We developed poly lactic-co-glycolic acid（PLGA） microspheres loaded with cefquinome and tested their effectiveness in a mouse model. The microspheres were prepared by optimizing several key parameters such as PLGA m...We developed poly lactic-co-glycolic acid（PLGA） microspheres loaded with cefquinome and tested their effectiveness in a mouse model. The microspheres were prepared by optimizing several key parameters such as PLGA molecular weight, drug/polymer ratio, internal water volume and ethyl acetate. Drug loading efficiency, stability, in vitro release and tissue distribution in mouse were evaluated. The average particle size of the microspheres was 27.84 μm. The drug loading efficiency was 64.57%. The in vitro release of cefquinome from microspheres after 4 h was about 40% compared with over 90% for the drug alone. The concentration of cefquinome in lung reached 25 μg/g 0.25 h after injection, and kept at 10 μg/g 4 h after injection. However, the concentration of cefquinome was very low in other organs even 0.25 h after injection. In conclusion, Cefquinome-loaded PLGA microspheres are compatible as an effective lung-targeting drug delivery system and have a good sustained release efficacy.展开更多
Projectile size effect is of great importance since the scaling researches are extensively applied to concrete penetration investigations. This paper numerically deals with the projectile size effect on penetration re...Projectile size effect is of great importance since the scaling researches are extensively applied to concrete penetration investigations. This paper numerically deals with the projectile size effect on penetration resistance via the recently developed Lattice Discrete Particles Model(LDPM) which is featured with mesoscale constitutive laws governing the interaction between adjacent particles to account for cohesive fracture, strain hardening in compression and compaction due to pore collapse. Simulations of two different penetration tests are carried to shed some light on the size effect issue. The penetration numerical model is validated by matching the projectile deceleration curve of and predicting the depth of penetration(DOP). By constant velocity penetration simulations, the target resistance is found to be dependent on the projectile size. By best fitting numerical results of constant velocity penetration, a size effect law for target resistance is proposed and validated against literature data. Moreover, the size effect is numerically obtained in the projectile with longer extended nose part meanwhile the shorter extended nose is found to improve the DOP since the projectile nose is sharpened.展开更多
The reasonable marketing orientation is related to the survival and the development of the enterprises. According to the disadvantages and superiority of the middle and small sized enterprises of our country, this pap...The reasonable marketing orientation is related to the survival and the development of the enterprises. According to the disadvantages and superiority of the middle and small sized enterprises of our country, this paper analyzes the new thought about the marketing orientation from the aspects of marketing product orientation, marketing way orientation, marketing target orientation, marketing strategy orientation and marketing idea orientation. It has great theoretical and practical significance.展开更多
In the past years, bistatic Radar Cross Section (RCS) characteristic has been caught increasing attention. The paper presents a bistatic RCS measurement system of full-size goals, which uses photoelectric conversion t...In the past years, bistatic Radar Cross Section (RCS) characteristic has been caught increasing attention. The paper presents a bistatic RCS measurement system of full-size goals, which uses photoelectric conversion technology to solve the problem that excessive electrical signal attenuation exits because of the large distance between sending and receiving antenna. The paper analyzes the basic principle of photoelectric conversion and RCS measurement system, applies photoelectric conversion technology to RCS measurement system, and tests whether RCS measurement system works well while using photoelectric conversion technology. The test results show that the system can efficiently obtain the bistatic RCS characteristic of full-size targets.展开更多
为了在水声测试过程中提供尺寸小、成本低、应用灵活、低频和高目标强度的目标模拟器,文中根据水中气泡群具有强散射这一特性,提出了一种面向主动声呐试验的气泡群模拟器设计方法。基于等效介质理论(Effective Medium Theory,EMT)建立...为了在水声测试过程中提供尺寸小、成本低、应用灵活、低频和高目标强度的目标模拟器,文中根据水中气泡群具有强散射这一特性,提出了一种面向主动声呐试验的气泡群模拟器设计方法。基于等效介质理论(Effective Medium Theory,EMT)建立了气泡群声散射模型。首先将气泡群划分成立方体网格,然后应用图像处理方法获取立方体网格内气泡群的尺寸分布函数,接着使用EMT计算了每个立方体网格中的声反射系数和声波入射到立方体网格中产生的衰减,最后利用声波叠加原理计算了模拟器的反向散射目标强度。不同参数下的数值分析结果表明,气泡群尺寸分布函数呈伽马分布时,目标强度较高;目标强度随着尺寸分布区间减小和孔隙率增大而变大;共振频率随孔隙率增大而降低。结合气泡群孔隙率分布模型,文中给出了一组在低频时具有较高目标强度的小尺寸模拟器设计参数,可供相关设计者参考。展开更多
基金Funded by the national key research and development plan(No.2016YFD0501309)the National Natural Science Foundation of China(31402256)the High-level Talent Research Foundation of Qingdao Agricultural University,China(631206)
文摘We developed poly lactic-co-glycolic acid（PLGA） microspheres loaded with cefquinome and tested their effectiveness in a mouse model. The microspheres were prepared by optimizing several key parameters such as PLGA molecular weight, drug/polymer ratio, internal water volume and ethyl acetate. Drug loading efficiency, stability, in vitro release and tissue distribution in mouse were evaluated. The average particle size of the microspheres was 27.84 μm. The drug loading efficiency was 64.57%. The in vitro release of cefquinome from microspheres after 4 h was about 40% compared with over 90% for the drug alone. The concentration of cefquinome in lung reached 25 μg/g 0.25 h after injection, and kept at 10 μg/g 4 h after injection. However, the concentration of cefquinome was very low in other organs even 0.25 h after injection. In conclusion, Cefquinome-loaded PLGA microspheres are compatible as an effective lung-targeting drug delivery system and have a good sustained release efficacy.
基金supported by the Natural Science Foundation of Jiangsu Province (No. BK20170824)the Fundamental Research Funds for the Central Universities (No. 30917011343)
文摘Projectile size effect is of great importance since the scaling researches are extensively applied to concrete penetration investigations. This paper numerically deals with the projectile size effect on penetration resistance via the recently developed Lattice Discrete Particles Model(LDPM) which is featured with mesoscale constitutive laws governing the interaction between adjacent particles to account for cohesive fracture, strain hardening in compression and compaction due to pore collapse. Simulations of two different penetration tests are carried to shed some light on the size effect issue. The penetration numerical model is validated by matching the projectile deceleration curve of and predicting the depth of penetration(DOP). By constant velocity penetration simulations, the target resistance is found to be dependent on the projectile size. By best fitting numerical results of constant velocity penetration, a size effect law for target resistance is proposed and validated against literature data. Moreover, the size effect is numerically obtained in the projectile with longer extended nose part meanwhile the shorter extended nose is found to improve the DOP since the projectile nose is sharpened.
文摘The reasonable marketing orientation is related to the survival and the development of the enterprises. According to the disadvantages and superiority of the middle and small sized enterprises of our country, this paper analyzes the new thought about the marketing orientation from the aspects of marketing product orientation, marketing way orientation, marketing target orientation, marketing strategy orientation and marketing idea orientation. It has great theoretical and practical significance.
文摘In the past years, bistatic Radar Cross Section (RCS) characteristic has been caught increasing attention. The paper presents a bistatic RCS measurement system of full-size goals, which uses photoelectric conversion technology to solve the problem that excessive electrical signal attenuation exits because of the large distance between sending and receiving antenna. The paper analyzes the basic principle of photoelectric conversion and RCS measurement system, applies photoelectric conversion technology to RCS measurement system, and tests whether RCS measurement system works well while using photoelectric conversion technology. The test results show that the system can efficiently obtain the bistatic RCS characteristic of full-size targets.
文摘为了在水声测试过程中提供尺寸小、成本低、应用灵活、低频和高目标强度的目标模拟器,文中根据水中气泡群具有强散射这一特性,提出了一种面向主动声呐试验的气泡群模拟器设计方法。基于等效介质理论(Effective Medium Theory,EMT)建立了气泡群声散射模型。首先将气泡群划分成立方体网格,然后应用图像处理方法获取立方体网格内气泡群的尺寸分布函数,接着使用EMT计算了每个立方体网格中的声反射系数和声波入射到立方体网格中产生的衰减,最后利用声波叠加原理计算了模拟器的反向散射目标强度。不同参数下的数值分析结果表明,气泡群尺寸分布函数呈伽马分布时,目标强度较高;目标强度随着尺寸分布区间减小和孔隙率增大而变大;共振频率随孔隙率增大而降低。结合气泡群孔隙率分布模型,文中给出了一组在低频时具有较高目标强度的小尺寸模拟器设计参数,可供相关设计者参考。
