Analysis of Technical Intelligence of Tumor Cell Therapy Based on Patent Map

Objective To analyze the technical information in the field of tumor cell therapy in China,and to provide reference for identifying technical trends and predicting technical opportunities.Methods Based on the patent data in the field of tumor cell therapy in China,the patent map method was used to construct a scientific technical information analysis model.Then,the technical status of new drug research and development in this field was explored to identify technical opportunities.Results and Conclusion Studies have found that China’s tumor immunotherapy is in the growth stage.The technical innovation regions are mainly distributed in the east and innovative entities are enterprises.Technology hotspots are concentrated in areas such as A61P35,C12N5,and the patented technical efficacy is high.Besides,the technical research and development opportunities identified are closely related to the background in this field.To better promote the development of the industry,enterprises and research institutions should strengthen cooperation in technological innovation Meanwhile,they should pay attention to technical efficacy analysis to identify more technical opportunities,thereby effectively guiding innovation strategic decisions.

Technical efficiency of cocoa farms at varying elevation levels in Davao City, Philippines: implications to sustainable upland farming systems

Elevation is one of many components that influence agriculture, and this in turn affects the level of both inputs and outputs of farmers. This article focuses on the productivity and technical efficiency of 100 cocoa farms using cross-sectional data from areas ranging from 190 to 1021 m above sea level which were classified as low, medium, and high elevation in Davao City, considered as the chocolate capital of the Philippines. Using stochastic frontier analysis, the results showed that the cost of inputs per ha and the number of cocoa trees per ha significantly increase yield. Farms at high elevations were less technically efficient, as this entails lower temperatures and increased rainfall, and cocoa farming in those areas and conditions can be more challenging, especially with changes in farming practices, terrain, and distance to markets. Other significant variables were age of cocoa farms, married farmers, and age of the farmers. Older farms may be more developed, farmers who are married benefit from their spouses being able to readily contribute as farm labor, and lastly, older farmers' inefficiency may likely stem from nonadaptation of newer farming practices. With an average technical efficiency of 0.61, 0.63, and 0.26 in low, medium, and high elevation areas, respectively, farmers therefore have an incentive to improve farm practices and consider topographical variations found in high elevation areas. Recommendations for the improvement of technical efficiency of cocoa farms are better connectivity to markets, enhancing farm practices, and continuation and improvement of government programs on cocoa with an added emphasis on research. For farmers in high elevation areas, mitigating solutions such as sustainable agriculture practices and ecolabelling are key to improving efficiency and minimizing the potential negative impact on upland farming systems. Moreover, such adaptation measures may also contribute to sustainability of cocoa farming in high elevation areas.

Construction of a nomogram model to predict technical difficulty in performing laparoscopic sphincter-preserving radical resection for rectal cancer

BACKGROUND Colorectal surgeons are well aware that performing surgery for rectal cancer becomes more challenging in obese patients with narrow and deep pelvic cavities.Therefore,it is essential for colorectal surgeons to have a comprehensive understanding of pelvic structure prior to surgery and anticipate potential surgical difficulties.AIM To evaluate predictive parameters for technical challenges encountered during laparoscopic radical sphincter-preserving surgery for rectal cancer.METHODS We retrospectively gathered data from 162 consecutive patients who underwent laparoscopic radical sphincterpreserving surgery for rectal cancer.Three-dimensional reconstruction of pelvic bone and soft tissue parameters was conducted using computed tomography(CT)scans.Operative difficulty was categorized as either high or low,and multivariate logistic regression analysis was employed to identify predictors of operative difficulty,ultimately creating a nomogram.RESULTS Out of 162 patients,21(13.0%)were classified in the high surgical difficulty group,while 141(87.0%)were in the low surgical difficulty group.Multivariate logistic regression analysis showed that the surgical approach using laparoscopic intersphincteric dissection,intraoperative preventive ostomy,and the sacrococcygeal distance were independent risk factors for highly difficult laparoscopic radical sphincter-sparing surgery for rectal cancer(P<0.05).Conversely,the anterior-posterior diameter of pelvic inlet/sacrococcygeal distance was identified as a protective factor(P<0.05).A nomogram was subsequently constructed,demonstrating good predictive accuracy(C-index=0.834).CONCLUSION The surgical approach,intraoperative preventive ostomy,the sacrococcygeal distance,and the anterior-posterior diameter of pelvic inlet/sacrococcygeal distance could help to predict the difficulty of laparoscopic radical sphincter-preserving surgery.

Analysis of the Impact of Technical Trade Barriers on the Export of Toys-Based on Analysis of Zhejiang,China

Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This article aims to explore the impact of technical trade barriers on toy exports in Zhejiang Province and analyze countermeasures.Through literature review and some empirical analysis,it is found that technical trade barriers have greatly promoted the development of Zhejiang’s toy industry;however,they have also subjected it to impacts and pressures such as cost and technology.In response to the impact of technical trade barriers on toy exports,this article proposes corresponding countermeasures to avoid such barriers:firstly,establish a quality management system that complies with export product regulations to ensure that the products produced can meet international requirements and standards;secondly,reduce dependence on overseas markets;then enhance one’s own technology,and strengthen product innovation,in order to enhance the international competitiveness of the product and oneself;in addition,we should also explore diversified markets and expand the sales channels and coverage of our products.

ISO Certification and Technical Efficiency in the Banking Sector:An Evidence from WAEMU’s Countries Using the DEA Method

In the view of the international organization of standardization,the introduction of ISO standards is typical of quality management systems oriented towards strengthening the efficiency of enterprises.Business banks are not excluded from this requirement.The current study aims to evaluate the effect of ISO certification on the technical performance of WAEMU banks.Using BCEAO data(2020),the DEA model and Tobit estimates show that ISO certification has no effect on the efficiency scores of the banks in the sample.It is therefore appropriate for these banks to work on improving their business climate.

Discussion on the Application of Technical and Tactical Skills in Mixed Martial Arts Competitions

This article mainly analyzes the application of technical and tactical skills in mixed martial arts competitions,including mixed martial arts and its competition characteristics,the main application significance of technical and tactical skills in mixed martial arts competitions,and its primary application strategies.It is hoped that this analysis can provide some guidelines for the appropriate application of mixed martial arts athletes’technical and tactical skills to improve their winning rate in mixed martial arts competitions.

Analysis on Technical Structure and Competitiveness of ICT Manufacturing Industries

In order to analyze the technical structure and international comparative advantage of the information and communication technology(ICT)manufacturing industry,a complete set of ICT manufacturing product categories has been constructed by matching National Economical Industry Classification(GB/T4754-2017)with Harmonized System(HS)Codes,based on the relevant definitions in International Standard Industrial Classification(ISIC).The proposed definition overcomes inherent defects such as inaccurate scopes,lagging data and rough categories,which are characterized by commonly utilized product-level based classification approaches.Within the given framework,this paper has designed the technology content related indicators from the perspective of production distribution,and divided ICT product categories into high-end,medium-end and lowend manufacturing classifications according to respective global shares.Then,we have calculated international market shares(IMS),revealed comparative advantages(RCA),and market penetration rates(MPR)of ICT manufacturing exports for major economies from 2010 to 2021.Finally,development characterizations of ICT manufacturing industries for China’s Mainland are analyzed,and several practical suggestions are provided.

Myth and Digital Fantasy from the Perspective of Technical Aesthetics

The surreal space of digital technology development has created an unprecedented utopian mythological world.The virtual reality research started in the 1960s has gradually become a reality with the support of hardware technology.The media mode of observing the world by simulating human eyes with cameras is being replaced by computer simulation technology.The metaverse global vision based on virtual space and sense of time obscures the traditional perspective,and a novel progressive aesthetic category gradual y emerges.Starting with the aesthetic experience of myth brought by digital technology,this paper reviews the history of myth and analyzes the mental image of myth and religion to push the origin of life to a more profound realm.The contemporary“myth”following technological development changes the situation of human cognition of the world,separates the myth from the historical frame and relates it to the contemporary ongoing.

Socio-Economic and Technical Characteristics of Beef Cattle Breeding in Ndé Division, West Region of Cameroon

Insight is here provided into the socio-economic and technical characteristics of cattle production in the Ndé Division (West Cameroon region). Using a semi-structured questionnaire, information on the activity was assessed following onsite visits and interviewing breeders. Through a random sampling scheme, 110 breeders in the four subdivisions of the Ndé Division were shadowed. The majority (98.18%) of breeders were men aged 20 to 40 and married (91.82%). They belong to the Mbororo ethnic group, having cumulated more than 10 years in the activity. Most respondents (50.91%) did not attend school and earn their living mainly from livestock (78.18%). Cattle were raised for sale and to feed the breeder’s family (77.27%). The main mode of acquisition of animals was through inheritance (81.82%). The cattle breeds were mostly made up of white Fulani (70%), living in private farms using a combination of stake and barbed wires (67.27%) as fences. The combination of natural fodder and cooking salt was used by most breeders (59.09%) as a daily ration. Reproduction was by natural mating (97.07%). Parasites (internal and external) and foot-and-mouth disease were the main diseases reported by the majority of farmers. Self-treatment (50%) was the main prophylactic measure taken by farmers in case of disease symptoms. Cattle herders faced several challenges, such as insufficient pasture (67.27%), agro-pastoral conflicts (76.36%) and diseases (90.91%). Cattle breeding was rather a widespread activity with no particular restriction.

Technical Efficiency of"Master Switch"in Widening the Human Living Space by Fenlong Tillage

This paper reports"the fourth set"of drilling tillage after"ploughing(hoeing)"by manpower,animal power and tractor——Fenlong tillage technology(referred to as"Fenlong technology").It makes the cultivated land and saline alkali land transformed into"sponge"farmland through"drill bit"vertically digging into the soil,one-time deep cultivation,not disturbing soil layer,and granulating the soil,to bring about the effects of"expanding the land,releasing the natural force,water conservation,disaster reduction,carbon reduction,tillage saving,fertilizer saving and grain increasing",and can broaden the space for human survival and development.It has been applied to more than 50 crops in 28 provinces,including Guangxi,Hebei and Tibet.Without increasing the use of fertilizer and water,the yield of varieties in cultivated land increased by 10%-50%,while that in saline and alkaline land increased by 20%-100%.The storage of natural precipitation increased by 100%,and drought,high temperature and low temperature decreased by 20%-30%,and carbon sequestration and emission reduction reached 20%.It is proposed that China can implement the"dual strategy"platform of farmland,saline alkali land,rivers and water bodies constructing the"incremental""five new warehouses"of grain,water,fish,sugar,etc.and"increased grain return"abroad,to ensure national security.

The Impact of Fabric Weave and Anisotropy on the Poisson’s Ratio in Technical Fabrics

Poisson’s ratio changes during the tensile stress of technical fabric samples due to the anisotropy of technical fabrics.This paper examines the effects of the type of weave and the anisotropic characteristics of the technical fabric on maximum tensile force,corresponding elongation,work-to-maximum force,elasticity modulus,and Poisson’s ratio when axial tensile forces are applied to samples cut at various angles in the direction of the weft yarns of the technical fabric.In the lab,3 cotton fabric samples of constant warp and weft density with different structural weave types(plain weave,twill weave,atlas weave)were subjected to the tensile force until they broke at the following angles:0°,15°,30°,45°,60°,75°,90°.Based on the different measured values of technical fabric stretching in the longitudinal direction and lateral narrowing,Poisson’s ratio is calculated.The Poisson’s ratio was calculated up to a relative elongation of the fabric of 8%,as the buckling of the fabric occurs according to this elongation value.According to the results presented in this paper,the type of weave of the fabric,the direction of tensile force,and the relative narrowing of the technical fabrics all play important roles in the Poisson’s ratio value.The Poisson’s ratio curve of a technical fabric under tensile stress(i.e.elongation)is primarily determined by its behaviour in the opposite direction of the elongation.The change in the value of the Poisson’s ratio is represented by a graph that first increases nonlinearly and then decreases after reaching its maximum value.

A STUDY ON THE TECHNICAL PROPERTIES OF PEPSET NO-BAKE RESIN-BONDED SAND AND FACTORS HAVING INFLUENCE

通过试验研究了PEPSET树脂自硬砂工艺应用于铝铸件生产的性能及其影响因素。指出 PEPSET 树脂自硬砂工艺在硬化速度、流动性、发气性、溃散性等方面性能良好, 利于复杂铝铸件的造型制芯,有望成为树脂自硬砂工艺的一个重要发展方向。

Analysis on the Technical Standardization System of Juvenile Product in Europe and the United States of America and Strategies of Technical Measures of Trade

China is the largest country in the trade of juvenile products in the world. However, the products suffered the loss of technical barriers to trade from Europe and the United States of America increased year by year. This paper analyzes the standard system of juvenile products in Europe and the United States of America with the method of standard comparison, to find its relative technical advantages, explore the reasons for the recall notification of juvenile products exported to the above regions by China, propose strategies for breaking down the technical measures of trade, and promote the development of international juvenile product export trade.

Technical foundation research on high resolution remote sensing system of China's coastal zone

China's coastal zone is a region with a highly developed economy that contrasts clearly with the slow paced regular investigation on its natural environment,which cannot keep pace with the requirement of economic development and modern management.Laying a theoretical foundation for the modern management of China's costal zone is aimed at. This research focuses on the following processing and analyzing technologies for coastal zone high-resolution remote sensing data: organization and management of large amounts of high-resolution remote sensing data, quick and precise spatial positioning system,algorithms for image fusion in feature level and coastal zone feature extraction. They will form a technical foundation of the system. And, if combined with other research results such as coastal zone remote sensing classification system and its mapping subsystem, an advanced technical frame for remote sensing investigation of coastal zone resource will be constructed.

Technical efficiency of hybrid maize growers: A stochastic frontier model approach

This study investigated the effect of credit constraints and credit unconstraints on the technical efficiency of hybrid maize growers in the Khyber Pakhtunkhwa Province(KPK) of Pakistan. The primary data were collected by a direct elicitation method from 510 maize growers of KPK Province. Stochastic frontier model techniques were used for technical efficiency analyses. The results revealed that the mean technical efficiency difference between the two groups was 10.2%. The results of technical inefficiency effect modeling demonstrated that education of the household head, family size, number of married family members, off-farm income, farming experience, tractor drill, water irrigation through a lined course, certified seed, extension services, household saving variables, and a credit size variable had positive effects on technical efficiency for both credit constrained farmers(CCFs) and credit unconstrained farmers(UCCFs). In addition, age of household head and fragmented land values had negative effects on technical efficiency for both groups. However, the interest rate had positive and negative impacts on the technical efficiency of CCFs and UCCFs, respectively. Our results have significant implications for policies related to land use, interest rate, and banking sector expansion in the rural areas of Pakistan.

Approach of technical decision-making by element flow analysis and Monte-Carlo simulation of municipal solid waste stream

This paper deals with the procedure and methodology which can be used to select the optimal treatment and disposal technology of municipal solid waste （MSW）, and to provide practical and effective technical support to policy-making, on the basis of study on solid waste management status and development trend in China and abroad. Focusing on various treatment and disposal technologies and processes of MSW, this study established a Monte-Carlo mathematical model of cost minimization for MSW handling subjected to environmental constraints. A new method of element stream （such as C, H, O, N, S） analysis in combination with economic stream analysis of MSW was developed. By following the streams of different treatment processes consisting of various techniques from generation, separation, transfer, transport, treatment, recycling and disposal of the wastes, the element constitution as well as its economic distribution in terms of possibility functions was identified. Every technique step was evaluated economically. The Mont-Carlo method was then conducted for model calibration. Sensitivity analysis was also carried out to identify the most sensitive factors. Model calibration indicated that landfill with power generation of landfill gas was economically the optimal technology at the present stage under the condition of more than 58% of C, H, O, N, S going to landfill. Whether or not to generate electricity was the most sensitive factor. If landfilling cost increases, MSW separation treatment was recommended by screening first followed with incinerating partially and composting partially with residue landfilling. The possibility of incineration model selection as the optimal technology was affected by the city scale. For big cities and metropolitans with large MSW generation, possibility for constructing large-scale incineration facilities increases, whereas, for middle and small cities, the effectiveness of incinerating waste decreases.

Comparison of Economical and Technical Indices on Rare Earth Separation Processes of Bastnasite by Solvent Extraction

According to the composition of rare earth ores and the market, several feasible separation processes of bastnasite in Baotou of Inner Mongolia and Mianning of Sichuan by solvent extraction in HEH(EHP) HCl system were presented. The parameters of the processes such as stage numbers, volume of mixer settler, fixed investment of extractant and rare earths, consumption of chemical reagents including HCl and NH 3 were calculated and compared. The results show that the novel scheme can save cost more than 20% compared with those of others. By the economical analysis, the optimized separation process of bastnasite was obtained, which can be applied to the treatment of monazite too.

Technical problems produced by the Bravo pH test in nonerosive reflux disease patients

AIM: To evaluate the technical failures of the Bravo pH test in a population with nonerosive gastroesophageal reflux disease. METHODS: Over the course of a year, we prospectively studied a population of 66 nonerosive reflux disease patients who received a Bravo pH test. The number and frequency of all technical failures were documented, quantified and analyzed. RESULTS: A total of 66 patients, with a mean age of 41.7 years, were studied. Technical failures occurred in 15.15% of the sample. The most frequent failures were due to poor data reception (4.5%), early dislodgement (4.5%) and capsule removal (6.1%). CONCLUSION: The Bravo capsule pH test involves a low but non-negligible rate of technical problems, a fact that must always be considered by physicians.

Technical and economic demands of HVDC submarine cable technology for Global Energy Interconnection

Power transmission across the sea is an important part of global energy interconnection(GEI).To support the construction of GEI and to serve the needs of future clean energy trans-sea transportation and offshore wind power development,this study a)analyzes the requirements of the GEI backbone network pertaining to direct current(DC)submarine cable technology,and b)defines the key technical and economic indices of ultrahigh-voltage direct current(UHVDC)submarine cable based on theoretical computations.The research is based on the thermoelectric coupling model and the finite element method.It is shown that the dielectric strength of the insulating materials of the±800 kV~±1100 kV/4000 MW^12000 MW UHVDC submarine cable(extrusion insulation)should be not less than 43~65 kV/mm,while the heat resistance is not less than 110°C.As the cost of submarine cable is 5~10 times higher than that of the overhead line,the project investment need to be decreased to a level within the economical carrying capacity to guarantee extensive applicability of the HVDC submarine cable technology.