BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various diseases.Several studies have demonstrated that tea drinking is a protective factor again...BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various diseases.Several studies have demonstrated that tea drinking is a protective factor against tuberculosis(TB).This study was designed to explore five single nucleotide polymorphisms(SNPs)of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to TB.AIM To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to TB.METHODS In this case-control study,503 patients with TB and 494 healthy controls were enrolled by a stratified sampling method.The cases were newly registered TB patients from the county-level centers for disease control and prevention,and the healthy controls were permanent residents from Xin'ansi Community,Changsha city.Demographic data and environmental exposure information including tea drinking were obtained from the study participants.We genotyped five potentially functional SNP sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment interactions.RESULTS The frequencies of four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with susceptibility to TB(P<0.05).Genotypes GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotypes CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotypes CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotypes CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more prevalent in TB patients than in healthy controls.The relative excess risk of interaction between the four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,P<0.05),-1.8270(95%CI:-2.3587,-1.2952,P<0.05),-2.3246(95%CI:-2.9417,-1.7076,P<0.05)and-0.4235(95%CI:-0.7756,-0.0714,P<0.05),respectively,which suggest negative interactions.CONCLUSION The polymorphisms of mTOR(rs2295080,rs2024627,rs1057079,and rs7525957)are associated with susceptibility to TB,and there is a negative interaction between each of the four SNPs and tea drinking.展开更多
When you visit a Chinese home, you will be given a cup of hot tea irrespective of the geographical location, cultural background and nationality of the host. This is part of China’s ritual and culture. However, tea d...When you visit a Chinese home, you will be given a cup of hot tea irrespective of the geographical location, cultural background and nationality of the host. This is part of China’s ritual and culture. However, tea drinking customs vary in certain parts of China. Min-chao congou tea. Min-chao refers to the areas covering southern Fujian Province and Chaozhou and Santou in Guangdong Province. congou means the special skill of making tea.展开更多
What methods would you choose apart from increasing sedatives for agitation in an advanced patient with hypercapnic encephalopathy due to AECOPD?This is a 94-year-old female who suffered from COPD for over 30 years,oc...What methods would you choose apart from increasing sedatives for agitation in an advanced patient with hypercapnic encephalopathy due to AECOPD?This is a 94-year-old female who suffered from COPD for over 30 years,occurred with an accelerated episode of cough,productive sputum and a dropping down to 86%in SatO₂due to a cold weather.A diagnosis of pulmonary encephalopathy(PE)was made on the basis of the subsequent agitation and delirium,and the sedatives,such as quatiepine and haloperidol,had to be given for her mental excitation respectively,but she still pulled out indwelling needle herself and refused to any infusion therapy.As an alternative,a vaporized therapy integrated with tea herb drinking had to be applied to relieving her agitation,being designed as the vaporization of the inhaled oxygenation by means of high-flow oxygenation device(HFOD),with an ampoule of ambroxol mixed into the inhaler and simultaneous drinking of TCM tea herb for reducing sputum,helping dissolve the mucoid bolts inside her terminal bronchioles when being infected.We thought that a better efficacy would be achieved for hypercapnic encephalopathy due to AECOPD if we concentrate on a good ventilation of small airway through the vaporized therapy.展开更多
喝茶,有益于健康。本文所说的是“红茶”(black tea),而非“绿茶”(green tea)。在美国喝茶者简直与时俱增:…total sales of tea in 2002 were$5.03 billion,up from$1.84 billion in 1990!本文用深入浅出的语言对喝茶的益处作了说明,...喝茶,有益于健康。本文所说的是“红茶”(black tea),而非“绿茶”(green tea)。在美国喝茶者简直与时俱增:…total sales of tea in 2002 were$5.03 billion,up from$1.84 billion in 1990!本文用深入浅出的语言对喝茶的益处作了说明,同时,其文字表达也不乏可以品味处,如下句中的动词saw:Those who bad regular tea saw their LDL levels drop about 11 percent comparedwith the caffeine placebo.展开更多
TEA plays an increasingly important role in the daily lives of Chinese people. As the English are particular to the afternoon tea, some Chinese, too, have the habit of
TEA is a necessity in Chinese life. According to historical records the Chinese had already learned how to plant and bake tea more than 2,000 years ago. Sipping tea has always been a favorite Chinese tradition. To the...TEA is a necessity in Chinese life. According to historical records the Chinese had already learned how to plant and bake tea more than 2,000 years ago. Sipping tea has always been a favorite Chinese tradition. To the south of the Changjiang River is a region with good irrigation and a climate favorable for growing tea: it is cool at night and often misty. Zhejiang Province is a well-known tea production area, and the famous Longjing Tea is solely produced along the West Lake in Hangzhou, capital of the province. Tea is produced in four areas of China:展开更多
基金the National Natural Science Foundation of China,No.81803298and Hunan Provincial Natural Science Foundation,No.2020JJ4762.
文摘BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various diseases.Several studies have demonstrated that tea drinking is a protective factor against tuberculosis(TB).This study was designed to explore five single nucleotide polymorphisms(SNPs)of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to TB.AIM To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to TB.METHODS In this case-control study,503 patients with TB and 494 healthy controls were enrolled by a stratified sampling method.The cases were newly registered TB patients from the county-level centers for disease control and prevention,and the healthy controls were permanent residents from Xin'ansi Community,Changsha city.Demographic data and environmental exposure information including tea drinking were obtained from the study participants.We genotyped five potentially functional SNP sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment interactions.RESULTS The frequencies of four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with susceptibility to TB(P<0.05).Genotypes GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotypes CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotypes CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotypes CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more prevalent in TB patients than in healthy controls.The relative excess risk of interaction between the four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,P<0.05),-1.8270(95%CI:-2.3587,-1.2952,P<0.05),-2.3246(95%CI:-2.9417,-1.7076,P<0.05)and-0.4235(95%CI:-0.7756,-0.0714,P<0.05),respectively,which suggest negative interactions.CONCLUSION The polymorphisms of mTOR(rs2295080,rs2024627,rs1057079,and rs7525957)are associated with susceptibility to TB,and there is a negative interaction between each of the four SNPs and tea drinking.
文摘When you visit a Chinese home, you will be given a cup of hot tea irrespective of the geographical location, cultural background and nationality of the host. This is part of China’s ritual and culture. However, tea drinking customs vary in certain parts of China. Min-chao congou tea. Min-chao refers to the areas covering southern Fujian Province and Chaozhou and Santou in Guangdong Province. congou means the special skill of making tea.
文摘What methods would you choose apart from increasing sedatives for agitation in an advanced patient with hypercapnic encephalopathy due to AECOPD?This is a 94-year-old female who suffered from COPD for over 30 years,occurred with an accelerated episode of cough,productive sputum and a dropping down to 86%in SatO₂due to a cold weather.A diagnosis of pulmonary encephalopathy(PE)was made on the basis of the subsequent agitation and delirium,and the sedatives,such as quatiepine and haloperidol,had to be given for her mental excitation respectively,but she still pulled out indwelling needle herself and refused to any infusion therapy.As an alternative,a vaporized therapy integrated with tea herb drinking had to be applied to relieving her agitation,being designed as the vaporization of the inhaled oxygenation by means of high-flow oxygenation device(HFOD),with an ampoule of ambroxol mixed into the inhaler and simultaneous drinking of TCM tea herb for reducing sputum,helping dissolve the mucoid bolts inside her terminal bronchioles when being infected.We thought that a better efficacy would be achieved for hypercapnic encephalopathy due to AECOPD if we concentrate on a good ventilation of small airway through the vaporized therapy.
文摘喝茶,有益于健康。本文所说的是“红茶”(black tea),而非“绿茶”(green tea)。在美国喝茶者简直与时俱增:…total sales of tea in 2002 were$5.03 billion,up from$1.84 billion in 1990!本文用深入浅出的语言对喝茶的益处作了说明,同时,其文字表达也不乏可以品味处,如下句中的动词saw:Those who bad regular tea saw their LDL levels drop about 11 percent comparedwith the caffeine placebo.
文摘TEA plays an increasingly important role in the daily lives of Chinese people. As the English are particular to the afternoon tea, some Chinese, too, have the habit of
文摘TEA is a necessity in Chinese life. According to historical records the Chinese had already learned how to plant and bake tea more than 2,000 years ago. Sipping tea has always been a favorite Chinese tradition. To the south of the Changjiang River is a region with good irrigation and a climate favorable for growing tea: it is cool at night and often misty. Zhejiang Province is a well-known tea production area, and the famous Longjing Tea is solely produced along the West Lake in Hangzhou, capital of the province. Tea is produced in four areas of China:
