Research Progress on Combined Chinese and Western Medicine Treatment of Mycoplasma pneumoniae Pneumonia in Children

With the continuous development of medical technology,combined treatment of Chinese and Western medicine has gradually become a research hotspot.As a common disease in pediatrics,the treatment of Mycoplasma pneumoniae pneumonia(MPP)in children is also being explored and improved.This article summarizes the research progress of combined Chinese and Western medicine treatment of MPP in children in recent years,aiming to provide a useful reference for the combined treatment of MPP in children.The article firstly introduces the etiology and pathogenesis of MPP in children,thereafter briefly introduces the Western anti-infective treatment and traditional Chinese medicine(TCM)diagnosis and treatment of MPP in children,and lastly introduces the methods of combined treatment of TCM and Western medicine in detail.The article points out that the combination of Chinese and Western medicine can give full play to the overall regulation of Chinese medicine and the precise treatment advantages of Western medicine,improve the therapeutic effect,reduce the use of antibiotics,and lower the recurrence rate of the disease,which is worthy of further research and promotion.

Analysis on Clinical Characteristics and Combination Medications of Elemene Injection in the Treatment of Esophageal Cancer in Real World Research

Objective:To explore the clinical characteristics of Elemene Injection in the treatment of patients with esophageal cancer.Methods:A total of 310 patients diagnosed with esophageal cancer from the Hoptital Information System(HIS)of 21 hospitals across the country were selected in the study,and these patients all had been treated with Elemene Injection.In this study,the clinical general medication record information,diagnosis scheme information,general treatment information and combined medications information were analyzed by frequency statistics and association rules.Results:Elemene Injection was used most in patients aged 46-65(177 cases,57.10%);male patients were more than female.Among the main diagnoses of the most seasons and solar terms in hospitalization,the top three diagnoses were esophageal malignant tumor,malignant tumor,and hypertension.In terms of combination medication,the combination of western medicine blood substitutes and perfusion fluids,general nutritional drugs,vitamins,antibacterial drugs,and immune-promoting drugs were the main ones;the combination of traditional Chinese medicine was mainly anti-tumor drugs(48.71%).In addition,among the combination medications,the highest frequency of Elemene Injection combined with western medicine and traditional Chinese medicine were Xiaoaiping Injection(消癌平注射液)and ascorbic acid.Conclusion:The main susceptible people of esophageal cancer was middle-aged around 46-65,and there were more male patients than female;through the first diagnosis of western medicine,it can be found that in addition to patients suffering from esophageal cancer or other cancers,patients with high blood pressure,heart disease,and diabetes could use Elemene Injection.Therefore,when receiving such patients,attention should be paid to checking whether the patient had such diseases.At the same time,when using Elemene Injection,it's necessary to pay attention to certain combined medications to avoid adverse reactions.

Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro

AIM: To elucidate whether human primary gastric cancer and gastric mucosa epithelial cells in vitro can grow normally in a methionine (Met) depleted environment, i.e. Met-dependence, and whether Met-depleting status can enhance the killing effect of chemotherapy on gastric cancer cells. METHODS: Fresh human gastric cancer and mucosal tissues were managed to form monocellular suspensions, which were then cultured in the Met-free but homocysteine-containing (Met(-)Hcy(+)) medium, with different chemotherapeutic drugs. The proliferation of the cells was examined by cell counter, flow cytometry (FCM) and microcytotoxicity assay (MTT). RESULTS: The growth of human primary gastric cancer cells in Met(-)Hcy(+) was suppressed, manifested by the decrease of total cell counts [1.46 +/- 0.42 (x 10(9).L(-1)) in Met(-)Hcy(+) vs 1.64 +/-0.44(x 10(9).L(-1)) in Met(+)Hcy(-), P【0.01], the decline in the percentage of G(0)G(1) phase cells (0.69 +/- 0.24 in Met(-)Hcy(+) vs 0.80 +/- 0.18 in Met(+)Hcy(-), P【0.01) and the increase of S cells (0.24 +/- 0.20 in Met(-)Hcy(+) vs 0.17 +/- 0.16 in Met(+)Hcy(-), P【0.01); however, gastric mucosal cells grew normally. If Met(-)Hcy(+) medium was used in combination with chemotherapeutic drugs, the number of surviving gastric cancer cells dropped significantly. CONCLUSION: Human primary gastric cancer cells in vitro are Met-dependent; however, gastric mucosal cells have not shown the same characteristics. Met(-)Hcy(+) environment may strengthen the killing effect of chemotherapy on human primary gastric cancer cells.

Experimental study on antitumor effect of arsenic trioxide in combination with cisplatin or doxorubicin on hepatocellular carcinoma

INTRODUCTIONThe main component of a traditional Chinese drug 'Pishuang'. arsenic trioxide (As2O3), has obviously selective anti-tumor effect on human hepatocellular carcinoma (HCC)in both in vitro and in vivo studies[1-5]. Due to limited effectiveness when any anti-carcinogen is used alone and obviously increased toxicity when the dose is raised, there is no exception for As2O3. Furthermore, combined chemotherapy contributes to improve therapeutic effectiveness, disperse toxicity and surmount drug-resistance,in which the combination of traditional Chinese and modern medicine has more advantages and characteristics. As a result,we made an experimental study on anti-tumor effect of As2O3in combination with cisplantin (PDD) or doxorubicin (ADM)on HCC. to investigate the possibility of AS2O3 in combination with PDD or ADM and nature of interaction between them,and to provide experimental basis for clinical application.

Application Research of Intake-Air Cooling Technologies in Gas-Steam Combined Cycle Power Plants in China

The generated power and efficiency of gas-steam combined cycle (GSCC) power plants depend on the temperature of the inlet air greatly. Based on the analysis of basic theory of inlet air cooling technologies, the application of evaporative cooling system and the absorption cooling system in GSCC power plants are discussed in this paper. Moreover, in China with high temperature and humidity, applied research and simulation analysis of the above two different cooling systems are conducted separately, the research results of which can provide certain reference for optimal design and economic operation of inlet air cooling system for GSCC power enterprises in China.

Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model

AIM:rAAV mediated endostatin gene therapy has been examined as a new method for treating cancer.However, a sustained and high protein delivery is required to achieve the desired therapeutic effects.We evaluated the impact of topoisomerase inhibitors in rAAV delivered endostatin gene therapy in a liver tumor model. METHODS:rAAV containing endostatin expression cassettes were transduced into hepatoma cell lines.To test whether the topoisomerase inhibitor pretreatment increased the expression of endostatin,Western blotting and ELISA were performed.The biologic activity of endostatin was confirmed by endothelial cell proliferation and tube formation assays. The anti-tumor effects of the rAAV-endostatin vector combined with a topoisomerase inhibitor,etoposide,were evaluated in a mouse liver tumor model. RESULTS:Topoisomerase inhibitors,including camptothecin and etoposide,were found to increase the endostatin exPression level in vitro.The over-expressed endostatin, as a result of pretreatment with a topoisomerase inhibitor, was also biologically active.In animal experiments,the combined therapy of topoisomerase inhibitor,etoposide with the rAAV-endostatin vector had the best tumor- suppressive effect and tumor foci were barely observed in livers of the treated mice.Pretreatment with an etoposide increased the level of endostatin in the liver and serum of rAAV-endostatin treated mice.Finally,the mice treated With rAAV-endostatin in combination with etoposide showed the longest survival among the experimental models. CONCLUSION:rAAV delivered endostatin gene therapy in combination with a topoisomerase inhibitor pretreatment is an effective modality for anticancer gene therapy.

Virus etiology research of trigeminal neuralgia combining arachnoids' adhesion

Objective To assess the relationship that trigeminal neuralgia combining arachnoids’adhesions and herpes simplex virus type 1. Methods There are fifty-nine patients with trigeminal neuralgia their trigeminal nerve root area combined with arachnoids’adhesion,

Survey of the research on dynamic weapon-target assignment problem

The basic concepts and models of weapon-target assignment （WTA） are introduced and the mathematical nature of the WTA models is also analyzed. A systematic survey of research on WTA problem is provided. The present research on WTA is focused on models and algorithms. In the research on models of WTA, the static WTA models are mainly studied and the dynamic WTA models are not fully studied in deed. In the research on algorithms of WTA, the intelligent algorithms are often used to solve the WTA problem. The small scale of static WTA problems has been solved very well, however, the large scale of dynamic WTA problems has not been solved effectively so far. Finally, the characteristics of dynamic WTA are analyzed and directions for the future research on dynamic WTA are discussed.

A new direction for Alzheimer's research

Despite decades of research, at present there is no curative therapy for Alzheimer＇s disease. Changes in the way new drugs are tested appear to be necessary. Three changes are presented here and will be discussed. The first change is that Alzheimer＇s disease must be considered a disease of four major pathological processes, not one. The four processes are： 1） vascular hy- poperfusion of the brain with associated mitochondrial dysfunction, 2） destructive protein inclusions, 3） uncontrolled oxidative stress, and 4） proinflammatory immune processes second- ary to microglial and astrocytic dysfunction in the brain. The second change recommended is to alter the standard cognitive measurement tools used to quantify mental decline in test patients. Specifically the Dementia Severity Rating Scale （DSRS） should supersede Mini-Mental State Examination （MMSE） and other popular tests, and a measurement scale developed in research should be used to produce a linear and non-irregular baseline. Finally, accepting the concept that four etiologies cause Alzheimer＇s disease leads to the last necessary change, that new thera- pies must be employed directed against all four causes, likely as a combination. There are drugs ready to be employed in such a combinations which are available and used clinically for other purposes so can be used ＂offlabel＂ and one such combination is suggested.

A review and research on comprehensive characterization of microscopic shale gas reservoir space

In this paper,substantial domestic and foreign research results of microscopic shale reservoir space were systemically reviewed,the research history consisting of simple observation and qualitative classification,quantitative research,the combination of qualitative and quantitative research successively as well as the characteristics of each research stage were summarized.In addition,the current problems existing in the characterization methods of shale reservoir space were also analyzed.Furthermore,based on massive actual detection of typical core samples obtained from more than 50 global shale gas wells and relevant practical experience,a comprehensive characterization method of combining qualitative with the semiquantitative characterization was put forward.In detail,the indicators of the qualitative characterization include pore combination type and organic-matter microscopic morphology type,while the core elements of the semi-quantitative characterization include the percentage of the organic-matter area and the plane porosity of the pores of different types.Based on the reference of the naming and classification of rocks,the three-end-member diagram method was used to characterize microscopic shale reservoir space.This is achieved by plotting the three end-member diagram of 3 kinds of first-order critical reservoir spaces,i.e.,organic-matter pores,matrix pores,and micro-fractures,in order to intuitively present the features of the microscopic pore combination.Meanwhile,statistic histograms of organic-matter microscopic morphology type and the plane porosity of different types of pores were adopted to characterize the development degree of second-order pores quantitatively.By this comprehensive characterization method,the importance of both pore combination and the microscopic morphology of organic matter were emphasized,revealing the control of organic-matter microscopic morphology over the organic-matter pores.What is more,high-resolution FE-SEM was adopted to obtain semi-quantitative statistics results.In this way,the features of pore development and pore combination were quantified,not only reflecting the types and storage capacity of the microscopic shale reservoir space,but also presenting the hydrocarbongenerating potential of organic matter in shale.Therefore,the results of this research are capable of providing in-depth microscopic information for the assessment and exploration and development of shale gas resources.

Historical Source of "Zhang and Li Combined Households" in Taomin Region

Folk activities are the most representative form of regional culture,the humanistic care,homeland affection and festival customs that run through them are all vivid and true embodiments of local life.The folk custom activity of"Zhang and Li combined households"is a living inheritance of the historical fact of Mongolian-Han fusion in Taomin region.It takes Shehuo(festival entertainment)as the carrier,and uses rich forms of performance to recognize relatives and worship ancestors.At the same time,as a kind of entertainment and catharsis,it also carries the social function of folk culture,such as maintaining and connecting the emotions between the ethnic groups and neighbors,etc.On the basis of field investigation,this paper deeply describes the folk custom event of"Zhang and Li combined households",shows the whole picture of the grand festival,and discusses the ancestral memory,identifies and ethnic integration process of"Zhang and Li combined households"as a cultural phenomenon.

Trend Analysis of Combined Drugs Creation （for Example Acetylsalicylic Acid）

The pharmaceutical market of Ukraine in January 2015 was registered 71 drug based acetylsalicylic acid （ASA）, for which 52% combined. The most common combinations of ASA with acetaminophen and caffeine （45.9%）, magnesium hydroxide （18.9%）, bisoprolol （10.8%）, ascorbic acid （8.1%）, clopidogrel （5.4%）. Comparing markets combined drugs ASA of Ukraine, the Russian Federation, 28 EU countries, Norway, Switzerland, India, Syria, Australia and the USA identified the active pharmaceutical ingredients, combined with ASA in a single dosage form. The analysis of questionnaires 40 pharmacists pharmacies Temopil, Khmelnytsky and Kyiv regions of Ukraine noted that the biggest demand is mono-drugs ASA, Citramon, Askofen and Cardiomagnyl Methods of pharmacoeconomic studies proved efficient use Upsaryn UPSA with vitamin C tabl. spike, tuba in box number 20 BMS （France）, Citramon tablets number 6 PJSC ＂Monfarm＂ （Ukraine） and Cardiomagnyl tabl. film-coated shell 75 mg in bottle number 100 Nycomed Austria （Austria）. On the basis of six State Forms of drugs in Ukraine （2009-2014） was found that the combination of drugs based on ASA is recommended to use of ascorbic acid （Aspiryn C, Asprovit C, Upsarin UPSA with vitamin C）, dipyridamole （Agrenox）, magnesium hydroxide （Cardiomagnyl, Cardiomagnyl Forte）. Some of the standard combination of ASA （combination of paracetamol and caffeine） are not in form. For optimize State Form of drugs by improving health system in Ukraine can be useful pharmacoeconomic analysis of combination therapies with the current official system to note the combination of ASA with statins, esomeprazole, isosorbide.

Research on the Teaching Reform of Tourism Vocational Education Based on the Idea of "Integration of Teaching and Doing"——Taking the Handicraft Course of Batik Dyeing as an Example

As a treasure of ethnic minority art and culture,in order to explore its value,inherit and develop the traditional handcrafts with national characteristics,batik has been included in the special elective courses system of tourism management,art design and other related majors in Guizhou Province;This article takes the Handicraft Course of Batik Dyeing of S Vocational School as an example,based on"teaching and doing"ideal research on the reform of classroom teaching practice to explore,and in view of the deficiency of the present teaching practice,to put forward the validity teaching design scheme,to improve Secondary Vocational Schools and Vocational Colleges students'personalized development space,to enhance the research ability of teachers'the handicraft Course of batik Dyeing,to provide reference examples for the tourism vocational education characteristic classroom teaching reform.

基于基础与专业相融合的研究型实验教学方法探索

以卓越工程师教育为背景,针对创新型、实践型工程技术人才培养目标,该文将笔者多年课堂教学、实验教学和相关科研工作的经验融入到实验教学中,探索基础与专业相融合的研究型实验教学方法。方法注重学生对基础知识与专业应用的融合训练,基于基础实验系统和综合开放式实验平台,通过对学生在基础电路测试、知识分解、电路独立设计与测试方面的训练,帮助学生创新性和科学研究素养的培养。该文方法在教学实践中进行应用,并起到较好的效果。

“植物生理学”理论结合实践的教学模式改革

“植物生理学”是高等农林院校植物生产类本科生的专业基础课,教学涉及的专业多,授课对象的知识结构和学习特点不断变化,且面临学时少、新知识和新技术层出不穷的窘境。因此,从甄选教学内容、丰富教学题材,改进教学方法,学以致用。建立“植物生理学”开放课堂,科研反哺教学、指导学生参加创新创业大赛、增强科研创新意识等方面对“植物生理学”进行了教学改革与实践。同时,“植物生理学”教学的研究对象选用本地的植物类型或地方品种并列举它们与当地生态环境之间的关系,使教学内容既贴近生活实际又符合学校的办学特色,既能提高学生的综合素质与实践能力,又可为培养创新型人才奠定基础。

“三结合”研究方法在弘扬重要农业文化遗产中的应用价值研究

历史学、民族学、考古学“三结合”研究方法乃是江应樑等老一辈学者所倡导的研究方法,相关的研究成果早已为学界同仁所熟知。而为了弘扬中国传统文化,评选、推荐中国重要农业文化遗产则是当代学界正在面对的新的研究领域。如何将这一研究思路和方法应用于弘扬重要农业文化遗产实践之中,至今尚待深入探讨。为此,以已立项保护的重要农业文化遗产为例,试用“三结合”研究方法澄清农业文化遗产的科学性和合理性,可望为弘扬中国优秀传统文化做出贡献。

功能纳米材料光热抗肿瘤实验设计

将科研课题和功能纳米材料实验教学有机融合,依托校仪器共享平台,设计了光热抗肿瘤综合实验。实验课前以视频、文献和课件等形式介绍背景知识,课堂上进行纳米材料光热抗肿瘤机制讲解,并结合实验目的启发学生自行设计实验方案。实验通过多元评价考核体系,促进学生综合能力提升;将大型仪器使用纳入实验教学,激发学生科研热情;在以科研带教学、以教学促科研方面取得了良好效果。

大庆油田化学驱油体系研究现状及发展方向

大庆油田经过多年的研究和实践,创新了聚合物黏弹性理论、表面活性剂与原油匹配关系理论,研制生产出了系列部分水解聚丙烯酰胺、烷基苯磺酸盐、石油磺酸盐,形成第一代化学驱油体系,推进了大庆油田化学驱工业化进程,使化学驱成为油田有效开发主导技术之一。随着大庆油田化学驱开发对象逐渐变差,建立聚合物分子构效关系和稀体系相态转化理论,研究出了系列抗盐聚合物和界面位阻表面活性剂,形成第二代高效化学驱油体系,推动化学驱提质增效。为更大幅度地提高采收率、降低化学剂成本,拓展化学驱应用领域,绿色环保、智能高效、成本低廉的化学驱油体系是今后化学驱油体系发展的主要方向。

基于病证结合特点的绝经后骨质疏松症动物模型分析

绝经后骨质疏松症(PMOP)病证结合动物模型在中医药研究中应用较多,但建立方法各式各样且缺乏统一的评价标准。文章从中医学和现代医学临床角度出发,就目前PMOP模型动物选择、构建方法和模型动物与临床吻合度进行对比,结合病证结合动物模型构建思路,从PMOP病证结合动物模型的构建和进一步完善评价方法进行归纳总结,以期为PMOP实验研究提供新思路。