To investigate the effect of a reagent's rotational and vibrational excitations on the stereo-dynamics of the reaction product, the title reaction is theoretically simulated using the quasi-classical trajectory (QCT...To investigate the effect of a reagent's rotational and vibrational excitations on the stereo-dynamics of the reaction product, the title reaction is theoretically simulated using the quasi-classical trajectory (QCT) method on the 3A~ and 3Aq potentiM energy surfaces (PESs). The reaction cross section is considered as the only scalar property in this work at four different collision energies. Furthermore the vector properties including two polarization-dependent differential cross sections (PDDCSs), the angular distributions of product' rotational momentum are discussed at one fixed collision energy. Effects of reagents' rotational excitation on the reaction do exist regularly.展开更多
A new method for speeding up the state augment operations involved in the compressed extended Kalman filter-based simultaneous localization and mapping (CEKF-SLAM) algorithm was proposed. State augment usually requi...A new method for speeding up the state augment operations involved in the compressed extended Kalman filter-based simultaneous localization and mapping (CEKF-SLAM) algorithm was proposed. State augment usually requires a fully-updated state eovariance so as to append the information of newly observed landmarks, thus computational volume increases quadratically with the number of landmarks in the whole map. It was proved that state augment can also be achieved by augmenting just one auxiliary coefficient ma- trix. This method can yield identical estimation results as those using EKF-SLAM algorithm, and computa- tional amount grows only linearly with number of increased landmarks in the local map. The efficiency of this quick state augment for CEKF-SLAM algorithm has been validated by a sophisticated simulation project.展开更多
The ductility map of 304HC stainless was determined by using the Gleeble-1500 dynamic thermal-mechanical simulator. The effect of Cu on the hot ductility of 304HC stainless steel was analyzed and the mathematical mode...The ductility map of 304HC stainless was determined by using the Gleeble-1500 dynamic thermal-mechanical simulator. The effect of Cu on the hot ductility of 304HC stainless steel was analyzed and the mathematical model of resistance to deformation was established. The microstructure, inclusion and fracture surface were studied by using the method of micro structure analysis, scanning, energy spectrum and electron microscope. The results show that Cu has effect on the hot ductility, and the hot ductility of 304HC stainless steel decrease with the increase of content of Cu. The deformation temperature also has much effect on the hot ductility, the suitable deformation temperature are 1100-1200℃. The reason of it is that the Cu rich chemical compounds were precipitated from austenite phase during cooling. The Cu rich chemical compounds are brittle substance such as Cu2S, Cu2O and ε-Cu etc.展开更多
The extreme summer precipitation over East China during 1982-2007 was simulated using the LASG/IAP regional climate model CREM(the Climate version of a Regional Eta-coordinate Model).The results show that the probabil...The extreme summer precipitation over East China during 1982-2007 was simulated using the LASG/IAP regional climate model CREM(the Climate version of a Regional Eta-coordinate Model).The results show that the probability density functions(PDFs) of precipitation intensities are reasonably simulated,except that the PDFs of light and moderate rain are underestimated and that the PDFs of heavy rain are overestimated.The extreme precipitation amount(R95p) and the percent contribution of extreme precipitation to the total precipitation(R95pt) are also reasonably reproduced by the CREM.However,the R95p and R95pt over most of East China are generally overestimated,while the R95p along the coastal area of South China(SC) is underestimated.The bias of R95pt is consistent with the bias of precipitation intensity on wet days(SDII).The interannual variation for R95p anomalies(PC1) is well simulated,but that of R95pt anomalies(PC2) is poorly simulated.The skill of the model in simulating PC1(PC2) increases(decreases) from north to south.The bias of water vapor transport associated with the 95th percentile of summer daily precipitation(WVTr95) explains well the bias of the simulated extreme precipitation.展开更多
In imaging on moving target, it is easy to get space- variant blurred image. In order to recover the image and gain recognizable target, an approach to recover the space-variant blurred image is presented based on ima...In imaging on moving target, it is easy to get space- variant blurred image. In order to recover the image and gain recognizable target, an approach to recover the space-variant blurred image is presented based on image segmentation. Be- cause of motion blur's convolution process, the pixels of observed image's target and background will be displaced and piled up to produce two superposition regions. As a result, the neighbor- ing pixels in the superposition regions will have similar grey level change. According to the pixel's motion-blur character, the target's blurred edge of superposition region could be detected. Canny operator can be recurred to detect the target edge which parallels the motion blur direction. Then in the segmentation process, the whole target image which has the character of integral convolution between motion blur and real target image can be obtained. At last, the target image is restored by deconvolution algorithms with adding zeros. The restoration result indicates that the approach can effectively solve the kind of problem of space-variant motion blurred image restoration.展开更多
In order to develop the best brewing condition for high-grade fruit wine from northern blueberry, on the basis of reviewing literatures about blueberry wine manufacturing process, this study put forward a new technolo...In order to develop the best brewing condition for high-grade fruit wine from northern blueberry, on the basis of reviewing literatures about blueberry wine manufacturing process, this study put forward a new technological process, including raw materials-juicing-addition of auxiliary materials including pectinase-primary fer- mentation with yeast-post-fermentation-hot and cold treatment-sterilization-packaging- finished product, and sensory indexes, physicochemical indexes and hygienic index- es of the product were inspected according to corresponding national standards and industry standards. The results showed that for northern blueberry pulp, the optimal addition amount of yeast was 1.1 g/L, the fermentation temperature was 22 ℃, and the addition amounts of pectinase and sulfurous acid were 0.3 ml/kg and 100 ppm, respectively; the alcohol degree of the finished product was adjusted to 15.6°; and alternated cold and heat treatment used instead of conventional clarifying agent for removing colloid-like impurities resulted in the brewed product with good wine fra- grance, taste and color.展开更多
We cast vehicle recognition as problem of feature representation and classification, and introduce a sparse learning based framework for vehicle recognition and classification in this paper. After objects captured wit...We cast vehicle recognition as problem of feature representation and classification, and introduce a sparse learning based framework for vehicle recognition and classification in this paper. After objects captured with a GMM background subtraction program, images are labeled with vehicle type for dictionary learning and decompose the images with sparse coding (SC), a linear SVM trained with the SC feature for vehicle classification. A simple but efficient active learning stategy is adopted by adding the false positive samples into previous training set for dictionary and SVM model retraining. Compared with traditional feature representation and classification realized with SVM, SC method achieves dramatically improvement on classification accuracy and exhibits strong robustness. The work is also validated on real-world surveillance video.展开更多
The weighted generalized inverses have several important applications in researching the singular matrices,regularization methods for ill-posed problems, optimization problems and statis- tics problems.In this paper w...The weighted generalized inverses have several important applications in researching the singular matrices,regularization methods for ill-posed problems, optimization problems and statis- tics problems.In this paper we further research inverse order rules of weighted generalizde inverse. From the view point of munerical algebra, the different methods we used in inverse order rules pro- vide beneficial means for theory and computing of generalized inverse matrices.展开更多
Cerium-substituted yttrium iron garnet(Ce x Y 3-xFe 5O 12, Ce∶YIG) was prepared via coprecipitation. The structu re, morphology, valence state and constituent of Ce ions were investigated respe ctively. X-ra...Cerium-substituted yttrium iron garnet(Ce x Y 3-xFe 5O 12, Ce∶YIG) was prepared via coprecipitation. The structu re, morphology, valence state and constituent of Ce ions were investigated respe ctively. X-ray powder diffraction(XRD) analysis shows that Ce∶YIG was of singl e cubic YIG phase. The result of X-ray photoelectron spectroscopy(XPS) indicate s the Ce ions in Ce∶YIG were in the state of trivalence. Scanning electron micr oscope(SEM) demonstrates the conglobation of Ce∶YIG particles about 0.2μm scal e.The magnetic properties were studied by a vibrating sample magnetometer(VSM) a nd the result exhibits that substitution of Ce 3+ changes the magnetic para meters of YIG. The effects of doping content of Ce ions and synthesis temperatu re on valence control were discussed in detail.展开更多
In the field of sequencing of secret number,an important problem is how to establish an efficient and secure protocol for sorting the secret number.As a powerful tool in solving privacy sequencing problems,secure mult...In the field of sequencing of secret number,an important problem is how to establish an efficient and secure protocol for sorting the secret number.As a powerful tool in solving privacy sequencing problems,secure multipart computation is more and more popular in anonymous voting and online auction.In the present study,related secure computation protocol for sequencing problem is not many by far.In order to improve the efficiency and safety,we propose a security sequencing protocol based on homomorphic encryption.We also give analysis of correctness and security to highlight its feasibility.展开更多
One of the great difficulties in understanding nitrogen plasma elementary processes is the lack of an available database of the cross-sections of electron-impact excitations and radiations. Ab initio calculations of v...One of the great difficulties in understanding nitrogen plasma elementary processes is the lack of an available database of the cross-sections of electron-impact excitations and radiations. Ab initio calculations of vibrational excitation cross sections for electron collisions with nitrogen molecules in low-lying states using similarity function approach, such as a-a', a-w, B-B' and B-W transition systems, are reported here for the first time. In the meantime, the average excitation energies of neighboring levels of these systems have been calculated. In order to obtain the cross sections, accurate spectroscopic constants and transition dipole moments have been investigated. Potential energy curves and other electronic transition dipole moments for the low-lying states of N2 have been re-evaluated using complete active space self-consistent field (CASSCF) approach with aug-cc-pVqZ basis set. The calculated cross-sections could provide a database for studying the elementary processes and the properties in N2 plasma.展开更多
The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline (NU...The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline (NURBS) entity. According to the characteristics of NURBS, a novel data structure, named NURBS material data structure, is proposed, in which the geometrical coordinates, weights and material coordinates of NURBS heterogene- ous objects can be represented simultaneously. Based on this data structure, both direct representation method and inverse construction method of heterogeneous NURBS objects are introduced. In the direct representation method, three forms of NURBS heterogeneous objects are introduced by giving the geometry and material information of con- trol points, among which the homogeneous coordinates form is employed for its brevity and easy programming. In the inverse construction method, continuous heterogeneous curves and surfaces can he obtained by interpolating discrete points and curves with specified material information. Some examples are given to show the effectiveness of the pro- posed methods.展开更多
A telescope with a larger primary mirror can collect much more light and resolve objects much better than one with a smaller mirror, and so the larger version is always pursued by astronomers and astronomical technici...A telescope with a larger primary mirror can collect much more light and resolve objects much better than one with a smaller mirror, and so the larger version is always pursued by astronomers and astronomical technicians. Instead of using a monolithic primary mirror, more and more large telescopes, which are currently being planned or in construction, have adopted a segmented primary mirror design. Therefore, how to sense and phase such a primary mirror is a key issue for the future of extremely large optical/infrared telescopes. The Dispersed Fringe Sensor (DFS), or Dispersed Hartmann Sensor (DHS), is a non-contact method using broadband point light sources and it can estimate the piston by the two-directional spectrum formed by the transmissive grating's dispersion and lenslet array. Thus it can implement the combination of co-focusing by Shack-Hartmann technology and phasing by dispersed fringe sensing technologies such as the template-mapping method and the Hartmann method. We introduce the successful design, construction and alignment of our dis- persed Hartmann sensor together with its design principles and simulations. We also conduct many successful real phasing tests and phasing corrections in the visible waveband using our existing indoor segmented mirror optics platform. Finally, some conclusions are reached based on the test and correction of experimental results.展开更多
Background: Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). Some HBV mutants and dysregulation of phosphatase and tensin homolog (PTEN) may promote the developmen...Background: Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). Some HBV mutants and dysregulation of phosphatase and tensin homolog (PTEN) may promote the development of HCC synergistically. We aimed to test the effects of PTEN genetic polymorphisms and their interactions with important HBV mutations on the development of HCC in HBV-infected subjects. Methods: Quantitative po[ymerase chain reaction was applied to genotype PTEN polymorphisms (rs1234220, rs2299939, rsl234213) in 1012 healthy controls, 302 natural clearance subjects, and 2011 chronic H BV-infected subjects including 1021 HCC patients. HBV mutations were determined by sequencing. The associations of PTEN polymorphisms and their interactions with HBV mutations with HCC risk were assessed using multivariate logistic regression analysis. Results: Rs1234220 C allele was significantly associated with HCC risk compared to healthy controls (adjusted odds ratio [AOR] = 1.35, 95% confidence interval [CI] = 1,07-1.69) and HCC-free HBV-infected subjects (AOR = 1.27, 95% CI = 1.01-1 .57). rsl234220 C allele was significantly associated with increased frequencies of HCC-risk A 1652G, C 1673T, and C 1730G mutations in genotype B H BV-in fected subjects. Rs2299939 GT genotype was inversely associated with HCC risk in HBV-infected patients (AOR 0.75, 95% CI 0.62-0.92). The interaction of rs2299939 variant genotypes (GT+TT) with A3054T mutation significantly increased HCC risk (AOR = 2.41, 95% CI = 1.08-5.35); whereas its interaction with C3116T mutation significantly reduced HCC risk (AOR = 0.34, 95% CI 0.18-0.66). These significant effects were only evident in males alter stratification. Conclusions: PTEN polymorphisms and their interactions with HBV mutations may contribute to hepatocarcinogenesis in males. The host-virus interactions are important in identifying HBV-infected subjects who are more likely to develop HCC.展开更多
Huashan Hospital Clinical Laboratory, Shanghai, China, has been awarded an accreditation by the Commission on Laboratory Accreditation of the College of American Pathologists (CAP), based on the results of a recent ...Huashan Hospital Clinical Laboratory, Shanghai, China, has been awarded an accreditation by the Commission on Laboratory Accreditation of the College of American Pathologists (CAP), based on the results of a recent on-site inspection.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 50972082 and 51072101)the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No.20090131120077)the Natural Science Foundation of Shandong Province, China (Grant Nos. ZR2011EMM019 and ZR2012AM007)
文摘To investigate the effect of a reagent's rotational and vibrational excitations on the stereo-dynamics of the reaction product, the title reaction is theoretically simulated using the quasi-classical trajectory (QCT) method on the 3A~ and 3Aq potentiM energy surfaces (PESs). The reaction cross section is considered as the only scalar property in this work at four different collision energies. Furthermore the vector properties including two polarization-dependent differential cross sections (PDDCSs), the angular distributions of product' rotational momentum are discussed at one fixed collision energy. Effects of reagents' rotational excitation on the reaction do exist regularly.
基金Sponsored by the Beijing Education Committee Cooperation Building Foundation Project
文摘A new method for speeding up the state augment operations involved in the compressed extended Kalman filter-based simultaneous localization and mapping (CEKF-SLAM) algorithm was proposed. State augment usually requires a fully-updated state eovariance so as to append the information of newly observed landmarks, thus computational volume increases quadratically with the number of landmarks in the whole map. It was proved that state augment can also be achieved by augmenting just one auxiliary coefficient ma- trix. This method can yield identical estimation results as those using EKF-SLAM algorithm, and computa- tional amount grows only linearly with number of increased landmarks in the local map. The efficiency of this quick state augment for CEKF-SLAM algorithm has been validated by a sophisticated simulation project.
基金This study was financially supported by both the National Natural Science Founda- tion of China (Grant No.59995440)the Natural Science Foundation of Liaoning Province (Grant No.2001101021).
文摘The ductility map of 304HC stainless was determined by using the Gleeble-1500 dynamic thermal-mechanical simulator. The effect of Cu on the hot ductility of 304HC stainless steel was analyzed and the mathematical model of resistance to deformation was established. The microstructure, inclusion and fracture surface were studied by using the method of micro structure analysis, scanning, energy spectrum and electron microscope. The results show that Cu has effect on the hot ductility, and the hot ductility of 304HC stainless steel decrease with the increase of content of Cu. The deformation temperature also has much effect on the hot ductility, the suitable deformation temperature are 1100-1200℃. The reason of it is that the Cu rich chemical compounds were precipitated from austenite phase during cooling. The Cu rich chemical compounds are brittle substance such as Cu2S, Cu2O and ε-Cu etc.
基金supported by the China-UK-Swiss Adapting to Climate Change in China Project (ACCC)- Climate Sciencethe Public Science and Technology Research Funds Projects of Ocean (Grant No. 201105019-3)the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KZCX2-YW-Q11-04)
文摘The extreme summer precipitation over East China during 1982-2007 was simulated using the LASG/IAP regional climate model CREM(the Climate version of a Regional Eta-coordinate Model).The results show that the probability density functions(PDFs) of precipitation intensities are reasonably simulated,except that the PDFs of light and moderate rain are underestimated and that the PDFs of heavy rain are overestimated.The extreme precipitation amount(R95p) and the percent contribution of extreme precipitation to the total precipitation(R95pt) are also reasonably reproduced by the CREM.However,the R95p and R95pt over most of East China are generally overestimated,while the R95p along the coastal area of South China(SC) is underestimated.The bias of R95pt is consistent with the bias of precipitation intensity on wet days(SDII).The interannual variation for R95p anomalies(PC1) is well simulated,but that of R95pt anomalies(PC2) is poorly simulated.The skill of the model in simulating PC1(PC2) increases(decreases) from north to south.The bias of water vapor transport associated with the 95th percentile of summer daily precipitation(WVTr95) explains well the bias of the simulated extreme precipitation.
文摘In imaging on moving target, it is easy to get space- variant blurred image. In order to recover the image and gain recognizable target, an approach to recover the space-variant blurred image is presented based on image segmentation. Be- cause of motion blur's convolution process, the pixels of observed image's target and background will be displaced and piled up to produce two superposition regions. As a result, the neighbor- ing pixels in the superposition regions will have similar grey level change. According to the pixel's motion-blur character, the target's blurred edge of superposition region could be detected. Canny operator can be recurred to detect the target edge which parallels the motion blur direction. Then in the segmentation process, the whole target image which has the character of integral convolution between motion blur and real target image can be obtained. At last, the target image is restored by deconvolution algorithms with adding zeros. The restoration result indicates that the approach can effectively solve the kind of problem of space-variant motion blurred image restoration.
基金Supported by College Students’Innovative Planning Project of Tiaan City(2015D001)~~
文摘In order to develop the best brewing condition for high-grade fruit wine from northern blueberry, on the basis of reviewing literatures about blueberry wine manufacturing process, this study put forward a new technological process, including raw materials-juicing-addition of auxiliary materials including pectinase-primary fer- mentation with yeast-post-fermentation-hot and cold treatment-sterilization-packaging- finished product, and sensory indexes, physicochemical indexes and hygienic index- es of the product were inspected according to corresponding national standards and industry standards. The results showed that for northern blueberry pulp, the optimal addition amount of yeast was 1.1 g/L, the fermentation temperature was 22 ℃, and the addition amounts of pectinase and sulfurous acid were 0.3 ml/kg and 100 ppm, respectively; the alcohol degree of the finished product was adjusted to 15.6°; and alternated cold and heat treatment used instead of conventional clarifying agent for removing colloid-like impurities resulted in the brewed product with good wine fra- grance, taste and color.
基金the National Natural Science Foundation of China under Grant NO 61472166,NO 61105015,Jiangsu Provincial Natural Science Foundation under Grant NO BK2010366 and Key Laboratory of Cloud Computing and Intelligent Information Processing of Changzhou City under Grand NO CM20123004
文摘We cast vehicle recognition as problem of feature representation and classification, and introduce a sparse learning based framework for vehicle recognition and classification in this paper. After objects captured with a GMM background subtraction program, images are labeled with vehicle type for dictionary learning and decompose the images with sparse coding (SC), a linear SVM trained with the SC feature for vehicle classification. A simple but efficient active learning stategy is adopted by adding the false positive samples into previous training set for dictionary and SVM model retraining. Compared with traditional feature representation and classification realized with SVM, SC method achieves dramatically improvement on classification accuracy and exhibits strong robustness. The work is also validated on real-world surveillance video.
文摘The weighted generalized inverses have several important applications in researching the singular matrices,regularization methods for ill-posed problems, optimization problems and statis- tics problems.In this paper we further research inverse order rules of weighted generalizde inverse. From the view point of munerical algebra, the different methods we used in inverse order rules pro- vide beneficial means for theory and computing of generalized inverse matrices.
文摘Cerium-substituted yttrium iron garnet(Ce x Y 3-xFe 5O 12, Ce∶YIG) was prepared via coprecipitation. The structu re, morphology, valence state and constituent of Ce ions were investigated respe ctively. X-ray powder diffraction(XRD) analysis shows that Ce∶YIG was of singl e cubic YIG phase. The result of X-ray photoelectron spectroscopy(XPS) indicate s the Ce ions in Ce∶YIG were in the state of trivalence. Scanning electron micr oscope(SEM) demonstrates the conglobation of Ce∶YIG particles about 0.2μm scal e.The magnetic properties were studied by a vibrating sample magnetometer(VSM) a nd the result exhibits that substitution of Ce 3+ changes the magnetic para meters of YIG. The effects of doping content of Ce ions and synthesis temperatu re on valence control were discussed in detail.
基金supported by the National Natural Science Foundation of China under Grant No.51307004
文摘In the field of sequencing of secret number,an important problem is how to establish an efficient and secure protocol for sorting the secret number.As a powerful tool in solving privacy sequencing problems,secure multipart computation is more and more popular in anonymous voting and online auction.In the present study,related secure computation protocol for sequencing problem is not many by far.In order to improve the efficiency and safety,we propose a security sequencing protocol based on homomorphic encryption.We also give analysis of correctness and security to highlight its feasibility.
基金supported by National Natural Science Foundation of China(Nos.11175035,10875023)the National Magnetic Confinement Fusion Science Program of China(No.2013GB109005)+1 种基金Chinesisch-Deutsches Forschungsprojekt(GZ768)the Fundamental Research Fundsfor the Central Universities of China(No.DUT12ZD(G)01)
文摘One of the great difficulties in understanding nitrogen plasma elementary processes is the lack of an available database of the cross-sections of electron-impact excitations and radiations. Ab initio calculations of vibrational excitation cross sections for electron collisions with nitrogen molecules in low-lying states using similarity function approach, such as a-a', a-w, B-B' and B-W transition systems, are reported here for the first time. In the meantime, the average excitation energies of neighboring levels of these systems have been calculated. In order to obtain the cross sections, accurate spectroscopic constants and transition dipole moments have been investigated. Potential energy curves and other electronic transition dipole moments for the low-lying states of N2 have been re-evaluated using complete active space self-consistent field (CASSCF) approach with aug-cc-pVqZ basis set. The calculated cross-sections could provide a database for studying the elementary processes and the properties in N2 plasma.
基金Supported by National Natural Science Foundation of China (No. 60973079)Natural Science Foundation of Hebei Province (No. E2006000039)
文摘The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline (NURBS) entity. According to the characteristics of NURBS, a novel data structure, named NURBS material data structure, is proposed, in which the geometrical coordinates, weights and material coordinates of NURBS heterogene- ous objects can be represented simultaneously. Based on this data structure, both direct representation method and inverse construction method of heterogeneous NURBS objects are introduced. In the direct representation method, three forms of NURBS heterogeneous objects are introduced by giving the geometry and material information of con- trol points, among which the homogeneous coordinates form is employed for its brevity and easy programming. In the inverse construction method, continuous heterogeneous curves and surfaces can he obtained by interpolating discrete points and curves with specified material information. Some examples are given to show the effectiveness of the pro- posed methods.
基金supported by the National Natural Science Foundation of China(Grant Nos. 10703008 and 11073035)also partly supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No. KJCX2-YW-T17)
文摘A telescope with a larger primary mirror can collect much more light and resolve objects much better than one with a smaller mirror, and so the larger version is always pursued by astronomers and astronomical technicians. Instead of using a monolithic primary mirror, more and more large telescopes, which are currently being planned or in construction, have adopted a segmented primary mirror design. Therefore, how to sense and phase such a primary mirror is a key issue for the future of extremely large optical/infrared telescopes. The Dispersed Fringe Sensor (DFS), or Dispersed Hartmann Sensor (DHS), is a non-contact method using broadband point light sources and it can estimate the piston by the two-directional spectrum formed by the transmissive grating's dispersion and lenslet array. Thus it can implement the combination of co-focusing by Shack-Hartmann technology and phasing by dispersed fringe sensing technologies such as the template-mapping method and the Hartmann method. We introduce the successful design, construction and alignment of our dis- persed Hartmann sensor together with its design principles and simulations. We also conduct many successful real phasing tests and phasing corrections in the visible waveband using our existing indoor segmented mirror optics platform. Finally, some conclusions are reached based on the test and correction of experimental results.
基金the National Key Basic Research Program (973 Project),the National Natural Science Foundation of China,the Science and Technology Commission of Shanghai Municipality No.12ZR1453600)
文摘Background: Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). Some HBV mutants and dysregulation of phosphatase and tensin homolog (PTEN) may promote the development of HCC synergistically. We aimed to test the effects of PTEN genetic polymorphisms and their interactions with important HBV mutations on the development of HCC in HBV-infected subjects. Methods: Quantitative po[ymerase chain reaction was applied to genotype PTEN polymorphisms (rs1234220, rs2299939, rsl234213) in 1012 healthy controls, 302 natural clearance subjects, and 2011 chronic H BV-infected subjects including 1021 HCC patients. HBV mutations were determined by sequencing. The associations of PTEN polymorphisms and their interactions with HBV mutations with HCC risk were assessed using multivariate logistic regression analysis. Results: Rs1234220 C allele was significantly associated with HCC risk compared to healthy controls (adjusted odds ratio [AOR] = 1.35, 95% confidence interval [CI] = 1,07-1.69) and HCC-free HBV-infected subjects (AOR = 1.27, 95% CI = 1.01-1 .57). rsl234220 C allele was significantly associated with increased frequencies of HCC-risk A 1652G, C 1673T, and C 1730G mutations in genotype B H BV-in fected subjects. Rs2299939 GT genotype was inversely associated with HCC risk in HBV-infected patients (AOR 0.75, 95% CI 0.62-0.92). The interaction of rs2299939 variant genotypes (GT+TT) with A3054T mutation significantly increased HCC risk (AOR = 2.41, 95% CI = 1.08-5.35); whereas its interaction with C3116T mutation significantly reduced HCC risk (AOR = 0.34, 95% CI 0.18-0.66). These significant effects were only evident in males alter stratification. Conclusions: PTEN polymorphisms and their interactions with HBV mutations may contribute to hepatocarcinogenesis in males. The host-virus interactions are important in identifying HBV-infected subjects who are more likely to develop HCC.
文摘Huashan Hospital Clinical Laboratory, Shanghai, China, has been awarded an accreditation by the Commission on Laboratory Accreditation of the College of American Pathologists (CAP), based on the results of a recent on-site inspection.