BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentrax...BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.展开更多
The linear dispersion relation of a trapezoidally corrugated slow wave structure （TCSWS） is analyzed and presented. The size parameters of the TCSWS are chosen in such a way that they operate in the x-band frequency...The linear dispersion relation of a trapezoidally corrugated slow wave structure （TCSWS） is analyzed and presented. The size parameters of the TCSWS are chosen in such a way that they operate in the x-band frequency range. The dispersion relation is solved by utilizing the Rayleigh-Fourier method by expressing the radial function in terms of the Fourier series. A highly accurate synthetic technique is also applied to determine the complete dispersion characteristics from experimentally measured resonances （cold test）. Periodic structures resonate at specific frequencies when the terminals are shorted numerical calculation, synthetic technique and cold appropriately. The dispersion characteristics obtained from test are compared, and an excellent agreement is achieved.展开更多
The analytical method (AM) for separation of composite waves is presented based on the Hilbert transform. It is applicable to both regular and irregular trains; of waves. The wave data series measured with two wave ga...The analytical method (AM) for separation of composite waves is presented based on the Hilbert transform. It is applicable to both regular and irregular trains; of waves. The wave data series measured with two wave gauges in the experiments are separated into two series of incident and reflected waves. Then, the reflection coefficient can be easily obtained. The arrival of reflected waves can also be detected for improvement of the accuracy of the reflection coefficient. The reflection performance of the physical model can be estimated exactly without calculation of wave height and phase difference. Numerical samples developed to test the method are proved to be accurate. Physical experiments are conducted and compared with Goda's method and satisfactory results are obtained.展开更多
In the paper, the variable separation approach, homoclinic test technique and bilinear method are successfullyextended to a (1+1)-dimensional Caudry-Dodd-Gibbon-Sawada-Kortera (CDGSK) system, respectively.Basedon the ...In the paper, the variable separation approach, homoclinic test technique and bilinear method are successfullyextended to a (1+1)-dimensional Caudry-Dodd-Gibbon-Sawada-Kortera (CDGSK) system, respectively.Basedon the derived exact solutions, some significant types of localized excitations such as standing waves, periodic waves,solitary waves are simultaneously derived from the (1+1)-dimensional Caudry-Dodd-Gibbon-Sawada-Kortera systemby entrancing appropriate parameters.展开更多
基金Supported by 2022 Educational Research Program for Young and Middle-aged Teachers in Fujian Province(Science and Technology),No.JAT220107.
文摘BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.
文摘The linear dispersion relation of a trapezoidally corrugated slow wave structure （TCSWS） is analyzed and presented. The size parameters of the TCSWS are chosen in such a way that they operate in the x-band frequency range. The dispersion relation is solved by utilizing the Rayleigh-Fourier method by expressing the radial function in terms of the Fourier series. A highly accurate synthetic technique is also applied to determine the complete dispersion characteristics from experimentally measured resonances （cold test）. Periodic structures resonate at specific frequencies when the terminals are shorted numerical calculation, synthetic technique and cold appropriately. The dispersion characteristics obtained from test are compared, and an excellent agreement is achieved.
基金This project was financially supported by the Trans-Century Training Program Fund for the Talent,Ministry of Education of China.
文摘The analytical method (AM) for separation of composite waves is presented based on the Hilbert transform. It is applicable to both regular and irregular trains; of waves. The wave data series measured with two wave gauges in the experiments are separated into two series of incident and reflected waves. Then, the reflection coefficient can be easily obtained. The arrival of reflected waves can also be detected for improvement of the accuracy of the reflection coefficient. The reflection performance of the physical model can be estimated exactly without calculation of wave height and phase difference. Numerical samples developed to test the method are proved to be accurate. Physical experiments are conducted and compared with Goda's method and satisfactory results are obtained.
基金Supported the Natural Science Foundation of Guangdong Province of China under Grant No.10151200501000008 the Special Foundation of Talent Engineering of Guangdong Province+2 种基金the Scientific Research Foundation of Key Discipline of Guangdong Shaoguan University under Grant No.KZ2009001the Natural Science Foundation of Zhejiang Province of China under Grant Nos.Y604106 and Y606181the Foundation of New Century "151 Talent Engineering" of Zhejiang Province
文摘In the paper, the variable separation approach, homoclinic test technique and bilinear method are successfullyextended to a (1+1)-dimensional Caudry-Dodd-Gibbon-Sawada-Kortera (CDGSK) system, respectively.Basedon the derived exact solutions, some significant types of localized excitations such as standing waves, periodic waves,solitary waves are simultaneously derived from the (1+1)-dimensional Caudry-Dodd-Gibbon-Sawada-Kortera systemby entrancing appropriate parameters.
