The aim of the study was to assess effect of the atipamezolc on talezol/xylazine induced expression of c-fos in rat brain. Rats were injected with the mixture of 13.81 mg· kg^-1 telazol and 5.21 mg· kg^-1 xy...The aim of the study was to assess effect of the atipamezolc on talezol/xylazine induced expression of c-fos in rat brain. Rats were injected with the mixture of 13.81 mg· kg^-1 telazol and 5.21 mg· kg^-1 xylazine, following 10 min later 0.522 mg· kg^-1 atipamezole injected, and then the cerebral cortex and thalamencephal were removed at 1 h after injected. Level of Fos protein was measured in the brain tissue by westem-blot. The results revealed that telazol/xylazine induction Fos protein expression in the thalamencephal and cerebral cortex during the period of anesthesia, atipamezole attenuated tclazol/ xylazine induction Fos protein expression in the thalamencephal and cerebral cortex. The results indicated that atipamezolc could inhibite telazol/xylazine-induced c-los expression in the rat brain, and played a protective role of neuronal injury.展开更多
基金Supported by the National Natural Science Foundation of China(31302150,31272617 and 31001092)
文摘The aim of the study was to assess effect of the atipamezolc on talezol/xylazine induced expression of c-fos in rat brain. Rats were injected with the mixture of 13.81 mg· kg^-1 telazol and 5.21 mg· kg^-1 xylazine, following 10 min later 0.522 mg· kg^-1 atipamezole injected, and then the cerebral cortex and thalamencephal were removed at 1 h after injected. Level of Fos protein was measured in the brain tissue by westem-blot. The results revealed that telazol/xylazine induction Fos protein expression in the thalamencephal and cerebral cortex during the period of anesthesia, atipamezole attenuated tclazol/ xylazine induction Fos protein expression in the thalamencephal and cerebral cortex. The results indicated that atipamezolc could inhibite telazol/xylazine-induced c-los expression in the rat brain, and played a protective role of neuronal injury.
