The Impact of Digital Technology on Healthcare Delivery and Patient Outcomes

Digital technology has fundamentally transformed healthcare delivery, exerting profound influence on patient outcomes. This paper delves into the roles played by telemedicine, electronic health records (EHRs), and mobile health applications in augmenting healthcare services. The objective is to scrutinize the ways in which these digital innovations enhance healthcare delivery and patient outcomes, while also identifying the attendant challenges in their adoption. To achieve this, a rigorous literature review encompassing peer-reviewed articles, reports, and case studies that examine the impact of digital technology in healthcare settings was conducted. The findings underscore that digital technology significantly bolsters patient care by enhancing access, operational efficiency, and diagnostic accuracy. Nonetheless, persistent challenges such as safeguarding data privacy, ensuring interoperability across systems, and managing implementation costs continue to pose significant hurdles.

Geospatial Technology Integration in Smart City Frameworks for Achieving Climate Neutrality by 2050: A Case Study of Limassol Municipality, Cyprus

This study investigated the integration of geospatial technologies within smart city frameworks to achieve the European Union’s climate neutrality goals by 2050. Focusing on rapid urbanization and escalating climate challenges, the research analyzed how smart city frameworks, aligned with climate neutrality objectives, leverage geospatial technologies for urban planning and climate action. The study included case studies from three leading European cities, extracting lessons and best practices in implementing Climate City Contracts across sectors like energy, transport, and waste management. These insights highlighted the essential role of EU and national authorities in providing technical, regulatory, and financial support. Additionally, the paper presented the application of a WEBGIS platform in Limassol Municipality, Cyprus, demonstrating citizen engagement and acceptance of the proposed geospatial framework. Concluding with recommendations for future research, the study contributed significant insights into the advancement of urban sustainability and the effectiveness of geospatial technologies in smart city initiatives for combating climate change.

Passive IoT Localization Technology Based on SD-PDOA in NLOS and Multi-Path Environments

Addressing the challenges of passive Radio Frequency Identification(RFID)indoor localization technology in Non-Line-of-Sight(NLoS)and multipath environments,this paper presents an innovative approach by introducing a combined technology integrating an improved Kalman Filter with Space Domain Phase Difference of Arrival(SD-PDOA)and Received Signal Strength Indicator(RSSI).This methodology utilizes the distinct channel characteristics in multipath and NLoS contexts to effectively filter out interference and accurately extract localization information,thereby facilitating high precision and stability in passive RFID localization.The efficacy of this approach is demonstrated through detailed simulations and empirical tests conducted on a custom-built experimental platform consisting of passive RFID tags and an R420 reader.The findings are significant:in NLoS conditions,the four-antenna localization system achieved a notable localization accuracy of 0.25 m at a distance of 5 m.In complex multipath environments,this system achieved a localization accuracy of approximately 0.5 m at a distance of 5 m.When compared to conventional passive localization methods,our proposed solution exhibits a substantial improvement in indoor localization accuracy under NLoS and multipath conditions.This research provides a robust and effective technical solution for high-precision passive indoor localization in the Internet of Things(IoT)system,marking a significant advancement in the field.

Enhancing transjugular intrahepatic portosystemic shunt procedure efficiency with digital subtraction angiography image overlay technology in esophagogastric variceal bleeding

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS procedure.METHODS We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided group.Our analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the surgery.RESULTS The study included 52 patients with esophagogastric varices due to chronic hepatic schistosomiasis.Results demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided group.Additionally,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both groups.Notably,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.

Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.

Application and prospects of spatial information technology in CO_(2)sequestration monitoring

This paper systematically reviews the current applications of various spatial information technologies in CO_(2)sequestration monitoring,analyzes the challenges faced by spatial information technologies in CO_(2)sequestration monitoring,and prospects the development of spatial information technologies in CO_(2)sequestration monitoring.Currently,the spatial information technologies applied in CO_(2)sequestration monitoring mainly include five categories:eddy covariance method,remote sensing technology,geographic information system,Internet of Things technology,and global navigation satellite system.These technologies are involved in three aspects:monitoring data acquisition,positioning and data transmission,and data management and decision support.Challenges faced by the spatial information technologies in CO_(2)sequestration monitoring include:selecting spatial information technologies that match different monitoring purposes,different platforms,and different monitoring sites;establishing effective data storage and computing capabilities to cope with the broad sources and large volumes of monitoring data;and promoting collaborative operations by interacting and validating spatial information technologies with mature monitoring technologies.In the future,it is necessary to establish methods and standards for designing spatial information technology monitoring schemes,develop collaborative application methods for cross-scale monitoring technologies,integrate spatial information technologies with artificial intelligence and high-performance computing technologies,and accelerate the application of spatial information technologies in carbon sequestration projects in China.

Advances in the Fabrication of Perovskite Solar Cells by RolltoRoll Technology

In recent years,perovskite solar cells(PSCs)have garnered significant attention as a potential mainstream technology in the future photovol-taic(PV)market.This is primarily attributed to their salient advantages including high efficiency,low cost,and ease of preparation.Nota-bly,the power conversion efficiency(PCE)of PSCs has experienced a remarkable increase from 3.8%in 2009 to over 26%at present.Conse-quently,the adoption of roll-to-roll(R2R)technology for PSCs is considered a crucial step towards their successful commercialization.This arti-de reviews the diverse substrates,scalable deposition techniques(such as solution-based knife-coating and spraying technology),and optimiza.tion procedures employed in recent years to enhance device performance within the R2R process.Additionally,novel perspectives are presented to enrich the existing knowledge in this field.

A Study on the Path of Promoting External Dissemination of Regional Culture with Translation Technology under the Background of New Quality Productivity

With the introduction of the concept of new quality productivity characterized by high technology,efficiency,and quality,various industries in China have ignited a high spirit of innovation and development.Against this background,this article analyzes the significance and current situation of the external dissemination of regional culture and combines the application of translation technology empowered by new quality productivity to explore a path suitable for the wider,more effective,and higher-quality external dissemination of regional culture.The aim is to provide practical experience for promoting the effective dissemination of regional culture in China to the world and better build a cultural power.

Development Trend and Prediction of Stem Cell Technology in China from the Perspective of Patent

Objective To provide new ideas for the effective treatment of many serious diseases and to solve many major medical problems faced by mankind.Methods In this paper,the invention patents in the field of stem cells in China from 2010 to 2020 were taken as the research object,and the technology status quo in the field of stem cells was analyzed to predict the future development direction through quantitative analysis method.Results and Conclusion The development of stem cell technology in China is in a period of growth with great potential.Therefore,it is necessary to strengthen the ability of Chinese universities to combine production,education and research.Nowadays,the hotspots in stem cell technology are using culture medium to improve cell proliferation ability,production efficiency,and to induce differentiated cells.Meanwhile,the production efficiency of embryonic stem cells should be improved,and the immunomodulatory effect of embryonic stem cells can be exerted to screen drugs.Besides,the function of hematopoietic stem cells should be enhanced and apply mesenchymal cells in therapy.Since the potential technological gaps are the improvement of therapy,induced differentiation and efficiency of pluripotent stem cells,the improvement of progenitor cell proliferation and the control of cost,we should strengthen R&D investment in culture medium,embryonic stem cells and other technical fields,and achieve the purpose of reducing R&D costs and improving R&D efficiency.

A new horizon for neuroscience:terahertz biotechnology in brain research

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain sciences.In this article,we review the development of terahertz biotechnology and its applications in the field of neuropsychiatry.Available evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin deficit.In vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric diseases.Although the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic applications.However,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical applications.This review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

Application of Participatory Monitoring and Evaluation in Development of Animal Husbandry Technology

[Objective] This study aimed to provide references for the application of participatory monitoring and evaluation in the development of animal husbandry tech- nology. [Method] With the livelihood improvement program for agricultural and pas- toral area in northern Yunnan as the example, the development process of partici- patory animal husbandry was overviewed. And the monitoring and evaluation pro- cesses of participatory animal husbandry were introduced and analyzed. [Result] The monitoring and evaluation indicator system of participatory animal husbandry technol- ogy included 4 layers, namely technology, institutional system, personnel ability con- struction and effectiveness, and 11 third-level indicators, namely, technical characteristics, superiority-inferiority comparison, community and farmers, technical personnel, project personnel, economic indicators and social indicators. [Conclusion] This study provided the references for the application of participatory monitoring and evaluation in the development of animal husbandry technology.

Study on Driving Technology Innovation Using Patent Management Mechanism

In order to improve the cigarette enterprise technology innovation and patent management status, the macro work should start from the four aspects of patent ideology introduction, patent organization design, perfecting patent system and implementation of specific measures, and attention should be attached to strengthen the cooperation of the cigarette enterprise management departments. On the other hand, Jn the microscopic work level, it should build the culture atmosphere of the entire tobacco industry respect intellectual property rights, actively cultivate the na- tional patent agents and patent engineers, and gradually promote the patent work to develop in the direction of specialization, self-independence, so as to construct a scientific mechanism for patent management, and enhance the core competitiveness of the tobacco industry.

基于QBD法和PAT法的经典名方制剂示例研究教学改革探讨

目的探究质量源于设计(QBD)法与过程分析技术(PAT)法在经典名方制剂示例研究课程教学中的应用及其推进教学改革中的作用。方法选择2023年1~12月两个学期选课成功的学生作为研究对象,采用传统教学模式与经QBD法设计的教学模式对比教学,通过学生的分段成绩和调查问卷的形式考察两种教学模式的教学效果。结果教学结束后,传统教学模式与经QBD法设计的教学模式学生得分情况:预实验设计平均成绩分别为54分和76分,实验操作技能平均成绩分别为75分和90分,实验报告平均成绩为69分和87分,期末实验方案设计平均成绩分别为65分和89分;学生的满意度调查结果:不满意为23%和5%,较为满意为38%和24%,满意为39%和71%。结论经QBD法设计的教学模式教学效果优于传统教学模式,能明显提升学生的课程学习和科研能力。同时,基于PAT理念,提出了对该课程教学的一些改革设想和具体实施方法。

基于PAT 模型的下肢骨折康复心流要素研究

研究基于PAT(个体-产品-任务模型,Person-Artifact-Task的简称)心流模型,对下肢骨折康复中的心流体验要素进行研究,以期提升下肢骨折康复人群训练体验。采用半结构化访谈提取心流关键词,再结合成熟的心流前因要素研究结果和PAT模型构建个体动机-康复产品-训练任务模型并设计量表,获取目标人群原始数据。以此为基础,建立下肢骨折康复心流体验结构方程模型,得到影响心流产生各项要素的权重分布,最后根据权重分布提出下肢骨折康复产品设计策略。研究深度解析心流体验要素的量化方法,提升康复产品的用户体验,为下肢骨折康复产品设计提供有益参考。

板栗PAT基因家族成员鉴定及不同胁迫响应分析

【目的】鉴定和分析板栗PAT基因家族及其对不同胁迫的响应,探究板栗PAT基因家族的抗逆功能。【方法】在板栗全基因组水平上进行搜索和鉴定板栗PAT基因家族成员,利用生物信息学方法研究其系统发育进化树、基因结构和motif、蛋白理化性质、染色体定位、共线性和启动子顺式元件等。以燕山红栗为试验材料,分析盐胁迫、抗病胁迫和干旱胁迫处理对板栗PAT基因家族表达模式的影响。【结果】在板栗基因组中共鉴定出包含DHHC结构域的21个PAT基因家族成员,他们与24个AtPAT基因家族成员共聚集为6个亚组;大多数CmPAT家族成员为具有亲水性的碱性稳定蛋白;21个PAT基因家族成员不均匀地分布在板栗的9条染色体上;在CmPAT基因启动子区域鉴定到多种非生物胁迫及激素响应元件;表达模式分析表明,多个CmPAT基因不同程度地参与抗病、干旱、盐胁迫响应。【结论】共鉴定了21个板栗PAT基因家族成员,同时筛选到CmPAT24、CmPAT7、CmPAT14可能共同参与了盐胁迫和干旱胁迫的调控,CmPAT7可能共同参与盐胁迫、干旱胁迫、抗病胁迫的调控。

Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: A review of current methods

Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.Data Sources: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key articles.Results: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR technology.Conclusions: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods.

Patent Citations Analysis and Its Value in Research Evaluation： A Review and a New Approach to Map Technology-relevant Research

Purpose： First, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a novel mapping approach to identify technology-relevant research based on the papers cited by and referring to the SNPRs. Design/methodology/approach： In the review part we discuss the context of SNPRs such as the time lags between scientific achievements and inventions. Also patent-to-patent citation is addressed particularly because this type of patent citation analysis is a major element in the assessment of the economic value of patents. We also review the research on the role of universities and researchers in technological development, with important issues such as universities as sources of technological knowledge and inventor-author relations. We conclude the review part of this paper with an overview of recent research on mapping and network analysis of the science and technology interface and of technological progress in interaction with science. In the second part we apply new techniques for the direct visualization of the cited and citing relations of SNPRs, the mapping of the landscape around SNPRs by bibliographic coupling and co-citation analysis, and the mapping of the conceptual environment of SNPRs by keyword co-occurrence analysis. Findings： We discuss several properties of SNPRs. Only a small minority of publications covered by the Web of Science or Scopus are cited by patents, about 3%-4%. However, for publications based on university-industry collaboration the number of SNPRs is considerably higher, around 15%. The proposed mapping methodology based on a ＂second order SNPR approach＂ enables a better assessment of the technological relevance of research. Research limitations： The main limitation is that a more advanced merging of patent and publication data, in particular unification of author and inventor names, in still a necessity. Practical implications： The proposed mapping methodology enables the creation of a database of technology-relevant papers （TRPs）. In a bibliometric assessment the publications of research groups, research programs or institutes can be matched with the TRPs and thus the extent to which the work of groups, programs or institutes are relevant for technological development can be measured. Originality/value： The review part examines a wide range of findings in the research of patent citation analysis. The mapping approach to identify a broad range of technologyrelevant papers is novel and offers new opportunities in research evaluation practices.

Influence of Information Technology on Social Spatial Behaviors of Urban Residents——Case of Nanjing City in China

Taking Nanjing as a case, the paper explains the spatial behavior differences existing in the information technology use among different groups of residents and households, by virtue of analyzing the survey data of urban households in the 11 districts of Nanjing, from the social, spatial, life and other non-technical angles. Also it makes various analyses and evaluation quantitatively and qualitatively on the social and spatial effect of information technology. The results show that the new technology is changing the social spatial behaviors of urban residents. New behavioral spaces of urban family such as telecommuting, email and QQ have begun to emerge. With the help of Internet, the communication scope of families has expanded greatly, and more new forms of publicizing community information have begun to emerge. Telecommunication contact forms have been developing swiftly, and their frequencies of contact have been increasing dramatically.

IMPACT OF OPERATING COSTS ON INVESTMENT STRATEGIES IN NEW TECHNOLOGY ADOPTION WITH A FURTHER NEW TECHNOLOGY ANTICIPATED

The adoption of new technologies often represents a crucial component of firms＇ investment decisions. This paper studies a dynamic duopoly model in which two firms compete in adoption of current technology with a further new technology anticipated. Here it is assumed that the operating costs are not zero which has more explanatory power of the real world. There exist three kinds of equilibria that may occur in adoption of current technology, which mainly depends on the level of operating costs and the first-move advantage. It shows that the faster technological substitution or innovation encourages the leader to invest earlier while induces the follower to invest later. Furthermore,like the investment costs,with the increase of operating costs the follower tends to invest later while the leader tends to invest earlier ,the investment thresholds are more sensitive to the change of operating costs than that of investment costs.

Digital Technology Empowers China's Service Sector Growth:Mechanism and Implementation Path

Digital technology is an instrument and vehicle for digital empowerment and the development of the digital economy.Digital applications in the service sector have spawned new business modes over recent years such as industrial internet platforms,new retail and online education,which have contributed to China s service sector growth and transition.With the help of digital technology,the service sector has maintained rapid growth,improved in terms of structure,quality and efficiency,increased public welfare,and enhanced indigenous innovation.In light of inadequate and uneven progress of digitalization and insufficient factor support and government incentives,we suggest that the government further advance digitalization development across the board,bolster factor support,and enhance policymaking.