulsed ion beam （HIPIB） and a double-layer target with titanium film on top of aluminum substrate was simulated. The two-dimensional nonlinear thermal conduction equations, with th...Interaction between high-intensity pulsed ion beam （HIPIB） and a double-layer target with titanium film on top of aluminum substrate was simulated. The two-dimensional nonlinear thermal conduction equations, with the deposited energy in the target taken as source term, were derived and solved by finite differential method. As a result, the two-dimensional spatial and temporal evolution profiles of temperature were obtained for a titanium/aluminum double-layer target irradiated by a pulse of HIPIB. The effects of ion beam current density on the phase state of the target materials near the film and substrate interface were analyzed. Both titanium and aluminum were melted near the interface after a shot when the ion beam current density fell in the range of 100 A/cm2 to 200 A/cm2.展开更多
In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of ...In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system(LDH/HA-PEG/5-FU)was conceived and manufactured by the adsorption of PEGylated hyaluronic acid(HA-PEG)on the surface of layered double hydroxide(LDH, prepared via hydrothermal method)and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5-FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of p Hdegradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed p H-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.展开更多
The complex operating environment in substations, with different safety distances for live equipment, is a typical high-risk working area, and it is crucial to accurately identify the type of live equipment during aut...The complex operating environment in substations, with different safety distances for live equipment, is a typical high-risk working area, and it is crucial to accurately identify the type of live equipment during automated operations. This paper investigates the detection of live equipment under complex backgrounds and noise disturbances, designs a method for expanding lightweight disturbance data by fitting Gaussian stretched positional information with recurrent neural networks and iterative optimization, and proposes an intelligent detection method for MD-Yolov7 substation environmental targets based on fused multilayer feature fusion (MLFF) and detection transformer (DETR). Subsequently, to verify the performance of the proposed method, an experimental test platform was built to carry out performance validation experiments. The results show that the proposed method has significantly improved the performance of the detection accuracy of live devices compared to the pairwise comparison algorithm, with an average mean accuracy (mAP) of 99.2%, which verifies the feasibility and accuracy of the proposed method and has a high application value.展开更多
基金supported by National Natural Science Foundation of China (No.10975026)
文摘Interaction between high-intensity pulsed ion beam （HIPIB） and a double-layer target with titanium film on top of aluminum substrate was simulated. The two-dimensional nonlinear thermal conduction equations, with the deposited energy in the target taken as source term, were derived and solved by finite differential method. As a result, the two-dimensional spatial and temporal evolution profiles of temperature were obtained for a titanium/aluminum double-layer target irradiated by a pulse of HIPIB. The effects of ion beam current density on the phase state of the target materials near the film and substrate interface were analyzed. Both titanium and aluminum were melted near the interface after a shot when the ion beam current density fell in the range of 100 A/cm2 to 200 A/cm2.
基金Supported by the National Natural Science Foundation of China(No.81371667,No.31271073)
文摘In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system(LDH/HA-PEG/5-FU)was conceived and manufactured by the adsorption of PEGylated hyaluronic acid(HA-PEG)on the surface of layered double hydroxide(LDH, prepared via hydrothermal method)and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5-FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of p Hdegradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed p H-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.
文摘The complex operating environment in substations, with different safety distances for live equipment, is a typical high-risk working area, and it is crucial to accurately identify the type of live equipment during automated operations. This paper investigates the detection of live equipment under complex backgrounds and noise disturbances, designs a method for expanding lightweight disturbance data by fitting Gaussian stretched positional information with recurrent neural networks and iterative optimization, and proposes an intelligent detection method for MD-Yolov7 substation environmental targets based on fused multilayer feature fusion (MLFF) and detection transformer (DETR). Subsequently, to verify the performance of the proposed method, an experimental test platform was built to carry out performance validation experiments. The results show that the proposed method has significantly improved the performance of the detection accuracy of live devices compared to the pairwise comparison algorithm, with an average mean accuracy (mAP) of 99.2%, which verifies the feasibility and accuracy of the proposed method and has a high application value.
